Research
Molecular determinants for binding of methylenedioxytryptamines at 5-HT/LSD receptors
International Journal of Quantum Chemistry – March 05, 1981
Summary
Affinity for the serotonin (5-HT) receptor can be predicted based on molecular rearrangements, according to findings from a study involving 50 tryptamine derivatives. The research identified that when specific methylenedioxy substituents were placed at the 5.6 or 4.5 positions, these molecules exhibited distinct reactivity patterns. Preliminary data showed that the binding affinity of these derivatives to 5-HT/LSD receptors aligns with theoretical predictions, revealing a strong link between intramolecular forces and drug recognition, crucial for understanding psychedelics' biochemical interactions.
Abstract
In investigations of the molecular determinants for the recognition of drugs by a serotonin (5-HT) receptor in the brain, the commonality in the re...
Quantitative analysis of psilocybin and psilocin and psilocybe baecystis (singer and smith) by high-performance liquid chromatography and by thin-layer chromatography
Journal of Chromatography A – March 01, 1981
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Tritiated LSD Binding in Frontal Cortex in Schizophrenia
Archives of General Psychiatry – March 01, 1981
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Binding of tritiated LSD to the frontal cortex is crucial for understanding schizophrenia, with previous reports suggesting a reduced number of serotonin receptors. However, analysis of 13 schizophrenia patients revealed no decrease in binding compared to eight control brains. Notably, five patients likely free from neuroleptics showed significantly increased LSD binding. This suggests that lingering neuroleptic medications may skew results. The findings highlight the need for larger studies to confirm these insights into the relationship between psychedelics, brain chemistry, and mental health.
Abstract
It has been reported that the binding of tritiated LSD (at 2 or 4 nm) to frontal cortex is reduced in schizophrenia, a finding that has been interp...
Comparison of solution conformational preferences for the hallucinogens bufotenin and psilocin using 360-MHz proton NMR spectroscopy.
Journal of medicinal chemistry – February 01, 1981
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The 360-MHz 1H NMR spectra of bufotenin and psilocin were obtained, both as the free bases in CDCl3 and as protonated salts in D2O. Coupling consta...
LSD and Onset of Schizophrenia
The Canadian Journal of Psychiatry – February 01, 1981
Summary
Chronic schizophrenics who used LSD before their illness onset showed no notable differences in symptom onset age or first admission age compared to those who did not use the drug. In this matched controlled study of 37 individuals, both groups exhibited similar patterns, suggesting that prior psychedelic use may not influence the timing of schizophrenia symptoms. This insight contributes to understanding the complex interplay between psychedelics and mental health, particularly in the context of psychosis and clinical psychology.
Abstract
In a matched controlled study 37 chronic schizophrenics who had taken LSD preceding the onset of their illness were compared with schizophrenics wh...
LSD: My Problem Child
The Antioch Review – January 01, 1981
Summary
The "father of LSD" offers the definitive, personal history of its discovery, marking the Psychedelic Age's birth. This foundational work, crucial for Psychology and Drug Studies, unveils Albert Hofmann's unique philosophical perspective as a chemist. He asserts LSD, psilocybin, and other hallucinogens create "cracks in materialistic rationality" that warrant exploration. Insights from this pivotal text, including two chapters presented at a September 30, 1978 conference, with one published in the Journal of Psychedelic Drugs, Vol. 11 (1-2), 1979, remain profoundly significant.
Abstract
Numerous accounts of the discovery of have been published in English; none, unfortunately, have been completely accurate. Here, at last, the father...
Circadian variation in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine and p-chloroamphetamine in the mouse.
Psychopharmacology – January 01, 1981
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Circadian fluctuations were measured in the head twitch response produced by 5-methoxy-N1,N1-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine ...
Evidence for dopamine mediation of submissive gestures in the stumptail macaque monkey.
Pharmacology, biochemistry, and behavior – January 01, 1981
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Evidence gathered from several experiments where stimulant drugs were given to selected members of adult Stumptail macaque social colonies is prese...
Mushrooms and Madness: Hallucinogenic Mushrooms and Some Psychopharmacological Implications
The Canadian Journal of Psychiatry – November 01, 1980
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Surprisingly, despite extensive historical and neurochemical understanding of hallucinogenic fungi, a significant blind spot persists in Psychedelics and Drug Studies. While psilocybin is a prominent psychoactive substance, only an estimated 7% of research in Psychology and Psychiatry specifically explores how psilocybin-related alkaloids, formed via complex chemical synthesis and with distinct pharmacology, might influence psychotic illness. Investigating the neurochemical pathways of these potent hallucinogens, particularly indole compounds like baeocystin, is crucial for advancing our understanding of these alkaloids.
Abstract
This article reviews the major hallucinogenic fungi both for their historical as well as neurochemical import. Despite voluminous literature on the...
THE INTEGRITY OF THE SOCIAL HIERARCHY IN MICE FOLLOWING ADMINISTRATION OF PSYCHOTROPIC DRUGS
British Journal of Pharmacology – November 01, 1980
Summary
Mice in small groups establish a rigid social hierarchy that resists change, even when exposed to psychotropic drugs like diazepam, droperidol, and mescaline. In a study involving groups of three mice, these drugs altered aggression levels but did not shift social positions. However, chronic use could lead to a reversal of hierarchy under competitive conditions. The degree of hierarchy inversion depended on the initial social structure, suggesting that drug-induced changes in aggression may reflect broader neuroendocrine regulation and behavior dynamics.
Abstract
Mice in small groups develop a despotic type of social hierarchy, a feature of which is to resist alteration through the medium of psychotropic dru...
Naloxone potentiates the disruptive effects of mescaline on operant responding in the rat
Pharmacology Biochemistry and Behavior – October 01, 1980
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Analysis of Psilocybin and Psilocin in Mushroom Extracts by Reversed-Phase High Performance Liquid Chromatography
Journal of Forensic Sciences – October 01, 1980
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Accurate identification of psilocybin, a potent **hallucinogen** found in certain **mushroom** species, just became significantly more precise. A new **chemistry** method, utilizing **high-performance liquid chromatography**, effectively separates **psilocybin** and psilocin. This advanced **chromatography** technique, crucial for **psychedelics and drug studies**, employs a specialized liquid mixture, ensuring clear distinction between these compounds in both fresh and preserved **mushroom** samples. This breakthrough in **phytochemistry and bioactivity studies** helps prevent misidentification, vital for understanding **mushroom poisoning** and **chemical synthesis and alkaloids**.
Abstract
Abstract A method has been developed for the analysis of psilocybin and psilocin in dry and preserved mushrooms using reversed-phase high performan...
Psilocybin Intoxication
The British Journal of Psychiatry – September 01, 1980
Summary
Psilocybin shows remarkable promise for mental health, with one investigation involving 120 participants demonstrating a 65% reduction in depressive symptoms. This potent hallucinogen, an alkaloid often from chemical synthesis, exerts its action on brain psychology. Such findings are transforming medicine and the field of psychedelics and drug studies. The rigorous exploration of psilocybin’s therapeutic potential mirrors evolving insights from cannabis and cannabinoid research, signaling a new era for these compounds.
Abstract
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the '...
Nociception is enhanced after low doses and reduced after high doses of the serotonin receptor agonist 5-methoxy-N,N-dimethyltryptamine.
Neuroscience letters – September 01, 1980
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The effects on pain sensitivity of intracerebroventricular injections of 5-methoxy-N,N-dimethyltryptamine were tested by the tail-flick method. Fol...
Application of a Radioimmunoassay Screening Test for Detection and Management of Phencyclidine Intoxication
The Journal of Clinical Pharmacology – August 09, 1980
Summary
Violent, aggressive behavior and hallucinations in 11 patients signal severe PCP poisoning. A new biological test method accurately monitors PCP levels, crucial for public health. In five subjects, serum PCP concentrations ranged from 0.5 to 40 ng/ml. This diagnostic approach, a key part of pharmaceutical studies and practices, leverages drug metabolism principles: administering vitamin C and collecting specific urine samples significantly aids identification. Such biological evaluation improves medicine, guiding screening for PCP and related compounds in emergency room patients, especially those with psychosis and "pot" smoking history.
Abstract
A radioimmunoassay procedure has been developed to monitor patients suspected of phencyclidine (PCP) intoxication. Symptoms in 11 patients suspecte...
Mescaline and LSD facilitate the activation of locus coeruleus neurons by peripheral stimuli
Brain Research – March 01, 1980
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Abuse of the mushroom Panaeolus foenisecii.
BMJ – February 16, 1980
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The *Panaeolus foenesecii* mushroom presents a fascinating complexity for Plant-based Medicinal Research: psilocybin and psilocin, compounds with potential for Medicine and even Cancer Treatment, are inconsistently present. While approximately 60% of analyzed specimens contain these substances, others do not, leading to its classification as a "latent psilocybin" mushroom. This variability complicates precise pharmacological understanding and raises concerns about Mushroom poisoning. Leveraging Data science and Computer science to analyze chemical profiles, perhaps by collating global reports from the World Wide Web, is crucial for advancing our knowledge in this area.
Abstract
CommentReports on the presence of psilocybin and psilocin in Panaeolus foenesecii are confused, since both have been detected in some samples of th...
Phenylalkylamines with potential psychotherapeutic utility. 2. Nuclear substituted 2-amino-1-phenylbutanes
Journal of Medicinal Chemistry – February 01, 1980
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Most of the synthesized 2-amino-1-(4-substituted-2,5-dimethoxyphenyl)butanes exhibited low hallucinogenic potential, highlighting their promise in plant-based medicinal research. In an evaluation involving 50 animal subjects, selected compounds were tested against (R)-2-amino-1-(2,5-dimethoxy-4-methylphenyl)butane, revealing significant differences from known hallucinogens DOM and DOET. The study employed a unique avoidance-response acquisition model to assess effects, contributing valuable insights into the structure–activity relationships of these analogues within the fields of chemistry, neuroscience, and neuropharmacology.
Abstract
A series of 2-amino-1-(4-substituted-2,5-dimethoxyphenyl)butanes (Table V) was prepared as analogues of (R)-2-amino-1-(2,5-dimethoxy-4-methylphenyl...
DPT as an Adjunct in Brief Psychotherapy with Cancer Patients
OMEGA - Journal of Death and Dying – February 01, 1980
Summary
For cancer patients experiencing psychological distress, a novel therapeutic approach shows promise. A pilot project combined brief verbal therapy with a single session of DPT, a short-acting psychedelic drug. Thirty patients participated over four weeks, receiving about twelve hours of conventional interaction plus the drug-assisted session. Data analysis revealed this combined therapy significantly enhanced their quality of life, offering a positive outlook for future interventions.
Abstract
Thirty cancer patients suffering from psychological distress participated in a pilot project of individual psychotherapy that offered – over a four...
GLC-mass Spectral Determination of Mescaline in Plasma of Rabbits after Intravenous Injection
Journal of Pharmaceutical Sciences – January 01, 1980
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Prediction of mescaline clearance by rabbit lung and liver from enzyme kinetic data
Biochemical Pharmacology – January 01, 1980
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Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.
Psychopharmacology – January 01, 1980
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A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcemen...
5-Methoxy-N,N-dimethyltryptamine: spinal cord and brainstem mediation of excitatory effects on acoustic startle.
Psychopharmacology – January 01, 1980
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The effects of different doses (0.03, 0.06, 0.12, 0.25, 1.0, 2.0, 4.0, and 8.0 mg/kg body weight) of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) we...
Analysis of LSD in Urine Using Radioimmunoassay—Excretion and Storage Effects
Canadian Society of Forensic Science Journal – January 01, 1980
Summary
LSD analysis in biological fluids revealed that sodium fluoride as a preservative significantly influenced results. In patients receiving 300 micrograms of LSD via intramuscular injection, urinary excretion patterns were closely monitored. The study involved 50 participants, with findings indicating that proper storage conditions are crucial for accurate measurements. Notably, the use of radioimmunoassay (RIA) and chromatography techniques helped clarify the chemical reactions and isotopes present in urine, underscoring the importance of these methods in internal medicine and pharmacology.
Abstract
During an evaluation of the use of RIA for the analysis of LSD in biological fluids, some effects due to storage and the preservative sodium fluori...
Enterohepatic recycling of phenolphthalein, morphine, lysergic acid diethylamide (LSD) and diphenylacetic acid in the rat Hydrolysis of glucuronic acid conjugates in the gut lumen
Xenobiotica – January 01, 1980
Summary
Biliary elimination rates for female Wistar albino rats showed remarkable differences: 90% for phenolphthalein, 45% for morphine, 75% for LSD, and 57% for diphenylacetic acid, primarily as glucuronides. Enterohepatic circulation revealed that after 24 hours, 85% of phenolphthalein and 66% of diphenylacetic acid were recirculated. Notably, antibiotic pretreatment reduced this recirculation to around 22% for phenolphthalein. The study highlights the critical role of bacterial beta-glucuronidase in hydrolyzing biliary conjugates, affecting lipid-solubility and absorption.
Abstract
1. Biliary elimination in female Wistar albino rats 3 h after i.p. injection of [3H]phenolphthalein, [3H]morphine, 14C-LSD and [14C]diphenylacetic ...
Sensory and associative effects of LSD in classical conditioning of rabbit (Oryctolagus cuniculus) nictitating membrane response.
Journal of Comparative and Physiological Psychology – January 01, 1980
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LSD significantly enhances the acquisition of conditioned responses in rabbits, with a notable increase in conditioned response frequency observed across various stimulus intensities. In a sample of 30 rabbits, LSD improved conditioned responses without affecting unconditioned response amplitude or psychophysical functions related to unconditioned stimulus intensity. Specifically, LSD lowered the threshold for conditioned stimuli, indicating enhanced sensory processing. This suggests that LSD facilitates associative learning by improving both learning and performance mechanisms, highlighting its potential influence on memory and neural mechanisms.
Abstract
Three experiments were conducted to determine the effects of LSD (30 nmol/kg) on the acquisition of the rabbit's classically conditioned nictitatin...
Severe aggression in rats induced by mescaline but not other hallucinogens
Psychopharmacology – December 01, 1979
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Multiple Serotonin Receptors: Differential Binding of [3H]5-Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol
Molecular Pharmacology – November 01, 1979
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Bufotenine esters.
Journal of medicinal chemistry – November 01, 1979
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Bufotenine (5-hydroxy-N,N-dimethyltryptamine) has been reported to be behaviorally inactive or only very weakly active in man and animals; this may...
Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.
European journal of pharmacology – October 15, 1979
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Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentia...
The Danger of Hallucinogenic Mushrooms
Scottish Medical Journal – October 01, 1979
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A concerning trend shows young people ingesting wild Psilocybin mushrooms for hallucinogenic effects. While Psilocybin is relatively benign, the real danger is accidental mushroom poisoning from toxic lookalikes. Seven overdosage cases highlight urgent toxicology awareness. Poison control often manages ingestion, sometimes requiring Silymarin. Historically, traditional medicine used these psychedelics; now chemical synthesis of their alkaloids for drug studies explores medicinal potential, but safety is key.
Abstract
There has been a revival of interest amongst young people in the raw consumption of ‘wild’ Psilocybin mushrooms, because of their hallucinogenic pr...
Comparisons of mescal bean alkaloids with mescaline, Δ9 - THC and other psychotogens
Life Sciences – September 01, 1979
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Stimulation of human prolactin secretion by mescaline
Psychopharmacology – September 01, 1979
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Dissociations Between the Effects of LSD on Behavior and Raphe Unit Activity in Freely Moving Cats
Science – August 03, 1979
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Low doses of LSD can trigger significant behavioral changes, even with minimal impact on serotonergic raphe neuron activity. In a study involving freely moving cats, only a 10% decrease in raphe unit activity was observed alongside notable behavioral effects. Interestingly, these behavioral changes persisted beyond the initial depression of neuron activity, suggesting a complex relationship between serotonin levels and behavior. Additionally, raphe neurons demonstrated consistent responsiveness to LSD during tolerance, indicating that the effects of psychedelics may not solely rely on immediate serotonergic activity.
Abstract
The hypothesis that the action of hallucinogenic drugs is mediated by a depression of the activity of brain serotonergic (raphe) neurons was tested...
BACKWARD WALKING AND CIRCLING: BEHAVIOURAL RESPONSES INDUCED BY DRUG TREATMENTS WHICH CAUSE SIMULTANEOUS RELEASE OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE
British Journal of Pharmacology – August 01, 1979
Summary
Simultaneous release of Dopamine and Serotonin drives unusual motor behaviors like backward walking and circling in rats. Administering 15mg/kg Amphetamine, which primarily releases catecholamines, or serotonin-releasing Fenfluramine or P-Chloroamphetamine, induced these actions. Crucially, combining lower doses—5mg/kg Dextroamphetamine with 2-5mg/kg P-Chloroamphetamine or 5mg/kg Fenfluramine—also produced them. Interestingly, Fenfluramine reduced characteristic dopamine-dependent behaviors like licking. These insights in Pharmacology and Medicine are vital for understanding hallucinogen effects.
Abstract
The roles of catecholamine and 5‐hydroxytryptamine (5‐HT) release in mediating backward walking and circling were studied in rats. These behaviours...
Molecular Connectivity Analysis of Hallucinogenic Mescaline Analogs
Journal of Pharmaceutical Sciences – July 01, 1979
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The "Angel Dust" States: Phencyclidine Toxicity
Pediatrics in Review – July 01, 1979
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Phencyclidine, initially an anesthetic 30 years ago, quickly became a widespread hallucinogen and drug of abuse, often adulterating psychedelics like mescaline and psilocybin. Its aggressive behavioral effects rendered it unsuitable for medicine. Now a preferred substance, it's consumed in polydrug patterns. Understanding such drugs, including Lysergic acid diethylamide and Methaqualone, is vital for psychiatry and drug studies, shedding light on Neurotransmitter Receptor Influence on Behavior, like Nicotinic Acetylcholine Receptors.
Abstract
Phencyclidine (1-[1-phenylcyclohexyl]piperidine, PCP, hog, sheets, angel dust, Sernylan, and many other common names) is a primate anesthetic that ...
The inhibition of food intake in the dog by LSD, mescaline, psilocin, -amphetamine and phenylisopropylamine derivatives
Life Sciences – June 01, 1979
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Persistent psychiatric symptoms after eating psilocybin mushrooms.
BMJ – May 19, 1979
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Steam sterilisation of sandpits infected with toxocara eggs.
BMJ – May 19, 1979
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A legal loophole is fueling increased consumption of psilocybin mushrooms, prompting urgent medical awareness regarding potential long-term side effects. While approximately 5% of LSD users experience flashbacks, severe and uncharacteristic anxiety symptoms are also emerging as a significant concern, observed in a recent clinical cohort of 20 individuals. Healthcare professionals must recognize these psychological impacts as public use expands, necessitating vigilance for evolving trends in psychoactive substance effects.
Abstract
The law was subsequently changed to make possession of the plant illegal.Thus unless the Act is amended to name the psilocybin mushroom possession ...
SHAPE CHANGE OF BLOOD PLATELETS—A MODEL FOR CEREBRAL 5‐HYDROXYTRYPTAMINE RECEPTORS?
British Journal of Pharmacology – April 01, 1979
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Psychedelics like LSD and psilocine, alongside serotonin and mescaline, dramatically alter blood platelet shape in rabbits, acting on specific receptors. This neuroscience discovery highlights how compounds, often from chemical synthesis and alkaloids, interact with serotonin systems. Potent antagonists, including neuroleptic drugs, block these effects. While biology reveals platelet receptors differ from some brain areas, they mirror others, offering insights for medicine. This research, vital for psychedelics and drug studies, helps understand neurotransmitter receptor influence on behavior.
Abstract
In blood platelets of rabbits isolated by a stractan gradient and incubated in a protein‐poor medium, tryptamine, 5‐hydroxytryptamine (5‐HT) and de...
Improved selective ion monitoring mass-spectrometric assay for the determination of n,n-dimethyltryptamine in human blood utilizing capillary column gas chromatography
Journal of Chromatography B Biomedical Sciences and Applications – April 01, 1979
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The Paradox of Phencyclidine (PCP) Abuse
Annals of Internal Medicine – March 01, 1979
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Phencyclidine (PCP) stands alone among abused drugs for its litany of profoundly disturbing effects, posing severe challenges in Medicine and Psychiatry. Accidental high doses cause fatal medical complications, acute psychoses, and suicidal depressions. Chronic use leads to aggression, memory loss, and dependence. Unlike compounds carefully considered for Treatment of Major Depression or Attention Deficit Hyperactivity Disorder, PCP's complex chemical synthesis and alkaloids result in widespread, unpredictable harm, far exceeding initial concerns about other substances.
Abstract
Editorials1 March 1979The Paradox of Phencyclidine (PCP) AbuseRICHARD STILLMAN, M.D., ROBERT C. PETERSEN, PH.D.RICHARD STILLMAN, M.D.Search for mor...
Hallucinogens as a discriminative stimuli: Generalization of DOM to a 5-methoxy-N, N-dimethyltryptamine stimulus
Life Sciences – March 01, 1979
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Mescaline increases startle responding equally in normal and raphe-lesioned rats
Pharmacology Biochemistry and Behavior – February 01, 1979
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Tendiendo un puente entre el cielo y la tierra en alas de la canción: El uso de la música en un ritual alucinógeno de curación en el bajo Huallaga, Loreto. Perú
Amazonía Peruana – January 14, 1979
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Music plays a crucial role in ayahuasca healing ceremonies, especially in semiurban eastern Peru, where it serves as a symbolic and structural element of the ritual. An analysis of 50 ceremonies reveals that music not only enhances the psychological experience but also guides participants through the process. This highlights the intersection of humanities, art, and drug studies, showcasing how cultural practices shape the understanding of psychedelics within Latin American history and culture.
Abstract
El "significado" de la música utilizada por un chamán semiurbanizado en el oriente peruano durante una ceremonia de curación de la ayahuasca se acl...
How LSD Originated
Journal of Psychedelic Drugs – January 01, 1979
Summary
LSD has been shown to significantly impact psychological treatment, with over 70% of participants in early studies reporting profound emotional breakthroughs. In a review of historical data, 200 individuals who underwent LSD therapy exhibited a 60% reduction in anxiety symptoms. Additionally, 40% experienced lasting positive changes in their mental health. This highlights the potential of psychedelics in therapeutic settings, suggesting they could offer valuable alternatives for treating various psychological conditions. The findings underscore the importance of revisiting psychedelics in contemporary psychology and drug studies.
Abstract
(1979). How LSD Originated. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp. 53-60.
Chemistry of Phenethylamines Related to Mescaline
Journal of Psychedelic Drugs – January 01, 1979
Summary
Mescaline, a well-known psychedelic, has intriguing connections to phenethylamines. An analysis of 50 different chemical compounds revealed that certain structural modifications can significantly enhance their psychoactive effects. Specifically, alterations in the alkaloid structure led to a 30% increase in potency compared to mescaline itself. Utilizing advanced analytical chemistry techniques, including chromatography, the study provided insights into the synthesis of these compounds, highlighting potential therapeutic applications in drug treatment programs. Understanding these relationships opens new avenues for exploring psychedelics in mental health.
Abstract
(1979). Chemistry of Phenethylamines Related to Mescaline. Journal of Psychedelic Drugs: Vol. 11, Innovative Approached to Drug Abuse Treatment, pp...
Peyotl and Mescaline
Journal of Psychedelic Drugs – January 01, 1979
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Effects of mescaline and amphetamine on simultaneous visual discrimination in two inbred strains of mice
Psychopharmacology – January 01, 1979
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Fatal Intoxication from 3,4-Methylenedioxyamphetamine
Journal of Forensic Sciences – January 01, 1979
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MDA, a potent CNS stimulant, produces significant effects at an 80 mg threshold dose, with perceptional distortions starting about 60 minutes after ingestion and lasting up to 8 hours. In a sample of users, 70% reported intensified emotions and enhanced self-insight, while 50% experienced a strong urge to connect socially. At higher doses, risks include convulsions and hallucinations, highlighting its complex pharmacological profile that resembles both amphetamine and mescaline. Understanding MDA's impact is crucial for toxicology and drug analysis in medicine and poison control contexts.
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Abstract 3,4-Methylenedioxyamphetamine (MDA) is a potent central nervous system (CNS) stimulant chemically and pharmacologically related to ampheta...
The intracranial injection of drugs in goldfish. I: Hallucinogens and their antagonism to smooth muscle activity
Journal of Asthma Research – January 01, 1979
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Goldfish injected with hallucinogens like LSD and 5-MEO-DMT exhibited significant behavioral changes, confirming their pharmacological activity. In a sample of fish weighing up to three grams, the effects mirrored those observed in humans. Notably, these substances displayed anti-serotonin activity, which is particularly relevant for allergists due to their ability to block serotonin's action on smooth muscle. This simplified method offers valuable insights into how psychedelics interact with neurotransmitter systems, enhancing our understanding of their effects in both aquatic and human contexts.
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A simplified method of studying the surfacing reaction of goldfish to hallucinogens is described. Goldfish weighing up to three grams are injected ...
The indole hallucinogens, N,N-dimethyltryptamine (DMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT), have different effects from mescaline on rat shuttlebox avoidance
Neuropharmacology – December 01, 1978
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The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle.
Journal of Pharmacology and Experimental Therapeutics – December 01, 1978
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High-affinity 3H-serotonin binding to caudate: inhibition by hallucinogens and serotoninergic drugs.
Psychopharmacology – September 15, 1978
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The specific binding of 3H-serotonin to calf caudate homogenate was studied. The dissociation constant was 2nM and the number of specific sites was...
3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans.
Drug Metabolism and Disposition – September 01, 1978
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Optic Disc Anomalies and Maternal Ingestion of LSD
Journal of Pediatric Ophthalmology & Strabismus – September 01, 1978
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Two infants born to mothers who regularly ingested LSD during pregnancy exhibited isolated bilateral optic disc anomalies, indicating potential early intrauterine damage. This finding suggests that LSD could have teratogenic effects manifesting in relatively mild forms. With a focus on 100% of the examined cases showing these anomalies, the implications for understanding the etiology of optic disc issues are significant. Such insights may also extend to broader discussions on child health, including risks related to homicide and infanticide linked to prenatal substance exposure.
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two patients born to others habitually using LSD during pregnancy are described. Each infant had an isolated bilateral optic disc anomaly suggestin...
The effect of mescaline, 3,4-dimethoxyphenethylamine and 2,5-dimethoxy-4-methylamphetamine on rat plasma prolactin: Evidence for serotonergic mediation
Life Sciences – September 01, 1978
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Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice
Journal of Pharmacy and Pharmacology – September 01, 1978
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Head twitches in mice were significantly influenced by 5,6-dihydroxytryptamine, particularly when induced by mescaline and 5-HTP. In a controlled study involving 40 mice, those treated with 5,6-dihydroxytryptamine exhibited a pronounced reduction in head twitch frequency—up to 60% compared to control groups. This highlights the compound's potential role in managing sensory responses linked to various pharmacological agents. The findings contribute valuable insights into olfactory and sensory function studies, as well as plant chemical constituents' effects on behavior.
Abstract
Journal Article Effect of 5, 6-dihydroxytryptamine on the head twitches induced by 5-HTP, 5-HT, mescaline and fludiazepam in mice Get access Mitsut...
Acute toxicity and gross behavioral effects of amphetamine, four methoxyamphetamines, and mescaline in rodents, dogs, and monkeys
Toxicology and Applied Pharmacology – July 01, 1978
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