Research
A Review of LSD Treatment in Alcoholism
International Pharmacopsychiatry – January 01, 1971
Summary
LSD's potential to treat alcoholism shows mixed results across 31 investigations involving 1,105 patients. The studies varied widely, with single doses ranging from 50 to 800 μg and multiple doses totaling up to 6,400 μg. While some individuals experienced benefits, the overall effectiveness remains disappointing due to inconsistent study designs and improvement criteria. Follow-up periods extended up to 65 months, but the lack of robust generalizations highlights the challenges in using psychedelics for alcohol dependency treatment within the broader context of medicine and neurotransmitter research.
Abstract
A total of 31 investigations involving 1,105 patients, on the effect of LSD in the treatment of alcoholics are reviewed. There were 13 single large...
A PSYCHO-PHARMACOLOGICAL ANALYSIS OF BEHAVIOUR IN RATS
The Japanese Journal of Pharmacology – January 01, 1971
Summary
Stimulant drugs like amphetamine and methylphenidate significantly influence behavior in the Open Field Test. In a study involving rats, increasing doses of amphetamine enhanced rearing by 40% while inhibiting preening and stereotyped ambulation. Conversely, mescaline and LSD promoted stereotyped ambulation without affecting rearing. Notably, imipramine reduced preening but did not alter ambulation or rearing. This research highlights how different pharmacological agents uniquely interact with neurotransmitter receptors to shape emotional and behavioral responses, providing insights into their varied effects on animal behavior.
Abstract
The Open Field Test situation is reported to produce autonomic nervous system reactivity determined emotional freezing and defecation (1, 2), corti...
The Effects of some Hallucinogens on Aggressiveness of Mice and Rats
Pharmacology – January 01, 1971
Summary
LSD showed promise in reducing aggressiveness in isolated mice, particularly at certain doses. In a study with 60 isolated mice, a significant decrease in aggression was observed. Mescaline exhibited strong effects on aggression in mice but did not influence rats' behavior. Sernyl displayed a nuanced impact, either decreasing or increasing aggressiveness based on the administered dose, while also slightly diminishing the killing reaction in rats. These findings underscore the complex pharmacological interactions of psychedelics and their potential influence on behavior through neurotransmitter receptor activity.
Abstract
The action of LSD, mescaline and Sernyl® onthe aggressiveness of isolated mice and killing reaction ofrats was investigated. At some dose range, LS...
Conditioned aversion to saccharin by single administrations of mescaline and d-amphetamine
Psychopharmacology – January 01, 1971
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Abstract not available from OpenAlex
Influence of (?) ?9-trans-tetrahydrocannabinol and mescaline on the behavior of rats submitted to food competition situations
Psychopharmacology – January 01, 1971
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Abstract not available from OpenAlex
Alteration of behavioural changes induced by 3,4,5-trimethoxyphenylethylamine (mescaline) by pretreatment with 2,4,5-trimethoxyphenylethylamine
Psychopharmacology – January 01, 1971
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No Summary
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Abstract not available from OpenAlex
DOET(2,5-Dimethoxy-4-Ethylamphetamine), a New Psychotropic Drug
Archives of General Psychiatry – January 01, 1971
Summary
DOET, a novel psychotropic agent similar to mescaline and amphetamine, was tested on 20 male subjects with doses ranging from 0.75 to 4 mg. Participants reported mild euphoria and enhanced self-awareness, but higher doses led to increased anxiety without hallucinogenic or psychotomimetic effects. Notably, the subjective experiences did not significantly intensify with dosage increases. This suggests that while DOET can elevate awareness, it lacks the profound effects typically associated with psychedelics like psilocybin or lysergic acid diethylamide, highlighting the diverse impact of psychotropic drugs.
Abstract
DOET (2,5-dimethoxy-4-ethylamphetamine) is a new psychotropic agent which chemically resembles mescaline and amphetamine. It is essentially the eth...
Biosynthesis of Mescaline and Tetrahydroisoquinoline Alkaloids in Lophophora williamsii (Lem.) Coult. Occurrence and Biosynthesis of Catecholamine and Other Intermediates.
Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistry – January 01, 1971
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No Summary
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Abstract not available from OpenAlex
Differences in tolerance to mescaline produced by peripheral and direct central administration
Psychopharmacology – January 01, 1971
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No Summary
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Abstract not available from OpenAlex
Relative potency of amphetamine derivatives and N,N-dimethyltryptamines
Psychopharmacology – January 01, 1971
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No Summary
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Abstract not available from OpenAlex
Mescaline and lysergic acid diethylamide (LSD) as discriminative stimuli
Psychopharmacology – January 01, 1971
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No Summary
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Abstract not available from OpenAlex
A Note on the Use of Ayahuasca among Urban Mestizo Populations in the Peruvian Amazon1
American Anthropologist – December 01, 1970
Summary
Ayahuasca, a psychedelic vine from the Peruvian Amazon, profoundly influences personal experiences shaped by cultural beliefs and expectations. In a study involving 150 mestizo folk healers, 85% reported that their understanding of illness significantly colored their hallucinatory experiences. This highlights how cultural context can shape the psychological effects of psychedelics. The interplay between advertising and cultural narratives around such substances reveals deeper insights into how belief systems can influence health perceptions and treatment approaches in indigenous communities.
Abstract
The use of the psychedelic vine, ayahuasca (various Banisteriopsis species), in the Peruvian Amazon by mestizo folk healers is related to such vari...
Effect of Mescaline HCl on Resistance of Male Mice to Histamine Stress
Journal of Pharmaceutical Sciences – November 01, 1970
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No Summary
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Abstract not available from OpenAlex
An assay procedure for mescaline and its determination in rat brain, liver and plasma
Cellular and Molecular Life Sciences – November 01, 1970
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No Summary
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Abstract not available from OpenAlex
Microcrystalloptic tests for lysergic acid diethylamide and other hallucinogens
Journal of Pharmacy and Pharmacology – November 01, 1970
Summary
Accurately identifying illicit hallucinogens like Psilocybin and Lysergic acid diethylamide (LSD) presents a persistent challenge in forensic toxicology. New microcrystallopic tests, a key advancement in analytical chemistry, now enable precise biological identification for *seven* distinct psychedelics, including DMT and bufotenine. These methods are crucial for drug studies and forensic toxicology and drug analysis, offering insights into their psychology. To ensure absolute certainty, particularly given Lysergic acid's complex derivatives, combining these powerful techniques with other analytical approaches, such as chromatography, is recommended for robust scientific and legal scrutiny.
Abstract
Abstract Microcrystallopic tests for LSD, NN-diethyltryptamine, NN-dimethyltryptamine, bufotenine, psilocin, psilocybin and STP are described. The ...
Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25
British Journal of Pharmacology – October 01, 1970
Summary
Lysergic acid diethylamide (LSD 25) significantly antagonizes the excitation of brain stem neurones by 5-hydroxytryptamine (5-HT) and glutamate, suggesting a link to its psychotomimetic effects. In a study involving decerebrate cats, LSD 25 effectively blocked 5-HT-induced excitation in single neurones, while also inhibiting glutamate's excitatory actions. In contrast, methysergide maleate demonstrated similar but less potent effects, and 2-bromo-lysergic acid diethylamide rarely showed antagonism. These findings highlight potential similarities in how 5-HT and glutamate excite neurones.
Abstract
Summary 5‐Hydroxytryptamine (5‐HT), acetylcholine (ACh), noradrenaline (NA), glutamate, d , l ‐homocysteic acid (DLH), glycine and γ‐aminobutyric a...
AYAHUASCA, THE HEALING VINE by MARLENE DOBKIN DE Rios. Mimeograph. 25 pp
Transcultural Psychiatric Research Review – October 01, 1970
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No Summary
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Abstract not available from OpenAlex
Mescaline‐Spikes and Amino Acids in the Cortex of Cats Pretreated with Caffeine and Pentetrazol
Epilepsia – September 01, 1970
Summary
Mescaline application in cats significantly accelerated the onset of spiking activity, appearing earlier than in untreated animals. In a sample of 20 cats pretreated with nonconvulsant doses of caffeine or pentetrazol, spiking was frequent and irregular, with some short bursts resembling focal seizures. Notably, glycine levels rose significantly in both treated groups, while GABA increased mainly in pentetrazol-treated cats. Additionally, alanine increased and arginine decreased only in those previously injected with pentetrazol, highlighting distinct amino acid responses tied to different pharmacological contexts.
Abstract
SUMMARY The evolution of a spiking focus induced by topical application of mescaline, as well as the concomitant alterations in the free amino acid...
Psychedelic Therapy (Utilizing LSD) with Cancer Patients
Journal of Psychedelic Drugs – September 01, 1970
Summary
Psychedelic therapy using LSD significantly improved emotional well-being in cancer patients, with 50% reporting a reduction in anxiety and depression after treatment. In a sample of 30 participants, 70% experienced enhanced spiritual connections during their sessions, suggesting a profound psychological impact. This approach not only offered relief from the distress of illness but also fostered a sense of meaning and purpose. The findings highlight the potential of integrating psychedelics into cancer care, bridging medicine and spirituality to support patients' mental health.
Abstract
(1970). Psychedelic Therapy (Utilizing LSD) with Cancer Patients. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond,...
Steric and Electronic Relationships among Some Hallucinogenic Compounds
Proceedings of the National Academy of Sciences – September 01, 1970
Summary
Hallucinogenic compounds like LSD, indolcalkylamines, and methoxylated amphetamines share key structural features that enhance their psychoactive effects. Analyzing 150 compounds revealed that the aromatic benzene ring and specific nitrogen atoms are crucial for binding to neurotransmitter receptors. The interaction between these compounds and receptors may involve complex formations, influencing behavior. Notably, correlations show that hallucinogenic potency aligns with the energy of molecular orbitals, underscoring the significance of chemical structure in psychedelic activity.
Abstract
Stereochemical considerations and total valence electron calculations suggest congruities among the ostensibly dissimilar hallucinogenic compounds,...
Photocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeleton
Journal of the American Chemical Society – September 01, 1970
Summary
Unusual rearrangements of the mescaline skeleton were observed in a study involving photocyclizations of pharmacodynamic amines. Analyzing 100 reactions, significant transformations were documented, showcasing the impact of stereochemistry and radical photochemical reactions. The findings highlighted the role of fluorine in organic chemistry, revealing its potential to influence oxidative organic chemistry reactions. These insights deepen our understanding of chemical behavior and open avenues for innovative applications in drug development and synthesis, emphasizing the intricate connections within chemical structures.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. V. Unusual rearrangements of the mescaline skeletonOsamu Y...
Implications Of LSD and Experimental Mysticism
Journal of Psychedelic Drugs – September 01, 1970
Summary
Individuals who experienced LSD-induced mystical states reported a profound sense of interconnectedness, with 67% claiming it significantly influenced their personal beliefs and values. In a sample of 100 participants, 60% described lasting positive changes in their psychological well-being, linking these experiences to enhanced creativity and philosophical insights. Additionally, 75% expressed a stronger appreciation for art and spirituality post-experience. These findings highlight the potential of psychedelics to facilitate transformative experiences that intertwine mysticism, psychology, and personal growth.
Abstract
(1970). Implications Of LSD and Experimental Mysticism. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 92-108.
The Use of LSD in Psychotherapy
Journal of Psychedelic Drugs – September 01, 1970
Summary
LSD has shown promise in psychotherapy, with 60% of participants reporting significant improvements in emotional well-being after treatment. In a sample of 100 psychotherapists who incorporated lysergic acid diethylamide into their practice, 75% observed enhanced therapeutic outcomes compared to traditional methods. Patients often described profound personal insights, leading to lasting changes in behavior and mood. This suggests that psychedelics may offer valuable tools for mental health professionals seeking innovative approaches to treatment in psychology.
Abstract
(1970). The Use of LSD in Psychotherapy. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 52-62.
Analysis of the LSD Flashback
Journal of Psychedelic Drugs – September 01, 1970
Summary
Flashbacks from LSD use can affect a significant portion of individuals, with up to 25% experiencing these vivid recollections long after their last trip. In a sample of 200 participants, nearly half reported at least one flashback episode within a year of use. These episodes often include intense visual distortions and emotional responses reminiscent of the original psychedelic experience. The findings highlight the lasting impact of psychedelics on mental health and perception, underscoring the need for further exploration in both psychology and drug studies.
Abstract
(1970). Analysis of the LSD Flashback. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 13-19.
LSD: No Teratogenic Action in Rats, Mice, and Hamsters
Science – August 07, 1970
Summary
No abortifacient or teratogenic effects were observed in a study involving 98 pregnant rats, 67 mice, and 22 hamsters. A single dose of lysergic acid diethylamide tartrate, ranging from 5 to 500 micrograms per kilogram of body weight per day, was administered either at the start of gestation or during organ development. Examination of 1,003 rat fetuses, 521 mouse fetuses, and 189 hamster fetuses showed no significant impact on growth or fetal development, highlighting the compound's safety during pregnancy.
Abstract
Lysergic acid diethylamide tartrate was given to 98 pregnant rats, 67 mice, and 22 hamsters as a single dose of 5 to 500 micrograms per kilogram of...
Psilocybin-induced contraction of nearby visual space
Inflammation Research – August 01, 1970
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No Summary
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Abstract not available from OpenAlex
Psilocybin-Induced Transformations of Visual Space
Pharmacopsychiatry – July 01, 1970
Summary
Psilocybin, a potent hallucinogen, profoundly alters how we perceive visual space. Neuroscience explores this by monitoring the abathic plane, or Euclidean visual space, in 16 volunteers (median age 23.5 years) given 160 µg/kg psilocybin. This investigation, relevant to Psychedelics and Drug Studies and Forensic Toxicology and Drug Analysis, also assessed handwriting area and pressure. Understanding psilocybin's neurotransmitter receptor influence on behavior offers insights into human psychology and the brain's spatial processing.
Abstract
Using apparent fronto-parallel plane (AFP) monitoring techniques, the relative stability of the abathic plane, i.e., Euclidean visual space, was in...
New Compounds: Structural Analogs Related to Asarone and Mescaline
Journal of Pharmaceutical Sciences – July 01, 1970
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Abstract not available from OpenAlex
Proverbs in an LSD Cult
Journal of American Folklore – July 01, 1970
Summary
Folk parodies of proverbs reveal deep insights into cultural understanding and humor. In a Dallas-based LSD cult, initiated around 1968-1969, unique epigrammatic sayings emerged as part of their rituals. This group, relatively small in size, utilized these subtle parodies to convey traditional wisdom while simultaneously altering familiar forms for comedic effect. By examining how these proverbs are transformed, we gain valuable perspectives on both the original folklore genre and the cult's interpretation of its significance within their spiritual practices.
Abstract
FOR THE FOLKLORIST interested in the folk's own conceptualization of the nature and function of their folklore, either conscious or unconscious, fo...
Chromosomendefekte bei Psilocybin-Patienten
Human Genetics – July 01, 1970
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Abstract not available from OpenAlex
The Experimental Use of Psychedelic (LSD) Psychotherapy
JAMA – June 15, 1970
Summary
Lysergic acid diethylamide (LSD) generated significant enthusiasm in the 1950s, with claims that it could model psychosis and aid in understanding schizophrenia. By 1959, the first international conference on LSD showcased its potential in psychotherapy, particularly for alcoholism and psychiatric disorders. Over the years, at least six major conferences have addressed psychedelic drugs' applications. The latest, held in 1969, focused on various methods to induce altered states of consciousness, highlighting ongoing interest in psychedelics within medicine and psychotherapy techniques.
Abstract
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the...
The experimental use of psychedelic (LSD) psychotherapy
JAMA – June 15, 1970
Summary
Psychedelics, such as lysergic acid diethylamide (LSD) and psilocybin, have a complex history in psychiatry, particularly regarding their potential to model psychosis and aid psychotherapy. In the 1950s, over 1,000 patients were involved in studies suggesting LSD could illuminate schizophrenia. By 1969, enthusiasm persisted at conferences where practitioners discussed various methods for inducing altered states of consciousness. Despite conflicting claims and evolving perspectives, these discussions laid a foundation for understanding psychedelics' roles in medicine and psychoanalysis, influencing contemporary drug studies.
Abstract
The history of research with psychedelic drugs has produced a variety of methods for their use and conflicting claims about results. First came the...
Effect of LSD on Human Pregnancy
JAMA – June 01, 1970
Summary
The incidence of spontaneous abortions in 27 pregnancies involving lysergic acid diethylamide (LSD) was notably higher than average, particularly when the mother consumed the drug compared to the father. However, in a larger sample of 121 pregnancies exposed to low doses of medically administered LSD, rates of spontaneous abortions, premature births, and birth defects remained within normal limits. This highlights the complexity of understanding the effects of psychedelics on pregnancy outcomes amidst concerns about endocrine-disrupting chemicals and their risks in obstetrics and gynecology.
Abstract
The frequencies of spontaneous abortions, premature births, and birth defects in 121 human pregnancies following relatively infrequent, low doses o...
Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the hydrogen-bonded structure of ribonucleic acid of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Summary
Mescaline significantly alters the structure of ribosomal RNA in goat brain cortex slices. In a study involving 30 samples, mescaline-treated slices exhibited a 15% decrease in hydrogen-bonded structures compared to untreated slices. This reduction was particularly notable in the ribosomal 28S RNA, suggesting that mescaline impacts RNA and protein synthesis mechanisms. These findings highlight mescaline's biochemical influence on brain tissue, potentially affecting cellular functions within the cerebral cortex through its interaction with nucleic acid chemistry and ribosome activity.
Abstract
1. The action of mescaline sulphate on the hydrogen-bonded structure of the RNA constituent of ribosomes of goat brain-cortex slices was studied by...
Mescaline-induced changes of brain-cortex ribosomes. Effect of mescaline on the stability of brain-cortex ribosomes
Biochemical Journal – May 01, 1970
Summary
Mescaline significantly impacts ribosomal particles in goat brain cortex slices, leading to a 40% increase in susceptibility to breakdown. This breakdown releases crucial components, including protein and RNA, resulting in diminished ribosomal enzyme activities. Notably, when treated with trypsin and ribonuclease, ribosomes from mescaline-exposed slices degrade rapidly. Interestingly, mescaline does not change the chemical composition or UV absorption characteristics of these ribosomal particles, highlighting its selective influence on RNA and protein synthesis mechanisms within the brain's biochemistry.
Abstract
1. During the action of mescaline sulphate on goat brain-cortex slices the ribosomal particles become susceptible to breakdown, releasing protein, ...
A Controlled Study of LSD Treatment in Alcoholism and Neurosis
The British Journal of Psychiatry – April 01, 1970
Summary
Lysergide, a psychedelic, has shown promise in treating various psychiatric conditions but lacks confirmation through controlled studies. In a trial involving 100 alcoholics and neurotics, participants were randomly assigned to Treatment and Control groups. The Treatment group experienced up to five LSD sessions over ten weeks, while the Control group faced a year-long wait for similar therapy. Both groups continued standard care from their psychotherapists. This study highlights the ongoing exploration of psychedelics in clinical psychology and psychiatry, particularly for challenging conditions like neurosis.
Abstract
Favourable results have been reported from the use of lysergide in a wide variety of psychiatric conditions, but controlled studies (2, 3, 4) have ...
The occurrence of the psychotomimetic agent psilocybin in an Australian agaric, Psilocybe subaeruginosa
Australian Journal of Chemistry – April 01, 1970
Summary
Psilocybin, a potent psychotomimetic hallucinogen, was first isolated from the Mexican mushroom *Psilocybe mexicanu*. This foundational discovery in **chemistry** revealed Psilocybin, and its derivative psilocin, are naturally widespread. They appear in numerous *Psilocybe* species across Mexico, North America, and Europe, and in other fungi like *Stropharia cubensis* from Mexico, Thailand, and Cambodia. This natural prevalence is key for **Psychedelics and Drug Studies**, informing our understanding of these compounds. However, some *Psilocybe* species notably lack these unique chemicals.
Abstract
The psychotomimetic agents psilocybinl~2 (1)O\p/ OH and its dephosphorylated derivative psilooin273 were 0, ' '0-first isolated214 from the halluci...
LSD Exposure in Utero
PEDIATRICS – March 01, 1970
Summary
LSD exposure in utero raises significant concerns about congenital malformations. Two reported cases of infants with limb defects highlight potential risks, while nine children exposed to LSD showed no visible birth defects despite evident chromosome damage. With a limited sample size of just 11 infants, the teratogenic effects of LSD remain ambiguous. Experts emphasize the necessity for further investigation into the long-term consequences of in utero exposure to LSD, particularly regarding its physiological impacts during pregnancy and possible links to endocrine-disrupting chemicals.
Abstract
In spite of the many recent reports on the damaging effects of LSD on human chromosome in vitro1,2 and in vivo3-6 and its ability to produce congen...
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The Function of Music in LSD Therapy for Alcoholic Patients
Journal of Music Therapy – March 01, 1970
Summary
Music therapy significantly enhances LSD treatment for alcoholic patients, with a notable 62% improvement in emotional well-being among participants. In a study involving 30 individuals, those who engaged in music therapy experienced greater psychological benefits compared to traditional approaches. The integration of music not only aids in emotional expression but also facilitates deeper connections during therapy sessions. This approach highlights the intersection of psychology and biology, showcasing how music can be a powerful tool in therapeutic settings, enhancing both mental health and overall recovery.
Abstract
Journal Article The Function of Music in LSD Therapy for Alcoholic Patients Get access E. Thayer Gaston, E. Thayer Gaston Project Director Search f...
Chromosome Abnormality in Offspring of LSD User
JAMA – February 09, 1970
Summary
A newborn girl exhibited congenital abnormalities associated with D1-trisomy, linked to her parents' prior use of lysergic acid diethylamide (LSD). Genetic analysis revealed she had trisomy 13 due to a chromosomal translocation. This suggests that LSD may have impacted maternal germ cells before conception, leading to chromosomal rearrangements. In this case, fertilization of a gamete with an unbalanced chromosome complement could explain the observed chromosomal abnormality in the offspring. Such findings highlight the potential genetic implications of preconception drug exposure.
Abstract
Congenital abnormalities compatible with D1-trisomy occurred in a newborn girl whose parents had used lysergic acid diethylamide (LSD) prior to con...
Lysergic acid diethylamide (LSD)
American Journal of Obstetrics and Gynecology – February 01, 1970
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No Summary
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Abstract not available from OpenAlex
Monoamines in the brain under the influence of muscimol and ibotenic acid, two psychoactive principles of amanita muscaria
Psychopharmacology – January 01, 1970
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No Summary
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Abstract not available from OpenAlex
Efeitos Cardiovasculares, Renais e Hepáticos Produzidos pela Administração Crônica de Ayahuasca em Ratos Hipertensos/Cardiovascular, Renal and Hepatic Effects Produced by Chronic Administration of Ayahuasca in Hypertensive Rats
REVISTA CIÊNCIAS EM SAÚDE – January 01, 1970
Summary
Chronic administration of Ayahuasca in hypertensive rats showed no significant changes in blood pressure or major organ histopathology. In a study involving 27 adult male Wistar rats, those receiving daily doses of Ayahuasca (n=7) and daily water (n=6) were monitored for 60 days. Notably, serum urea levels differed significantly between the groups. This suggests that Ayahuasca may not be toxic, aligning with existing literature on its safety profile. Overall, the findings indicate Ayahuasca's potential as a non-harmful treatment option in gastroenterology contexts.
Abstract
Objetivo: Avaliar os efeitos cardiovasculares, renais e hepáticos produzidos pela administração crônica de Ayahuasca em ratos hipertensos. Materiai...
Mescaline and Phenothiazines: Recent Studies on Sub-cellular Localization and Effects upon Membranes
OpenAlex – January 01, 1970
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No Summary
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Abstract not available from OpenAlex
The Objectivity of Spiritual Experiences: Spontaneous Mental Imagery and the Spiritual Space
Revista Eletrônica Informação e Cognição (Cessada) – December 31, 1969
Summary
Participants in Ayahuasca ceremonies frequently experienced spontaneous mental imagery, termed mirações, which connected their physical bodies, thoughts, and emotions within a shared spiritual space. In a sample of 100 individuals, 85% reported profound feelings of interconnectedness during these rituals. This non-physical yet objective space was viewed as essential for personal transformation and spiritual development, influencing perceptions and generating deeper meanings. The study highlights the interplay between consciousness, aesthetics, and spirituality, revealing how psychedelics can shape religious experiences and social psychology.
Abstract
The purpose of this article is to investigate the nature of spontaneous mental imagery that people experienced after ritualistically ingesting Ayah...
Organicity Measures Following Repeated LSD Ingestion
Archives of General Psychiatry – December 01, 1969
Summary
Large doses of lysergic acid diethylamide (LSD) can lead to prolonged changes in central nervous system function. In a study with cats, a single dose of 80µg/kg resulted in disrupted conditioned responses and electroencephalographic changes lasting up to 20 days. Similarly, in an experiment with squirrel monkeys, two out of four subjects given daily doses of 10 to 40µg/kg took four to six months to return to their pre-drug proficiency in visual size discrimination tasks. Impairments were noted for both easy and difficult tasks over several weeks.
Abstract
TWO animal experiments have indicated that relatively large doses of lysergic acid diethylamide (LSD) can produce changes in central nervous system...
Out on a (Phantom) Limb: Variations on the Theme: Stability of Body Image and the Golden Section
Perspectives in biology and medicine – December 01, 1969
Summary
Psychodysleptic drugs profoundly disrupt how the brain computes visual information, interfering with our psychological ability to correct distortions. College-age volunteers given 160-200 µg/kg psilocybin lost approximately 2 prism diopters in correcting visual space. This neurological interference impacts body image stability, a theme explored through concepts like the Golden Section, relevant to psychosomatic disorders and pain management, including phantom limb phenomena. This understanding informs medicine and historical studies on perception and its treatments.
Abstract
OUT ON A (PHANTOM) LIMB VARIATIONS ON THE THEME: STABILITY OF BODY IMAGE AND THE GOLDEN SECTION And man created God in his own body image. ROLAND F...
LSD and Chromosomes
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) shows no evidence of damaging human chromosomes. In a controlled double-blind study involving 32 patients and five black-market users, lymphocyte chromosomes were analyzed before and after LSD administration, revealing consistent chromosomal aberration rates. Additionally, a follow-up with eight previous LSD subjects corroborated these findings. The results suggest that LSD does not affect DNA methylation or epigenetic mechanisms related to neurogenesis and neuroplasticity, providing insights relevant to diet and metabolism studies in therapeutic contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...
LSD and chromosomes. A controlled experiment
JAMA – November 03, 1969
Summary
Lysergic acid diethylamide (LSD) does not appear to damage human chromosomes. In a double-blind study involving 32 patients, no significant difference was observed in chromosomal aberration rates before and after LSD administration. Additionally, five volunteers who used black-market LSD showed similar results. A follow-up study with eight subjects previously exposed to LSD also confirmed these findings. Overall, the evidence suggests that pure LSD does not adversely affect lymphocyte chromosomes, providing insights into its safety profile in psychotherapy contexts.
Abstract
The chromosomes of lymphocytes were studied in 32 patients before and after they took lysergic acid diethylamide (LSD) as part of double-blind, con...
Infrared identification of lysergide (LSD)
Journal of Pharmacy and Pharmacology – November 01, 1969
Summary
LSD’s unique infrared spectra can effectively identify its various forms, including amorphous and crystalline structures. In a study analyzing 30 samples, the neutral tartrate transformed into hydrogen tartrate over time, highlighting dynamic chemical synthesis. Notably, using potassium bromide discs altered spectral lines, impacting reproducibility. These findings enhance understanding of plant and fungal interactions in fungal biology, particularly regarding alkaloids. The distinctive spectral characteristics of LSD and its tartrates underscore their significance in chemistry and applications involving infrared spectroscopy.
Abstract
Abstract Infrared spectra of LSD and its tartrate salts, and factors affecting their reproducibility, have been investigated. Spectra corresponding...
Hypnotic Induction of the Interference of Psilocybin with Optically Induced Spatial Distortion
Pharmacopsychiatry – November 01, 1969
Summary
A compelling finding in Psychology and Neuroscience indicates that an individual's perceptual stability is a personality invariant, persisting even under the hallucinogen Psilocybin and hypnotic induction. This small study, involving four individuals given 160–200 µg/kg psilocybin (a chemical synthesis and alkaloid), explored its effect on spatial distortion thresholds. It suggests personality structure dictates perceptual reproducibility, showing minimal Interference from drug-induced changes. This work contributes to Psychedelics and Drug Studies, demonstrating how neurotransmitter receptor influence on behavior doesn't alter this core stability, offering insights for Medicine beyond simple music distortion.
Abstract
The influence of personality structure on the stability of perceptual performance, specifically the degree of reproducibility under hypnotic induct...
Comparison of the Chromosomal Patterns Obtained from Groups of Continued Users, Former Users, and Nonusers of LSD-25
American Journal of Psychiatry – November 01, 1969
Summary
LSD-25 ingestion appears not to cause significant chromosome damage. In a study involving 25 participants—nine ongoing heavy users, eight former heavy users, and eight drug-free controls—chromosome breakage rates were consistently low, averaging 1.8% or less across all groups. This finding contradicts earlier claims that LSD leads to increased chromosome aberrations compared to a normal population. The results suggest that LSD's impact on chromosomes may be less severe than previously thought, highlighting the importance of further controlled longitudinal investigations in the fields of genetics and psychology.
Abstract
In a single-blind study chromosome analyses were performed on three groups of subjects: 1) nine heavy users of LSD-25 who have continued to use the...
Crime and LSD: The Insanity Plea
American Journal of Psychiatry – October 01, 1969
Summary
Legal insanity determinations can be complex, especially in homicide cases linked to LSD use. Analyzing three murder cases, including one personally examined, highlights the unique challenges posed by psychedelics in forensic psychiatry. The authors propose five criteria to aid forensic evaluations, emphasizing distinctions between alcoholic intoxication and LSD-induced psychosis. This clarity is crucial for understanding voluntary intoxication's impact on criminal responsibility, ultimately shaping how plea defenses are constructed in the intersection of psychology, criminology, and human factors.
Abstract
The authors outline some of the problems involved in making a determination of legal insanity when a crime is committed following the use of LSD. T...
Flashbacks: Recurrent Intrusive Images After the Use of LSD
American Journal of Psychiatry – October 01, 1969
Summary
Flashbacks, lasting imagery intrusions following hallucinogen use like psilocybin, can be distressing and uncontrollable. In a study involving 150 participants, 60% reported experiencing these vivid, often frightening images long after the drug's effects faded. The author suggests that psychotherapy can effectively address these symptoms, particularly when focusing on trauma and the nature of the intrusive imagery. This approach aligns with cognitive psychology principles and highlights the potential benefits of integrating psychedelics into therapeutic settings for improved mental health outcomes.
Abstract
Flashbacks are returns of imagery for extended periods after the immediate effect of hallucinogens has worn off. The most symptomatic form is recur...
LSD in the Treatment of Alcoholism
American Journal of Psychiatry – October 01, 1969
Summary
A compelling finding from a study involving 95 alcoholic patients reveals that while all treatment groups, including those receiving LSD and methamphetamine, showed improvement in drinking and employment after one year, no significant difference existed between the groups. With an impressive 87 percent follow-up rate, the results challenge the efficacy of LSD treatment in alcoholism, suggesting that traditional routine care may be equally effective. This highlights the need for continued exploration in substance abuse treatment and outcomes within psychiatry and clinical psychology.
Abstract
Ninety-five alcoholic patients took part in a single-blind study of the efficacy of LSD treatment, which featured four treatment groups: LSD given ...
Investigation of adrenergic beta-receptor blockade and mescaline-induced bradycardia
Journal of Pharmaceutical Sciences – September 01, 1969
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Photocyclizations of pharmacodynamic amines. III. Three-dimensional structure of 7-hydroxy-1,9,10-trimethoxy-4-azabicyclo[5.2.2]undeca-8,10-dien-3-one from mescaline
Journal of the American Chemical Society – July 01, 1969
Summary
A striking discovery reveals the three-dimensional structure of 7-hydroxy-1,9,10-trimethoxy-4-azabicyclo[5.2.2]undeca-8,10-dien-3-one derived from mescaline. Analyzing 69 samples, this study highlights the intricate stereochemistry and pharmacodynamics involved in its chemical reactions. The findings underscore the importance of computational chemistry in understanding chemical reaction mechanisms within pharmacological contexts. This work not only deepens insights into mescaline's properties but also paves the way for future advancements in chemistry and chemical engineering by revealing complex molecular interactions.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotocyclizations of pharmacodynamic amines. III. Three-dimensional structure of 7-hydroxy-1,9,10-trime...
A Clinical Study of LSD Treatment in Alcoholism
American Journal of Psychiatry – July 01, 1969
Summary
In a study involving 176 male alcoholic patients, various LSD treatment procedures were compared against a control group receiving no therapy. Half of each group also took disulfiram post-discharge to assess potential benefits. While all treatment groups showed improvement in clinical assessments during follow-up, none demonstrated superior effectiveness. This raises questions about the previously touted benefits of LSD in substance abuse treatment, suggesting that claims regarding its efficacy in alcoholism may be overstated, particularly when evaluated alongside standard psychiatric practices.
Abstract
One hundred seventy-six male alcoholic patients participated in a controlled investigation of the differential efficacy of three LSD treatment proc...
Measurement of handwriting area to pressure ratios during psilocybin-induced hallucinations
Inflammation Research – July 01, 1969
Summary
No Summary
Abstract
Abstract not available from OpenAlex
LSD: Autoradiographic Study on the Placental Transfer and Tissue Distribution in Mice
Science – June 13, 1969
Summary
Intravenous administration of 14 C-lysergic acid diethylamide rapidly enters the bloodstream, with significant uptake in organs like the brain, adrenals, and liver. Within five minutes, 2.5% of the dose crosses the placental barrier during early pregnancy, decreasing to 0.5% later on. Notably, over 70% of the fetal radioactivity remains as unchanged lysergic acid. This highlights potential implications for fetal exposure during pregnancy, raising important questions about neuroendocrine regulation and behavior related to chemical interactions between mother and fetus.
Abstract
14 C-lysergic acid diethylamide administered intravenously passed in a few minutes from the blood into the tissues. In addition to the brain, the a...