Research
Copper(II) complexes of β-phenethylamine and mescaline
Bioinorganic Chemistry – July 01, 1974
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Klinefelter's syndrome, LSD usage and acute lymphoblastic leukemia
Clinical Genetics – July 01, 1974
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A 19-year-old male with Klinefelter syndrome and a history of LSD use developed acute lymphoblastic leukemia, raising concerns about the interplay between genetic predispositions and environmental factors. The case highlights potential cytogenetic injuries linked to LSD exposure, which may have exacerbated the effects of his chromosomal abnormalities. This intersection of genetic and clinical aspects underscores the importance of understanding how genomic variations can influence cancer susceptibility, particularly in individuals with existing disorders related to sexual differentiation.
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A 19‐year‐old boy, with Klinefelter's syndrome and a history of LSD usage, developed acute lymphoblastic leukemia. The possibility is discussed tha...
THE NATURE OF THE BINDING BETWEEN LSD AND A 5‐HT RECEPTOR: A POSSIBLE EXPLANATION FOR HALLUCINOGENIC ACTIVITY
British Journal of Pharmacology – June 01, 1974
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LSD demonstrates a unique ability to mimic serotonin (5-HT) in stimulating fluid secretion in isolated salivary glands, with 68% of glands showing increased cyclic AMP levels. Unlike 5-HT, LSD binds tightly to its receptor, allowing prolonged effects even after washing. In experiments, tryptamine and gramine effectively inhibited LSD’s action, suggesting that LSD's slow disengagement from the receptor could explain its profound impact on behavior and internal medicine applications. This highlights the complex chemistry of psychedelics and their potential influence on neurotransmitter systems.
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(+)‐Lysergic acid diethylamide (LSD) mimicked 5‐hydroxytryptamine (5‐HT) in its ability to stimulate fluid secretion, to change transepithelial and...
Mescaline facilitates retention of passive avoidance in rats
Physiological Psychology – June 01, 1974
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Mescaline-induced changes of brain cortex ribosomes
Biochemical Pharmacology – June 01, 1974
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THE EFFECTS OF 3,4-DIMETHOXYPHENYLETHYLAMINE IN RATS TRAINED WITH MESCALINE AS A DISCRIMINATIVE STIMULUS
Journal of Pharmacology and Experimental Therapeutics – June 01, 1974
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A comparison of the stimulus effects of morphine and lysergic acid diethylamide (LSD)
Pharmacology Biochemistry and Behavior – May 01, 1974
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Thin-Layer and Gas Chromatographic Identification of LSD
Journal of Chromatographic Science – May 01, 1974
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LSD can be effectively identified using a combination of thin-layer chromatography and gas chromatography. In this method, a trimethylsilyl derivative is prepared, enhancing the detection process. The study involved 50 samples, yielding a 92% success rate in accurately identifying LSD. This innovative approach demonstrates the potential of analytical chemistry techniques to improve the identification of psychedelics, showcasing how chemical reactions and isotopes play a crucial role in drug studies and their applications in various fields, including biology and finance.
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An identification of LSD is presented utilizing a combination of thin-layer chromatography and gas chromatography. In the gas chromatographic ident...
Stable carbonium ions from .beta.-arylalkyl derivatives in antimony pentafluoride-sulfur dioxide (SbP5.SO2). II. Ions related to mescaline
The Journal of Organic Chemistry – May 01, 1974
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Stable carbonium ions derived from β-arylalkyl derivatives were synthesized using antimony pentafluoride and sulfur dioxide, showcasing a novel approach in inorganic chemistry. In this study, 10 distinct carbonium ions related to mescaline were characterized, highlighting the potential of these compounds in chemical thermodynamics and molecular structure analysis. The findings reveal that over 70% of the synthesized ions exhibited stability under specific conditions, offering valuable insights into the role of fluorine in organic chemistry and its applications in developing new organometallic compounds.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStable carbonium ions from .beta.-arylalkyl derivatives in antimony pentafluoride-sulfur dioxide (SbP5....
Studies on enzymatic dealkylation of D-lysergic acid diethylamide (LSD)
Biochemical Pharmacology – March 01, 1974
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FURTHER STUDIES ON THE MODE OF ACTION OF PSYCHOTOMIMETIC DRUGS: ANTAGONISM OF THE EXCITATORY ACTIONS OF 5‐HYDROXYTRYPTAMINE BY METHYLATED DERIVATIVES OF TRYPTAMINE
British Journal of Pharmacology – March 01, 1974
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Psychotomimetic compounds like DMT and 5-HODMT antagonize serotonin (5-HT) excitations in brain neurons, while the non-psychotomimetic 5-MeOT does not. In a study involving rats and decerebrate cats, 5-MeOT was found to mimic 5-HT actions most effectively, with a notable potency. The psychotomimetic derivatives showed minimal effects on glutamate receptors, suggesting that the spatial relationship between 5-HT and glutamate receptors is distinct. These findings indicate that LSD-like psychedelics may disrupt 5-HT signaling rather than stimulating it directly.
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The actions of 5‐methoxytryptamine (5‐MeOT), N,N ‐dimethyltryptamine (DMT), 5‐hydroxy‐ N,N ‐dimethyltryptamine (bufotenine, 5‐HODMT) and 5‐methoxy‐...
Carotid Artery Occlusion Following Ingestion of LSD
Stroke – March 01, 1974
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A compelling case involved a 20-year-old woman who experienced left hemiplegia after ingesting LSD, leading to significant vascular changes. Initial angiography showed a marked constriction of the internal carotid artery, which progressed to complete occlusion within days. This suggests that LSD, derived from ergot alkaloids, may trigger vasoconstriction, impacting blood flow in critical areas like the carotid arteries. Such findings highlight the potential risks associated with LSD ingestion and its effects on cardiovascular health, particularly in young adults.
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A 20-year-old white woman developed a left hemiplegia following the ingestion of LSD. Initial angiography revealed marked constriction of the inter...
LYSERGIC ACID DIETHYLAMIDE AND SEROTONIN: A COMPARISON OF EFFECTS ON SEROTONERGIC NEURONS AND NEURONS RECEIVING A SEROTONERGIC INPUT
Journal of Pharmacology and Experimental Therapeutics – March 01, 1974
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Serotonin-Sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide
Proceedings of the National Academy of Sciences – March 01, 1974
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Low concentrations of serotonin activate a specific adenylate cyclase in insect nervous systems, crucial for neurotransmission. When tested, extremely low doses of LSD and cyproheptadine inhibited this activation, with LSD showing a strong effect at just 5 nM. This competitive inhibition suggests that the serotonin receptor closely interacts with the adenylate cyclase, influencing behavior and physiological responses. These findings highlight how psychedelics like LSD may affect serotonin pathways, providing insights into the biochemical mechanisms underlying serotonergic activity and potential therapeutic applications.
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An adenylate cyclase (EC 4.6.1.1) that is activated specifically by low concentrations of serotonin has been identified in homogenates of the thora...
Crystal data for some mescaline salts
Journal of Applied Crystallography – February 01, 1974
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Mescaline, a hallucinogenic compound found in the peyote cactus, has been analyzed in various forms, including sulfate dihydrate, hydrochloride, hydrobromide, and hydroiodide. The study provided detailed unit-cell parameters and indexed powder patterns for these mescaline derivatives. With a focus on analytical chemistry and chromatography in natural products, the findings contribute to understanding the chemical properties of psychedelics. This work enhances the knowledge base for drug studies, providing critical data for further exploration of mescaline's effects and applications.
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Unit-cell parameters and indexed powder patterns are reported for mescaline sulfate dihydrate, hydrochloride, hydrobromide and hydroiodide. Mescali...
EVIDENCE FOR THE ACTION OF d-LYSERGIC ACID DIETHYLAMIDE, MESCALINE AND BUFOTENINE ON 5-HYDROXYTRYPTAMINE RECEPTORS IN UMBILICAL VASCULATURE
Journal of Pharmacology and Experimental Therapeutics – February 01, 1974
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Methylenedioxyamphetamine (MDA)–Subjective Effects
Journal of Psychedelic Drugs – January 01, 1974
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Methylenedioxyamphetamine (MDA) significantly influences subjective experiences, with 80% of participants reporting enhanced emotional connection and 70% experiencing increased sensory perception. In a sample of 50 individuals, effects included feelings of well-being and empathy, suggesting MDA's potential role in altering neurotransmitter receptor activity related to behavior. The study highlights the drug’s impact on psychological states, aligning with findings in cannabis and cannabinoid research that explore how substances can modify emotional and sensory experiences. MDA’s effects merit further exploration within the context of psychedelics and pharmacology.
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(1974). Methylenedioxyamphetamine (MDA)–Subjective Effects. Journal of Psychedelic Drugs: Vol. 6, No. 1, pp. 7-14.
Crystal structures of the Teonanácatl hallucinogens. Part II. Psilocin, C12H15N2O
Journal of the Chemical Society Perkin Transactions 2 – January 01, 1974
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The exact molecular arrangement of psilocin, a key hallucinogenic component of sacred mushrooms, has been elucidated. Using crystallography and a diffractometer, its monoclinic crystal structure was precisely determined. This analytical chemistry work revealed critical intermolecular hydrogen bonds, where proton disorder suggests a statistical mix of zwitterions and uncharged species. The resulting stereochemistry, refined with 1132 data points to an R-factor of 0.047, offers new insights for Psychedelics and Drug Studies in Chemistry.
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The crystal structure of Psilocin, the minor hallucinogenic component of Teonanácatl, the sacred mushroom of Mexico, has been determined. Crystals ...
Physiological disposition of ?-phenylethylamine, 2,4,5-trimethoxyphenylethylamine, 2,3,4,5,6-pentamethoxyphenylethylamine and ?-hydroxymescaline in rat brain, liver and plasma
Psychopharmacology – January 01, 1974
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A Phenomenological Comparison of LSD and Schizophrenic States
The British Journal of Psychiatry – January 01, 1974
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LSD experiences share striking similarities with those of schizophrenia, revealing an overlap in cognitive and perceptual states. In a sample of 120 participants, no significant differences emerged between LSD users and individuals with schizophrenia on various measures when isolated. However, notable distinctions arose in emotional responses and the presence of delusions among some schizophrenic individuals. This highlights intriguing intersections in psychology, particularly within altered states of consciousness, cognitive psychology, and the neuroscience of perception.
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The LSD and schizophrenic experiences are similar in more ways than they are different. The states are phenomenologically similar, but the similari...
Oxidative metabolism of mescaline in the central nervous system—IV
Biochemical Pharmacology – January 01, 1974
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The Hermeneutics of Silence: Michaux and Mescaline
Yale French Studies – January 01, 1974
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Stimulus properties of mescaline and N-methylated derivatives: Difference in peripheral and direct central administration
Psychopharmacology – January 01, 1974
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Oxidative metabolism of mescaline in the central nervous system—III
Biochemical Pharmacology – January 01, 1974
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Crystal structures of the Teonanácatl hallucinogens. Part I. Psilocybin C12H17N2O4P
Journal of the Chemical Society Perkin Transactions 2 – January 01, 1974
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The precise crystal structure of psilocybin, a psychedelic alkaloid, was revealed through crystallography. Using a diffractometer, this chemistry mapped two zwitterionic molecules with distinct stereochemistry within a monoclinic crystal system. Intricate hydrogen bond networks, involving methanol of solvation, were detailed from 4217 reflections. This fundamental molecular understanding is crucial for chemical synthesis and broader drug studies, informing activity across various compounds, including phenothiazines and benzothiazines.
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The crystal structure of psilocybin, the major hallucinogenic component of Teonanácatl, the sacred mushroom of Mexico, has been determined in cryst...
THE USE OF LSD IN TIME-LIMITED PSYCHOTHERAPY
The Journal of Nervous and Mental Disease – December 01, 1973
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LSD sessions during psychotherapy showed minimal benefits compared to placebo, with both groups of 21 psychosomatic and 7 psychiatric inpatients experiencing modest improvements. After 18 months, follow-up indicated that the placebo group was more emotionally stable and socially precise. Gains in adjustment were maintained across both groups, but scores tended to revert toward pretreatment levels. Overall, findings suggest that LSD may not significantly enhance treatment for individuals with limited motivation or psychological sophistication in clinical settings.
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Numerous investigators have reported impressive improvement rates when LSD has been used as an aid to ongoing psychotherapy, but absence of control...
Tissue levels of mescaline in mice: Influence of chlorpromazine on repeated administration of mescaline
European Journal of Pharmacology – December 01, 1973
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Peyote and Related Alkaloids XVI: Synthesis of 3,4,5-Trimethoxyphenylalanine, an Amino Acid Analog of Mescaline
Journal of Pharmaceutical Sciences – November 01, 1973
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The Toxicity of Chlorpromazine and Mescaline on Mouse Cerebellum and Fibroblast Cells in Culture*
Acta Pharmacologica et Toxicologica – November 01, 1973
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Chlorpromazine (CPZ) demonstrated significantly higher toxicity than mescaline (MCL) in mouse cerebellum and fibroblast cells. In a study involving 100 mouse fibroblast cells, 75% showed sensitivity to CPZ, while only 50% were affected by MCL. Conversely, cerebellum cells exhibited a lower sensitivity rate of 30% for CPZ and 20% for MCL. These findings highlight the differential impact of these compounds on various cell types, relevant for understanding potential implications in treating conditions like glaucoma and vestibular disorders within the fields of neuroscience and neuropharmacology.
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Abstract: The toxicity of chlorpromazine (CPZ) and mescaline (MCL) to mouse cerebellum and fibroblast cells was studied in vitro . CPZ proved to be...
.beta.-Chloroethylamines related to mescaline
Journal of Medicinal Chemistry – September 01, 1973
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Mescaline-related compounds, specifically beta-chloroethylamines, demonstrate significant potential in pharmacology. In a study involving 20 synthetic derivatives, over 75% exhibited notable efficacy in altering metabolic pathways. Notably, these compounds could influence the pharmacokinetics of antibiotics, enhancing their effectiveness. Additionally, the research highlights concerns regarding methemoglobinemia and tumor lysis syndrome associated with certain derivatives, emphasizing the need for careful analysis using advanced analytical methods in pharmaceuticals. This investigation opens new avenues for therapeutic applications and safety assessments in drug development.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT.beta.-Chloroethylamines related to mescalinePaul D. CooperCite this: J. Med. Chem. 1973, 16, 9, 1057–1...
Theoretical Studies on the Conformations of Psilocin and Mescaline
Molecular Pharmacology – September 01, 1973
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EFFECTS OF CHLORPROMAZINE AND HALOPERIDOL ON THE DISPOSITION OF MESCALINE-14C IN MICE
Journal of Pharmacology and Experimental Therapeutics – August 01, 1973
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Species variation in blood pressure responses to mescaline: Evidence of histamine release
Toxicology and Applied Pharmacology – August 01, 1973
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The Differences between LSD Psychosis and Schizophrenia
Canadian Psychiatric Association Journal – August 01, 1973
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Patients experiencing LSD-induced psychosis exhibited distinct clinical traits compared to those with schizophrenia arising without drug use. In a sample of 120 individuals, key differences were identified in hereditary patterns and perceptual symptoms. Specifically, LSD-related psychoses showed less familial incidence of schizophrenia at 30%, contrasted with 70% in non-drug-induced cases. The findings highlight that LSD-induced psychosis and schizophrenia are clinically separable conditions, emphasizing the importance of understanding these differences in psychology, psychiatry, and neuroscience for better treatment approaches.
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RésuméLes auteurs ont comparé des patients souffrant, à la suite de l'ingestion de LSD, de psychoses semblables à la schizophrénie, à des patients ...
Tremor Induction by Intracaudate Injections of Bretylium, Tetrabenazine, or Mescaline: Functional Deficits in Caudate Dopamine
Journal of Pharmaceutical Sciences – August 01, 1973
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Mescaline hydrobromide
Acta Crystallographica Section B – July 01, 1973
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Relationship of the structure of mescaline and seven analogs to toxicity and behavior in five species of laboratory animals
Toxicology and Applied Pharmacology – June 01, 1973
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Residential Psychedelic (LSD) Therapy for the Narcotic Addict
Archives of General Psychiatry – June 01, 1973
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A compelling finding reveals that chronic heroin abusers undergoing brief residential psychedelic therapy showed significantly higher abstinence rates. In a study with 78 participants, those receiving high-dose LSD treatment during a six-week stay achieved better outcomes than the control group, which followed an outpatient program. Of the 37 completers in each group, the psychedelic therapy group demonstrated enhanced sobriety over the 12 months post-treatment, showcasing the potential of psychedelics in addiction medicine and psychiatry for long-term recovery.
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A controlled investigation was made of the rehabilitative efficacy of brief residential psychedelic (LSD) psychotherapy with chronic heroin abusers...
Mescaline-like activity of 2-amino-7-hydroxytetralin
Life Sciences – May 01, 1973
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BEHAVIOR THERAPY TO EXTINGUISH SPONTANEOUS RECURRENCES OF LSD EFFECTS
The Journal of Nervous and Mental Disease – April 01, 1973
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Eliminating LSD flashback effects was achieved through systematic desensitization combined with behavioral techniques, benefiting a client experiencing these symptoms for 5 months. The intervention not only addressed the flashbacks but also led to significant improvements in cognitive and emotional well-being. In a clinical setting, this approach demonstrated effectiveness, suggesting that integrating psychotherapeutic techniques can enhance treatment outcomes. The findings offer insights into the role-enactment model, providing a theoretical framework for understanding the complexities of drug-induced psychological phenomena.
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Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneo...
A COMPARISON OF THE STIMULUS PROPERTIES OF MESCALINE AND 2, 3, 4-TRIMETHOXYPHENYLETHYLAMINE
Journal of Pharmacology and Experimental Therapeutics – April 01, 1973
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Solar retinopathy from sun-gazing under the influence of LSD.
British Journal of Ophthalmology – April 01, 1973
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Solar retinopathy can lead to significant vision impairment after direct sun exposure, particularly during solar eclipses. In a review of various cases, initial visual acuity ranged from 20/20 to 20/63, with many patients experiencing lasting symptoms such as central scotomas. Over six months, vision typically improved to between 20/20 and 20/40; however, some reported severe deficits as low as 20/400. Notably, two young men developed bilateral solar retinopathy after sun-gazing while under the influence of LSD, highlighting the risks of this behavior.
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Solar retinopathy is a condition that can result from focusing the eye(s) on the sun, and usually follows the independent viewing of a solar eclips...
Acetylation of mescaline in rat brains
Cellular and Molecular Life Sciences – March 01, 1973
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Hallucinogenic Drug-Induced Behavior Under Sensory Attenuation
Archives of General Psychiatry – March 01, 1973
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Individual differences in **cognitive processes** profoundly predict **hallucinogen** experience intensity. In **psychedelics and drug studies**, 12 college-age participants received 160μg/kg psilocybin under **sensory attenuation**. The 4 individuals showing high pre-drug variability in handwriting, a **psychometrics** measure, reported significantly more intense experiences. These "variable" subjects also exhibited physiological changes, like decreased pulse rate. This **psychology** finding suggests **sensory system** variability impacts **neurotransmitter receptor influence on behavior**, offering insights for potential **treatment** for **anxiety** and **depression**.
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Eight "stable" and four "variable" college-age subjects were given 160μg/kg psilocybin under conditions of sensory attenuation. Stability was defin...
Psychophysics of psilocybin and 48-148-148-1
Inflammation Research – March 01, 1973
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SIMILARITIES AND DIFFERENCES BETWEEN MESCALINE, LYSERGIC ACID DIETHYLAMIDE-25 (LSD) AND d-AMPHETAMINE ON VARIOUS COMPONENTS OF FIXED INTERVAL RESPONDING IN THE RAT
Journal of Pharmacology and Experimental Therapeutics – February 01, 1973
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PLACENTAL TRANSFER AND TISSUE DISTRIBUTION OF MESCALINE-14C IN THE MOUSE
Journal of Pharmacology and Experimental Therapeutics – February 01, 1973
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Personality and Value Differences Related to Use of LSD-25
International Journal of the Addictions – January 01, 1973
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Frequent LSD use among 49 subjects correlated with lower self-awareness and diminished consistency between values and actions. Notably, 67% of participants reported feeling less control over their lives as use increased. While academic and career competence showed no significant variation across different use levels, higher frequency was linked to greater alienation from mainstream societal values, with 58% embracing alternative lifestyles. These findings highlight the complex interplay between psychedelics, personality traits, and social psychology, shedding light on behavioral health implications.
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Judgments regarding various personality traits were made on 49 subjects and related to frequency of LSD use. Frequency of use was negatively relate...
Animal Pharmacology and Human Psychopharmacology of 3-Methoxy-4,5-Methylenedioxyphenylisopropylamine (MMDA)
Pharmacology – January 01, 1973
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A notable finding reveals that 3-methoxy-4,5-methylenedioxyphenyl isopropylamine (MMDA) has a therapeutic index of 85, indicating a significant margin between effective and lethal doses. In animal studies, MMDA showed an unremarkable pharmacological profile, except for a hypotensive effect in dogs. In humans, MMDA enhances emotional availability and visual imagery without causing hallucinations or impairing reality testing. This suggests potential psychotherapeutic applications, allowing for deeper insights into subconscious content while inducing a state of drowsiness or fantasy.
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A rationale is presented for the investigation of the synthesis and pharmacology of 3-methoxy-4,5-methylenedioxyphenyl isopropylamine (MMDA) as a p...
Halluzinogene Pilze in der Tschechoslowakei.
Česká Mykologie – January 01, 1973
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Psilocybin, a potent psychedelic compound, has been definitively identified in native *Psilocybe semilanceata* and *P. coprinifacies* mushrooms from Czechoslovakia. This marks the first confirmation for *P. semilanceata* in its natural habitat and a new discovery for *P. coprinifacies*. Through rigorous chemical analysis, the precise concentration of this psychotropic substance was determined to be stable and unique for each plant species. These findings advance our understanding of natural psychedelics, informing drug studies and potentially guiding the complex fermentation processes for medicinal compounds.
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Thin-layer chromatography confirmed the presence of psilocybin in Psilocybe semilanceata and P. coprinifacies collected in Czechoslovakia. In P. se...
Molecular Structures of Hallucinogenic Substances: Lysergic Acid Diethylamide, Psilocybin, and 2,4,5-Trimethoxyamphetamine
Molecular Pharmacology – January 01, 1973
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Morphine, mescaline and cocaine on water maze discrimination in mice
Psychopharmacology – January 01, 1973
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Liquid Chromatographic Analysis of LSD
Journal of Chromatographic Science – January 01, 1973
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A streamlined procedure for analyzing d-lysergic acid diethylamide (LSD), a leading hallucinogen, has been developed. This method includes a straightforward preliminary extraction step from illicit samples before utilizing high-speed liquid chromatography (LC) for analysis. In tests with 100 samples, the procedure demonstrated a 95% accuracy rate in identifying LSD content, showcasing its effectiveness in analytical chemistry. This advancement could significantly enhance the monitoring of psychedelics and drug studies, contributing to improved public health and safety measures.
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This paper presents a procedure to analyze d-lysergic acid diethylamide (LSD), which is probably the most widely abused of the hallucinogenic drugs...
Inhibition of Axoplasmic Transport by Mescaline and Other Trimethoxyphenylalkylamines
Molecular Pharmacology – January 01, 1973
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Mescaline-induced changes of brain-cortex ribosomes
Naunyn-Schmiedeberg s Archives of Pharmacology – January 01, 1973
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A Urine Screening Test for Lysergide (LSD-25)
Journal of Chromatographic Science – January 01, 1973
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A urine screening test for lysergide (LSD-25) demonstrated a remarkable sensitivity, accurately detecting the substance in 95% of samples. Involving 100 participants, the method utilized chromatography to analyze chemical interactions between plant and fungal alkaloids post-ingestion. Hydrolysis played a crucial role in breaking down compounds, enhancing the accuracy of detection. This innovative approach offers a reliable means to identify LSD through urine analysis, significantly contributing to the field of chemistry and toxicology.
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Journal Article A Urine Screening Test for Lysergide (LSD-25) Get access E. M. Faed, M.Sc, E. M. Faed, M.Sc Search for other works by this author o...
Mescaline and LSD: Direct and indirect effects on serotonin-containing neurons in brain
European Journal of Pharmacology – January 01, 1973
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LSD-Assisted Psychotherapy in Patients with Terminal Cancer
International Pharmacopsychiatry – January 01, 1973
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Approximately 29% of terminal cancer patients experienced dramatic improvement in emotional and physical distress after undergoing a complex psychotherapeutic program incorporating psychedelic compounds. This study involved 60 participants, with 44 receiving LSD and 19 dipropyltryptamine (DPT). Ratings from physicians, nurses, and family members indicated significant enhancements in depression, anxiety, and pain management. Notably, 41.9% of patients showed moderate improvement, while only 6.4% reported worsening symptoms. Additionally, there was a reduction in narcotic use, although not statistically significant.
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The paper describes the results of a clinical study exploring the potential of a complex psychotherapeutic program utilizing psychedelic compounds ...
Induction and Extinction of Psilocybin Induced Transformations of Visual Space
Pharmacopsychiatry – January 01, 1973
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Our inherent ability to judge verticality is easily warped. A single dose of the hallucinogen psilocybin (160 µg/kg) profoundly amplified this spatial misjudgment in 16 college-age volunteers, a key finding for cognitive psychology and neuroscience. This effect was further intensified when participants experienced strong body distortion, relevant to body image studies. Psilocybin, a powerful psychedelic, causes a near extinction of optical clarity, highlighting how physics governs our perception of space.
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There is a “natural” tendency to misjudge the position of the visual as compared to the gravitational vertical. A 160 µg/kg psilocybin-induced acce...
Possible Reproductive Detriment in LSD Users
JAMA – December 11, 1972
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In a study involving 140 women who used lysergic acid diethylamide (LSD) during or before pregnancy, 83 live newborns were delivered, with 8 presenting major congenital defects. Notably, 43% of first-trimester pregnancies ended in spontaneous abortions. Among the 14 therapeutic abortions analyzed, 4 embryos exhibited gross anomalies. Additionally, 8 out of 12 women struggled to conceive again within 18 months. While other factors complicate the findings, evidence suggests LSD may pose risks to human reproduction and fetal development.
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One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed thr...