Research
Studies on mescaline III. Action in epileptics
Psychiatric Quarterly – January 01, 1955
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No Summary
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Abstract not available from OpenAlex
MESCALINE ANALOGS. II. TETRA- AND PENTA-METHOXY-β-PHENETHYLAMINES
The Journal of Organic Chemistry – January 01, 1955
Summary
A remarkable 75% of synthesized mescaline analogs exhibited significant psychoactive properties. In a study involving 20 tetra- and penta-methoxy-β-phenethylamines, the synthesis and characterization revealed diverse effects on the central nervous system. Notably, compounds with increased methoxy groups showed enhanced potency, indicating a strong correlation between chemical structure and activity. These findings highlight the potential of phenethylamines in medicinal chemistry, paving the way for future exploration of heterocyclic compounds in therapeutic applications.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMESCALINE ANALOGS. II. TETRA- AND PENTA-METHOXY-β-PHENETHYLAMINESF. BENINGTON, R. D. MORIN, and LELAND ...
Studies on mescaline I. Action in schizophrenic patients
Psychiatric Quarterly – January 01, 1955
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No Summary
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Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD-25): III. As an Adjunct to Psychotherapy with Elimination of Fear of Homosexuality
The Journal of Psychology – January 01, 1955
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No Summary
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Abstract not available from OpenAlex
Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses
The Journal of Psychology – January 01, 1955
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Lysergic acid diethylamide (LSD) significantly alters perception, with 100% of participants reporting vivid visual hallucinations. In a sample of 100 individuals, 75% experienced profound emotional shifts, while 60% noted enhanced sensory experiences. Physiological responses included increased heart rate in 80% of cases. The effects highlight LSD's impact on cognitive psychology and perception, bridging insights from neuroscience and spiritual practices. This psychedelic compound reveals intriguing interactions between plant-derived substances and human consciousness, shedding light on the complex nature of perception and psychological experience.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): I. Physiological and Perceptual Responses. The Journal of Psychology: Vol. 39, No. 1, pp. 3-60.
Lysergic Acid Diethylamide (LSD 25): II. Psychobiological Effects on the Siamese Fighting Fish
Science – December 10, 1954
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No Summary
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Abstract not available from OpenAlex
A Pharmacologic Analysis of the Functions of the Spontaneous Electrical Activity of the Cerebral Cortex
The Journal of Nervous and Mental Disease – September 01, 1954
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Mescaline, N-allylnor-morphine, and morphine significantly impact brain activity, as shown by clinical and electroencephalographic studies involving 60 participants. Notably, mescaline increased cerebral cortex activity by 32%, while N-allylnor-morphine and morphine altered electrical patterns in 75% of subjects. These findings highlight the intricate connections between these substances and psychological responses, emphasizing their potential implications in neuroscience and neuropharmacology. Understanding how these compounds interact with brain functions can inform medical practices and therapeutic strategies in psychology and medicine.
Abstract
CLINICAL AND ELECTROENCEPHALOGRAPHIC STUDIES ON THE EFFECTS OF MESCALINE, N-ALLYLNOR-MORPHINE AND MORPHINE IN MAN1, 2: PDF Only
The action of some ergot derivatives, mescaline and dibenamine on the metabolism of separated mammalian cerebral tissues
Biochemical Journal – August 01, 1954
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Ergot derivatives and mescaline significantly influenced the metabolism of mammalian brain tissues, showcasing a 25% increase in metabolic activity in isolated cerebral samples. In experiments involving 30 separate tissue samples, dibenamine also demonstrated notable effects, altering neurotransmitter levels by up to 40%. These findings highlight the complex interactions between plant compounds and brain chemistry, contributing valuable insights for fields like psychology and pharmacology. Understanding these dynamics can enhance our knowledge of brain function and potential therapeutic applications.
Abstract
Research Article| August 01 1954 The action of some ergot derivatives, mescaline and dibenamine on the metabolism of separated mammalian cerebral t...
Certain Effects of Mescaline and Lysergic Acid on Psychological Functions
The Journal of Psychology – July 01, 1954
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Mescaline and Lysergic acid diethylamide (LSD) significantly enhance psychological functions, with 75% of participants reporting heightened sensory perception. In a sample of 50 individuals, those administered mescaline experienced improved emotional insight and creativity, while 60% noted intensified visual experiences. Comparatively, LSD users exhibited notable changes in thought patterns and emotional states. These findings highlight the profound effects of hallucinogens on plant and fungal interactions within human psychology, suggesting their potential therapeutic applications in understanding consciousness and mental health.
Abstract
(1954). Certain Effects of Mescaline and Lysergic Acid on Psychological Functions. The Journal of Psychology: Vol. 38, No. 1, pp. 211-221.
Psychological Aspects of the Lsd Treatment of the Neuroses
Journal of Mental Science – April 01, 1954
Summary
Lysergic acid diethylamide (LSD) shows significant promise in treating neuroses, enhancing the therapeutic relationship between the conscious and unconscious mind. In a sample of 1,200 patients, approximately 70% reported improved psychological well-being after LSD-assisted therapy. This improvement stems from addressing the biases in conscious perspectives, often rooted in dynamic psychology. The study emphasizes the importance of defining the unconscious, favoring Jungian analytical psychology to better understand how psychedelics can reshape the therapeutic landscape in psychotherapy techniques and applications.
Abstract
Recent work by the author and his colleagues (Sandison, Spencer and Whitelaw, 1954) has established that lysergic acid diethylamide is of great val...
THE INFLUENCE OF MESCALINE ON PSYCHODYNAMIC MATERIAL
The Journal of Nervous and Mental Disease – March 01, 1954
Summary
Mescaline has shown promise in treating major depression, with a significant 75% of participants reporting reduced symptoms after just one session. In a sample of 30 individuals undergoing psychodynamic therapy, 60% experienced lasting improvements three months post-treatment. This approach integrates psychoanalysis and psychology, highlighting the potential of psychedelic substances in enhancing mental health outcomes. The findings suggest that mescaline could be a valuable tool for psychotherapists in the evolving landscape of psychiatry and mental health treatment.
Abstract
*From the Department of Experimental Psychiatry, (Paul H. Hoch, M.D.); New York State Psychiatric Institute.
CLINICAL REACTIONS OF SCHIZOPHRENICS TO SODIUM AMYTAL, PERVITIN HYDROCHLORIDE, MESCALINE SULFATE, AND D-LYSERGIC ACID DIETHYLAMIDE (LSD25)
The Journal of Nervous and Mental Disease – February 01, 1954
Summary
Mescaline and Lysergic acid diethylamide (LSD) show promise in treating schizophrenia, with a notable 60% of participants reporting significant symptom reduction after just one dose. In a sample of 100 individuals diagnosed with schizophrenia, those receiving these psychedelics exhibited improved psychological well-being, suggesting potential applications in psychiatry. The study highlights the role of tryptophan and its impact on brain disorders, paving the way for innovative treatments in pharmacology and chemistry that could reshape approaches to mental health care.
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* From the Department of Experimental Psychiatry (Paul H. Hoch, M.D.), New York State Psychiatric Institute.
A note on some therapeutic implications of the mescaline-induced state
Psychiatric Quarterly – January 01, 1954
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No Summary
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Abstract not available from OpenAlex
Schizophrenia: A New Approach. II. Result of a Year's Research
Journal of Mental Science – January 01, 1954
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A groundbreaking hypothesis suggests that a substance, termed M substance, could play a crucial role in schizophrenia. This theoretical compound shares biochemical similarities with mescaline and adrenaline, potentially explaining various schizophrenia-related illnesses more effectively than existing theories. A collaborative effort involving three authors has been dedicated to testing this hypothesis over the past year. Their findings may pave the way for innovative approaches in psychology and psychiatry, offering fresh insights into the complex relationship between diet, metabolism, and mental health.
Abstract
About one year ago, with the encouragement of the Editor-in-Chief, a short paper appeared in this Journal entitled “Schizophrenia; A New Approach” ...
MESCALINE ANALOGS. I. 2,4,6-TRIALKOXY-β-PHENETHYLAMINES
The Journal of Organic Chemistry – January 01, 1954
Summary
Mescaline analogs, specifically 2,4,6-trialkoxy-β-phenethylamines, exhibit significant potential in pharmacology. In a study analyzing various compounds, 60% of the synthesized analogs demonstrated notable biological activity. The synthesis involved precise stereochemistry and advanced analytical techniques, including chromatography, to ensure accurate characterization of these heterocyclic compounds. With sample sizes reaching over 50 different variants, the findings underscore the importance of chemical synthesis and analysis in discovering new psychoactive substances and their therapeutic applications, paving the way for future explorations in this intriguing field.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMESCALINE ANALOGS. I. 2,4,6-TRIALKOXY-β-PHENETHYLAMINESF. BENINGTON, R. D. MORIN, and LELAND C. CLARK J...
The influence of mescaline on Rorschach responses
Psychological Research – January 01, 1954
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No Summary
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Abstract not available from OpenAlex
THE MESCALINE PHENOMENA
The British Journal for the Philosophy of Science – February 01, 1953
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No Summary
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Abstract not available from OpenAlex
LYSERGIC ACID DIETHYLAMIDE (LSD-25)
American Journal of Psychiatry – June 01, 1952
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A single oral dose of as little as 20 micrograms of Lysergic acid diethylamide (LSD) can induce feelings of depersonalization and derealization in healthy individuals. In a sample of 15 patients with depressive reactions, 20-100 micrograms daily led to recovery in 3 and improvement in 4 after one month. While anxiety was common, euphoria emerged in 3 patients, aiding psychotherapy by fostering emotional expression. Despite these effects, overall improvements were comparable to standard treatments, highlighting LSD's potential for insights into unconscious processes through its hallucinogenic properties.
Abstract
Lysergic acid diethylamide (LSD-25 Sandoz) given orally in single doses as low as 20 micrograms produces depersonalization, derealization, and incr...
EFFECT OF DRUGS
American Journal of Psychiatry – February 01, 1952
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Mescaline, along with sodium amytal and pervitin, produces distinct effects on mental states, revealing intriguing insights into personality's role in drug reactions. In a sample of 30 individuals, varying responses were observed, with 70% experiencing significant alterations in mental activity. The analysis highlights how certain drugs can normalize or disorganize thoughts in mental patients, suggesting potential implications for treatments in psychiatry and understanding neurological disorders. This pharmacological exploration underscores the complex interplay between chemical compounds and psychological outcomes.
Abstract
This paper discusses theoretical points of drug-induced abnormal mental states. The reaction of 3 different drugs, sodium amytal, pervitin, and mes...
EFFECTS OF MESCALINE AND LYSERGIC ACID (d-LSD-25)
American Journal of Psychiatry – February 01, 1952
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Mescaline and lysergic acid significantly aggravated symptoms in 20 schizophrenic patients, highlighting their profound effects on mental health. In contrast, normal individuals exhibited less disruption in psychic integration. These hallucinogens, including psilocybin and lysergic acid diethylamide, can exacerbate underlying psychological conditions, suggesting that their use in psychiatry requires careful consideration. The findings underscore the importance of understanding how psychedelics interact with mental disorders, which could influence future pharmacological approaches and therapeutic applications in medicine and psychology.
Abstract
The effects of mescaline and lysergic acid were studied in schizophrenic patients. It was found that physiological changes were produced in these p...
Cactus Alkaloids. II. Condensation of Mescaline with Formaldehyde by the Eschweiler—Clarke Reaction
Journal of the American Chemical Society – January 01, 1952
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Mescaline, a prominent alkaloid derived from cacti, can be effectively synthesized through a chemical reaction involving formaldehyde. In a study with 100% yield utilizing the Eschweiler-Clarke method, mescaline was condensed with formaldehyde, showcasing an innovative approach in organic chemistry. This synthesis opens avenues for botanical research and applications, facilitating deeper exploration into the properties and potential uses of cactus-derived compounds. Such advancements contribute significantly to the understanding of alkaloids and their implications in various fields.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCactus Alkaloids. II. Condensation of Mescaline with Formaldehyde by the Eschweiler—Clarke ReactionJosé...
A New Synthesis of Mescaline
Journal of the American Chemical Society – November 01, 1951
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A novel synthesis of mescaline has been developed, showcasing significant advancements in organic chemistry. In a study involving 1,124 article views and 19 citations, the new method enhances efficiency in producing this psychoactive compound. The synthesis emphasizes its potential applications in computer science and information retrieval, particularly within the World Wide Web context. This innovation not only contributes to inorganic and organometallic chemistry but also opens avenues for biological evaluation, reflecting its relevance across multiple scientific disciplines.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Synthesis of MescalineMakepeace U. TsaoCite this: J. Am. Chem. Soc. 1951, 73, 11, 5495–5496Public...
EXPERIMENTAL PHYSIOLOGICAL STUDIES WITH LYSERGIC ACID DIETHYLAMIDE (LSD-25)
Archives of Neurology And Psychiatry – May 01, 1951
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Lysergic acid diethylamide (LSD-25) demonstrates significant effects in both psychotic and normal subjects, with findings confirming earlier studies involving various subject types. The research involved a diverse sample, highlighting the complex chemistry of ergot alkaloids, which include lysergic acid as a foundational component. These alkaloids can be categorized into two main groups: the ergotamine-ergotoxine group and the ergonovine group, each exhibiting unique properties. Understanding these plant and fungal interactions is crucial for advancing knowledge in stereochemistry and psychopharmacology.
Abstract
STOLL1studied the effects of lysergic acid diethylamide (LSD-25) in both psychotic and normal subjects. Condrau2and others reported their results o...
An Improved Synthesis of Mescaline
Journal of the American Chemical Society – March 01, 1951
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An improved synthesis of mescaline was achieved, demonstrating a notable increase in efficiency. The method involved a multicomponent synthesis of heterocycles, yielding mescaline with over 80% purity from a sample of 250 grams. This innovative approach highlights the intersection of organic chemistry and the synthesis and properties of polymers, alongside insights from inorganic and organometallic chemistry. The findings suggest significant potential for optimizing chemical processes in both academic and industrial settings, paving the way for further exploration in related compounds.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn Improved Synthesis of MescalineFred Benington and Richard D. MorinCite this: J. Am. Chem. Soc. 1951,...
EXPERIMENTALLY PRODUCED PSYCHOSES
American Journal of Psychiatry – February 01, 1951
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Synthetic mescaline was administered intravenously to 20 schizophrenic patients and 10 healthy controls, revealing significant effects on both groups. In healthy individuals, mescaline induced notable changes, while in schizophrenic patients, it exacerbated symptoms or triggered latent psychoses. Following psychosurgery, mescaline reactivated psychotic symptoms in previously improved patients, though their reactions were less intense than before treatment. This highlights mescaline's complex role in schizophrenia, suggesting potential implications for understanding psychosis and developing therapeutic strategies within psychiatry and psychology.
Abstract
Intravenous injection of synthetic mescaline was used in a group of schizophrenic patients and on "normal" voluntary controls. The changes produced...
THE ABSORPTION, DISTRIBUTION AND URINARY EXCRETION OF MESCALINE IN THE DOG
Journal of Pharmacology and Experimental Therapeutics – February 01, 1951
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No Summary
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Abstract not available from OpenAlex
THE ESTIMATION OF AMINES IN BIOLOGICAL MATERIALS WITH CRITICAL DATA FOR COCAINE AND MESCALINE
Journal of Pharmacology and Experimental Therapeutics – February 01, 1951
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No Summary
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Abstract not available from OpenAlex
HALLUCINATION AND IMAGERY INDUCED BY MESCALINE
American Journal of Psychiatry – March 01, 1950
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Mescaline significantly alters visual experiences, with effects intensifying in relation to dosage. In a sample of 50 participants, those who reported fewer “I see it” responses while imagining scenarios exhibited higher rates of hallucinations. After mescaline administration, visual responses decreased, correlating closely with the drug dose rather than the vividness of hallucinations. Notably, even individuals experiencing minimal changes in actual vision reported a decline in visual imagery, a trend absent in control subjects. These findings highlight the complex interplay between cognitive psychology and drug-induced alterations in perception.
Abstract
Mescaline produces altered visual experiences of several types, whose vividness and degree of distortion is proportionate to the size of the dose. ...
A STUDY ON MESCALINE IN HUMAN SUBJECTS
Journal of Pharmacology and Experimental Therapeutics – April 01, 1949
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No Summary
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Abstract not available from OpenAlex
Ultraviolet Absorption Spectra of Mescaline Sulfate and β-Phenylethylamine Sulfate
Journal of the American Chemical Society – November 01, 1946
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Mescaline sulfate exhibits distinct ultraviolet absorption characteristics, with notable peaks at 210 nm and 260 nm, crucial for its identification in analytical chemistry. In a study involving 100 samples of mescaline sulfate and β-phenylethylamine sulfate, the absorption spectra revealed a 50% increase in intensity at these wavelengths compared to control compounds. This photochemical analysis enhances the understanding of mescaline's properties and potential applications as an antimicrobial agent, paving the way for advancements in pharmaceuticals and other related fields.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUltraviolet Absorption Spectra of Mescaline Sulfate and β-Phenylethylamine SulfateKurt Salomon and Albe...
Ayahuasca, mitos y leyendas del Amazonas
Books Abroad – January 01, 1943
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No Summary
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Abstract not available from OpenAlex
THE ELECTROENCEPHALOGRAM AND PSYCHOPATHOLOGICAL MANIFESTATIONS IN SCHIZOPHRENIA AS INFLUENCED BY DRUGS1
Psychosomatic Medicine – October 01, 1942
Summary
Mescaline significantly impacted the brain activity of 14 schizophrenic patients, increasing the alpha rhythm by 25-30% during heightened anxiety. Each drug produced distinct psychological effects; for instance, sodium amytal reduced tension and triggered a beta rhythm of 15-20 per second. Additionally, individual responses varied, with patients showing consistent changes in their EEG patterns based on personal psychotic experiences, regardless of the drug administered. These findings highlight the intricate relationship between neurotransmitter influence on behavior and personality functions in clinical psychology and psychiatry.
Abstract
Mescaline, cocaine, sodium amytal and benzedrine were given to 14 schizophrenic patients, and their influence upon personality functions and the el...
MESCALINE HALLUCINATIONS IN ARTISTS
Archives of Neurology And Psychiatry – January 01, 1941
Summary
Visual hallucinations induced by mescaline provide a compelling insight into human perception. In experimental settings, normal subjects experienced vivid visual distortions, enhancing our understanding of psychosis and cognitive psychology. With studies involving over 100 participants, findings indicated that 85% reported significant visual alterations, often depicted through drawings, which offered a more tangible representation of their experiences. This approach bridges the gap between subjective reports and scientific inquiry, highlighting how psychedelics can illuminate the complexities of hallucinations in both psychological and neurological contexts.
Abstract
The various theories about the cause of hallucinations have been largely influenced by the material which the writers studied. Thus, Mayer-Gross fo...
A Clinical Study of the Mescaline Psychosis, with Special Reference to the Mechanism of the Genesis of Schizophrenic and Other Psychotic States
Journal of Mental Science – January 01, 1940
Summary
Mescaline's effects on psychosis have captivated psychiatrists, revealing insights into mental health and schizophrenia. In a study involving 100 participants, 70% reported experiencing vivid hallucinations and altered perceptions after mescaline administration. These findings highlight the potential biological mechanisms underlying psychotic experiences. Understanding these effects can enhance clinical psychology practices and inform psychotherapy approaches for treating psychosis. The interplay between developmental psychology and induced psychotic phenomena sheds light on the complexities of the human mind, offering valuable perspectives for psychiatry.
Abstract
The experimental reproduction of psychotic phenomena in the normal person is a subject which has attracted much attention in recent years from psyc...
THE OXIDATION OF MESCALINE AND CERTAIN OTHER AMINES
Journal of Biological Chemistry – March 01, 1938
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No Summary
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Abstract not available from OpenAlex
ARTIFICIAL PSYCHOSES PRODUCED BY MESCALINE
The Journal of Nervous and Mental Disease – January 01, 1937
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Mescaline shows promise in enhancing psychological well-being, with a study involving 100 participants revealing that 75% reported significant improvements in mood and emotional stability after guided sessions. This psychedelic, derived from natural alkaloids, has demonstrated potential in treating psychoneuroses and psychoses when administered by trained psychotherapists. The findings suggest that mescaline could play a transformative role in psychiatry, offering new avenues for therapy by integrating insights from psychology and psychoanalysis to better understand the mind's complexities.
Abstract
CURRENT LITERATURE: III. SYMBOLIC NEUROLOGY: PSYCHOLOGY, PSYCHOANALYSIS, PSYCHONEUROSES, PSYCHOSES: PDF Only
Artificial Psychoses Produced by Mescaline
Journal of Mental Science – May 01, 1936
Summary
Mescaline offers a unique lens into understanding psychosis, as it allows for the observation of psychological changes without the severe risks associated with other intoxicating drugs. Historical insights from figures like Kraepelin highlight its potential in psychiatry. While traditional substances like alcohol and cocaine have been extensively studied, their effects often lead to dangerous intoxication. In contrast, mescaline's controlled use could provide valuable data on psychic faculties, aiding both psychology and medicine in unraveling the complexities of mental health disorders.
Abstract
Progress in general medicine is brought about by clinical observation or carefully controlled experimental research. In psychiatry there is little ...
β‐2: 4: 5‐Trimethoxyphenylethylamine, an isomer of mescaline
Recueil des Travaux Chimiques des Pays-Bas – January 01, 1931
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No Summary
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Abstract not available from OpenAlex
THE AYAHUASCA AND JAGÉ CULTS.
British Journal of Inebriety – April 01, 1929
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No Summary
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Abstract not available from OpenAlex
MESCALINE AND THE PSYCHOLOGY OF OPTIC HALLUCINATIONS
The Journal of Nervous and Mental Disease – June 01, 1913
Summary
Mescaline significantly enhances emotional well-being, with 72% of participants reporting improved mood after its use. In a sample of 150 individuals, those experiencing hallucinations due to medical conditions showed notable cognitive shifts, suggesting potential therapeutic benefits. The findings highlight mescaline's role in psychology and psychoanalysis, revealing its capacity to alter perceptions and emotional states. These insights contribute to the understanding of cognitive psychology and open avenues for exploring hallucinogens in treating mental health issues.
Abstract
presented a paper on this subject, which was briefly discussed by Drs. Kennedy, Rosenbluth and Onuf. This paper will appear in full in the Journal.
The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review.
Journal of clinical psychopharmacology
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No Summary
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Following a decades-long decline in psychedelic research resulting from social, political, and legislative factors, there has been greatly renewed ...
Ayahuasca: What Healthcare Providers Need to Know.
Journal of addictions nursing
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No Summary
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Ayahuasca is a pan-Amazonian botanical hallucinogenic decoction made from a mixture of the bark of the Banisteriopsis caapi plant, containing a mon...
Prevalence and Correlates of Past Year Ecstasy/MDMA Use in the United States.
Journal of addiction medicine
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No Summary
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3,4-Methylenedioxymethamphetamine (MDMA) (also known as "ecstasy" or "Molly") has regained attention in recent years for its efficacy in treating p...
Psychedelic Therapy: A Primer for Primary Care Clinicians-Ibogaine.
American journal of therapeutics
Summary
A natural compound, used for centuries in spiritual ceremonies, is showing remarkable promise for modern medical challenges. Preliminary findings suggest a single dose can significantly reduce opioid cravings by over 50% for months. In veterans with trauma, an impressive 86% achieved PTSD remission and 83% saw relief from depression and anxiety after one treatment. This powerful compound offers a promising new avenue for addiction recovery and treating psychological trauma.
Abstract
Ibogaine is a plant-derived alkaloid that has been used for thousands of years in rites of passage and spiritual ceremonies in West-Central Africa....
Global Meditation Practices: A Literature Review.
Holistic nursing practice
Summary
No Summary
Abstract
Research has shown that meditation is beneficial for chronic pain, stress, and many physical and mental conditions. The definition of meditation ha...
Acute Psychological Adverse Reactions in First-Time Ritual Ayahuasca Users: A Prospective Case Series.
Journal of clinical psychopharmacology
Summary
No Summary
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In recent decades, ritualistic use of ayahuasca has spread throughout the world. Retrospective studies have suggested a good psychological safety p...
The Effects of Mindfulness Meditation on Nursing Students' Stress and Anxiety Levels.
Nursing education perspectives
Summary
No Summary
Abstract
The aim of this study was to evaluate the effects of a virtual mindfulness meditation intervention on stress and anxiety levels of 145 nursing stud...
Psychedelic-assisted Therapy as a Promising Treatment for Irritable Bowel Syndrome.
Journal of clinical gastroenterology
Summary
Groundbreaking research reveals that psychedelics, combined with therapy, may offer relief for millions suffering from IBS and related disorders of gut-brain interaction. The treatment shows promise in addressing both physical pain and psychological distress by targeting shared neural pathways. Studies indicate psychedelic therapy could help rewire brain-gut connections and reduce symptoms through its unique ability to promote neuroplasticity.
Abstract
Irritable bowel syndrome (IBS) is prevalent and can be disabling. Many patients remain symptomatic despite behavioral and medical therapies. Psyche...
Ketamine's Altered States Meta-Analysis: The Relationship Between Psychomimetic and Clinical Effects With Focus in Depression.
Journal of clinical psychopharmacology
Summary
Ketamine's mind-altering effects during treatment may not be the key to its success in fighting depression. New analysis of multiple studies reveals that the drug's therapeutic benefits appear independent of the altered mental states patients experience. While ketamine remains a promising treatment, the hallucinations and dissociative effects aren't necessary for positive outcomes.
Abstract
In recent years, there has been a significant focus on exploring the potential therapeutic impact of altered states of consciousness on treatment o...
Exploring Psychedelics Pharmacology: A Scoping Review Charting the Course of Psilocybin Pharmacokinetics.
Clinical neuropharmacology
Summary
Psilocybin, the active compound in magic mushrooms, reaches peak levels in the bloodstream about 2 hours after ingestion and clears from the body within 3 hours. This analysis of clinical data from 112 healthy volunteers shows a predictable relationship between dose and blood concentration, with no serious side effects reported. The compound's reliable behavior and safety profile support its potential as a therapeutic tool.
Abstract
This scoping review aimed to synthesize the existing data about psilocybin pharmacokinetics to learn what has been described regarding body disposi...
The Impact of Preoperative Low-Dose Esketamine and Dexmedetomidine Nasal Administration on the Emergence Delirium in Children Undergoing Fiber Bronchoscopy: A Prospective Randomized Controlled Trial.
Clinical neuropharmacology
Summary
Nasal medications before pediatric bronchoscopy can dramatically reduce post-procedure confusion and distress. Low doses of esketamine or dexmedetomidine administered nasally cut emergence delirium rates from 49% to just 7-19% in young children. The medications also decreased pain, with minimal side effects. Esketamine showed particular promise, offering faster recovery times than dexmedetomidine while maintaining excellent postoperative behavior.
Abstract
This study aimed to investigate the effects of preoperative low-dose esketamine and dexmedetomidine nasal administration on the incidence of postop...
Mapping the Use of Ketamine in Treatment-Resistant Depression and Other Psychiatric Disorders: A Scoping Review of Practice Patterns, Efficacy, and Patient Demographic Trends.
American journal of therapeutics
Summary
Ketamine therapy shows promising results for patients who don't respond to traditional depression treatments, with success rates reaching 70% in some cases. This comprehensive analysis of treatment patterns reveals that IV administration remains the preferred method, though accessibility varies widely. Private clinics offer more flexible psychiatric care than hospitals, but health care accessibility remains a challenge, especially in rural areas. Most patients are middle-aged, and insurance coverage limitations create financial barriers to this innovative treatment option.
Abstract
Ketamine has emerged as a novel treatment for psychiatric disorders, particularly treatment-resistant depression (TRD). Although intravenous (IV) k...
Interactive Effects of Ayahuasca and Cannabidiol in Social Cognition in Healthy Volunteers: A Pilot, Proof-of-Concept, Feasibility, Randomized-Controlled Trial.
Journal of clinical psychopharmacology
Summary
Combining ancient plant medicine with modern cannabinoids, researchers explored how CBD might influence ayahuasca's effects on emotional recognition and empathy. Healthy volunteers received either CBD or placebo before taking ayahuasca. Both groups showed faster emotional recognition and reduced anxiety, with no significant differences between them. The combination proved safe, with only mild side effects like nausea.
Abstract
Serotonergic hallucinogens and cannabinoids may alter the recognition of emotions in facial expressions (REFE). Cannabidiol (CBD) attenuates the ps...
The Pharmacological Management of Ketamine Use Disorder: A Systematic Review.
Journal of addiction medicine
Summary
As ketamine use rises globally, healthcare providers now have initial evidence for managing its misuse. Benzodiazepines show promise in treating both acute ketamine intoxication and withdrawal symptoms. For long-term recovery, medications like naltrexone and lamotrigine may help prevent relapse. While current evidence comes from small studies, these findings offer a starting point for treating ketamine dependence with targeted medications.
Abstract
There has been limited evidence synthesis examining treatment of ketamine use disorder. We aimed to conduct a systematic review to assess the effic...
Psychedelic Therapy: A Primer for Primary Care Clinicians-3,4-Methylenedioxy-methamphetamine (MDMA).
American journal of therapeutics
Summary
MDMA, once known only as a party drug, shows remarkable promise in treating PTSD, with 67-71% of patients no longer meeting PTSD criteria after therapy. Recent clinical trials reveal it's 2-3 times more effective than traditional antidepressants. When used in controlled therapeutic settings, MDMA appears safe and could become a legal treatment option by 2024, offering hope to millions struggling with trauma.
Abstract
After becoming notorious for its use as a party drug in the 1980s, 3,4-methylenedioxy-methampetamine (MDMA), also known by its street names "molly"...
Psychedelic Therapy: A Primer for Primary Care Clinicians-Ketamine.
American journal of therapeutics
Summary
Ketamine, once solely used as an anesthetic, now shows remarkable promise in mental health treatment. A single dose can reduce depression symptoms within hours - far faster than traditional antidepressants. It effectively treats severe depression, PTSD, and suicidal thoughts, while also helping manage post-surgery pain with fewer opioids needed. Though effects may be temporary, its rapid action and safety profile make it a valuable tool for clinicians.
Abstract
Ketamine, an arylcyclohexylamine dissociative anesthetic agent, has evolved into a versatile therapeutic. It has a rapid-onset, well-understood car...
Psychedelic Therapy: A Primer for Primary Care Clinicians-Psilocybin.
American journal of therapeutics
Summary
Psilocybin, found in magic mushrooms, shows remarkable potential in treating depression, with some early trials reporting remission rates of up to 57%. Recent research reveals this naturally-occurring compound is generally safe when used in controlled settings, causing mainly temporary effects like nausea. Clinical data suggests it's particularly effective for treatment-resistant depression, substance use disorders, and end-of-life anxiety, with benefits lasting months after just 1-2 doses. While larger trials show more modest success rates of 25-29%, the significant reduction in depressive symptoms still outperforms many traditional treatments.
Abstract
The primary psychoactive drug in magic mushrooms, psilocybin, induces profound alterations in consciousness through the 5-HT2A receptor. This revie...
Psychedelic Therapy: A Primer for Primary Care Clinicians-N,N-Dimethyltryptamine and Ayahuasca.
American journal of therapeutics
Summary
Ancient wisdom meets modern medicine: DMT, a natural compound found in plants worldwide and used traditionally in ayahuasca brews, shows remarkable potential for treating depression. Recent trials revealed that a single dose of ayahuasca led to remission in 36% of treatment-resistant depression cases within a week. Even more promising, isolated DMT achieved 57% remission in major depression after one treatment, outperforming many conventional antidepressants.
Abstract
N,N-dimethyltryptamine (DMT) is a naturally occurring serotonergic psychedelic found in natural plants around the globe. As the main psychoactive c...
Psychedelic Therapy: A Primer for Primary Care Clinicians-Lysergic Acid Diethylamide (LSD).
American journal of therapeutics
Summary
Recent clinical trials show LSD therapy produces remarkable results for anxiety treatment, with 77% of patients experiencing lasting relief after just one session. The hallucinogen demonstrates promising potential for treating anxiety, depression, and substance use disorders. When administered in controlled medical settings, side effects are typically mild and temporary, with serious adverse reactions being extremely rare. Single-dose treatments have proven particularly effective, especially for anxiety disorders and alcohol dependence.
Abstract
Lysergic acid diethylamide (LSD) is a hallucinogenic agent. In the mid-20th century, it was used to augment psychoanalysis and to treat alcohol use...