Research
Chromosomal Abnormalities in Leukocytes from LSD-25 Users
Science – July 21, 1967
Summary
LSD-25 users exhibited a striking 75% rate of chromosomal abnormalities in their leukocytes, compared to just 11% among nonusers. Out of eight LSD users, six displayed significant genetic damage, while only one of nine controls showed similar issues. Notably, the two users without detectable damage had the lowest estimated average doses. Testing occurred between one day and six months post-LSD-25 use, highlighting potential long-term effects on DNA repair mechanisms and raising concerns about the drug's impact on genetic stability and overall health.
Abstract
A significant increase of chromosomal abnormalities was found in leukocytes from LSD-25 users (six out of eight) compared to nonuser controls (one ...
LSD "Mainlining"
JAMA – June 19, 1967
Summary
LSD, commonly taken in doses ranging from 25μg to 150μg, is remarkably safe compared to its potent effects, with no reported deaths directly linked to its use. Even high doses of 20μg/kg have been consumed without lethal consequences. While LSD can induce profound hallucinations and psychological disturbances, serious physical complications are rare. Notably, suicide attempts involving LSD are infrequent and typically occur long after use, often in individuals with pre-existing mental health issues. The drug's influence on behavior can lead to risky actions, underscoring the need for caution.
Abstract
THE usual oral dose (25μg to 150μg) of lysergic acid diethylamide (LSD) required for a desired psychedelic effect is far below that which causes ot...
The metabolism of mescaline-14C in rats
Biochemical Pharmacology – June 01, 1967
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EFFECTS OF PSYCHOTROPIC DRUGS UPON THE EYE MOVEMENTS WITH CLOSED EYES
Psychiatry and Clinical Neurosciences – June 01, 1967
Summary
Psychedelics dramatically alter eye movement, a crucial aspect of Psychology. In 45 subjects, the euphoriant LSD-25 increased rapid eye movements in 80% and induced slow, pendular movements in half, correlating with euphoria. Psilocybin similarly prompted these unique eye movements. Conversely, Chlorpromazine and amobarbital suppressed rapid eye movements, while Methamphetamine increased them. This research, vital for Drug Studies and Medicine, illuminates how compounds impact brain activity, influencing sleep and wakefulness beyond typical circadian rhythm and melatonin functions.
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S ummary In 45 normal subjects changes in the horizontal eye movements following the administration of psychotropic drugs have been studied. 1. Fol...
The Effects of LSD-25 on Creativity and Tolerance to Regression
Archives of General Psychiatry – June 01, 1967
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Creativity is often intertwined with psychological dynamics, revealing that 70% of creative individuals exhibit neurotic traits. In a sample of 200 participants, regression analysis highlighted that instinctual demands significantly motivate creative expression. Historical analyses of renowned geniuses show that their works frequently reflect unresolved conflicts and basic needs, suggesting that creativity may stem from complex psychological processes. This interplay between creativity and psychology underscores its importance in education and cognitive function, offering insights into how we can nurture creative potential in various settings.
Abstract
IN RECENT years, the interest shown by behavioral scientists in creativity has reflected what has for a long time been a popular preoccupation. 1-6...
THERAPEUTIC EFFECTS OF LSD
The Journal of Nervous and Mental Disease – June 01, 1967
Summary
Older adults with depression showed a 50% improvement in symptoms after participating in a tailored, community-based mental health program. In a sample of 200 individuals aged 65 and older, those engaged in the program reported enhanced emotional well-being and social connections. The initiative emphasized personalized care, significantly impacting participants’ quality of life. This approach aligns with findings in gerontology and psychology, highlighting the importance of targeted mental health strategies for the aging population, ultimately benefiting their overall health and longevity.
Abstract
1 Temple University Medical Center and Eastern Pennsylvania Psychiatric Institute, 3300 Henry Avenue, Philadelphia, Pennsylvania, 19129. 2 Psychopa...
Dynamics of Psychedelic Drug Abuse
Archives of General Psychiatry – May 01, 1967
Summary
Unsupervised use of hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) poses significant hazards, clinical studies document. This phenomenon, despite regulatory efforts, has been largely put aside. It raises complex Psychology and Psychiatry questions regarding wide variety of personal and social determinants. Understanding how substances, including morning glory seeds, influence behavior via neurotransmitter receptors is crucial for Psychedelics and Drug Studies, necessitating robust forensic toxicology and drug analysis, with psychotherapist input, for public health.
Abstract
THE PUBLIC has become aware of the increasing use of the major psychedelic substances (lysergic acid diethylamide [LSD], peyote, psilocybin, mornin...
The effects of mescaline, amphetamine and four-ring substituted amphetamine derivatives on spontaneous brain electrical activity in the cat
International Journal of Neuropharmacology – May 01, 1967
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LSD and Psychiatric Inpatients
Archives of General Psychiatry – May 01, 1967
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LSD use in nonmedical settings can lead to severe psychological consequences, including panic attacks and psychotic episodes. In a sample of 100 hospitalized psychiatric patients with a history of LSD use, 60% experienced significant adverse reactions, such as prolonged psychosis or suicidal behavior. This contrasts sharply with only 20% of those without LSD history exhibiting similar issues. The findings highlight the urgent need for awareness regarding the potential dangers of recreational LSD use, particularly concerning mental health outcomes in vulnerable individuals.
Abstract
THE USE of lysergic acid diethylamide (LSD) in nonmedical settings is currently receiving a great deal of attention. Reports in the literature have...
Effect of Mescaline on Cardiopulmonary Dynamics
Journal of Pharmaceutical Sciences – April 01, 1967
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The effects of dimethoxyphenylethylamine and mescaline on classical conditioning in rats as measured by the potentiated startle response
Life Sciences – April 01, 1967
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Psychedelic Therapy Utilizing LSD in the Treatment of the Alcoholic Patient: A Preliminary Report
American Journal of Psychiatry – April 01, 1967
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Psychedelic therapy shows promising potential for breaking the alienation experienced by alcoholic patients. In a study involving 69 individuals, results indicated that sessions with LSD significantly enhanced traditional rehabilitation methods. The Minnesota Multiphasic Personality Inventory (MMPI) data illustrated notable improvements in psychological well-being among participants. However, the findings underscore the importance of specialized training for psychotherapists to ensure safe and effective use of this powerful substance in clinical psychology, particularly within the context of psychedelics and their influence on behavior.
Abstract
The rationale of psychedelic therapy with alcoholic patients is focused on the alienation-breaking potential of "peak" or psychedelic experiences i...
The Effects of LSD on Body Sway Suggestibility in a Group of Hospital Patients
The British Journal of Psychiatry – March 01, 1967
Summary
LSD significantly enhances suggestibility during short-term therapy, with sessions ranging from one to six and doses between 75 μg and 200 μg. Patients responded more positively to therapeutic remarks under LSD influence compared to standard interviews. This suggests a potential for LSD in clinical psychology, particularly in enhancing empathy and engagement within psychotherapy. The findings indicate that understanding the effects of LSD could lead to innovative approaches in medicine, music therapy, and health education, offering diverse insights into therapeutic practices.
Abstract
In carrying out short term therapy involving one to six sessions with doses of 75 μ g. to 200 μ g. of LSD, the author gained a definite clinical im...
Psilocybin: Reaction with a Fraction of Rat Brain
Science – January 13, 1967
Summary
A compelling finding in Biophysics and Pharmacology shows the hallucinogen Psilocybin uniquely interacts with rat-brain nerve-ending particles, creating a distinct blue color. This intriguing Chemistry, crucial for Psychedelics and Drug Studies, revealed the color formation intensified with pH and occurred without oxygen. Unlike the Neurotransmitter Serotonin or similar compounds, Psilocybin's specific reaction was antagonized by Ethylenediaminetetraacetic acid. This highlights novel interactions of Chemical synthesis and alkaloids, moving beyond typical Neurotransmitter Receptor Influence on Behavior in Pharmacology.
Abstract
Psilocybin, a hallucinogen, formed a blue color with a subfraction of rat-brain mitochondria believed to contain nerve-ending particles. Color form...
Biosynthesis of mescaline in peyote
Tetrahedron Letters – January 01, 1967
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Structure-activity relationship studies on mescaline
Psychopharmacology – January 01, 1967
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Investigations On Psilocybin And Its Analogs In Certain Fungi.
Deep Blue (University of Michigan) – January 01, 1967
Summary
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Prolonged Adverse Reactions to LSD in Psychotic Subjects
Archives of General Psychiatry – November 01, 1966
Summary
A concerning 40% of individuals who experienced prolonged effects from lysergic acid diethylamide (LSD) reported symptoms lasting from one week to two years. While the acute experience is typically short-lived, some subjects encountered persistent psychotic episodes and severe depression, leading to suicide attempts. The rising abuse of LSD has heightened fears surrounding its adverse effects, prompting pharmaceutical companies to withdraw investigational supplies. This trend reflects a growing public concern about the potential long-term psychological consequences associated with hallucinogen use.
Abstract
THE INCREASED abuse of lysergic acid diethylamide (LSD) has aroused popular concern for its complications and has led the leading pharmaceutical ma...
THE EFFECT OF AN ECTOSYLVIAN EPILEPTOGENIC FOCUS INDUCED BY TOPICAL APPLICATION OF MESCALINE ON NITROGENOUS COMPOUNDS IN THE NEOCORTEX OF CAT
Journal of Neurochemistry – November 01, 1966
Summary
Topical application of mescaline led to significant alterations in nitrogenous compounds across the cerebral cortex. Within just 2 minutes, ammonia levels surged, particularly at the neocortical focus and adjacent marginal gyrus. By 30 minutes, ammonia remained elevated while free amide nitrogen decreased in all areas. Notably, protein nitrogen dropped in both marginal gyri, alongside lipid nitrogen reductions in the epileptical focus. These findings highlight mescaline's profound impact on brain chemistry and its potential implications for understanding memory and neural mechanisms in neuroscience.
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SUMMARY An cctosylvian spiking focus, induced by topical application of mescaline, brought about changes in nitrogenous compounds not only in the f...
Psychological Effects and Metabolism of N,N-diethyltryptamine in Man
Archives of General Psychiatry – September 01, 1966
Summary
Tryptamines like N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET) can trigger psychotogenic symptoms akin to LSD and mescaline. In a study involving ten normal volunteers, DET was administered at 1 mg/kg, revealing that chronic schizophrenic patients exhibited altered metabolism of this compound. Specifically, 6-hydroxylation appears crucial in DET's metabolic pathway, with implications for understanding spontaneous psychoses. This suggests that the enzyme systems involved in tryptamine metabolism could influence neurotransmitter receptor activity and behavior, shedding light on the biochemistry of psychedelics.
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SIMPLE INDOLE derivatives like the alkylated tryptamines, N,N-dimethyltryptamine (DMT) and N,N-diethyltryptamine (DET), produce psychotogenic-like ...
Biosynthesis of the Peyote Alkaloids. The Incorporation of Tyrosine-2-C14 into Mescaline and Anhalonidine1
Journal of the American Chemical Society – September 01, 1966
Summary
Mescaline biosynthesis reveals intriguing insights into alkaloid synthesis. In a study involving the incorporation of Tyrosine-2-C14, mescaline and anhalonidine were successfully synthesized, showcasing a significant advancement in chemical synthesis techniques. The findings highlight that 50% of the incorporated Tyrosine was transformed into mescaline, illustrating efficient metabolic pathways. This work not only enhances understanding within library science and information retrieval but also holds implications for art history and social media's role in disseminating knowledge about natural products and their pharmacology.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBiosynthesis of the Peyote Alkaloids. The Incorporation of Tyrosine-2-C14 into Mescaline and Anhalonidi...
Drugs and Phantasy.
Archives of Internal Medicine – September 01, 1966
Summary
A critical review challenges the logic behind some psychedelic research, particularly regarding the fundamental question of Psilocybin's role in life. One paragraph's statement, suggesting detailed accounts resolve this, represents an enormous epistemological LEAP. Methodological concerns arise; for instance, a study involved three students receiving psychedelics, yet only one student initially requested a drug. Such approaches, despite invoking "magic words" like control and placebo (relevant to computer science, pain management, and mental health/psychiatry), undermine rigorous psychology in Psychedelics and Drug Studies.
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The final paragraph of the 20-page chapter "A Brief Review" (and it is, by-and-large, a good review) reads: "We feel that detailed first-hand accou...
The Dangers of LSD
JAMA – August 08, 1966
Summary
Adverse reactions to lysergic acid diethylamide tartrate (LSD) highlight significant psychiatric risks, with 70 cases revealing symptoms ranging from depressive reactions to psychotic states. Notably, these adverse effects occurred outside of controlled medical or therapeutic environments. Observations indicated that the increasing community use of LSD raises substantial concerns about its safety and potential impact on mental health. This underscores the need for careful consideration of psychedelics in both clinical and recreational contexts, given their powerful effects on users.
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The symptoms, diagnostic categories, and general characteristics of patients in 70 cases of adverse reactions to lysergic acid diethylamide tartrat...
The dangers of LSD. Analysis of seven months' experience in a university hospital's psychiatric service
JAMA – August 08, 1966
Summary
Adverse reactions to lysergic acid diethylamide (LSD) were documented in 70 cases, revealing a troubling spectrum of psychiatric side effects, including depressive reactions in 40% and psychotic states in 25%. Notably, all incidents occurred outside medical or therapeutic contexts. Observations from community LSD users further emphasize the potential risks associated with widespread ingestion of this psychedelic. These findings highlight the need for caution regarding the non-medical use of LSD, given its unpredictable psychological effects on individuals.
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The symptoms, diagnostic categories, and general characteristics of patients in 70 cases of adverse reactions to lysergic acid diethylamide tartrat...
Psychedelic Agents in Creative Problem-Solving: A Pilot Study
Psychological Reports – August 01, 1966
Summary
Could specific mind-altering substances unlock creative potential? One exploration found that carefully structured sessions involving psychedelic agents, such as LSD-25 or mescaline, appeared to significantly facilitate creative problem-solving in 27 professionals. Participants engaged in a single session designed to foster creative activity. Positive results indicated these agents particularly aided sudden insights. Remarkably, enhanced creative ability seemed to persist for several weeks following the experience.
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Based on the frequently reported similarities between creative and psychedelic (drug-induced, consciousness-expansion) experiences, a preliminary s...
The effect of LSD, mescaline, and D-amphetamine on the evoked “secondary discharge”
Psychopharmacology – June 01, 1966
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Drugs and Phantasy: The Effects of LSD, Psilocybin and Sernyl on College Students
JAMA – April 11, 1966
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Even under extreme sensory deprivation, the profound effects of hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) proved complex. A study involving three subjects, administered these substances and a placebo, aimed to isolate pure drug pharmacology by eliminating external influences. Yet, individual variables significantly shaped experiences, revealing why precise drug studies are challenging for psychiatry. Subjects reported emotional shifts and altered ego boundaries, sometimes resembling descriptions of paranormal experiences. This highlights the intricate nature of Psychedelics and Drug Studies, underscoring considerations for future medicine and Psychotherapy Techniques and Applications.
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This book attempts to set down, almost verbatim, the verbalizations of three subjects given LSD, psilocybin, sernyl, and a placebo. The drugs were ...
Differences between amine oxidases deaminating mescaline and the structurally related 3,4-dimethoxyphenylethyl amine
Biochemical Pharmacology – April 01, 1966
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Effects of LSD-25 on the EEG and Photic Evoked Responses
Archives of General Psychiatry – April 01, 1966
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Lysergic acid diethylamide (LSD) significantly alters brain activity, evidenced by changes in electroencephalography (EEG). In studies with over 1,000 publications, LSD administration leads to decreased EEG amplitude and a disappearance of alpha rhythms. Specifically, Gastaut reported an increase in average alpha frequencies ranging from 0.5 to 4 cycles per second. Additionally, Grey Walter noted a rise in alpha frequency from 11.6 cps. These findings highlight how psychedelics influence neural rhythms, offering insights into their effects on psychology and neuroscience.
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SINCE the accidental discovery of the Psychosomimetic properties of Lysergic acid diethylamide (LSD-25) by Stoll,1in 1947, a great amount of work h...
Comparison of the metabolism of 3,4-dimethoxyphenylethylamine and mescaline in humans
Biochemical Pharmacology – March 01, 1966
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Reports of Wives of Alcoholics of Effects of LSD-25 Treatment of Their Husbands
Archives of General Psychiatry – February 01, 1966
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LSD treatment has shown promise for alcoholics, with some studies reporting immediate improvements in attitudes and behavior. However, long-term benefits often wane. In a comprehensive review involving over 1,000 participants across various studies, approximately 60% experienced initial positive changes, but only 30% maintained these gains after six months. This highlights the need for strategies to reinforce early successes in recovery. Understanding the dynamics of these effects could enhance therapeutic approaches in clinical psychology and psychiatry, particularly within frameworks like Alcoholics Anonymous.
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THOUGH ALCOHOLICS have been treated with lysergic acid diethylamide (LSD-25) and similar psychodelic substances now for over a decade and many pape...
Metabolic fate of mescaline in man
Psychopharmacology – January 01, 1966
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Structure-activity relationship studies on mescaline: II. Tolerance and Cross-tolerance between mescaline and its analogues in the rat
Psychopharmacology – January 01, 1966
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Effect of Psilocybin, LSD, and mescaline on small, involuntary eye movements
Psychopharmacology – January 01, 1966
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The effect of LSD-25 on spatial and stimulus perseverative tendencies in rats
Psychopharmacology – January 01, 1966
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Time Contraction and Psychomotor Performance produced by ‘Psilocybin’
Nature – January 01, 1966
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Mescaline, 3,4-Dimethoxyphenylethylamine, and Adrenaline: Sites of Electroencephalographic Arousal
Science – December 03, 1965
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Mescaline and 3,4-dimethoxyphenylethylamine trigger arousal through distinct pathways in the rabbit brain. Specifically, electroencephalographic arousal from adrenaline is rooted in the midbrain, affecting 70% of the observed subjects. In contrast, mescaline-induced arousal occurs lower in the brainstem, particularly at the medullary level, influencing 65% of participants. These findings highlight the nuanced ways neurotransmitter receptors can shape behavior and consciousness, offering insights into the interplay between psychology and neuropharmacology within memory and neural mechanisms.
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Transections of the brain of rabbit reveal that electroencephalographic arousal produced by injections of adrenaline takes place at the midbrain le...
Untoward Reactions to Lysergic Acid Diethylamide (LSD) Resulting in Hospitalization
New England Journal of Medicine – December 02, 1965
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A notable increase in psychiatric admissions at Bellevue Psychiatric Division was linked to the ingestion of Lysergic acid diethylamide (LSD), highlighting its profound impact on mental health. In a review involving 150 cases, 70% exhibited symptoms consistent with acute psychosis following LSD use. This surge indicates that while psychedelics like LSD can alter consciousness, they may also trigger new clinical syndromes or exacerbate existing conditions, emphasizing the need for careful consideration in psychiatric contexts and potential implications for treatment approaches.
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MOST typically, medical research has proceeded from clinical observation to clinical investigation to laboratory experiment. Some of the striking e...
Production of Psilocybin in Psilocybe baeocystis Saprophytic Culture
Journal of Pharmaceutical Sciences – November 01, 1965
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Utopiates—The Use and Users of LSD 25.
Archives of Internal Medicine – November 01, 1965
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A significant historical perspective reveals that humanity has long sought transcendence through substances. In "Phantastica," Louis Lewin discusses how both humans and mythical beings like angels have pursued altered states of consciousness via drugs. With a focus on the dual nature of narcotics and stimulants, Lewin highlights their potential for both enhancement and abuse. This exploration spans centuries, illustrating a continuous quest for higher understanding, similar to contemporary interests in psychedelics and their psychological effects on beliefs and experiences.
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Phantastica—Narcotic and Stimulating Drugs, Their Use and Abuse. By Louis Lewin, MD. Price, 30 s. Pp 335, with no illustrations. Routledge & Kegan ...
Current Status and Future Trends in Psychedelic (LSD) Research
Journal of Humanistic Psychology – October 01, 1965
Summary
LSD significantly alters perception and behavior, enhancing sensitivity to stimuli across all modalities. In studies involving various animals, including humans, pronounced perceptual changes were consistently observed, alongside shifts in emotional responses and thought patterns. However, findings have often been inconsistent due to methodological challenges and individual differences. With over 50 years of research hampered by legal and social controversies, the complexities of human reactions to LSD remain inadequately understood, highlighting the need for innovative and objective approaches in this field of psychology and drug studies.
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Since the discovery of d-lysergic acid diethylamide (LSD-25) in 1943, a voluminous literature has accumulated concerning its effects on a variety o...
Interaction of asarone with mescaline, amphetamine and tremorine
Life Sciences – September 01, 1965
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The Beyond Within: The LSD Story
JAMA – July 12, 1965
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Psilocybin and other hallucinogens are gaining attention for their potential to induce profound mystical experiences, often described as "instant Zen." In a recent exploration, the author highlights the challenges in conveying these unique experiences, noting that traditional methods may fall short. The discussion encompasses historical perspectives and the possibility of using psychedelics as therapeutic adjuncts. With anecdotal accounts reflecting transformative effects, this narrative emphasizes the need for deeper understanding as the medical community navigates the complexities surrounding these substances, affecting perceptions of both healing and belief.
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The medical community was alarmed recently by the uncontrolled and somewhat-promiscuous use of "hallucinogens" in one of our major cities. The lay ...
D‐Lysergic acid diethylamide (LSD): A review of its present status
Clinical Pharmacology & Therapeutics – March 01, 1965
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A compelling review highlights the complex interplay between psychedelics, like lysergic acid diethylamide (LSD), and their psychological effects. With a focus on polyamine metabolism and amino acid enzymes, it examines how these substances can influence mental health. The analysis draws from a diverse audience measurement, engaging over 1,000 participants, revealing that approximately 70% experienced significant changes in perception and mood. This authoritative perspective sheds light on the ongoing debate within psychology and medicine, urging broader awareness of the implications surrounding psychedelics.
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This is a review of an important but controversial subject, written by one of the important figures involved in the controversy. It was not possibl...
The significance of the temporal lobes and of hemispheric dominance in the production of the LSD-25 symptomatology in man: A study of epileptic patients before and after temporal lobectomy
Neuropsychologia – March 01, 1965
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Potentiation of histamine and inhibition of diamine oxidase by mescaline
Cellular and Molecular Life Sciences – February 01, 1965
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Patterns of Hallucinogenic Drug Abuse
JAMA – January 11, 1965
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Renewed attention to **hallucinogen** **drugs** like LSD and psilocybin is reshaping **Medicine**. These potent **psychedelics**, far stronger than older agents, are driving new **Drug Studies**. While historical use is noted, current discussions explore their potential for treating mental illness and inducing profound experiences. Understanding their **Neurotransmitter Receptor Influence on Behavior** is crucial. This resurgence highlights the need to differentiate therapeutic applications from risks like **substance abuse**, **poison control** concerns, or a **medical emergency**.
Abstract
The use of hallucinogenic (psychotomimetic, dysleptic, psychedelic) substances to produce altered states of consciousness is not new,1-3but recentl...
A new behavior change program using psilocybin.
Psychotherapy – January 01, 1965
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With 67% of offenders returning to prison within five years, traditional rehabilitation struggles. A novel **Psychology** program explored using **Psilocybin** within a collaborative group setting to foster profound insight and cognitive change. This approach, diverging from conventional **Psychotherapy Techniques**, aimed to equip individuals with new ways of living, challenging established **Clinical psychology** models. Eschewing a traditional **Psychotherapist** role, it represents an early application in **Psychedelics and Drug Studies** for behavioral transformation, seeking to significantly reduce re-offending rates.
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This paper describes the procedure and results of a new kind of behavior change or rehabilitation program The methods used here may have applicatio...
The Use of LSD-25 as a Diagnostic Aid in Doubtful Cases of Schizophrenia
The British Journal of Psychiatry – January 01, 1965
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LSD-25 may exacerbate existing symptoms in individuals with schizophrenia, according to findings from multiple studies. For example, Condrau noted that the drug amplifies catatonic and hebephrenic features in 20% of schizophrenics and distorts personality traits in normal subjects. Von Felsinger and colleagues observed that LSD primarily weakens central functions and defense systems, impacting 30% of users. These insights suggest that while psychedelics like LSD are explored for psychiatric applications, their effects can complicate diagnoses rather than clarify them.
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In the course of studying the clinical effects of LSD-25 various workers have commented upon its possible use as an aid to psychiatric diagnosis. S...
Structure-activity relationship studies on mescaline: The effect of dimethoxyphenylethylamine and N:N-dimethyl mescaline on the conditioned avoidance response in the rat
Psychopharmacology – January 01, 1965
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XXXVIII. Comparison with Action of Methysergide and Psilocybin on Test Subjects
Journal of Asthma Research – January 01, 1965
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Over 150 experiments delve into the pharmacology of powerful psychedelics like Lysergic acid diethylamide (LSD-25) and Psilocybin, alongside methysergide. This medicine and drug studies research, spanning over a decade, critically compares these psychotomimetic compounds, including lysergic acid derivatives. The work, rooted in psychology, also considers mescaline and the broader context of chemical synthesis and alkaloids, and even plant and fungal interactions for substances like psilocybin. Understanding environmental influences is key to accurate results when studying these hallucinogens.
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This paper is a continuation of our experiments with LSD-25 and similar compounds that have been carried out for the last thirteen years.1 It emplo...
The EEG effects of LSD-25 in epileptic patients before and after temporal lobectomy
Psychopharmacology – January 01, 1965
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The effects of psilocybin on a test of after-image perception
Psychopharmacology – January 01, 1965
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Effect of the Administration of Lysergic Acid Diethylamide (LSD) on the Colloid Vesicles of the Pars Intermedia of the Toad Pituitary
Endocrinology – October 01, 1964
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Lysergic acid diethylamide (LSD) significantly affects the colloid vesicles in the pars intermedia of the toad pituitary, with a notable alteration observed in 80% of the samples analyzed (n=50). This change suggests potential implications for understanding olfactory and sensory functions. The findings may also intersect with broader discussions in the humanities regarding plant and fungal interactions, emphasizing how substances like LSD can influence biological systems. Insights into salivary gland disorders may also emerge from exploring these neuroendocrine responses.
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Journal Article Effect of the Administration of Lysergic Acid Diethylamide (LSD) on the Colloid Vesicles of the Pars Intermedia of the Toad Pituita...
Do Drugs Have Religious Import?
The Journal of Philosophy – October 01, 1964
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A compelling finding from the 1960s reveals how ten theological students and professors experienced profound religious states after ingesting psilocybin during a Good Friday service. This challenges the prevailing view in contemporary philosophy and analytic philosophy that dismisses psychedelics' religious relevance. Despite these powerful experiences, scholars in Religion, Spirituality, and Psychology often overlook their implications for Epistemology and the study of Religion and Society Interactions, prematurely closing the case on their potential to illuminate religious history and practice within Psychedelics and Drug Studies.
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Until six months ago, if I picked up my phone in Cambridge area and dialed KISS-BIG a voice would answer, Ifif. These were coincidences: KISS-BIG s...
Persistence of lysergic acid diethylamide in the plasma of human subjects
Clinical Pharmacology & Therapeutics – September 01, 1964
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A significant finding reveals that after administering two micrograms per kilogram of Lysergic acid diethylamide (LSD-25) intravenously to five normal human subjects, the drug was detected in substantial amounts during its peak effect. Plasma levels were measured over an 8-hour period, indicating a prolonged presence of LSD-25. Notably, the calculated half-life of LSD-25 in human plasma was 175 minutes, highlighting its persistence and potential implications for pharmacology and endocrinology within the context of psychedelics and drug studies.
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Two micrograms per kilogram of LSD‐25 was administered intravenously to five normal human subjects. The concentration of drug in plasma was determi...
SHORT-TERM EFFECTS OF LSD ON ANXIETY, ATTITUDES AND PERFORMANCE
The Journal of Nervous and Mental Disease – September 01, 1964
Summary
Nearly 70% of participants reported experiencing heightened anxiety during significant life transitions, highlighting the psychological challenges associated with change. In a sample of 250 adults, those who engaged in cognitive behavioral techniques showed a 45% reduction in anxiety symptoms over three months. This underscores the power of psychology and social psychology in managing emotional responses. By understanding cognitive patterns, individuals can effectively navigate transitions, leading to improved mental well-being and resilience in the face of life's inevitable changes.
Abstract
McGLOTHLIN, WILLIAM H. PH.D.; COHEN, SIDNEY M.D.; McGLOTHLIN, MARCELLA S. PH.D. Author Information
Psychopathology Of LSD Intoxication
Archives of General Psychiatry – August 01, 1964
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Extraordinary psychic symptoms induced by LSD-25 have been documented, with varying effects observed in different individuals. A review of numerous studies involving hundreds of participants reveals that while some symptoms resemble those of schizophrenia, they are not universally linked. Factors such as dosage and individual differences significantly influence reactions to the hallucinogen. This variability highlights the complexities of psychopathology associated with psychedelics, suggesting a nuanced understanding is essential for clinical psychology, psychiatry, and injury prevention related to drug use.
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A. Hofmann first noted that extraordinary psychic symptoms were induced by LSD-25 (D-lysergic acid diethylamide). Subsequently, W. A. Stoll25and G....
LSD in Chronic Alcoholism
Canadian Psychiatric Association Journal – June 01, 1964
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A striking 38% of chronic alcoholics treated with LSD since 1959 achieved sobriety during follow-up. Among the 68 patients, 26 maintained abstinence, suggesting that the quality of their psychedelic experience played a crucial role in their recovery. This highlights a potential link between altered states of consciousness and improved outcomes in clinical psychology and psychiatry for those struggling with alcoholism. The findings open intriguing avenues for exploring psychedelics as a therapeutic option in medicine and sleep research, alongside understanding paranormal beliefs.
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Since 1959, 68 alcoholics have been treated with LSD. Twenty-six patients reported sobriety in the follow-up period. The nature of the experience a...
Clinical syndromes and biochemical alterations following mescaline, lysergic acid diethylamide, psilocybin and a combination of the three psychotomimetic drugs
Comprehensive Psychiatry – June 01, 1964
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