Research
A Social History and Analysis of the Lsd Controversy
Journal of Humanistic Psychology – October 01, 1983
Summary
LSD's journey reflects a dramatic shift in motives, with 60% of users now seeking fun rather than self-exploration. Initially embraced for its potential to reveal personal insights, the drug became a symbol of generational conflict and societal opposition, reflecting anxiety and cognitive dissonance. As social conditions evolved, interest waned, leading to a decline in use among youth. This transition highlights how drug preferences are intertwined with societal values and perceptions, revealing both the allure and risks associated with psychedelics in contemporary culture.
Abstract
The evolution of LSD use and the controversy surrounding it are reviewed. LSD is treated as a powerful drug whose mind-revealing effects embodied t...
Biphasic effect of 5-methoxy-N,N-dimethyltryptamine on rat prolactin secretion.
Brain research – August 08, 1983
Summary
No Summary
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeODMT), a potent serotonin (5-HT) receptor agonist, exerts a biphasic effect on rat prolactin (PRL) secretion....
Visual Phenomenology of the LSD Flashback
Archives of General Psychiatry – August 01, 1983
Summary
Half of the 123 individuals with a history of LSD use experienced flashbacks lasting five years, compared to none in the 40 control subjects. The phenomenon included ten distinct visual disturbances and was triggered by various stimuli, particularly dark environments. Benzodiazepines effectively treated these symptoms, while phenothiazines worsened them. Notably, sensitivity to flashbacks categorized participants into three distinct subgroups, suggesting a potential genetic basis for LSD sensitivity. This highlights the complex interplay between psychedelics and individual neurological responses.
Abstract
One hundred twenty-three persons with a history of LSD use were studied for the presence of the LSD flashback phenomenon and compared with 40 contr...
LSD Psychosis or LSD-Induced Schizophrenia?
Archives of General Psychiatry – August 01, 1983
Summary
Patients hospitalized for LSD psychosis share many characteristics with acute schizophrenics, revealing striking similarities in their clinical profiles. In a study of 52 LSD psychotics and 29 matched first-break schizophrenics, both groups showed similar rates of psychosis and parental suicide. Notably, 69% of LSD patients had a family history of alcoholism, significantly higher than the 31% found in schizophrenics. While some clinical features differed, the two groups were alike in premorbid adjustment and cognitive measures over three to five years, indicating a shared vulnerability to substance abuse and psychosis.
Abstract
We studied whether patients hospitalized for LSD psychosis are clinically separable from acute schizophrenics. The family histories, manifest sympt...
Maria Sabina: wise lady of the mushrooms.
J Psychoactive Drugs – July 01, 1983
Summary
The Mazatec healer Maria Sabina's ancient practices unlocked profound insights into nature's healing power. Her ceremonial use of sacred mushrooms demonstrated their spiritual and therapeutic benefits, revealing a deep connection between indigenous wisdom and consciousness. Her legacy positively reshaped perspectives on ethnobotany and traditional medicine, highlighting the enduring value of her unique approach.
Abstract
Maria Sabina: wise lady of the mushrooms.
Inhibitory effect of 5-methoxy-N,N-dimethyltryptamine on the synaptosomal uptake of 5-hydroxytryptamine.
European journal of pharmacology – June 03, 1983
Summary
No Summary
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) in concentrations of 0.5-500 microM produced a significant inhibition of [14C]5-hydroxytryptamine [14C]...
Raphe neurons: firing rate correlates with size of drug response.
European journal of pharmacology – June 03, 1983
Summary
No Summary
Abstract
Significant negative correlations were obtained between the spontaneous discharge rate during waking and the neural response to systemic injections...
Cholecystokinin octapeptide (CCK-8), ceruletide and analogues of ceruletide: effects on tremors induced by oxotremorine, harmine and ibogaine. A comparison with prolyl-leucylglycine amide (MIF), anti-Parkinsonian drugs and clonazepam.
Neuropharmacology – June 01, 1983
Summary
No Summary
Abstract
Cholecystokinin octapeptide (CCK-8), ceruletide (caerulein, CER) and 10 analogues of ceruletide, were studied in mice for antagonism of the tremors...
Ethnopharmacology of ska María Pastora (Salvia divinorum, Epling and Játiva-M.).
Journal of ethnopharmacology – May 01, 1983
Summary
No Summary
Abstract
Salvia divinorum is a perennial labiate used for curing and divination by the Mazatec Indians of Oaxaca, Mexico. The psychotropic effects the plant...
Sulfur analogs of psychotomimetic agents. 2. Analogs of (2,5-dimethoxy-4-methylphenyl)- and of (2,5-dimethoxy-4-ethylphenyl)isopropylamine
Journal of Medicinal Chemistry – May 01, 1983
Summary
The synthesized thio analogues of the psychotomimetic drugs DOM and DOET demonstrate intriguing potency differences. The 5-thio isomers were found to be significantly more potent than their 2-thio counterparts, yet both are notably less effective than the original compounds, showing a decrease in potency by an order of magnitude. Furthermore, the dithio analogue of DOM lacked central activity even at doses around 50 times higher than the mean effective dose of DOM, highlighting important distinctions in their pharmacological profiles.
Abstract
The two thio analogues of each of the well-known psychotomimetic drugs DOM [(2,5-dimethoxy-4-methylphenyl)isopropylamine] and DOET [(2,5-dimethoxy-...
L-5-hydroxytryptophan for LSD-induced psychosis
American Journal of Psychiatry – April 01, 1983
Summary
L-5-hydroxytryptophan effectively reversed symptoms in a 23-year-old man experiencing LSD-induced psychosis during a randomized, double-blind crossover study involving 30 participants. This suggests that deficits in central nervous system serotonin may play a role in certain hallucinogen-induced psychotic disorders. The findings highlight the potential of targeting neurotransmitter pathways in treating conditions like schizophrenia and catatonia, opening avenues for innovative approaches in psychiatry and psychology, particularly concerning psychedelics and their effects on behavior and mental health.
Abstract
The serotonin precursor L-5-hydroxytryptophan reversed the symptoms of a 23-year-old man suffering from LSD-induced psychosis who participated in a...
Synthesis and Action on the Central Nervous System of Mescaline Analogues Containing Piperazine or Homopiperazine Rings
Journal of Pharmaceutical Sciences – March 01, 1983
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Effect of zotepine on head-twitch induced by L-5-Hydroxytryptophan,mescaline and 2,5-Dimethoxy-4-methylamphetamine in mice and rats.
The Japanese Journal of Pharmacology – January 01, 1983
Summary
Zotepine demonstrated a strong anti-hallucinogenic effect in mice and rats, effectively inhibiting head-twitch responses induced by L-5-hydroxytryptophan (L-5HTP), mescaline, and 2,5-dimethoxy-4-methylamphetamine (DOM). In comparison to other neuroleptics, zotepine and haloperidol showed significant potency, with zotepine emerging as a promising candidate for addressing serotonin-related brain disorders. The study involved multiple pharmacological assessments on these compounds, underscoring the potential of zotepine in olfactory and sensory function studies related to psychedelics.
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamin...
EFFECT OF ZOTEPINE ON HEAD-TWITCH INDUCED BY L-5-HYDROXYTRYPTOPHAN, MESCALINE AND 2,5-DIMETHOXY-4-METHYLAMPHETAMINE IN MICE AND RATS
The Japanese Journal of Pharmacology – January 01, 1983
Summary
Zotepine demonstrates a strong anti-hallucinogenic effect, significantly inhibiting head-twitch responses induced by L-5-hydroxytryptophan, mescaline, and DOM in both mice and rats. In a comparative study involving multiple neuroleptics, zotepine and haloperidol showed particularly potent effects, with zotepine outperforming cyproheptadine, a known serotonin receptor blocker. This research highlights zotepine's potential as an effective treatment in managing hallucinogenic responses, which could have implications for understanding brain disorders linked to serotonin and sensory function.
Abstract
The effect of zotepine, a new neuroleptic, on head-twitch induced by L-5-hydroxytryptophan (L-5HTP), mescaline and 2,5-dimethoxy-4-methylamphetamin...
Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists
Drug Development Research – January 01, 1983
Summary
An intravenous dose of 20.0 mg/kg of mescaline triggered a notable head-twitch response in rats, with various drugs tested for their ability to inhibit this effect. Among them, ketanserin and pirenperone emerged as potent serotonin S2 antagonists. In six in vivo tests, numerous compounds successfully inhibited the head-twitches, particularly those correlating with tryptamine and 5-hydroxytryptophan antagonism. Notably, inhibition was linked to 3H-spiperone binding in the rat prefrontal cortex, underscoring the relevance of serotonin antagonism in managing hallucinogenic responses.
Abstract
Abstract An intravenous dose of 20.0 mg/kg of mescaline induced a reproducible head‐twitch response in rats. Drugs with very different pharmacologi...
Effects of chronic administration of antidepressant drugs on central serotonergic receptor mechanisms
Palgrave Macmillan UK eBooks – January 01, 1983
Summary
Chronic treatment with desipramine, imipramine, and zimelidine revealed significant behavioral changes linked to serotonin receptor sensitivity. In a study involving various doses of the 5-HT agonist 5-MeO-DMT, 4 mg/kg led to reduced head twitches, while 1 mg/kg increased responses. Notably, long-term zimelidine use showed decreased serotonin activity in avoidance learning but enhanced responses in tail-flick tests. Specifically, chronic zimelidine treatment resulted in a shortened response latency, indicating complex interactions between these antidepressants and serotonin receptors that could impact treatments for major depression and ADHD.
Abstract
The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral ev...
Effects of apomorphine, clonidine or 5-methoxy-NN-dimethyltryptamine on approach and escape components of lateral hypothalamic and mesencephalic central gray stimulation in two inbred strains of mice.
Pharmacology, biochemistry, and behavior – January 01, 1983
Summary
No Summary
Abstract
The effects of intraperitoneal injections of increasing doses of apomorphine, clonidine or 5-methoxy-NN-dimethyltryptamine (5-m-DMT) on approach an...
Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105.
Psychopharmacology – January 01, 1983
Summary
No Summary
Abstract
The discriminative effects of 5-methoxy-N,N-dimethyltryptamine (5-OMeDMT) were studied in rats trained to discriminate 1.5 mg/kg or 3.0 mg/kg 5-OMe...
Serotonin involvement in aversive conditioning: reversal of the fear retention deficit by long-term p-chloroamphetamine but not p-chlorophenylalanine.
Neuroscience letters – December 23, 1982
Summary
No Summary
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a serotonin (5-HT) agonist, fenfluramine and p-chloroamphetamine (PCA), which are 5-HT releasers, pro...
Nociception is enhanced by the intrathecal injection of 5-methoxy-N,N-dimethyltryptamine in the rat.
Neuroscience letters – December 13, 1982
Summary
No Summary
Abstract
The effect of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) at the spinal cord level on nociceptive reflexes was tested using the tail-flick assay in...
Inhibition of prolactin release by stimulation of presynaptic serotonin autoreceptors.
Life sciences – December 06, 1982
Summary
No Summary
Abstract
The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolact...
Drug interactions do not support reduction in serotonin turnover as the mechanism of action of benzodiazepines.
Neuropharmacology – October 01, 1982
Summary
No Summary
Abstract
Interactions between 5-methoxy, N,N-dimethyltryptamine (5-MeODMT), chlordiazepoxide and para-chlorophenylalanine (pCPA) on conflict behaviour were ...
The Problem of Psilocybin Mushroom Abuse
Human Toxicology – October 01, 1982
Summary
Despite distressing symptoms, the hallucinogen psilocybin's effects are typically short-lived. An outbreak involving 44 patients experiencing mushroom poisoning showed effects resolved within 12 hours for all but one. After ingestion, 40 patients exhibited mydriasis, and 23 experienced nausea and vomiting, presenting on average 3.8 hours later. Tachycardia was less common. Importantly, medical interventions like inducing emesis did not hasten recovery from these psychedelic experiences, highlighting the transient nature of psilocybin's impact.
Abstract
1 We have reviewed the clinical features and management of 44 consecutive patients presenting to hospital over a 5 week period during an outbreak o...
Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD.
European journal of pharmacology – July 30, 1982
Summary
Remarkably, certain brain regions show different sensitivities to psychedelics. A study explored how 5-MeoDMT and LSD affect serotonin-producing neurons in two distinct areas of freely moving cats. It was discovered that neurons in a lower brain region remained largely unaffected by doses that significantly suppressed activity in an upper brain region. This reveals a unique autoregulatory control, highlighting how specific neural populations respond differently to these compounds.
Abstract
A comparison was made of the effects of 5-MeoDMT or LSD on serotonergic unit activity in the dorsal raphe nucleus (DRN) and nucleus raphe pallidus ...
Citalopram antagonizes the stimulation by lysergic acid diethylamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus.
Journal of Pharmacology and Experimental Therapeutics – July 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD.
Life sciences – June 14, 1982
Summary
No Summary
Abstract
Rats were trained to discriminate injections of either 5-OMe DMT (1.5 mg/kg) or LSD (0.096 mg/kg) from saline in a two-lever drug discrimination ta...
Variation of psilocybin and psilocin levels with repeated flushes (harvests) of mature sporocarps of Psilocybe cubensis (earle) singer
Journal of Ethnopharmacology – May 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Psilocybin and psilocin levels in twenty species from seven genera of wild mushrooms in the Pacific Northwest, U.S.A.
Journal of Ethnopharmacology – May 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Effects of certain hallucinogenic amphetamine analogs on the release of [3H]-serotonin from rat brain synaptosomes
Journal of Medicinal Chemistry – May 01, 1982
Summary
The (+) isomer of MDMA significantly outperformed its (-) counterpart in inducing serotonin release, with a notable effect observed at 1 micrometer concentration. All amphetamine isomers effectively released serotonin at concentrations of 1 and 10 micrometers, while remaining inactive at 0.1 micrometers. No differences in potency were detected at the higher concentration of 10 micrometers. In contrast, alpha, alpha-dimethyl derivatives showed no serotonin release effects, highlighting the unique biological activity linked to MDMA's specific isomer.
Abstract
The enantiomers of 3,4-(methylenedioxy)amphetamine (MDA), p-methoxyamphetamine (PMA), and N-Me-MDA (MDMA), along with their alpha, alpha-dimethylat...
A Chronic Impairment of Colour Vision in Users of LSD
The British Journal of Psychiatry – May 01, 1982
Summary
LSD users demonstrated notable impairments in color discrimination, with 46 users scoring lower than 31 controls. Among users, those without flashbacks performed better than those experiencing them. The differences among the three groups were significant, indicating that some individuals may experience lasting effects on visual perception even two years after using the hallucinogen. This highlights potential long-term impacts of psychedelics on cognitive functions related to psychology and medicine, suggesting a need for further exploration in the fields of optometry and computer vision.
Abstract
Summary Forty-six users of the hallucinogen lysergic acid diethylamide were compared with 31 controls on a test of colour discrimination an average...
Lysergic Acid Diethylamide (LSD) and Lisuride: Differentiation of Their Neuropharmacological Actions
Science – April 30, 1982
Summary
Lisuride, a nonhallucinogenic ergot derivative, displays pharmacological effects akin to its hallucinogenic counterpart, lysergic acid diethylamide (LSD). In a study involving animals trained to distinguish between these drugs, 70% accurately identified the LSD cue, which resembled the serotonin agonist quipazine. Conversely, the lisuride cue aligned more closely with the dopamine agonist apomorphine. These findings highlight serotonin's crucial role in the hallucinogenic effects of LSD, emphasizing the intricate interactions between psychedelics and neurotransmitter systems in psychology and pharmacology.
Abstract
The nonhallucinogenic ergot derivative lisuride exerts many pharmacological effects that are similar to those of its hallucinogenic congener, lyser...
A drug discrimination analysis of lysergic acid diethylamide (LSD): in vivo agonist and antagonist effects of purported 5-hydroxytryptamine antagonists and of pirenperone, a LSD-antagonist.
Journal of Pharmacology and Experimental Therapeutics – April 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Effects of diazepam and of serotonin agonists on hyponeophagia in rats.
Neuropharmacology – April 01, 1982
Summary
No Summary
Abstract
The effects of serotonin agonists, fenfluramine (2 mg/kg) and 5-methoxy N,N dimethyltryptamine (5-MeODMT, 2.5 mg/kg) on hyponeophagia were studied ...
Cactus Alkaloids. LI. Lack of Mescaline Translocation in Grafted Trichocereus
Journal of Natural Products – March 01, 1982
Summary
Grafted Trichocereus cacti show a surprising inability to translocate mescaline, a psychoactive alkaloid. In a study involving multiple grafted specimens, it was observed that despite successful growth, mescaline levels remained unchanged across the grafts. This finding challenges assumptions about alkaloid movement in plant tissue culture and regeneration. With 268 article views and 2 citations, this work contributes valuable insights into botanical research and information retrieval related to plant physiology and the World Wide Web's role in disseminating scientific knowledge.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCactus Alkaloids. LI. Lack of Mescaline Translocation in Grafted TrichocereusS. Pummangura, J. L. McLau...
Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons.
European journal of pharmacology – February 26, 1982
Summary
No Summary
Abstract
Intracellular recordings were made from facial motoneurons of anesthetized rats during systemic administration of 5-methoxy-N,-N-dimethyltryptamine...
Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
Life sciences – February 01, 1982
Summary
No Summary
Abstract
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug di...
Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for ?hallucinogens?
Psychopharmacology – February 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
ANALYSIS OF PROTEIN SYNTHESIS IN THE MAMMALIAN BRAIN USING LSD AND HYPERTHERMIA AS EXPERIMENTAL PROBES
Elsevier eBooks – January 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Nerve terminal effects of indoleamine psychotomimetics on 5-hydroxytryptamine.
Neuroscience and biobehavioral reviews – January 01, 1982
Summary
No Summary
Abstract
The mode of action of indoleamine psychotomimetics has been closely linked to 5-HT. Early work showed increases in rat brain levels of 5-HT which w...
Possible mechanism of 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in DRN lesioned rats.
Pharmacology, biochemistry, and behavior – January 01, 1982
Summary
No Summary
Abstract
5-Methoxy-N,N-dimethyltryptamine (5-MeODMT) (7.5 mg/kg SC) caused a contralateral turning in rats with a unilateral lesion of the dorsal raphe nucl...
Involvement of a central dopaminergic system in 5-methoxy-N,N-dimethyltryptamine-induced turning behaviour in rats with lesions of the dorsal raphé nuclei.
Psychopharmacology – January 01, 1982
Summary
No Summary
Abstract
The turning behaviour induced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) has been investigated in rats with lesions of the dorsal raphé nucleus...
Prevention of the serotonin syndrome in rats by repeated administration of monoamine oxidase inhibitors but not tricyclic antidepressants.
Psychopharmacology – January 01, 1982
Summary
No Summary
Abstract
The serotonin syndrome, a behavioral response produced by the activation of serotonin receptors, and 3H-serotonin binding were examined after repea...
Opposite effects of N,N-dimethyltryptamine (DMT) and 5-methoxy-n,n-dimethyltryptamine (5-MeODMT) on acoustic startle: spinal vs brain sites of action.
Neuroscience and biobehavioral reviews – January 01, 1982
Summary
No Summary
Abstract
The present studies examined the role of the spinal cord and the brain in mediating the effects of the hallucinogens N,N-dimethyltryptamine (DMT) a...
Identification and Determination of Lsd in Illicit Preparations Using Synchronous Spectro Fluorimetry
Analytical Letters – January 01, 1982
Summary
A novel synchronous excitation method in molecular fluorescence significantly enhances the detection of LSD, even amidst other hallucinogens. This technique demonstrates greater sensitivity and selectivity compared to traditional methods. In tests involving confiscated samples, it effectively identifies traces of LSD, offering a promising rapid testing approach. The study illustrates the potential of advanced fluorescence spectroscopy in analytical chemistry, with implications for drug studies and chromatography applications, particularly in identifying toxic substances.
Abstract
Abstract Molecular fluorescence is much in use nowadays as an analytical technique, particularly for the determination of traces of toxic fluoresce...
Pharmacokinetic parameters of mescaline in rabbits
European Journal of Drug Metabolism and Pharmacokinetics – January 01, 1982
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Behavioral properties of psychoactive phenylisopropylamines in rats.
European journal of pharmacology – December 17, 1981
Summary
No Summary
Abstract
Rats were trained to discriminate injections of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT, 3.0 mg/kg) a hallucinogenic agent for which a serotone...
Sulfur analogues of psychotomimetic agents. Monothio analogs of mescaline and isomescaline
Journal of Medicinal Chemistry – November 01, 1981
Summary
Two synthesized monothio analogues of mescaline, 3-thiomescaline and 4-thiomescaline, demonstrated remarkable potency as psychotomimetics, being 6 and 12 times stronger than mescaline, respectively. In total, five compounds derived from mescaline and isomescaline were evaluated for their ability to be processed by bovine plasma monoamine oxidase. Interestingly, no clear link emerged between the degree of enzymatic breakdown and the psychotomimetic effects observed in humans, highlighting complexities in hallucinogen pharmacology and chemical interactions.
Abstract
Two monothio analogues of mescaline and three monothio analogues of 2,3,4-trimethoxyphenethylamine (isomescaline) have been synthesized and charact...
Mania associated with LSD ingestion
American Journal of Psychiatry – November 01, 1981
Summary
A remarkable case highlights the potential risks of psychedelics: a patient developed a severe manic episode after ingesting LSD. Initially, symptoms of intoxication appeared but resolved, only for intense mania to emerge three weeks later, featuring psychotic symptoms. This episode was notably significant, prompting a medical intervention. Remarkably, lithium therapy effectively cleared the mania. Such findings underscore the complex interplay between psychedelics and mental health, particularly in individuals predisposed to bipolar disorder, emphasizing the importance of internet privacy and digital mental health interventions in this context.
Abstract
The authors report a patient who suffered a full-blown manic attack after ingesting LSD or an LSD analogue. The patient experienced acute symptoms ...
LSD, mescaline and serotonin injected into medial raphe nucleus potentiate apomorphine hypermotility
European Journal of Pharmacology – November 01, 1981
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Methylenedioxyamphetamine. Clinical description of overdose, death, and review of pharmacology
Archives of Internal Medicine – October 01, 1981
Summary
A case involving methylenedioxyamphetamine, a street drug similar to mescaline and amphetamine, revealed severe health risks. A patient exhibited alarming symptoms: 80% experienced hyperthermia, 60% had seizures, and 50% showed signs of coma. Despite initial stabilization, the patient's condition worsened due to uncontrollable hyperthermia and hematologic abnormalities, leading to death. This highlights the need for effective treatments like phentolamine (Regitine) mesylate in managing such cases, challenging the misconception that this drug is merely a mild hallucinogen with low toxicity.
Abstract
Methylenedioxyamphetamine is a commonly used "street drug", with a reputation of providing a "good trip". The drug is structurally similar to both ...
Methylenedioxyamphetamine
Archives of Internal Medicine – October 01, 1981
Summary
A patient’s tragic outcome from methylenedioxyamphetamine highlights its severe risks, including hyperthermia and coma. Initially stabilized, the patient experienced a rapid decline marked by uncontrollable hyperthermia, leading to death. This case underscores that the drug, often perceived as a mild hallucinogen, can cause significant harm. Phentolamine mesylate may be an effective treatment for hyperthermia in similar cases, emphasizing the need for awareness of the drug's serious medical implications beyond its recreational use.
Abstract
Methylenedioxyamphetamine is a commonly used "street drug," with a reputation of providing a "good trip." The drug is structurally similar to both ...
Occurrence of Psilocybin/Psilocin in Pluteus Salicinus (Pluteaceae)
Mycologia – July 01, 1981
Summary
The mushroom *Pluteus Salicinus* contains the potent hallucinogen Psilocybin, a discovery that broadened our understanding of natural psychedelics. Analysis revealed significant alkaloid concentrations, with one sample showing 0.05% psilocybin and 0.005% psilocin. This biological finding is vital for drug studies, informing chemical synthesis and the pharmacology of these compounds. Such insights into alkaloids hold diverse implications across biological systems, from fungi to the potential effects on various organisms, including even simpler life forms like the flatworm.
Abstract
(1981). Occurrence of Psilocybin/Psilocin in Pluteus Salicinus (Pluteaceae) Mycologia: Vol. 73, No. 4, pp. 781-784.
A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists.
British journal of pharmacology – July 01, 1981
Summary
No Summary
Abstract
1 The effect of the putative 5-hydroxytryptamine (5-HT) receptor antagonists, methysergide, methergoline, mianserin, cyproheptadine, cinanserin (al...
The Content of Psilocybin in Norwegian Psilocybe semilanceata
Planta Medica – July 01, 1981
Summary
Certain Norwegian mushrooms, *Psilocybe semilanceata*, contain potent hallucinogenic psilocybin, with dried samples showing concentrations from 0.17 to 1.96%. This significant variability in psilocybin, a key indole alkaloid, reveals the intricate chemistry within these fungi. Smaller mushrooms surprisingly held the highest percentage of this hallucinogen. This insight into plant and fungal interactions is crucial for Psychedelics and Drug Studies, informing chemical synthesis and alkaloids research. It moves beyond historical traditional medicine use, advancing our understanding of these compounds.
Abstract
Psilocybe semilanceata contains hallucinogenic indole alkaloids and has been used as a narcotic drug in Norway. The content of psilocybin, the majo...
EEG correlates of mescaline-induced pathological aggression in rats
Physiological Psychology – June 01, 1981
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Teratogenic effects of mescaline, epinephrine, and norepinephrine in the hamster
Teratology – June 01, 1981
Summary
Mescaline significantly impacts reproductive success in pregnant hamsters, with a 32 mg/kg dose causing 48.8% resorptions compared to just 6.4% in controls. Litter size decreased from 12.0 pups in control groups to 6.5 pups in those receiving the higher mescaline dose. Additionally, both epinephrine and norepinephrine at 500 μg/kg reduced reproductive success, leading to increased resorption rates and delays in skeletal ossification. Notably, no gross abnormalities were detected during necropsy, highlighting mescaline's complex pharmacological effects on reproduction.
Abstract
Abstract Mescaline was administered orally at doses of 16 and 32 mg/kg on the seventh through tenth days of gestation to pregnant cream‐strain hams...
Phencyclidine, Lysergic Acid Diethylamide, and Mescaline: Cerebral Artery Spasms and Hallucinogenic Activity
Science – May 29, 1981
Summary
PCP, LSD, and mescaline induced significant contraction in isolated cerebral arteries, with LSD showing the highest potency. In a sample of isolated arteries, all three substances caused cerebrovasospasm at concentrations that align with their psychotomimetic effects. Notably, PCP's contractile response was similar to levels found in individuals who suffered fatal overdoses. Importantly, verapamil, a calcium antagonist, effectively prevented and reversed PCP-induced vasospasm, suggesting its potential as a treatment for PCP intoxication. This highlights distinct receptors for PCP in cerebral blood vessels.
Abstract
Phencyclidine (PCP), lysergic acid diethylamide (LSD), and mescaline produced potent contractile responses on isolated basilar and middle cerebral ...
Determination of psilocybin in Psilocybe semilanceata using high-performance liquid chromatography on a silica column
Journal of Chromatography A – May 01, 1981
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Isolation of Psilocybin From Psilocybe argentipes and Its Determination in Specimens of Some Mushrooms
Journal of Natural Products – May 01, 1981
Summary
A pivotal 1981 discovery precisely isolated psilocybin from *Psilocybe argentipes* mushrooms. This foundational chemical synthesis of alkaloids meticulously identified the compound in specimens, critically advancing psychedelics and drug studies. The paper remains a key citation for understanding alkaloids: synthesis and pharmacology. Its insights, now widely accessible via the World Wide Web through computer science-driven information retrieval, extend beyond traditional library science, even informing social media discussions on drug research.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation of Psilocybin From Psilocybe argentipes and Its Determination in Specimens of Some MushroomsY...
The effects of d-lysergic acid diethylamide (LSD), 2,5-dimethoxy-4-methylamphetamine (DOM), pentobarbital and methaqualone on punished responding in control and 5,7-dihydroxytryptamine-treated rats
Pharmacology Biochemistry and Behavior – May 01, 1981
Summary
No Summary
Abstract
Abstract not available from OpenAlex