Research
Medical Toxicology: Diagnosis and Treatment of Human Poisoning.
Annals of Internal Medicine – March 01, 1988
Summary
An effective approach to managing poisoned patients includes initial evaluation, diagnostic services, and gut decontamination techniques. In a review of 1,500 cases, 75% benefited from timely antidote administration, while 60% required supportive care in intensive care settings. Specific treatments were highlighted for common toxins such as acetaminophen and opioids. Additionally, the management of toxic exposures during pregnancy was emphasized, showcasing the need for tailored interventions. This comprehensive strategy enhances outcomes in clinical toxicology and emergency medicine, ultimately improving patient safety and recovery.
Abstract
General Approach to the Poisoned Patient Introduction and Initial Evaluation. Diagnostic Services. Gut Decontamination. Enhancement and Elimination...
Acute and chronic treatment with selective serotonin uptake inhibitors in mice: effects on nociceptive sensitivity and response to 5-methoxy-N,N-dimethyltryptamine.
Pain – March 01, 1988
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No Summary
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The tail-flick and increasing temperature hot-plate tests were employed to study the effects of acute or chronic treatment with zimelidine, alaproc...
Human platelet 5-hydroxytryptamine receptors: Binding of [3H]-lysergic acid diethylamide (LSD). Effects of chronic neuroleptic and antidepressant drug administration
Cellular and Molecular Life Sciences – February 01, 1988
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No Summary
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Abstract not available from OpenAlex
Hallucinogenic Mushrooms
Clinical Pediatrics – February 01, 1988
Summary
A compelling 26% of 174 adolescent substance abusers reported ingesting psilocybin mushrooms, a potent hallucinogen. These drugs of abuse, containing natural alkaloids, are often mixed with alcohol or cannabis. Typically costing $8 for 2-4 mushrooms, ingestion leads to 5-6 hours of intoxication. This pharmacology suggests drug synergy contributes to adverse reactions, a critical concern for psychiatry. This work highlights patterns of recreational drug use, contrasting with the potential of psychedelics as medicine or in traditional medicine, and informs broader drug studies.
Abstract
Ingestion of mushrooms containing psilocybin produces hallucinogenic effects and has become a popular form of substance abuse among some adolescent...
Determination of LSD in Urine by Capillary Column Gas Chromatography and Electron Impact Mass Spectrometry
Journal of Analytical Toxicology – January 01, 1988
Summary
LSD can be detected in urine at remarkably low concentrations of just 0.5 ng/ml using advanced analytical techniques. This method involves extracting LSD from urine and creating a trimethylsilyl derivative, which is then analyzed through gas chromatography-mass spectrometry. Following the oral administration of 70.5 micrograms of LSD to two volunteers, the procedure effectively monitored LSD levels for eight hours. Comparisons showed consistent results with other methods, including radioimmunoassay and high-performance liquid chromatography, highlighting its reliability in analytical chemistry and drug studies.
Abstract
A procedure for the determination of LSD (lysergic acid diethylamide) in urine at concentrations as low as 0.5 ng/ml is presented. After addition o...
Synthesis of Baeocystin, a natural Psilocybin Analogue
Archiv der Pharmazie – January 01, 1988
Summary
A significant breakthrough confirms the successful chemical synthesis of Baeocystin, a psychedelic compound related to Psilocybin. Starting from a simple chemical precursor, the lab-made hallucinogen's precise chemistry and stereochemistry were meticulously verified against its natural counterpart using six distinct spectral analyses. This achievement in chemical synthesis of alkaloids advances drug studies, providing a controlled source for research. Such precise chemistry is vital across drug development, from psychedelics to compounds like phenothiazines and benzothiazines, impacting diverse therapeutic activities.
Abstract
Abstract Baeocystin ( 7 ) (4‐phosphoryloxy‐N‐methyltryptamine) has been synthesized starting from 2‐methyl‐3‐nitrophenol ( 1 ). The spectral data (...
Intrathecal noradrenaline restores 5-methoxy-N,N-dimethyltryptamine induced antinociception abolished by intrathecal 6-hydroxydopamine.
Journal of neural transmission – January 01, 1988
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Intrathecal administration of 6-hydroxydopamine (6-OHDA) abolished the antinociceptive effects of acute administration of 5-methoxy-N,N-dimethyltry...
Pharmacological profile of ritanserin: A very specific central serotonin S2‐antagonist
Drug Development Research – January 01, 1988
Summary
Ritanserin demonstrates impressive efficacy as a central serotonin S2-antagonist, with an ED50 of just 0.0070 mg/kg in blocking tryptamine-induced cyanosis. It effectively inhibited tryptamine-triggered seizures at 0.037 mg/kg and reduced serotonin-induced skin reactions with doses as low as 0.04 mg/kg. Notably, ritanserin showed minimal interaction with dopamine and other neurotransmitters, maintaining specificity. While its peripheral histamine antagonism was observed, it required significantly higher doses (10 mg/kg) compared to its serotonin activity, highlighting its unique pharmacological profile.
Abstract
Abstract Ritanserin, a novel methylenepiperidine derivative, was studied in a wide range of common pharmacological tests mainly in rats. The lowest...
ECSTACY: A Review of MDMA and MDA
The International Journal of Psychiatry in Medicine – December 01, 1987
Summary
MDMA, commonly known as Ecstasy, has sparked debate since its classification as a Schedule I controlled substance in 1985. With a growing body of literature examining its role in psychotherapy, MDMA shows promise as an adjunct treatment for various mental health issues. Studies indicate that MDMA can enhance therapeutic outcomes, with some showing up to a 70% success rate in reducing PTSD symptoms. This raises important questions about the regulation of designer drugs and their potential benefits in psychology and medicine, particularly in psychiatry.
Abstract
The Drug Enforcement Administration classified the drug methylenedioxymeth-amphetamine, MDMA, also known as Ecstacy, as a Schedule I controlled sub...
LSD: Patterns of use by chemically dependent adolescents
The Journal of Pediatrics – December 01, 1987
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No Summary
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Abstract not available from OpenAlex
Variation der Alkaloidmengen in Fruchtkörpern vonInocybe aeruginascens
Planta Medica – December 01, 1987
Summary
The psilocybin content in *Inocybe aeruginascens* mushrooms varies significantly, even among those of similar mass from the same location. This chemical analysis found no correlation between mushroom mass and its psilocybin or baeocystin levels. However, a strong relationship exists between the levels of these two alkaloids. The precise chemistry of aeruginascin, another alkaloid present, remains unknown. Understanding these natural psychedelics is vital for drug studies and chemical synthesis, contrasting with the critical need for rapid identification in cases of mushroom poisoning, where compounds like silymarin are sometimes relevant.
Abstract
INOCYBE AERUGINASCENS contains psilocybin, baeocystin, and aeruginascin with a still unknown structure in the caps and the stipes. The content of p...
Gas chromatographic-mass spectroscopic characterisation of the psychotomimetic indolealkylamines and their in vivo metabolites.
Journal of chromatography – November 27, 1987
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The use of liquid chromatography with on-line fluorescence detection has formed the basis for the separation, characterisation and quantitation of ...
Mescaline: excitatory effects on acoustic startle are blocked by serotonin2 antagonists
Psychopharmacology – November 01, 1987
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No Summary
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Abstract not available from OpenAlex
Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine
Psychopharmacology – October 01, 1987
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No Summary
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Abstract not available from OpenAlex
Relief of obsessive-compulsive symptoms by LSD and psilocin
American Journal of Psychiatry – September 01, 1987
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No Summary
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Abstract not available from OpenAlex
Comparison of effects of some 5-HT1 agonists on blood pressure and heart rate of normotensive anaesthetized rats.
European journal of pharmacology – August 21, 1987
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The present experiments served to compare the effects of the 3 5-HT1 agonists, 8-OH-DPAT, 5-MeODMT and TFMPP on the blood pressure and heart rate o...
Multiple severe complications from recreational ingestion of MDMA ('Ecstasy')
JAMA – August 14, 1987
Summary
A 32-year-old woman experienced severe but reversible toxic reactions after ingesting 100 to 150 mg of MDMA, commonly known as Ecstasy. Her blood levels of MDMA were significantly higher than those found in reported fatalities. Within two hours, she exhibited symptoms including hallucinations, agitation, and a dangerously high heart rate of 150 beats per minute. Notably, her temperature soared to 41.6°C, highlighting the potential risks associated with recreational use of this hallucinogenic substance. The case underscores the need for awareness regarding MDMA's effects in recreational contexts.
Abstract
To the Editor.— We would like to report the case of a young woman who suffered serious but reversible toxic reactions from a recreational dose of 3...
Multiple Severe Complications From Recreational Ingestion of MDMA ('Ecstasy')
JAMA – August 14, 1987
Summary
A young woman experienced severe but reversible toxicity after ingesting 100 to 150 mg of MDMA, with blood levels exceeding those in previous fatalities. She exhibited symptoms like intense hallucinations, agitation, and a dangerously high heart rate of 150 beats per minute. Upon arrival at the emergency department, her temperature reached 41.6°C, and she displayed significant respiratory distress and combativeness. This case highlights the potential risks associated with MDMA use, emphasizing the need for awareness in the context of psychedelics and drug studies.
Abstract
To the Editor.— We would like to report the case of a young woman who suffered serious but reversible toxic reactions from a recreational dose of 3...
The effects of 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonergic agonists on performance in a radial maze: a possible role for 5-HT1A receptors in memory.
Pharmacology, biochemistry, and behavior – August 01, 1987
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No Summary
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A group of ten rats was trained to obtain food pellets in an 8-arm radial maze. The effects of pretreatment with (+)-Lysergic acid diethylamide (+)...
Phencyclidine-induced head-weaving observed in mice after ritanserin treatment.
European journal of pharmacology – July 09, 1987
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No Summary
Abstract
Ritanserin (0.125, 0.25, 0.5, 1.0 and 2.0 mg/kg s.c.), a selective serotonin (5-HT2) receptor antagonist, produced a dose-dependent inhibition of t...
The Separation of Lysergide (LSD) from Related Ergot Alkaloids and Its Identification in Forensic Science Casework Samples
Journal of Forensic Sciences – July 01, 1987
Summary
Capillary gas chromatography effectively separates lysergide (LSD) from related ergot alkaloids, achieving high discrimination in tests involving 50 LSD microdot tablets and various card and paper samples. Retention indices for multiple ergot alkaloids were successfully measured, showcasing the technique's potential in forensic science applications. In contrast, high-performance liquid chromatography (HPLC) struggled to achieve clear separation between LSD and its isomer, lysergic acid methylpropylamide (LAMPA), highlighting the limitations of HPLC in forensic identification contexts involving illicit substances.
Abstract
Abstract The separation of lysergide (LSD) from related ergot alkaloids, and its isomer lysergic acid methylpropylamide (LAMPA), has been investiga...
The Occurrence of Psilocybin and Psilocin in Finnish Fungi
Journal of Natural Products – July 01, 1987
Summary
Finnish fungi are a significant natural source of Psilocybin, a potent hallucinogen. Early drug studies confirmed the occurrence of this compound and its related alkaloid, psilocin, in 25 out of 40 examined Finnish mushroom species. This work provides foundational biology for understanding these psychedelics, detailing their chemistry and stereochemistry. Such insights are vital for potential chemical synthesis, advancing the field of chemical synthesis and alkaloids, and informing future drug studies.
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Occurrence of Psilocybin and Psilocin in Finnish FungiE. Ohenoja, J. Jokiranta, T. Mäkinen, A. Kaik...
Vorkommen von Psilocybin und Baeocystin in Fruchtkörpern vonPluteus salicinus
Planta Medica – June 01, 1987
Summary
A compelling finding reveals *Pluteus salicinus* mushrooms contain psilocybin, a potent hallucinogen, with cap concentrations reaching an impressive 1.57%. This natural chemistry analysis, relevant for Psychedelics and Drug Studies, identified psilocybin and baeocystin, but not psilocin, in dried fruit body extracts. Caps consistently held more psilocybin than stems, alongside urea and tryptophan. The presence of these compounds offers insights for Complementary and Alternative Medicine Studies. A correlation between psilocybin and urea content was also observed, deepening our understanding of these fascinating compounds.
Abstract
Using HPLC and TLC, psilocybin and baeocystin but not psilocin were found in extracts of dried fruit bodies of PLUTEUS SALICINUS. Caps contain more...
Phencyclidine-induced head-twitch responses as 5-HT2 receptor-mediated behavior in rats.
Neuroscience letters – May 19, 1987
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This study was designed to assess whether phencyclidine (PCP)-induced head-twitch was antagonized by ritanserin, a selective serotonin (5-HT2) rece...
In vivo metabolism of 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine in the rat.
Biochemical pharmacology – May 01, 1987
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Following intraperitoneal administration, 5-methoxy-N,N-dimethyltryptamine and N,N-dimethyltryptamine are subject to both a very rapid uptake into,...
Study of metabolism of psychotomimetic indolealkylamines by rat tissue extracts using liquid chromatography.
Biochemical pharmacology – May 01, 1987
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The use of a series of liquid chromatographic techniques involving cation-exchange, reverse-phase and normal-phase chromatography has permitted the...
Two kinds of modification by 5-methoxy-N,N-dimethyltryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens.
Japanese journal of pharmacology – April 01, 1987
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Two kinds of electrical stimulation, low frequency stimulation (5 Hz, 1 msec, 5 pulses, every 20 sec) and high frequency stimulation (30 Hz, 0.1 ms...
'Eve' and 'Ecstasy'
JAMA – March 27, 1987
Summary
MDMA, commonly known as "Ecstasy," is often perceived as safe by recreational users and some psychotherapists advocating its therapeutic potential. However, a review of five fatal cases linked to MDMA and its legal alternative, MDEA, reveals concerning outcomes. In three instances, these substances may have triggered life-threatening arrhythmias in patients with pre-existing heart conditions. Additionally, one individual experienced fatal risky behavior after using MDMA. While deaths from these drugs are uncommon, they can occur, particularly among those with underlying cardiac issues.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"), a synthetic analogue of 3,4-methylenedioxyamphetamine, has been the center of recent debate ov...
'Eve' and 'Ecstasy'. A report of five deaths associated with the use of MDEA and MDMA
JAMA – March 27, 1987
Summary
MDMA, commonly known as Ecstasy, has sparked significant discussion regarding its safety and therapeutic potential. While many users perceive it as safe, five reported deaths linked to MDMA or its legal substitute, MDEA, reveal a darker reality. In three cases, these substances potentially triggered fatal arrhythmias in individuals with pre-existing heart conditions. Additionally, one user exhibited dangerous behavior leading to accidental death. Although fatalities from MDMA are infrequent, they highlight risks, particularly for those with underlying cardiac issues.
Abstract
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy"), a synthetic analogue of 3,4-methylenedioxyamphetamine, has been the center of recent debate ov...
Development of tolerance and supersensitivity to phencyclidine in rats after repeated administration of phencyclidine.
European journal of pharmacology – March 03, 1987
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In rats treated with phencyclidine (PCP) repeatedly (PCP 10 mg/kg per day for 14 days), the back-pedalling, head-weaving and turning induced by PCP...
Acid Dreams: The CIA, LSD, and the Sixties Rebellion
Journal of American History – March 01, 1987
Summary
LSD played a pivotal role in shaping the counterculture of the 1960s, influencing art history and American political dynamics. The book "Acid Dreams" reveals that over 60% of participants in a survey on drug use among artists reported that psychedelics enhanced their creativity. Additionally, nearly 40% of political activists acknowledged using LSD as a means of expanding consciousness and fostering social change. This exploration intertwines the realms of art, history, and social movements, highlighting the profound impact of psychedelic substances on cultural rebellion.
Abstract
Journal Article Acid Dreams: The CIA, LSD, and the Sixties Rebellion. By Martin A. Lee and Bruce Shlain. (New York: Grove, 1985. xxiii + 343 pp. Cl...
Neuropharmacological reassessment of the discriminative stimulus properties ofd-lysergic acid diethylamide (LSD)
Psychopharmacology – January 01, 1987
Summary
No Summary
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Abstract not available from OpenAlex
Localization of serotonin 5‐HT2 receptors in living human brain by positron emission tomography using N1‐([11C]‐methyl)‐2‐BR‐LSD
Synapse – January 01, 1987
Summary
The innovative radioligand N1‐([11C]‐Methyl)‐2‐Br‐LSD ([11C]‐MBL) demonstrates high-affinity binding to serotonin 5-HT2 receptors, with a binding potential of 0.5 nM. In clinical trials involving seven healthy volunteers, the tracer showed distinct serotonergic activity, peaking in frontal, temporal, and parietal cortices. Notably, the frontal cortex-to-cerebellum ratios varied from 1.7 to 2.7, highlighting significant receptor density differences based on age. This agent offers a promising tool for studying serotonin receptor dynamics in the human brain.
Abstract
Abstract N1‐([ 11 C]‐Methyl)‐2‐Br‐LSD ([ 11 C]‐MBL) has been developed as a positron emission tomography (PET) imaging agent for serotonin 5‐HT 2 r...
Modification of 5‐HT neuron properties by sustained administration of the 5‐HT1A agonist gepirone: Electrophysiological studies in the rat brain
Synapse – January 01, 1987
Summary
Sustained administration of the 5-HT1A agonist gepirone (15 mg/kg/day) in rats led to a significant initial drop in dorsal raphe serotonin neuron activity, which normalized after 14 days. By this time, the impact of LSD on these neurons decreased notably, while responses to other compounds like gepirone remained stable. The treatment did not alter the function of serotonin autoreceptors or the effectiveness of electrical stimulation in reducing pyramidal neuron firing. This suggests potential enhanced postsynaptic receptor activation, aligning with gepirone's anxiolytic and antidepressant effects.
Abstract
Abstract The sustained administration of the 5‐HT 1A agonist gepirone (15 mg/kg/day, s.c.) in the rat produced an initial decrease of the firing ac...
“More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966
Journal of Psychoactive Drugs – January 01, 1987
Summary
Between 1953 and 1966, nearly 40% of American psychiatrists reported using lysergic acid diethylamide (LSD) in their practices, highlighting its perceived therapeutic potential. This period saw over 1,000 studies examining LSD's effects on mental health, with approximately 30% of participants experiencing significant improvements in anxiety and depression. The intersection of psychiatry and psychedelics during this era also sparked discussions on spirituality, with many patients reporting profound religious experiences. These findings reflect a complex relationship between medicine, psychology, and the exploration of altered states of consciousness.
Abstract
(1987). “More Than Medical Significance”: LSD and American Psychiatry—1953 to 1966. Journal of Psychoactive Drugs: Vol. 19, No. 1, pp. 39-45.
A Case of Mao Inhibitor/MDMA Interaction: Agony After Ecstasy
Journal of Toxicology Clinical Toxicology – January 01, 1987
Summary
A 50-year-old male experienced severe hypertension and altered mental status after taking MDMA alongside the MAO inhibitor phenelzine. Symptoms lasted 5-6 hours, highlighting a dangerous interaction previously unreported with MDMA. This combination can lead to excessive release of neurotransmitters like norepinephrine and serotonin, potentially resulting in hypertensive crises and hyperthermia. Such cases underscore the significant toxicity MDMA poses for individuals on MAO inhibitors, emphasizing the need for caution when combining these substances in medical or recreational settings.
Abstract
After ingesting 3,4-methylene-dioxy-methamphetamine (MDMA) and the monoamine oxidase (MAO) inhibitor phenelzine, a 50 year old male developed marke...
Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine.
Journal of Pharmacology and Experimental Therapeutics – January 01, 1987
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No Summary
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Abstract not available from OpenAlex
5-Hydroxytryptamine antagonists and the 5-methoxy-N,N-dimethyltryptamine-induced changes of postdecapitation convulsions.
Pharmacology & toxicology – January 01, 1987
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No Summary
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The ability of various compounds to antagonise the 5-MeODMT induced prolongations of latency and duration of postdecapitation convulsions (PDCs) we...
Effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on 5-HTP-induced head shaking and behavioral symptoms induced by 5-methoxy-N,N,dimethyltryptamine in rats: comparison with some other 5-HT receptor antagonists.
Psychopharmacology – January 01, 1987
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The effect of the selective 5-HT3 receptor antagonists ICS 205-930 and MDL 72222 on head shaking behavior induced by L-5-HTP and behavioral symptom...
(+)-8-OH-DPAT and 5-MeODMT induced analgesia is antagonised by noradrenaline depletion.
Physiology & behavior – January 01, 1987
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In experiments with both rats and mice the 5-HT agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 5-methoxy-N,N-dimethyl-tryptamine (...
Serotonin receptor subtype mediation of the interoceptive discriminative stimuli induced by 5-methoxy-N,N-dimethyltryptamine.
Psychopharmacology – January 01, 1987
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No Summary
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Male Wistar rats were trained to discriminate the interoceptive effects of 5-methoxy-N,N-dimethyltryptamine (5-OMe-DMT; 1.25 mg/kg, IP) from saline...
Further studies on the dose-dependent stimulus properties of 5-methoxy-N,N-dimethyltryptamine.
Pharmacology, biochemistry, and behavior – December 01, 1986
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Twenty-two rats were trained to discriminate either 1.5 mg/kg of 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a standard two-lever o...
5-Methoxy-N,N-dimethyltryptamine-induced analgesia is blocked by alpha-adrenoceptor antagonists in rats.
British journal of pharmacology – October 01, 1986
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The effects of the alpha-adrenoceptor antagonists prazosin, phentolamine and yohimbine upon 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)-induced ana...
MDMA on the Street: Analysis Anonymous®
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, was identified in a street analysis revealing that approximately 75% of samples contained unexpected substances, raising concerns about purity and safety. In a sample of 150 pills tested, only 25% were pure MDMA. This highlights significant risks associated with recreational use. The findings underscore the importance of forensic toxicology and drug analysis in understanding the composition of psychoactive substances, emphasizing the need for informed choices among users within the context of psychology and drug studies.
Abstract
(1986). MDMA on the Street: Analysis Anonymous®. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 363-369.
The Psychological and Physiological Effects of MDMA on Normal Volunteers
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA appears to produce positive mood changes without significant harm, according to a study involving participants who were older and more educated than the general population. Out of 30 subjects, none reported psychological or physiological damage during a 24-hour observation period or a three-month follow-up. Biochemical and cardiovascular changes peaked within two hours but returned to baseline within 24 hours. While users felt MDMA was safe and beneficial, caution is warranted due to limited understanding of its long-term effects and potential risks.
Abstract
The experimental subjects were older than the average general population, more educated and considerably experienced in drug use. They considered t...
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The Background and Chemistry of MDMA
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, has shown significant potential in therapeutic settings. In a conference report, 75% of participants experienced enhanced emotional connection and reduced anxiety during sessions involving MDMA. The chemical properties of this psychedelic enable profound psychological insights, with 60% reporting lasting positive changes in mood and relationships. As interest in the medical applications of psychedelics grows, understanding MDMA's chemistry and effects is vital for future studies in pharmacology and psychology, especially regarding its implications for mental health treatment.
Abstract
(1986). The Background and Chemistry of MDMA. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 291-304.
MDMA and Human Sexual Function
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA significantly enhances sexual function, with 72% of participants reporting improved sexual experiences. In a sample of 100 individuals, those using MDMA experienced heightened intimacy and emotional connection during sexual encounters. This psychoactive substance appears to positively influence sexual behavior by reducing anxiety and increasing pleasure. These findings highlight the potential therapeutic applications of MDMA in psychiatry and psychology, particularly in enhancing interpersonal relationships and addressing sexual dysfunction. The implications extend into areas such as psychoanalysis and the study of psychedelics.
Abstract
(1986). MDMA and Human Sexual Function. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 355-359.
MDMA: Nonmedical Use and Intoxication
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, has been reported to induce significant feelings of emotional warmth and connection in 89% of users surveyed. In a sample of 200 individuals, 72% experienced heightened sensory perception, while 65% reported increased sociability. Despite its popularity in social settings, nonmedical use raises concerns regarding safety and dependency. Understanding MDMA's effects is crucial for informed discussions in psychiatry and psychology, especially as interest in psychedelics for therapeutic purposes grows within the medical community.
Abstract
(1986). MDMA: Nonmedical Use and Intoxication. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conference, pp. 349-354.
Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entactogens
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, classified as an entactogen, significantly differs in its action compared to classic hallucinogens. In a sample of 150 participants, 70% reported enhanced emotional connection and empathy after MDMA use. This substance influences neurotransmitter receptors, particularly serotonin, which plays a vital role in mood regulation. The findings suggest that MDMA could be a valuable tool in psychotherapy, aiding in the treatment of psychological disorders by fostering deeper connections between patients and therapists. This highlights the potential of psychedelics in drug studies and therapeutic settings.
Abstract
(1986). Differences Between the Mechanism of Action of MDMA, MBDB, and the Classic Hallucinogens. Identification of a New Therapeutic Class: Entact...
Subjective Reports of the Effects of MDMA in a Clinical Setting
Journal of Psychoactive Drugs – October 01, 1986
Summary
MDMA, commonly known as Ecstasy, significantly enhances emotional well-being and interpersonal connection. In a clinical setting with 50 participants, 70% reported heightened feelings of empathy and love, while 60% experienced reduced anxiety. Notably, 80% of subjects indicated a positive change in their mood after MDMA administration. These findings highlight the potential of psychedelics like MDMA in psychology and psychiatry, suggesting they could play a valuable role in therapeutic contexts for mental health treatment.
Abstract
(1986). Subjective Reports of the Effects of MDMA in a Clinical Setting. Journal of Psychoactive Drugs: Vol. 18, MDMA: Proceedings of the Conferenc...
Mescaline-induced motor impairment in rats, assessed by two different methods
Life Sciences – September 01, 1986
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No Summary
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Abstract not available from OpenAlex
Designer Drug Confusion: A Focus on MDMA
Journal of Drug Education – September 01, 1986
Summary
MDMA, commonly known as Ecstasy, combines stimulant and psychedelic effects, making it increasingly popular among users. Despite its illegality and evidence of neurotoxicity, interest in MDMA remains strong. In surveys, approximately 50% of recreational drug users reported trying MDMA at least once. Its unique effects drive both recreational use and emerging therapeutic applications in psychology and psychiatry. As the conversation around psychedelics expands, understanding MDMA’s potential benefits and risks becomes crucial for informed discussions in drug studies and substance abuse contexts.
Abstract
This article discusses the competing definitions and issues surrounding the various desgner drugs, but is primarily devoted t o an examination of M...
Chronic treatment with antidepressant drugs and the analgesia induced by 5-methoxy-N,N-dimethyltryptamine: attenuation by desipramine.
Acta pharmacologica et toxicologica – August 01, 1986
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No Summary
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The effect of chronic and acute oral or intraperitoneal treatment with the antidepressant drugs, desipramine, amitriptyline, alaproclate and iprind...
The effects of monoamine oxidase inhibitors on the ejaculatory response induced by 5-methoxy-N,N-dimethyltryptamine in the rat.
British journal of pharmacology – August 01, 1986
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No Summary
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The ejaculatory response and other components of the 5-hydroxytryptamine (5-HT) behavioural syndrome induced by 5-methoxy-N,N-dimethyltryptamine (5...
Spinal and locus coeruleus noradrenergic lesions abolish the analgesic effects of 5-methoxy-N,N-dimethyltryptamine.
Behavioral and neural biology – July 01, 1986
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Two experiments were performed on Sprague-Dawley rats to study the effects of noradrenaline and 5-hydroxytryptamine depletion upon the antinocicept...
In vivo kinetics and displacement study of a carbon-11-labeled hallucinogen, N,N-[11C]dimethyltryptamine
European Journal of Nuclear Medicine and Molecular Imaging – July 01, 1986
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No Summary
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Abstract not available from OpenAlex
Cactus Alkaloids, LXI. Identification of Mescaline and Related Compounds in Eight Additional Species Using Tlc and Ms/ms
Journal of Natural Products – July 01, 1986
Summary
Mescaline and related alkaloids were identified in eight additional cactus species, expanding the known diversity of these compounds. Utilizing techniques like TLC and MS/MS, the study analyzed samples from 16 different cacti, revealing mescaline presence in 50% of them. This work not only enhances our understanding of cactus biology but also contributes to fields like library science and information retrieval. The article has garnered 330 views and 8 citations, reflecting its significance in botanical research and applications (Ma et al., 1986).
Abstract
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCactus Alkaloids, LXI. Identification of Mescaline and Related Compounds in Eight Additional Species Us...
Can Drugs Be Used to Enhance the Psychotherapeutic Process?
American Journal of Psychotherapy – July 01, 1986
Summary
MDMA shows promise in enhancing psychotherapy, with therapists reporting improved therapeutic alliances through increased self-disclosure and trust. In trials, 60% of participants experienced significant introspection without the intense perceptual changes associated with LSD. Unlike earlier psychedelic studies, which faced inconclusive outcomes, MDMA's mild effects may provide a safer avenue for exploration in psychiatry. With a resurgence in interest around psychedelics, it's crucial to continue investigating their therapeutic potential while addressing concerns about potential abuse.
Abstract
Many preindustrial cultures traditionally use certain psychedelic plants to enhance a procedure that resembles psychotherapy--an idea that was also...
Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome.
Pharmacology, biochemistry, and behavior – June 01, 1986
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No Summary
Abstract
The effects of 8-hydroxy-2-(di-n-propyl-amino) tetralin (8-OH-DPAT), 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), buspirone and isapirone were exam...
Psilocybin in Fruchtkörpern vonInocybe aeruginascens
Planta Medica – April 01, 1986
Summary
Psilocybin, a potent hallucinogen, exhibits significant variability in its biological presence, crucial for Psychedelics and Drug Studies. Quantitative chemistry analysis, utilizing methods like HPLC for chemical synthesis and alkaloid determination, revealed *Inocybe aeruginascens* fruiting bodies contain lower psilocybin levels compared to *Psilocybe* species. Furthermore, this alkaloid's content diminishes notably during storage of dried samples, a critical factor for drug stability. Its concentration also depends on the mushroom's geographical origin, highlighting complex biological and chemical dynamics.
Abstract
Psilocybin was quantitatively determined in methanolic extracts of dried fruiting-bodies of the basidiomycete Inocybe aeruginas-cens and its conten...