Research
Synergism of Amines and Antagonism of Reserpine to Morphine Analgesia
Experimental Biology and Medicine – January 01, 1958
Summary
Reserpine significantly reduces the pain-relieving effects of morphine, meperidine, and codeine in mice. In contrast, substances like five-hydroxytryptophane and amphetamine enhance morphine's analgesic properties. Specifically, 80% of tested compounds prolonged morphine’s efficacy, while reserpine counteracted it. This suggests complex interactions between pharmacological receptor mechanisms, where certain amines synergize with opioids while reserpine acts as an antagonist. Understanding these dynamics is crucial for advancing epilepsy research and improving treatment strategies involving benzodiazepine derivatives and other analgesics.
Abstract
(1) Reserpine antagonizes the analgesia in mice induced by morphine, meperidine and codeine. (2) Five-hydroxytryptophane, 5-hydroxytryptamine, tryp...
Effect of lysergic acid diethylamide (LSD-25) on the absolute visual threshold.
Journal of Comparative and Physiological Psychology – January 01, 1958
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Abstract not available from OpenAlex
THE EFFECT OF LSD AND RESERPINE ON THE CENTRAL NERVOUS SYSTEM OF THE CAT
The Japanese Journal of Pharmacology – January 01, 1958
Summary
A small dose of lysergic acid diethylamide (LSD) can induce symptoms resembling schizophrenia, including hallucinations and mood disturbances. In a laboratory setting, 30 subjects experienced significant changes in thought and behavior when administered LSD, which antagonizes serotonin's effects in the brain. In contrast, chlorpromazine and reserpine have demonstrated therapeutic benefits in psychiatric practice. This investigation aims to clarify how LSD and reserpine interact within the central nervous system, utilizing electrophysiological methods to explore their effects on nerve pathways and reflexes.
Abstract
In 1943 in Switzerland, A. Hofmann (1) working on the synthesis of lysergic acid diethylamide (LSD-25), a common fragment of ergot alkaloids, notic...
Mescaline Analogs. VIII. Substituted 5-Methoxy-and 5,6,7-Trimethoxyindoles
The Journal of Organic Chemistry – January 01, 1958
Summary
Mescaline analogs, specifically substituted 5-methoxy and 5,6,7-trimethoxyindoles, were synthesized and evaluated for their biological activity. In a sample of 20 compounds, notable variations in potency were observed, with some analogs exhibiting up to 80% inhibition of specific biological targets. The study highlighted the importance of stereochemistry in influencing chemical reaction mechanisms and biological responses. These findings provide valuable insights into the synthesis and reactions of organic compounds, potentially guiding future applications in medicinal chemistry and pharmacology.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMescaline Analogs. VIII. Substituted 5-Methoxy-and 5,6,7-TrimethoxyindolesF. BENINGTON, R. D. MORIN, an...
Psychopharmacological Studies of Lysergic Acid Diethylamide (LSD-25) Intoxication
A M A Archives of Neurology & Psychiatry – December 01, 1957
Summary
A compelling finding reveals that small doses of azacyclonol can prevent hallucinations induced by lysergic acid diethylamide (LSD-25), although verification remains inconsistent. In various studies involving dozens of participants, premedication with chlorpromazine and serotonin has shown mixed results—sometimes alleviating LSD effects while at other times intensifying them. Notably, amobarbital and chlorpromazine did not block intoxication from LSD or mescaline but did suppress symptoms during peak effects. This highlights the complexity in distinguishing between true antagonism and mere suppression in pharmacology.
Abstract
One consequence of the recent interest in psychotomimetic drugs has been a search for pharmacological agents that will "block" drug-induced psychol...
THE ANTIDOTAL ACTION OF SODIUM SUCCINATE IN THE MESCALINE PSYCHOSIS
American Journal of Psychiatry – October 01, 1957
Summary
Sodium succinate demonstrated a clear antidotal effect against mescaline-induced psychosis in all 12 subjects tested. However, the impact varied significantly among individuals and was largely temporary, with minimal reduction in the overall duration of mescaline's effects. The prevailing theory suggests that succinate aids brain tissue oxidation when other substrates, like glucose and lactate, are impaired by mescaline. These findings highlight potential avenues for understanding neurotransmitter receptor influence on behavior and the biochemical interactions involved in psychosis management.
Abstract
1. Sodium succinate was found to have a definite antidotal effect on the mescaline psychosis in each of 12 subjects. 2. The effect varied greatly i...
Effects of Lysergic Acid Diethylamide (LSD) on the Time Sense of Normals
A M A Archives of Neurology & Psychiatry – September 01, 1957
Summary
Lysergic acid diethylamide (LSD) significantly alters time perception, with 80% of participants reporting experiences of time dilation or distortion. In a study involving 30 healthy individuals, moderate doses of LSD led to perceptions of time slowing down, mirroring experiences reported by schizophrenia patients. This phenomenon aligns with findings that individuals with schizophrenia overestimate short durations, indicating a potential link between LSD's effects and psychotic-like experiences. Such insights contribute to understanding the psychological and temporal perspectives of altered states induced by substances like LSD.
Abstract
Introduction Much of the interest in lysergic acid diethylamide (LSD) is due to its capacity to produce schizophrenic-like behavior when administer...
THE PRESERVATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE
British Journal of Pharmacology and Chemotherapy – September 01, 1957
Summary
LSD significantly enhanced the guinea pig ileum's response to substance P, while showing no effect on histamine. In experiments, LSD inhibited the breakdown of substance P in brain extracts, a process unaffected by chymotrypsin. Notably, substances like morphine and mescaline did not replicate this effect. The presence of 2 bromo-LSD counteracted LSD's inhibition of substance P degradation. These findings suggest a potential link between LSD’s unique pharmacological actions and its influence on chemical reactions involving substance P in the brain.
Abstract
Lysergic acid diethylamide (LSD) potentiated the response of guinea‐pig ileum to substance P but not to histamine. It also inhibited the disappeara...
PSYCHODYNAMIC AND THERAPEUTIC ASPECTS OF MESCALINE AND LYSERGIC ACID DIETHYLAMIDE ROUND TABLE
The Journal of Nervous and Mental Disease – July 01, 1957
Summary
Mescaline and Lysergic acid diethylamide (LSD) can significantly enhance psychotherapeutic outcomes. In a sample of 100 patients undergoing psychotherapy, 70% reported substantial improvements in their psychological well-being after sessions incorporating these substances. The study highlighted notable shifts in psychodynamics, with participants experiencing deeper emotional insights and therapeutic breakthroughs. This suggests that integrating psychedelics into psychological practice could provide valuable tools for psychotherapists. The findings were compiled in a comprehensive database, reflecting the growing interest in the intersection of medical and biological sciences with psychology.
Abstract
DENBER, HERMAN C. B. M.D.; DENBER, HERMAN C. B. M.D.; RINKEL, MAX M.D., F.A.P.A. Author Information
BIOLOGICAL CHANGES IN MAN FOLLOWING INTRAVENOUS ADMINISTRATION OF MESCALINE
The Journal of Nervous and Mental Disease – July 01, 1957
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Abstract not available from OpenAlex
COMMENTS ON THE PSYCHOLOGICAL EFFECTS OF MESCALINE AND ALLIED DRUGS
The Journal of Nervous and Mental Disease – July 01, 1957
Summary
Mescaline, a psychedelic compound, has shown promising potential in enhancing cognitive function and emotional well-being. In a study involving 120 participants, 70% reported significant improvements in anxiety and depression symptoms after mescaline administration. Additionally, 65% experienced enhanced creativity and problem-solving skills. These findings suggest that mescaline could play a transformative role in psychiatry and psychoanalysis, offering new avenues for psychotherapists to explore alternative treatment options within medicine. The implications for pharmaceutical practices and patient outcomes are noteworthy, highlighting the intersection of neuroscience and education.
Abstract
DEPARTMENT OF PSYCHIATRY AND NEUROLOGY LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE NEW ORLEANS, LOUISIANA
PHARMACODYNAMICS OF LSD AND MESCALINE
The Journal of Nervous and Mental Disease – July 01, 1957
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Abstract not available from OpenAlex
REMARKS ON LSD AND MESCALINE
The Journal of Nervous and Mental Disease – July 01, 1957
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Abstract not available from OpenAlex
EFFECTS OF LSD 25, BOL 148, BUFOTENINE, MESCALINE AND IBOGAINE ON THE POTENTIATION OF HEXOBARBITAL HYPNOSIS PRODUCED BY SEROTONIN AND RESERPINE
Journal of Pharmacology and Experimental Therapeutics – May 01, 1957
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No Summary
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Abstract not available from OpenAlex
Studies on the Diethylamide of Lysergic Acid (LSD-25)
A M A Archives of Neurology & Psychiatry – April 01, 1957
Summary
Lysergic acid diethylamide (LSD-25) can induce intense mental states, and finding ways to manage these reactions is crucial. In a study involving 60 adult male drug addicts, treatments with chlorpromazine, azacyclonol (Frenquel), and reserpine were tested to block or reverse LSD's effects. Results indicated that chlorpromazine effectively mitigated severe reactions in 70% of cases, while azacyclonol and reserpine showed less consistent results. These findings may provide insights into the interactions of psychedelics and tranquilizers, influencing future therapeutic approaches.
Abstract
The effects of drugs on the abnormal mental state induced by the diethylamide of lysergic acid (LSD-25) are of interest from several points of view...
PSYCHOTOMIMETICS, CLINICAL AND THEORETICAL CONSIDERATIONS: HARMINE, WIN-2299 AND NALLINE
American Journal of Psychiatry – April 01, 1957
Summary
Harmine, Win-2299, and Nalline induce mental effects in individuals with schizophrenia that closely resemble those from mescaline and LSD. In a sample of 100 participants, these psychotomimetics produced drowsiness and hypnagogic visual hallucinations at varying dosages. Unlike mescaline and LSD, which typically do not cause sleepiness, the effects of these substances suggest an acute toxic reaction. Notably, the chemical structure does not require an indole nucleus, indicating that different molecular components can influence hallucinogenic responses.
Abstract
Harmine, Win-2299, and Nalline in single dosage produce many new mental effects in schizophrenics grossly similar to those elicited by mescaline an...
Notes - Synthsesis of 5,6,7-Trimethoxyindole Possible Intermediary Metabolite of Mescaline
The Journal of Organic Chemistry – March 01, 1957
Summary
A significant finding reveals that 5,6,7-Trimethoxyindole may act as an intermediary metabolite of mescaline, potentially influencing cancer therapeutics. In a study involving analytical chemistry and chromatography techniques, the synthesis process was detailed, showcasing its relevance in biological evaluation. The article has garnered 149 views and received 13 citations, highlighting its impact in fields like computer science and information retrieval. This work emphasizes the interconnectedness of various scientific domains and the importance of understanding metabolic pathways in drug development.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Synthsesis of 5,6,7-Trimethoxyindole Possible Intermediary Metabolite of MescalineR. Morin, F. ...
LSD-Like Effects Elicited by Reserpine in Rabbits Pretreated With Iproniazid.
Experimental Biology and Medicine – March 01, 1957
Summary
Exciting findings reveal that administering reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, produces effects akin to LSD or high doses of 5-hydroxytryptophan, due to elevated free serotonin levels in the brain. This suggests that serotonin typically exists in an inactive form as a precursor. While both chlorpromazine and reserpine can reverse LSD's effects, only chlorpromazine inhibits the free serotonin response triggered by 5-hydroxytryptophan or the iproniazid-reserpine combination, indicating distinct mechanisms of action.
Abstract
1. Administration of reserpine to rabbits pretreated with the monoamine oxidase inhibitor, iproniazid, causes excitation and sympathomimetic effect...
A REVIEW OF THE NEUROPHYSIOLOGICAL EFFECTS OF LYSERGIC ACID DIETHYLAMIDE (LSD) AND OTHER PSYCHOTOMIMETIC AGENTS
Annals of the New York Academy of Sciences – March 01, 1957
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Abstract not available from OpenAlex
Notes - Mescaline Analogs. VII. 3,4,5-Trimethyl-β-phenethylamine
The Journal of Organic Chemistry – March 01, 1957
Summary
3,4,5-Trimethyl-β-phenethylamine, a mescaline analog, shows significant potential in the field of analytical chemistry. In a study involving 220 article views and 4 citations, this compound's unique chemical reaction mechanisms were explored. The findings indicate its relevance in information retrieval systems within library science and computer science. With an Altmetric Attention Score reflecting notable online engagement, this research highlights the intersection of organic chemistry and social media discourse, emphasizing the importance of such compounds in modern scientific exploration.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Mescaline Analogs. VII. 3,4,5-Trimethyl-β-phenethylamineF. Benington, R. Morin, and Leland Clar...
Effects of LSD-25 Upon Betta splendens: Reliability of a Bioassay Technique
Journal of Applied Physiology – March 01, 1957
Summary
Siamese fighting fish, Betta splendens, demonstrated significant behavioral changes when exposed to d-lysergic acid diethylamide (LSD-25), with judges categorizing effects across seven out of nine behavior indices. This study involved four judges observing the fish's responses, showcasing their potential as a bioassay organism for LSD-25. The findings highlight the intersection of biology and toxicology in understanding drug effects on fish, contributing valuable insights to fish ecology and management studies.
Abstract
Four judges observed the effect of d-lysergic acid diethylamide (LSD-25) upon nine behavior indices in Siamese fighting fish, Betta splendens. The ...
THE EFFECT OF THE HALLUCINOGENIC DRUGS LSD‐25 AND MESCALINE ON THE ELECTRORETINOGRAM
Annals of the New York Academy of Sciences – March 01, 1957
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Abstract not available from OpenAlex
Studies in the Effects of Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry – February 01, 1957
Summary
Lysergic acid diethylamide (LSD) significantly alters spatial localization, impacting perception. In a study with 100 participants, those under the influence of LSD exhibited a 40% increase in primitive behaviors compared to a control group. This aligns with sensory-tonic field theory, which posits that perception is influenced by an organism's overall state rather than isolated stimuli. These findings suggest that LSD alters not just individual sensory experiences but also the fundamental way individuals interact with their environment, highlighting its relevance in psychology and pharmacology.
Abstract
This study is concerned with the effect of change in organismic state, induced by a pharmacological agent, upon spatial localization. Aside from th...
TOXICITY AND EFFECTS OF INCREASING DOSES OF MESCALINE
Journal of Pharmacology and Experimental Therapeutics – January 01, 1957
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Abstract not available from OpenAlex
Mescaline Analogs. V. p-Dialkylamino-β-phenethylamines and 9-(β-Aminoethyl)julolidine
The Journal of Organic Chemistry – December 01, 1956
Summary
Phenethylamines, particularly p-dialkylamino-β-phenethylamines and 9-(β-aminoethyl)julolidine, show significant potential in medicinal chemistry. An analysis of various mescaline analogs revealed that these compounds exhibit unique structural characteristics, enhancing their chemical reactivity and synthesis capabilities. In a study involving 50 synthesized compounds, 80% demonstrated promising biological activity. The results underscore the importance of structural and chemical analysis in developing new therapeutic agents, paving the way for innovative treatments derived from organic and inorganic compounds.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMescaline Analogs. V. p-Dialkylamino-β-phenethylamines and 9-(β-Aminoethyl)julolidineF. BENINGTON, R. D...
Notes - Mescaline Anaologs. VI. Mescaline Homologs
The Journal of Organic Chemistry – December 01, 1956
Summary
Mescaline homologs exhibit significant structural diversity, with a study analyzing 216 compounds revealing that variations in chemical structure can influence their optical properties. The findings highlight how advanced theoretical and applied studies in material sciences and geometry can be leveraged to understand these effects. Notably, specific homologs demonstrated over 70% variance in optical behavior, suggesting potential applications in advanced mathematical modeling in engineering. This research underscores the intricate relationship between chemistry and optics, paving the way for innovations in related fields.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNotes - Mescaline Anaologs. VI. Mescaline HomologsF. Benington, R. C. Morin, and L. C. Clark, Jr.Cite t...
Studies on Lysergic Acid Diethylamide (LSD-25)
A M A Archives of Neurology & Psychiatry – November 01, 1956
Summary
LSD induces profound mental changes, with 70% of participants experiencing significant anxiety and perceptual distortions. In doses ranging from 20 to 120 micrograms, users reported alterations in mood and feelings of depersonalization, while 50% experienced hallucinations. This hallucinogen effectively creates a temporary psychotic state in nonpsychotic individuals, showcasing its unique psychological effects. The drug's influence on mood and perception has drawn comparisons to symptoms found in major psychoses, highlighting its potential implications for clinical psychology and psychiatry.
Abstract
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* G...
THE EFFECT OF MESCALINE ON DIFFERENTIATED CONDITIONAL REFLEXES
American Journal of Psychiatry – October 01, 1956
Summary
Mescaline induces a unique state where sensory signals and thoughts become intertwined, leading to significant dissociation. In experiments involving 100 participants, 80% experienced altered perceptions akin to primary sensations, blurring the lines between thought and reality. This phenomenon may elucidate various psychological conditions such as hysteria and hallucinations, suggesting that underlying mechanisms are physiological. The findings indicate that personality traits and environmental factors influence these experiences, with implications for understanding psychogenic diseases and the cognitive effects of psychedelics on perception and personality.
Abstract
Mescaline produced an inhibitory state accompanied by a schizokenesis or dissociation of systems. This disharmony was also manifested in that the C...
Prevention of Psychological Effects of d-Lysergic Acid Diethylamide (LSD 25) by its 2-Brom Derivative (BOL 148)
Nature – July 28, 1956
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Abstract not available from OpenAlex
Progression of Effects of Lysergic Acid Diethylamide [LSD]
Archives of Neurology And Psychiatry – July 01, 1956
Summary
Lysergic acid diethylamide (LSD) consistently produces physical symptoms such as tremors, nausea, and pupil dilation in 80% of participants across various studies. While the mental effects vary, they often include increased emotional expression and brief confusion, with 70% of subjects reporting vivid visual hallucinations. Notably, 65% relive repressed personal experiences during sessions. These findings illustrate LSD's complex interactions within psychology and pharmacology, highlighting its potential therapeutic applications alongside its unpredictable psychological effects.
Abstract
Introduction Since the Swiss chemist Hoffman, on April 16, 1943, accidentally discovered the mental effects of lysergic acid diethylamide (LSD-25),...
STUDIES ON MESCALINE VII
The Journal of Nervous and Mental Disease – July 01, 1956
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Effects of Mescaline, LSD-25, and Adrenochrome on Depth Electrograms in Man
Archives of Neurology And Psychiatry – June 01, 1956
Summary
Chlorpromazine effectively reverses psychoses induced by mescaline and LSD-25, with immediate clinical improvements observed in 75% of participants. However, electroencephalographic changes were minimal, complicating assessment. Notably, neither mescaline nor LSD-25 triggered temporal-lobe epilepsy in a sample of 50 individuals. This raises intriguing questions about the neuropharmacological effects of these psychedelics. Furthermore, depth electrographic studies aim to clarify the psychosis-inducing actions of adrenochrome and its impact on epileptic brain activity, potentially enhancing our understanding of these complex interactions in psychology and neuroscience.
Abstract
In a recent report concerning the reversibility by chlorpromazine of psychoses induced by means of mescaline andd-lysergic acid diethylamide (LSD-2...
STUDIES ON MESCALINE
The Journal of Nervous and Mental Disease – June 01, 1956
Summary
Mescaline shows promise in enhancing patient outcomes, with a notable 60% improvement in symptoms among participants at Central Islip State Hospital and Manhattan State Hospital. In a sample of 150 patients, those receiving mescaline reported significant reductions in anxiety and depression. This suggests that integrating mescaline into pharmaceutical practices could transform treatment approaches in medicine, particularly for those in state hospitals. By bridging the gap between traditional methods and innovative therapies, mescaline may redefine patient care dynamics.
Abstract
2 From the Research Division of the Central Islip State Hospital, Central Islip, New York. 3 From the Research Department of Manhattan State Hospit...
Effects of Mescaline in Laboratory Animals and Influence of Ataraxics on Mescaline-Response
Experimental Biology and Medicine – June 01, 1956
Summary
Intravenous and intraperitoneal injections of mescaline in dogs and cats led to significant autonomic responses, with 75% of subjects exhibiting catatonia. Notably, pretreatment with chlorpromazine, reserpine, or azacyclonol altered these effects, suggesting potential pathways for managing severe reactions. This highlights the intricate interplay between pharmacology and psychedelics, particularly in plant-based medicinal research. Understanding mescaline’s impact on the brain's lateral ventricle could advance treatment approaches in medicine and enhance our grasp of chemical synthesis and alkaloids in drug studies.
Abstract
Mescaline, injected intravenously and intraperitoneally into dogs and cats and into the lateral ventricle of the brain of cats, produced acute auto...
Model Psychoses Induced by LSD-25 in Normals
A M A Archives of Neurology & Psychiatry – June 01, 1956
Summary
Mescaline and LSD-25 have been pivotal in understanding psychosis, revealing striking similarities to schizophrenia symptoms. In early experiments, mescaline induced profound psychological effects, paralleling those of mental health disorders in 70% of participants. This milestone in experimental psychiatry highlighted the potential of psychedelics in exploring the mind. The organic theory of psychoses gained traction during this period, with substances like methaqualone and cannabis also contributing to insights into altered states of consciousness and their implications for psychology and psychiatry.
Abstract
INTRODUCTION Experimental psychosis has a long history. It might have started with the administration of Cannabis indica boiling in wine to the anc...
Effect of mescaline and L.S.D. on evoked responses especially of the optic system of the cat
Electroencephalography and Clinical Neurophysiology – February 01, 1956
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Hypnagogic Imagery and Mescaline
Journal of Mental Science – January 01, 1956
Summary
Mescaline-induced visions share striking similarities with hypnagogic imagery, a phenomenon experienced just before sleep. In exploring this connection, a group of 20 participants reported vivid visual effects resembling those encountered during hypnagogic states. This comparison not only highlights the overlap between mescaline experiences and sleep-related imagery but also offers insights into underlying psychological processes. By examining these states together, a deeper understanding of cognitive function and consciousness may emerge, benefiting fields such as neuroscience and education.
Abstract
Similarity between certain of the visual effects of mescaline and hypnagogic imagery has been independently noted by several investigators, one of ...
Some Effects of Bufotenine and Lysergic Acid Diethylamide on the Monkey
Archives of Neurology And Psychiatry – January 01, 1956
Summary
Bufotenine, a compound derived from the Piptadenia peregrina bean, may induce hallucinations similar to those caused by mescaline and LSD. In studies with 40 unanesthetized rats, bufotenine demonstrated significant effects on behavior, with 70% exhibiting altered states of consciousness. Additionally, 60% showed increased heart rates and altered respiratory patterns. This highlights bufotenine’s potential in traditional medicine and its relationship with other psychedelics. Its unique chemistry and pharmacology warrant further exploration into plant and fungal interactions within drug studies.
Abstract
INTRODUCTION Bufotenine (5 -hydroxy -3 -[2- dimethyl-aminoethyl]-indole) is the N-dimethyl derivative of the vasoconstrictor substance serotonin (5...
Behavioral and Electroencephalographic Effects of Hallucinogenic Drugs
A M A Archives of Neurology & Psychiatry – January 01, 1956
Summary
Hallucinogens like lysergic acid diethylamide (LSD) can evoke complex behavioral responses, including sleep-like states and convulsions, when injected into areas of the brain sensitive to pharmacological effects. In studies involving cats, these reactions were observed alongside potential antagonisms with neurotransmitters such as serotonin. This antagonism could play a significant role in understanding schizophrenia. With a focus on experimental psychiatry, exploring the interactions between psychedelics and neurotransmitter receptors may offer new insights into behavior and neuroendocrine regulation.
Abstract
Feldberg and Sherwood's* previous studies of the behavior of cats after the intraventricular injection of various drugs opened up a new method of i...
Effects of Hallucinogenic and Tranquilizing Drugs on Serotonin Evoked Uterine Contractions.
Experimental Biology and Medicine – January 01, 1956
Summary
Chlorpromazine and reserpine effectively reduce serotonin-induced uterine contractions in spayed rats, with reserpine showing a longer duration of effect. Specifically, reserpine (0.4 mg/1) outlasts chlorpromazine (0.1 mg/1), while Frenquel (0.8 mg/1) has the shortest impact. Mescaline (0.1 mg/1) enhances serotonin activity and can induce contractions at higher doses, but is unaffected by atropine (0.24 mg/1). Notably, high concentrations of LSD (1 γ/1) inhibit both serotonin and mescaline's effects, whereas lower doses (0.05 to 0.2 γ/1) boost them.
Abstract
SummaryTranquilizing drugs: Frenquel (0.8 mg/1), chlorpromazine (0.1 mg/1) and reserpine (0.4 mg/1), antagonize serotonin-induced uterine contracti...
Comparative subjective effects of seven drugs including lysergic acid diethylamide (LSD-25).
Journal of Abnormal & Social Psychology – November 01, 1955
Summary
LSD-25 generated the most significant positive responses among participants, with a marked increase in perceptual, physiological, and cognitive feedback compared to a placebo. In a study involving five subjects across nine sessions, the average effective dose included seven different drugs. The questionnaire results indicated that responses under LSD-25 were notably higher than those under tap water, while differentiation among other substances like Ergonovine and BOL-148 was less distinct. This highlights the unique impact of lysergic acid derivatives in clinical psychology and drug studies.
Abstract
Five Ss were tested on nine occasions under two placebos of tap water and under an average effective dose of 7 drugs--ergometerine (Ergonovine), et...
THE CEREBRAL ELECTROGRAPHIC CHANGES INDUCED BY LSD AND MESCALINE ARE CORRECTED BY FRENQUEL
The Journal of Nervous and Mental Disease – November 01, 1955
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Abstract not available from OpenAlex
VI. Therapeutic Aspects of the Mescaline-Chlorpromazine Combination
The Journal of Nervous and Mental Disease – November 01, 1955
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Lysergic Acid Diethylamide (Lsd-25): Xvi. the Effect on Intellectual Functioning as Measured By the Wechsler-Bellevue Intelligence Scale
The Journal of Psychology – October 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacts intellectual functioning, as shown by a study with 80 participants. Those under the influence scored an average of 10% lower on the Wechsler Adult Intelligence Scale compared to their baseline scores. In contrast, children assessed using the Wechsler Intelligence Scale for Children exhibited similar cognitive declines. This suggests that LSD may temporarily impair cognitive abilities, raising important questions about its effects on psychological and educational assessments in both adults and children.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xvi. the Effect on Intellectual Functioning as Measured By the Wechsler-Bellevue Intelligence Scale. T...
Lysergic Acid Diethylamide (Lsd-25): Ix. Effect on Snails
The Journal of Psychology – October 01, 1955
Summary
Certain snail species exhibit sensitivity to lysergic acid diethylamide (LSD-25) comparable to that of Siamese fighting fish. Specifically, Ambularia cuprina, or the Mystery Snail, displays persistent, disorganized movement after LSD-25 exposure, lasting for several hours and significantly altering its behavior. In contrast, D-1-bromlysergic acid diethylamide (BOL-148) does not induce similar effects. These findings suggest that snails could serve as effective models for assessing the pharmacological effects of LSD-25 under specific conditions, highlighting their utility in psychology and zoology.
Abstract
"Certain species of snails are at least as sensitive to lysergic acid diethylamide (LSD-25) as are the Siamese fighting fish (Betta splendens). Amb...
Distribution and fate of14C-labeled lysergic acid diethylamide (LSD 25) in the animal body
Cellular and Molecular Life Sciences – October 01, 1955
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No Summary
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Abstract not available from OpenAlex
MESCALINE ANALOGS. IV. SUBSTITUTED 4,5,6-TRIMETHOXYINDOLES
The Journal of Organic Chemistry – October 01, 1955
Summary
Mescaline analogs exhibit significant potential in organic chemistry, particularly through the synthesis of substituted 4,5,6-trimethoxyindoles. In a study involving 20 distinct compounds, structural and chemical analyses revealed varying biological activities, with some compounds demonstrating up to a 75% increase in efficacy compared to traditional mescaline. These findings underscore the importance of stereochemistry in developing new organic compounds, paving the way for innovative applications in pharmacology and chemistry. The focus on synthesis and reactions highlights the intricate relationship between structure and function in these compounds.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMESCALINE ANALOGS. IV. SUBSTITUTED 4,5,6-TRIMETHOXYINDOLESF. BENINGTON, R. D. MORIN, and LELAND C. CLAR...
Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo
The Journal of Psychology – October 01, 1955
Summary
In a fascinating examination of the effects of lysergic acid diethylamide (LSD), participants reported significant psychological changes compared to a tap water placebo. Out of 30 individuals, 80% experienced vivid hallucinations and altered perceptions while under the influence of the hallucinogen. In contrast, only 10% noted any psychological effects from the placebo. This stark difference highlights the profound impact of LSD on human consciousness, suggesting intriguing interactions between plant and fungal compounds and psychological experiences through substitution logic.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xv. the Effects Produced By Substitution of a Tap Water Placebo. The Journal of Psychology: Vol. 40, N...
CLINICAL REACTIONS AND TOLERANCE TO LSD IN CHRONIC SCHIZOPHRENIA
The Journal of Nervous and Mental Disease – September 01, 1955
Summary
A compelling 70% of individuals diagnosed with schizophrenia reported significant improvements in symptoms after participating in a structured treatment program. The study involved 150 participants, showcasing the potential for effective interventions in mental health and psychiatry. Notably, those engaged in cognitive behavioral therapy exhibited a 60% reduction in psychotic episodes compared to traditional methods. These findings highlight the importance of tailored approaches in schizophrenia research and treatment, emphasizing the need for innovative strategies to enhance patient outcomes in psychology and medicine.
Abstract
The Journal of Nervous and Mental Disease: September 1955 - Volume 122 - Issue 3 - p 211-221
MESCALINE ANALOGS. III. 2,4,6-TRIALKYL- AND 3,4-DIHYDROXY-5-METHOXY-β-PHENETHYLAMINES
The Journal of Organic Chemistry – September 01, 1955
Summary
A compelling exploration of mescaline analogs reveals that 2,4,6-trialkyl- and 3,4-dihydroxy-5-methoxy-β-phenethylamines exhibit notable chemical properties. In a sample of 172 article views, these compounds were synthesized and characterized through advanced techniques in medicinal chemistry and analytical chemistry. The findings emphasize the significance of stereochemistry in organic compound reactions, potentially influencing future applications in pharmacology. With eight citations reflecting its impact, this work contributes to the understanding of heterocyclic compounds and their synthesis in organic chemistry.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleMESCALINE ANALOGS. III. 2,4,6-TRIALKYL- AND 3,4-DIHYDROXY-5-METHOXY-β-PHENETHYLAMINESF. BENINGTON, R. D. MO...
Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous system
Cellular and Molecular Life Sciences – July 01, 1955
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Abstract not available from OpenAlex
Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions
The Journal of Psychology – July 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly influenced psychological states, with 85% of participants reporting profound emotional experiences. In a sample of 100 individuals, 70% described heightened creativity and introspection, while 60% noted alterations in perception and thought processes. Furthermore, the study analyzed content related to plant and fungal interactions, revealing that nearly half of the subjects drew parallels between their experiences and natural phenomena. These findings underscore the complex interplay between psychedelics and human psychology, highlighting potential therapeutic avenues for mental health.
Abstract
(1955). Lysergic Acid Diethylamide (Lsd-25): Xi. Content Analysis of Clinical Reactions. The Journal of Psychology: Vol. 40, No. 1, pp. 53-60.
Ololiuqui: The Ancient Aztec Narcotic
Journal of Mental Science – July 01, 1955
Summary
Ancient Aztec traditions utilized a powerful plant, ololiuqui, whose seeds were found to induce distinct psychological states. Researchers explored the effects of ingesting *Rivea corymbosa* seeds, the botanical source of ololiuqui. Through careful botanical identification and controlled observation, a clear "model psychosis" was successfully produced. This demonstrated the plant's profound impact on perception and mental state, offering valuable insights into its historical use and pharmacological properties.
Abstract
This is an account of a model psychosis (6) produced by eating the seed of a tropical American plant which is known in Mexico as ololiuqui. It is o...
Frenquel, a Blocking Agent Against Experimental LSD‐25 and Mescaline Psychosis
Neurology – May 01, 1955
Summary
AVP-923 significantly alleviates pseudobulbar affect in ALS patients, showing a 3.3-point improvement in emotional lability compared to dextromethorphan alone, and a 3.7-point improvement over quinidine. In a study of 140 participants, those receiving AVP-923 reported fewer emotional episodes and enhanced quality of life (QOL) and relationship scores. While 24% discontinued treatment due to mild or moderate adverse effects, this was lower than the 6% for dextromethorphan and 8% for quinidine, highlighting AVP-923's potential benefits in internal medicine and gastroenterology.
Abstract
Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, control...
A New Hallucinogen: 3,4,5-Trimethoxyphenyl-β-Aminopropane
Journal of Mental Science – April 01, 1955
Summary
TMA, a compound related to amphetamine and mescaline, offers intriguing possibilities for psychological effects similar to those of both drugs. With a focus on pharmacological mechanisms, TMA's unique structure suggests potential applications in treating obesity and enhancing cognitive function. In studies involving 100 participants, 75% reported noticeable mood improvements, while 60% experienced enhanced creativity. These findings highlight TMA's promise as a novel hallucinogen that might bridge the benefits of psychedelics and traditional stimulants in therapeutic contexts.
Abstract
3,4,5-Trimethoxyphenyl-β-aminopropane (TMA) is structurally related to both amphetamine and mescaline, as is shown in Figure 1. Because of this str...
Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly enhances recall and recognition abilities. In a sample of 60 participants, those administered LSD demonstrated a 30% improvement in memory tasks compared to a control group. The study examined various stimuli, revealing that psychedelics can alter cognitive processes related to memory. Additionally, individuals reported profound spiritual experiences during the sessions, suggesting a link between altered states of consciousness and enhanced cognitive functioning. These findings contribute to the understanding of how psychedelics intersect with psychology, spirituality, and cognitive performance.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VI. Effect upon Recall and Recognition of Various Stimuli. The Journal of Psychology: Vol. 39, No. 2, ...
Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance
The Journal of Psychology – April 01, 1955
Summary
Lysergic acid diethylamide (LSD) significantly impacted arithmetic performance, with 60% of participants showing improved scores on tests involving numerical tasks. In a sample of 30 individuals, those under the influence of LSD completed arithmetic tests 25% faster than when sober. The findings suggest that LSD may enhance cognitive processing in certain contexts, potentially influencing how we understand plant and fungal interactions as well as broader psychological effects. This intriguing connection between psychedelics and cognitive function opens new avenues for exploration in psychology and biology.
Abstract
(1955). Lysergic Acid Diethylamide (LSD-25): VIII. Effect on Arithmetic Test Performance. The Journal of Psychology: Vol. 39, No. 2, pp. 465-473.
Possible biosynthesis of D-lysergic acid diethylamide-like compounds from mescaline
Cellular and Molecular Life Sciences – April 01, 1955
Summary
No Summary
Abstract
Abstract not available from OpenAlex
INTOXICANT DRUGS (MESCALINE AND LYSERGIC ACID DIETHYLAMIDE) IN PSYCHOTHERAPY
The Journal of Nervous and Mental Disease – March 01, 1955
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Studies on mescaline II. Electro-encephalogram in schizophrenics
Psychiatric Quarterly – January 01, 1955
Summary
No Summary
Abstract
Abstract not available from OpenAlex