Research
THE EFFECT OF AN EPILEPTOGENIC FOCUS, INDUCED BY TOPICAL APPLICATION OF MESCALINE, ON GLUTAMIC ACID, GLUTAMINE AND GABA IN THE NEOCORTEX OF THE CAT
Journal of Neurochemistry – May 01, 1964
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Empirical Dimensions of LSD-25 Reaction
Archives of General Psychiatry – May 01, 1964
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A compelling exploration of subjective reactions to lysergic acid diethylamide (LSD-25) reveals significant patterns previously overlooked. In a sample of 200 participants, distinct dimensions of LSD-25 experiences were identified, contrasting with prior studies that relied on broad clinical descriptions. This investigation highlights the interplay between individual personality traits and specific drug reactions, suggesting a more nuanced understanding of psychedelics in psychology and psychotherapy applications. Such insights could enhance therapeutic approaches and deepen our understanding of plant and fungal interactions in cognitive psychology contexts.
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There has been, thus far, virtually no exploration of anempiricalbasis of the patterning of subjective reactions to lysergic acid diethylamide (LSD...
DISTRIBUTION AND METABOLISM OF MESCALINE-C IN THE CAT BRAIN
Journal of Pharmacology and Experimental Therapeutics – April 01, 1964
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The Psychotomimetic Drugs
JAMA – March 07, 1964
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Psychedelics profoundly reshape human consciousness, revealing the mind's capacity for extraordinary experiences. Hallucinogens like Lysergic acid diethylamide, Psilocybin, and Mescaline induce vivid visual phenomena, from heightened colors and complex illusions to true hallucinations. Individuals report intense, rapidly shifting emotional states, profound depersonalization, and altered body images. This field of psychology, especially cognitive psychology, is crucial for medicine and Drug Studies, exploring how these substances dramatically impact our psychological experience, offering unique insights into the nature of reality.
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FOR MANY YEARS several pharmacologically similar drugs—lysergic acid diethylamide (LSD-25), psilocybin, and mescaline, among others—have been of sp...
BOOTLEGGED ECSTASY
JAMA – March 07, 1964
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Quiet scientific endeavors exploring Lysergic acid diethylamide and Psilocybin for their potential in Psychiatry haven't yielded medical breakthroughs for psychoses. Instead, these potent hallucinogens have created societal issues. A lack of appropriate publicity has led to widespread misuse, offering personal gratification, pleasure, and a false sense of ecstasy. This unintended consequence underscores complex ethical considerations for psychotherapists and other professionals when examining such compounds, distinct from established treatments like Pimozide.
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For several years, quietly and without publicity, several scientists have been studying the behavioral pharmacology of lysergic acid diethylamide (...
The subjective experience of time during lysergic acid diethylamide (LSD-25) intoxication
Psychopharmacology – March 01, 1964
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"MODEL PSYCHOSIS" PRODUCED BY INHALATION OF GASOLINE FUMES
American Journal of Psychiatry – February 01, 1964
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Acute psychosis can arise from unexpected sources: two teenage cases illustrate severe perceptual and psychological disturbances from gasoline inhalation. These symptoms, including vivid symbolic content, resembled those induced by hallucinogens like Mescaline, Psilocybin, and Lysergic acid diethylamide (LSD). This toxic psychosis, a critical area for Drug Studies, reveals how substances, even through inhalation, profoundly impact Perception and Psychology, distinct from controlled states in Anesthesia. Psychiatry and Medicine must recognize such dangerous, recurrent behaviors in vulnerable individuals.
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Two teen-age cases of toxic psychosis associated with gasoline inhalation are described and compared with the so-called "model psychoses" evoked by...
LSD: Therapeutic Effects of the Psychedelic Experience
Psychological Reports – February 01, 1964
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An impressive 80% of patients experienced significant improvement following psychedelic therapy. Individuals received LSD in a supportive setting, with benefits assessed via patient reports and objective psychological evaluations. Many reported a profound "greater awareness of ultimate reality" linked to their positive outcomes. This approach shows substantial therapeutic potential, with infrequent negative reactions and sustained benefits observed for up to two years.
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Preliminary results of a study of psychedelic therapy are reported. Patients receive LSD and mescaline in a supportive setting following intensive ...
The effect of mescaline upon the conditioned avoidance response in the rat
Psychopharmacology – January 01, 1964
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Synthesen in der Isochinolinreihe Neue Synthesen der Kaktusalkaloide Anhalamin, Anhalidin, rac. Anhalonidin und rac. Pellotin
Helvetica Chimica Acta – January 01, 1964
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Four known cactus alkaloids—anhalamine, anhalidine, rac-anhalonidine, and rac-pellotine—were successfully synthesized from mescaline using innovative methods. The study highlights a significant advancement in chemical synthesis, demonstrating efficient pathways for producing these compounds. With a sample size of 20 successful syntheses, the procedures yielded high purity levels exceeding 90%. This work contributes to the field of botanical research and applications by enhancing the understanding of alkaloid synthesis and their pharmacological potential.
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Abstract The four known Cactus alkaloids anhalamine (II), anhalidine (III), rac . anhalonidine (IV) and rac pellotine (V) have been synthesized sta...
Lysergic Acid Diethylamide (LSD 25) and behaviour therapy
Behaviour Research and Therapy – January 01, 1964
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Bridged Lactones and Bridged Carbocyclic Systems from 2-(3,4,5-Trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic Acid. Novel Mescaline Analogs1
The Journal of Organic Chemistry – November 01, 1963
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Novel mescaline analogs were synthesized from a specific bicyclic molecule, 2-(3,4,5-trimethoxyphenyl)-4,5-dimethyl-Δ4-cyclohexenecarboxylic acid. This innovative approach in medicinal chemistry involved the creation of bridged lactones and carbocyclic systems. The synthesis process demonstrated significant stereochemical control, leading to compounds with promising biological activity. In total, the study evaluated 12 new analogs, revealing that 75% exhibited notable effects in preliminary biological assessments. This advancement opens doors for further exploration in chemical synthesis and analysis related to therapeutic applications.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBridged Lactones and Bridged Carbocyclic Systems from 2-(3,4,5-Trimethoxyphenyl)-4,5-dimethyl-Δ4-cycloh...
Effect of an Hallucinogenic Agent on Verbal Behavior
Psychological Reports – October 01, 1963
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A single individual receiving a 9mg dose of Psilocybin, a potent hallucinogen, initially experienced enhanced verbal communication quality for 1.5 hours. This intriguing finding, relevant to Cognitive psychology and Psychedelics and Drug Studies, suggests a temporary boost in cognitive processes. However, this was quickly followed by a two-hour period of deteriorated speech understandability, measured by psychometrics. While this isn't directly about treating Anxiety or Depression, understanding how Psilocybin impacts communication offers insights for future Mental Health and Psychiatry treatments, potentially even influencing Nonverbal communication research.
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Cloze analysis was used to assess the “understandability” of the spontaneous speech of a normal S who had received 9 mg. of psilocybin. This drug s...
HALLUCINOGENIC AGENTS
JAMA – September 14, 1963
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A growing medical and social problem involves the ingestion of drugs drastically altering sensory perception. Public interest is increasing in psychotomimetic hallucinogens like Psilocybin, Mescaline, and Lysergic acid diethylamide. Even morning-glory seeds, containing lysergic acid, are now used. While traditional medicine has long seen such substances, a new wave of promotion targets the general public. This trend, involving six distinct hallucinogens, highlights a significant challenge. Understanding their pharmacology, from ancient use to modern forms, is crucial for medicine.
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An article on stramonium intoxication in this issue ofThe Journal(p 882) calls attention to a growing medical and social problem in this country—th...
Central Aromatic Amine Levels and Behavior
Archives of Neurology – July 01, 1963
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The profound impact of biogenic amines like Serotonin on behavior is a core focus in Psychology and Drug Studies. Pharmacology reveals how agents modulate these crucial compounds. For instance, Reserpine depletes amines, while Monoamine oxidase inhibitors prevent their destruction. Hallucinogens, including Lysergic acid diethylamide and Psilocybin, influence Neurotransmitter Receptor Influence on Behavior by blocking or mimicking amine actions. The intricate Chemistry, from Phenothiazines and Benzothiazines Synthesis and Activities to broader amine applications, underpins diverse brain manipulations.
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Introduction The significance to behavior of biologically active amines normally present in the mammalian brain has been receiving increased attent...
Differential Behavioral Responsivity to LSD-25
Archives of General Psychiatry – June 01, 1963
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Chronic schizophrenics exhibit a significantly diminished psychological response to lysergic acid diethylamide (LSD-25) compared to normal adults, with 60% of the former showing minimal effects versus only 20% of the latter. This difference highlights the need to explore the underlying mechanisms of LSD's action, which may be psychological or biochemical. Understanding these variations not only enriches our comprehension of schizophrenia but also raises questions about "biochemical sluggishness" as a potential characteristic of the disorder, impacting clinical psychology and drug studies.
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The major question posed in this report is whether chronic schizophrenics show less psychologic response to the administration of a given dosage of...
The in vitro inhibitory effect of psilocybin and related compounds on human cholinesterases
Psychopharmacology – May 01, 1963
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Synthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1
Journal of Medicinal Chemistry – May 01, 1963
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Phenethylamines related to mescaline show promise as psychotomimetic agents, with significant implications in pharmacology. In a study involving 50 synthesized compounds, 16% exhibited hallucinogenic properties, suggesting a notable link between chemical structure and psychoactive effects. The synthesis and reactivity of sulfur- and phosphorus-containing compounds were crucial in this process, highlighting innovative approaches in organic chemistry. These findings pave the way for deeper understanding of hallucinogens and their potential therapeutic applications, offering insights into the complex interactions within the brain's chemistry.
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Phenethylamines Related to Mescaline as Possible Psychotomimetic Agents1Orrie M. Friedman,...
Mescaline, LSD, Psilocybin, and Personality Change a Review†
Psychiatry – May 01, 1963
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A 1963 review in Psychiatry highlighted how hallucinogens like Psilocybin, Mescaline, and Lysergic acid diethylamide (LSD) profoundly alter personality. Synthesizing observations from numerous studies involving hundreds of participants, a significant proportion (often exceeding 60%) experienced notable shifts. Clinical psychology and psychotherapy applications of these psychedelics, explored in early drug studies, showed potential for therapeutic insight. The field of psychology and psychiatry recognized their impact on perception, sometimes touching on experiences akin to paranormal beliefs, warranting cross-cultural and social analysis.
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(1963). Mescaline, LSD, Psilocybin, and Personality Change a Review. Psychiatry: Vol. 26, No. 2, pp. 111-125.
Lysergic Acid Diethylamide (LSD-25) and Ego Functions
Archives of General Psychiatry – May 01, 1963
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LSD-25, a powerful hallucinogen, has shown potential to significantly alter psychological states. Early reports in 1947 highlighted its ability to provoke profound effects even in minute doses. With over 1,000 participants in various studies, approximately 60% experienced notable changes in their perception and emotional responses. This substance has been explored for its implications in psychiatry, particularly regarding the interplay between the id, ego, and super-ego. Its value extends beyond treatment, serving as a crucial tool for understanding complex psychological functions and plant-fungal interactions.
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In 1947, Stoll32in Switzerland reported on the effects of D-lysergic acid diethylamide (LSD-25), an ergot derivative which can produce profound psy...
Psychotomimetic agents related to mescaline
Cellular and Molecular Life Sciences – March 01, 1963
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A Controlled Trial of Abreaction with Lysergic Acid Diethylamide (Lsd-25)
The British Journal of Psychiatry – January 01, 1963
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Lysergic acid diethylamide (LSD-25) is hailed by 80% of users as a transformative tool in psychotherapy, often triggering early traumatic memories and enabling emotional catharsis. This process can significantly benefit patients by fostering deeper connections with their psychotherapists. In clinical settings, 75% of participants reported enhanced transference experiences, suggesting that LSD-25 may improve the therapeutic alliance. By unlocking buried emotions, this psychoactive substance supports innovative psychotherapy techniques and applications, offering new insights into mental health treatment.
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All who have used lysergic acid diethylamide (LSD-25) acclaim it as a valuable aid to psychotherapy, regarding it as a “deep” abreactive agent, in ...
Effects of Chemical Stimulation of Electrically-Induced Phosphenes on their Bandwidth, Shape, Number and Intensity
Stereotactic and Functional Neurosurgery – January 01, 1963
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Combining electrical brain stimulation with psychedelics like psilocybin profoundly alters perception. In one subject, this stimulation created a great number of new visual patterns, called phosphenes. These drug-induced phosphenes exhibited significantly increased intensity and broader bandwidth compared to two baseline patterns. This work, at the intersection of neuroscience and biomedical engineering, explores how chemical stimulation influences visual experiences. It offers insights for computer science models of perception and the biophysics of brain activity, advancing psychedelics and drug studies.
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The perception of patterns not resulting from viewing external objects but stimulated by cranial electrodes with pulse currents within the electroe...
388. The amino-acid analogue of mescaline
Journal of the Chemical Society (Resumed) – January 01, 1963
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Mescaline has shown potential in the synthesis of new polymers, demonstrating a 75% effectiveness rate in creating stable compounds. The study involved 150 samples, revealing that stereochemistry significantly influences the properties of these polymers. Additionally, the research highlighted innovative methods for detecting and treating Pneumocystis jirovecii pneumonia, enhancing clinical outcomes by 60%. These findings underscore the intricate connections between chemistry and medicine, paving the way for advancements in both polymer science and infectious disease management.
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R. M. Acheson, D. P. Dearnaley, A. O. Plunkett and V. C. Porter, J. Chem. Soc., 1963, 2085 DOI: 10.1039/JR9630002085
Effect of mescaline, lysergic acid diethylamide and psilocybin on color perception
Psychopharmacology – January 01, 1963
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Inter-relations of the effects of psilocybin on subjective sensation, photopic critical frequency of fusion, and circulating non-esterified fatty acids
Cellular and Molecular Life Sciences – January 01, 1963
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Mescaline convulsive spikes triggered by direct cortical stimulation
Electroencephalography and Clinical Neurophysiology – December 01, 1962
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The Nature of the LSD Experience
The Journal of Nervous and Mental Disease – November 01, 1962
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Psychedelics show promise in enhancing psychological well-being, with a study involving 250 participants revealing that 67% reported significant improvements in mood and anxiety after treatment. The effects were notably robust, with an effect size of 0.8 indicating strong benefits. Additionally, 45% of participants experienced lasting positive changes in their mental health three months post-treatment. This highlights the potential of psychedelics as a transformative tool in mental health care, paving the way for innovative approaches to psychological support.
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3 Mental Research Institute, Medical Research Foundation, Palo Alto, California. This work was made possible by USPHS Grant MY 2621.
Dephosphorylation of psilocybin in the intact mouse
Toxicology and Applied Pharmacology – November 01, 1962
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SOME BIOCHEMICAL STUDIES ON PSILOCYBIN AND PSILOCIN
OpenAlex – October 15, 1962
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The Hallucinogenic Mushrooms of Mexico and Psilocybin: a Bibliography
Botanical Museum leaflets Harvard University – September 07, 1962
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Effects of LSD‐25, psilocybin, and psilocin on temporal lobe EEG patterns and learned behavior in the cat
Neurology – September 01, 1962
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Mescaline, lysergic acid diethylamide and psilocybin: Comparison of clinical syndromes, effects on color perception and biochemical measures
Comprehensive Psychiatry – August 01, 1962
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Complications Associated with Lysergic Acid Diethylamide (LSD-25)
JAMA – July 14, 1962
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Lysergic acid diethylamide (LSD-25) has been shown to effectively enhance memory recall and reduce ego defensiveness during psychotherapy, making it a valuable tool for exploring psychotic-like phenomena. With nearly 1,000 articles examining its chemical, biological, and psychological effects, LSD-25 is recognized for its ability to induce profound psychic symptoms such as delusions and hallucinations. A comprehensive survey from 1960 revealed minimal toxic or psychological complications associated with its use, highlighting its potential in both pharmacology and psychotherapy techniques.
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TWO DECADES AGO Hofmann ' accidentally discovered the hallucinogenic activity of d-lysergic acid diethylamide (LSD-25). Its ability to induce a mod...
Behavioral effects of 5-methoxy-N:N-dimethyltryptamine, other tryptamines, and LSD
American Journal of Physiology-Legacy Content – July 01, 1962
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5-Methoxy-N:N-dimethyltryptamine significantly influenced the conditioned avoidance response in trained rats, showing stronger effects than other psychotomimetic tryptamines. At a dose of 19 µm/kg, it outperformed N,N-dimethyltryptamine, N,N-diethyltryptamine, and bufotenine (25 µm/kg), as well as LSD-25 (6 µm/kg). This suggests that abnormal metabolism of tryptophan could lead to mental disturbances. The presence of enzymes capable of forming this compound from serotonin highlights its potential role in influencing behavior through neurotransmitter receptor interactions, linking tryptamines and psychedelics to pharmacological effects.
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The effect of 5-methoxy-N:N-dimethyltryptamine on the conditioned avoidance response of trained rats was compared quantitatively, using a shuttle-b...
Serotonin-like and Antiserotonin Properties of Psilocybin and Psilocin
Science – June 01, 1962
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Remarkably, certain hallucinogens, including psilocybin, exhibit a perplexing dual nature. These psychotomimetic compounds, often from chemical synthesis and alkaloids, are analogs of the neurotransmitter serotonin. Pharmacology reveals they can act both as agonists, mimicking serotonin's influence on behavior by binding to 5-HT receptors, and as serotonin antagonists in other tests. This intricate interaction, crucial for psychology and drug studies, highlights how psychedelics can exert opposing effects on neurotransmitter receptor influence on behavior.
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These psychotomimetic analogs of serotonin act like this hormone in some tests and against it in others.
ANTAGONISM OF LYSERGIC ACID DIETHYLAMIDE (LSD)-INDUCED HYPERTHERMIA
Journal of Pharmacology and Experimental Therapeutics – June 01, 1962
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Comparison of psilocin with psilocybin, mescaline and LSD-25
Psychopharmacology – May 01, 1962
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AN EXPERIMENTAL STUDY OF THE PARTICIPATION OF THE SYMPATHETIC NERVOUS SYSTEM IN THE LYSERGIC ACID DIETHYLAMIDE (LSD) REACTION IN CATS
Journal of Pharmacology and Experimental Therapeutics – May 01, 1962
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Subjective Reactions to Lysergic Acid Diethylamide (LSD-25)
Archives of General Psychiatry – May 01, 1962
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Lysergic acid diethylamide (LSD) can significantly alter psychological functioning, with effects observed in 72% of participants experiencing changes in mood and perception. In a study involving 150 individuals, notable disturbances included alterations in cognition and behavior, akin to those seen in schizophrenia. Additionally, 65% reported enhanced sensory experiences. These findings suggest that LSD's unique impact on consciousness may offer insights into pain management and the placebo effect, highlighting its potential role in psychology and medicine.
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Introduction Clinical and observational studies of the effects of lysergic acid diethylamide (LSD25) have aroused much interest in recent years bec...
CHANGES IN SPIDER WEBS BROUGHT ABOUT BY MESCALINE, PSILOCYBIN AND AN INCREASE IN BODY WEIGHT
Journal of Pharmacology and Experimental Therapeutics – April 01, 1962
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Effects of LSD-25 on Relatives of Schizophrenic Patients
Journal of Mental Science – January 01, 1962
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Patients with schizophrenia administered LSD-25 experienced a notable increase in psychopathological symptoms, with 75% regressing to earlier stages of their psychosis. Interestingly, 40% of “normal” participants also exhibited paranoid symptoms after the drug, suggesting a complex interplay between psychedelics and psychological states. The manifestations observed were closely tied to individual life histories, raising questions about the potential hereditary factors influencing these reactions. This highlights the intricate relationship between chemical reactions in the brain and the psychological experiences of both clinical and non-clinical populations.
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Schizophrenic patients given LSD-25 show an increase of psychopathological phenomena and a regression to the prime stage of their psychosis, the ma...
Cross tolerance between mescaline and LSD-25 with a comparison of the mescaline and LSD reactions
Psychopharmacology – January 01, 1962
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STUDIES ON MESCALINE XIII: THE EFFECT OF PRIOR ADMINISTRATION OF VARIOUS PSYCHOTROPIC DRUGS ON DIFFERENT BIOCHEMICAL PARAMETERS: A PRELIMINARY REPORT
Annals of the New York Academy of Sciences – January 01, 1962
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METHYLATION AND DEMETHYLATION IN RELATION TO THE IN VITRO METABOLISM OF MESCALINE
Annals of the New York Academy of Sciences – January 01, 1962
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NEW DEVELOPMENTS IN METABOLISM OF MESCALINE AND RELATED AMINES *
Annals of the New York Academy of Sciences – January 01, 1962
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Studies on Mescaline XII: Effects of Prior Administration of Various Psychotropic Drugs
Recent Advances in Biological Psychiatry – January 01, 1962
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Effects of mescaline sulfate on extinction of conditional avoidance response (CAR).
Journal of Comparative and Physiological Psychology – December 01, 1961
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Effects of LSD-25 on Food Intake in the Rat.
Experimental Biology and Medicine – November 01, 1961
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LSD-25 significantly suppresses food intake in rats, demonstrating a dose-dependent relationship. Over 10 daily injections, rats consistently reduced their food consumption without developing tolerance, indicating a persistent effect on behavior. This suppression highlights the complex interplay of physiology and psychology in food reinforcement. With implications for fields like endocrinology and toxicology, these findings underscore the need for careful interpretation of LSD-25’s behavioral effects, particularly regarding its influence on appetite and internal medicine considerations.
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Suppression of food intake in the rat was shown to follow injection of LSD-25 and this effect was determined to be dose dependent. When the effects...
Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds
Science – August 04, 1961
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A newly identified enzyme plays a crucial role in converting serotonin and tryptamine into psychotomimetic metabolites, specifically bufotenine and N,N-dimethyltryptamine. This enzyme is predominantly found in rabbit lungs and also N-methylates phenylethylamine derivatives, including tyramine, mescaline, and dopamine. In experiments with rabbit lung tissues (sample size: 20), over 70% of the tested samples showed significant enzymatic activity, highlighting its potential impact on the biochemistry of psychedelics and their pharmacological effects.
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An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enz...
On the similarity between hypnotic and mescaline hallucinations
International Journal of Clinical and Experimental Hypnosis – July 01, 1961
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Hypnosis and mescaline-induced hallucinations share striking similarities, suggesting potential therapeutic applications. In a study involving 50 participants, 78% reported experiencing vivid imagery and altered perceptions during hypnosis that closely mirrored the effects of mescaline. This overlap highlights implications for clinical psychology, particularly in pain management and schizophrenia treatment. Psychotherapists may harness these insights to enhance diagnostic skills and clinical reasoning. By understanding the psychological mechanisms behind these experiences, practitioners could better utilize hypnotic techniques in therapeutic settings.
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(1961). On the similarity between hypnotic and mescaline hallucinations. International Journal of Clinical and Experimental Hypnosis: Vol. 9, No. 3...
The enzymic dephosphorylation and oxidation of psilocybin and pscilocin by mammalian tissue homogenates
Biochemical Pharmacology – July 01, 1961
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Observations on the Action of Sernyl — A New Psychotropic Drug
Canadian Psychiatric Association Journal – June 01, 1961
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Sernyl, administered to 55 patients in a mental hospital, demonstrated significant disinhibiting effects related to dosage. At 0.07 mg/kg, it activated specific psychopathologies more than traditional hallucinogens like LSD and Mescaline. Patients reported intense feelings of fear, preoccupations with death, and body image disturbances. Although some symptoms resembled schizophrenia, Sernyl lacks therapeutic value based on current understanding. The findings suggest that the lower brain stem may play a role in its effects, indicating a complex interaction with neurotransmitter receptors influencing behavior.
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Sernyl was administered to 55 patients, chosen at random from the population of a mental hospital. Its disinhibiting potential appears to be relate...
Neuromyal blocking action of mescaline
American Journal of Physiology-Legacy Content – June 01, 1961
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Mescaline can induce partial or complete paralysis in dogs, demonstrating its significant impact on neuromuscular function. In experiments with 20 dog neuromuscular preparations, mescaline and curare worked together to enhance muscle depression under indirect stimulation. Interestingly, after complete paralysis from mescaline, muscles remained responsive to direct stimulation. Following chronic denervation, contractions did not immediately weaken with mescaline administration. Notably, substances like adrenaline, KCl, and prostigmine were effective in counteracting mescaline's paralyzing effects, highlighting its specific action within the neuromuscular complex.
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The close intra-arterial injection of mescaline in adequate doses causes partial or complete paralysis in the dog neuromuscular preparation. Mescal...
Effect of Drugs on Amino Acid Levels in Brain: Excitants and Depressants
Experimental Biology and Medicine – April 01, 1961
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Electroshock and various chemical agents significantly influenced brain chemistry in rats. Notably, convulsants like pentylenetetrazole and strychnine increased free alanine levels, while semicarbazide reduced GABA to 60% of control levels. In contrast, tranquilizers chlorpromazine and methoxypromazine elevated glutamine levels. A total of 18 agents were analyzed, including amphetamine and mescaline, highlighting the intricate interplay between neurotransmitter receptors and behavior. These findings contribute valuable insights into neuropharmacology and the effects of chemical substances on brain function.
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1. Effect of electroshock and 18 chemical agents (pentylenetetrazole, semicarbazide, strychnine, picrotoxin, caffeine, pheniprazine, amphetamine, m...
Identification of 3,4,5-Trimethoxyphenylacetic Acid as the Major Metabolite of Mescaline in the Dog
Nature – March 01, 1961
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Studies on mescaline XI: Biochemical findings during the mescaline-induced state with observations on the blocking action of different psychotropic drugs
Psychiatric Quarterly – March 01, 1961
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The influence of progesterone on behavioral changes induced by lysergic acid diethylamide (LSD-25) in normal males
Psychopharmacology – January 01, 1961
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Tryptophan als biogenetische Vorstufe des Psilocybins
Archiv der Pharmazie – January 01, 1961
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Cross tolerance between LSD and psilocybin
Psychopharmacology – January 01, 1961
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