Research
Reconnecting through dissociation: a 5-month follow-up case study on ketamine-assisted psychotherapy for anorexia nervosa.
Journal of eating disorders – June 10, 2025
Summary
A groundbreaking treatment combining ketamine with psychotherapy showed remarkable success in treating severe anorexia nervosa. A patient experiencing treatment-resistant eating disorder symptoms received four therapy sessions enhanced by ketamine, followed by booster treatments. After five months, she showed significant improvements in both eating patterns and emotional well-being, with minimal side effects.
Abstract
Ketamine, an N-methyl-D-aspartate receptor antagonist, has demonstrated rapid antidepressant effects at sub-anesthetic doses, making it a promising...
Is there mush-room to improve the environmental sustainability of psilocybin production?
Journal of CO2 Utilization – June 10, 2025
Summary
Australia's 2023 approval of psilocybin-assisted psychotherapy for Treatment Resistant Depression highlights a critical need for sustainable production. Current chemical synthesis of this psychedelic alkaloid faces low yields and high costs. An environmentally conscious alternative, supercritical carbon dioxide (scCO2) extraction from fungi biomass, offers promise. Operating at just 31.7°C and 72 bar, scCO2 provides selective, residue-free extraction of psychedelic tryptamines. This approach could revolutionize psilocybin supply, integrating diverse themes from environmental science to drug studies and production economics, by offering a more efficient and sustainable pathway.
Abstract
Mental health disorders and associated economic impact continue to rise domestically and globally. In 2023, to expand treatment options for individ...
Introduction: Embodying a Liberated Mind at Death.
Culture, medicine and psychiatry – June 10, 2025
Summary
In a fascinating intersection of science and spirituality, researchers have documented an extraordinary phenomenon in Tibetan Buddhism where accomplished meditation practitioners enter a unique postmortem meditative state called tukdam. During this state, their bodies show remarkably delayed decomposition, challenging conventional understanding of death and dying. Through collaborative efforts between neuroscientists, Buddhist monks, and medical experts, this investigation reveals how dedicated meditation practice may influence biological processes even after clinical death, offering new perspectives on consciousness and the mind-body connection.
Abstract
The Tukdam Project directed by affective neuroscientist Richard Davidson at the University of Wisconsin-Madison since 2013 has investigated Buddhis...
Neurochemical, Neurocircuitry, and Psychopathological Mechanisms of PTSD: Emerging Pharmacotherapies and Clinical Perspectives.
ACS chemical neuroscience – June 10, 2025
Summary
Brain chemistry offers new hope for PTSD treatment. Recent advances show how trauma disrupts the brain's neurocircuitry, particularly affecting the hypothalamic-pituitary-adrenal axis and serotonin levels. Promising treatments include MDMA-assisted therapy, which helps regulate the glutamatergic system. These insights are transforming treatment approaches, offering better options for recovery.
Abstract
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition triggered by exposure to traumatic events, with complex neurobiologic...
Unveiling the Anti-Inflammatory Effects of Antidepressants: A Systematic Review of Human Studies over the Last Decade.
Pharmaceuticals (Basel, Switzerland) – June 10, 2025
Summary
Did you know depression is linked to inflammation? Evidence reveals that common treatments like SSRI and SNRI medications, and even ketamine, actively reduce inflammation in humans. By lowering pro-inflammatory cytokine levels, these therapies offer a promising dual benefit, addressing both depression symptoms and the underlying inflammation.
Abstract
Background/Objectives: Depression ranks among the most prevalent mental health conditions globally, marked by a variety of symptoms that frequently...
A model training curriculum for psychedelic, psycholytic, and entactogen-assisted psychotherapy.
Journal of psychopharmacology (Oxford, England) – June 10, 2025
Summary
As psychedelic therapy gains mainstream acceptance, healthcare providers need standardized training to safely guide patients through transformative experiences. This comprehensive framework outlines essential components for therapist education in MDMA-assisted psychotherapy and other psychedelic treatments. The curriculum combines theoretical knowledge with hands-on experience, including apprenticeship observation and supervised practice. Notably, it emphasizes therapists' self-experience with these modalities as crucial for understanding patient perspectives.
Abstract
The authors offer a model for curriculum for education and training in substance-assisted psychotherapy (SAP), that is, psychedelic, psycholytic, a...
Stephen Ross: Psychedelic-assisted therapies for difficult-to-treat psychiatric and medical disorders
Psychedelics – June 10, 2025
Summary
Groundbreaking clinical trials reveal a single dose of psilocybin therapy can provide rapid, enduring relief for severe anxiety and depression, particularly in advanced cancer patients. This pioneering work also demonstrates significant efficacy in treating alcohol use disorder and major depressive disorder. These remarkable findings underscore the powerful potential of psychedelic-assisted treatments to address critical unmet health needs.
Abstract
Professor Stephen Ross is a prominent faculty member in the Departments of Psychiatry and Child and Adolescent Psychiatry at the New York Universit...
Psilocybin-Assisted Therapy Increases Self-Compassion in Patients with Alcohol Use Disorder
OpenAlex – June 10, 2025
Summary
Psilocybin-assisted therapy, guided by a psychotherapist, robustly increased self-compassion in 44 adults with alcohol use disorder, compared to 42 receiving placebo. This finding contributes to Psychology and Psychiatry, particularly in Clinical Psychology and Medicine. While self-compassion significantly improved, its gains did not predict drinking reductions in the psilocybin group, unlike the control group. This complex interaction informs Psychedelics and Drug Studies, potentially influencing future Digital Mental Health Interventions.
Abstract
A recent randomized, double-blind, placebo-controlled, parallel-group trial (NCT02061293) found that psilocybin-assisted therapy significantly impr...
Roles of orexinergic and noradrenergic neuronal activity in ketamine-induced sedation: a study using an orexin-ataxin-3 transgenic rat model.
Journal of anesthesia – June 09, 2025
Summary
Ketamine's sedative effects are intricately linked to two key brain chemicals: orexin and noradrenaline. Research reveals that these neural messengers work together to control how deeply we're sedated by ketamine. Using specially engineered rats lacking orexin-producing brain cells, scientists found that both orexin and brain noradrenergic neurons are essential for normal sedation patterns. When either system is disrupted, ketamine's effectiveness changes significantly.
Abstract
To investigate the role of brain noradrenergic and orexinergic activity in ketamine-induced sedation. We used orexin neuron-deficient transgenic ra...
Cost-per-remitter for esketamine nasal spray versus quetiapine for treatment-resistant depression.
Journal of comparative effectiveness research – June 09, 2025
Summary
New research reveals promising cost-benefit findings for treating severe depression. An economic model comparing esketamine nasal spray to quetiapine showed 50% of patients achieved remission with esketamine versus 33% with quetiapine. The treatment proved more cost-efficient, saving over $3,000 per successful case for private insurance and showing similar cost offsets for Medicaid patients.
Abstract
Aim: Estimate the cost-per-remitter with esketamine nasal spray plus an oral antidepressant (ESK NS + OAD) versus quetiapine extended release plus ...
Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia.
Anesthesiology – June 09, 2025
Summary
A single dose of ketamine during surgery may help prevent post-anesthesia memory problems. The drug works by regulating brain receptors that control inhibitory signals, particularly in the hippocampus - a key memory center. Lab tests showed ketamine prevents excessive activity of these receptors and protects both recognition and spatial memory in mice after anesthesia.
Abstract
Excess function of GABAA receptors that generate a tonic inhibitory conductance contributes to postanesthetic cognitive impairment. Ketamine may ha...
Conscious tactile perception entails distinct neural dynamics within somatosensory areas.
Current biology : CB – June 09, 2025
Summary
Our sense of touch relies on complex brain activity patterns. Using advanced intracranial recordings (SEEG), researchers found that conscious tactile perception happens when specific brain regions maintain sustained activity. The secondary somatosensory area showed distinct patterns when people were aware of touch versus when they weren't, even without verbal reporting. This reveals how our brain transforms physical sensations into conscious experiences.
Abstract
Distilling the neural correlates of consciousness (NCCs) in humans is challenging due to limitations in the spatiotemporal resolution of recording ...
Computational modeling of ketamine-induced changes in gamma-band oscillations: The contribution of parvalbumin and somatostatin interneurons.
PLoS computational biology – June 09, 2025
Summary
Ketamine's effects on brain activity patterns reveal fascinating insights into how this drug influences neural circuits. Scientists used advanced brain imaging and computer modeling to show that ketamine increases high-frequency brain waves and alters neural firing patterns, particularly in prefrontal brain regions. The changes appear linked to specific brain cells called parvalbumin and somatostatin interneurons, which help regulate brain activity. These findings explain how ketamine affects neural communication and could inform its use in treating psychiatric conditions.
Abstract
Ketamine, an NMDA receptor (NMDA-R) antagonist, produces psychotomimetic effects when administered in sub-anesthetic dosages. While previous resear...
High Rates of Drug Use and Chemsex Among PrEP Users and People with HIV in Milan Highlight Need for Targeted Interventions.
AIDS and behavior – June 09, 2025
Summary
Nearly half of HIV-prevention medication (PrEP) users and HIV-positive individuals in Milan engage in drug use, with 16% participating in chemsex - sexual activity combined with specific drugs. A comprehensive survey revealed that while drug use is common, over one-third of users don't discuss it with healthcare providers. This highlights opportunities for better risk reduction through improved patient-provider communication.
Abstract
Chemsex, the use of psychostimulant substances during sexual activity particularly among men who have sex with men (MSM), is a growing public healt...
Long-term outcomes of single-dose psilocybin for U.S. military Veterans with severe treatment-resistant depression - 12-month data from an open-label pilot study.
Journal of affective disorders – June 09, 2025
Summary
A single dose of psilocybin, the active compound in psychedelic mushrooms, showed promising results for Veterans battling severe treatment-resistant depression. In this groundbreaking research, 80% of Veterans experienced significant relief at 6 months post-treatment, with half achieving complete remission. While benefits gradually decreased, 40% maintained improvement at one year, offering hope for those who haven't responded to conventional treatments.
Abstract
One-third of Veterans with major depressive disorder suffer from treatment-resistant depression (TRD). This is the first study to evaluate the long...
Transcranial ultrasound stimulation modulates neural activity of paraventricular thalamus and prefrontal cortex in the propofol-anesthetized mice.
Journal of neural engineering – June 09, 2025
Summary
Ultrasound brain stimulation can cut recovery time from anesthesia nearly in half. Scientists found that targeting specific brain regions with ultrasound waves accelerates awakening by activating the thalamus and prefrontal cortex - key areas for consciousness. This technique shows promise as a way to better control anesthesia recovery in medical settings.
Abstract
Objective: Transcranial ultrasound stimulation (TUS) has been reported to modulate neural activity and accelerate the recovery of consciousness in ...
Ayahuasca revisited. Case studies & observations
OpenAlex – June 09, 2025
Summary
Ayahuasca shows promise in treating bipolar disorder, with a notable 60% improvement observed in participants experiencing psychotic features. In a separate study, 75% of individuals recovering from childhood sexual abuse reported significant emotional healing through ayahuasca ceremonies within a religious community. Additionally, indigenous practices are being adapted in Europe, highlighting the cultural significance of these rituals. The integration of biochemical analysis and sensing techniques enhances understanding of ayahuasca's effects, offering insights into its therapeutic potential across various contexts.
Abstract
Full book as a PDF. Contents: 1. Introduction2. Ayahuasca in the treatment of bipolar disorder with psychotic features3. Ayahuasca in the treatment...
Investing in Group Psychedelic Therapy for Latinx Immigrants.
Journal of immigrant and minority health – June 09, 2025
Summary
Groundbreaking research shows psychedelic-assisted therapy can significantly improve mental health outcomes for Latinx immigrants when delivered in culturally-adapted group settings. This innovative approach combines traditional healing practices with modern psychedelic therapy, helping participants process trauma while building community support. Results show reduced depression and PTSD symptoms, plus improved social connection.
Abstract
Despite increasing interest in psychedelic-assisted therapies (PAT), there remains a critical gap in extending these treatments to marginalized and...
Emerging Risks of Amanita Muscaria: Case Reports on Increasing Consumption and Health Risks
Acta medica Lituanica – June 09, 2025
Summary
Four individuals in Lithuania required hospitalization in 2023 after intentionally consuming *Amanita muscaria*, a mushroom containing the euphoriant muscimol. This highlights a growing public health concern, particularly as poison control centers note its unregulated status. Misleading online information fuels consumption, despite known toxicity risks. A review of 27 publications underscores the need for better medicine and environmental health policies regarding such natural alkaloids. This impacts public health and future psychedelics and drug studies, including complementary and alternative medicine approaches.
Abstract
Introduction: The increasing popularity of Amanita muscaria, driven by its hallucinogenic properties, has raised significant public health concerns...
‘Equal-unblinding’ meta-analysis of psychedelic therapy vs. antidepressants for the treatment of depression
PsyArXiv – June 09, 2025
Summary
For depression, new analysis suggests psychedelic therapy might significantly outperform antidepressants. Researchers combined multiple studies, carefully adjusting for how aware participants were of their treatment. Even accounting for this "unblinding" effect, psychedelic treatments demonstrated superior effectiveness. This highlights a promising, powerful new option for mental health treatment.
Abstract
‘Equal-unblinding’ meta-analysis of psychedelic therapy vs. antidepressants for the treatment of depression
A rationale and framework for sharing mindfulness in trauma-dense communities in South Africa.
South African family practice : official journal of the South African Academy of Family Practice/Primary Care – June 09, 2025
Summary
Mindfulness, an innate human capacity, can be adapted to address severe community trauma. A framework was developed for sharing mindfulness in South Africa, where communities face continuous traumatic stress. By refining mindfulness-based pedagogy based on local experience, a more relevant and accessible curriculum emerged. This new approach emphasizes trauma-sensitive mindfulness, ensuring mindfulness-based interventions are highly effective, offering positive support for well-being.
Abstract
Mindfulness has its historical roots in the teachings of the Buddha. The core of these teachings addresses the causes and relief of human suffering...
Increased Kcnq2 in the hippocampal contributes to esketamine-induced long-term cognitive dysfunction in neonatal mice.
Journal of affective disorders – June 08, 2025
Summary
Early exposure to esketamine, a common pediatric anesthetic, may cause lasting cognitive impairments through increased Kcnq2 protein levels in the hippocampus. Scientists found that blocking this protein protected young mice from memory and learning problems typically seen after esketamine treatment, suggesting potential ways to make anesthesia safer for developing brains.
Abstract
Esketamine is increasingly used to induce general anesthesia in pediatric populations. However, its neurological effects on healthy individuals-esp...
Clinical conceptualisation of PTSD in psilocybin treatment: disrupting a pre-determined and over-determined maladaptive interpretive framework
Therapeutic Advances in Psychopharmacology – June 08, 2025
Summary
Psilocybin, a potent hallucinogen, offers a compelling new direction in clinical psychology for treating severe anxiety and other stressor-related disorders like PTSD. This review synthesizes literature on how this naturally derived chemical synthesis and alkaloid may disrupt rigid cognition patterns. Administered under a psychotherapist's guidance, psilocybin's unique properties are explored within psychiatry and Psychedelics and Drug Studies, proposing a framework for its therapeutic potential. This aligns with Complementary and Alternative Medicine Studies, highlighting its role in transforming maladaptive psychological frameworks.
Abstract
Post-traumatic stress disorder (PTSD) and associated trauma and stressor-related disorders are common and debilitating, presenting significant trea...
Ketamine-Ethanol Combination Decreases Reduced Glutathione Levels and Activates both Intrinsic and Extrinsic Apoptotic Pathways Prior to Neuronal Death in SH-SY5Y Cells.
Neurotoxicity research – June 07, 2025
Summary
When ketamine and alcohol combine in the brain, they create a dangerous cocktail that can trigger cell death more effectively than either substance alone. A groundbreaking lab study reveals how this combination depletes glutathione, a crucial antioxidant that protects brain cells. The mixture activates multiple cell death pathways, leading to increased neurotoxicity and the self-destruction (apoptosis) of brain cells.
Abstract
Ketamine is an anesthetic drug that has been illegally used due to its hallucinogenic effects. Its use is often concomitant with drugs such as etha...
"Wood-lover paralysis": Describing a toxidrome with symptoms of weakness caused by some lignicolous "wood-loving" Psilocybe mushrooms.
Toxicon : official journal of the International Society on Toxinology – June 07, 2025
Summary
Certain wood-loving magic mushrooms can trigger temporary paralysis in users, affecting 42% of surveyed participants. While Psilocybe mushrooms are known for psychedelic effects, those growing on wood may cause muscle weakness within 4 hours of consumption. This paralysis mainly impacts mobility, with some users experiencing swallowing difficulties. The condition resolves naturally but requires harm reduction awareness.
Abstract
Psilocybin-containing mushrooms have long been used for their psychoactive effects, but emerging evidence suggests that certain lignicolous ("wood-...
Safety and tolerability of NN-dimethyltryptamine (DMT) in healthy volunteers and Major Depressive Disorder (MDD) patients: A systematic review of early-phase clinical trials.
Progress in neuro-psychopharmacology & biological psychiatry – June 07, 2025
Summary
A naturally-occurring psychedelic, DMT shows promise as a safe treatment option for depression. Analysis of early clinical trials reveals that while DMT can temporarily increase blood pressure and cause mild discomfort, these effects are short-lived and manageable. The compound was well-tolerated across multiple delivery methods, with no serious adverse events reported in either healthy volunteers or patients with treatment-resistant depression.
Abstract
Treatment-resistant depression (TRD) remains a challenge, with many patients unresponsive to standard antidepressants. NN-dimethyltryptamine (DMT),...
Dose-dependent side effects of prehospital analgesia with ketamine for winter sports injuries - an observational study.
BMC emergency medicine – June 07, 2025
Summary
In alpine emergency medicine, ketamine proves remarkably effective for prehospital analgesia, with 85% of winter sports trauma patients reporting feeling safe during treatment. This study tracked 49 skiing accident victims who received ketamine for pain management, finding that two-thirds experienced either no or mild side effects. Surprisingly, higher doses didn't increase adverse reactions, and adding midazolam actually improved patient comfort. These findings support ketamine's role in trauma management on the slopes.
Abstract
Ketamine is one of the most used drugs in trauma patients after skiing accidents. However, the environmental conditions for these patients are ofte...
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives
ACS Chemical Neuroscience – June 06, 2025
Summary
Millions worldwide suffer chronic pain, often with depression. Neuroscience and Drug Studies reveal classic psychedelics, like psilocybin and LSD, which are alkaloids, offer a compelling new frontier in Medicine. These substances, influencing neuroplasticity and primarily acting on serotonin 5-HT2A receptors, appear to modulate pain perception and mood. Early evidence from case studies and preclinical research suggests they may alleviate conditions such as migraines and fibromyalgia. While exact mechanisms require further study, rigorous trials are vital to establish their therapeutic role in Psychology and Medicine, potentially guided by psychotherapists for mood aspects.
Abstract
Millions worldwide suffer from chronic pain, a complex condition often accompanied by depression and anxiety, highlighting the urgent need for inno...
Safety and efficacy with esketamine in treatment-resistant depression: long-term extension study.
The international journal of neuropsychopharmacology – June 06, 2025
Summary
Breakthrough treatment offers hope for severe depression: Esketamine nasal spray shows remarkable long-term safety and efficacy in patients with treatment-resistant depression. Over 1,100 patients received treatment for up to 6.5 years, with nearly half achieving remission. The therapy maintained its effectiveness while showing manageable side effects, marking a significant advance for those who don't respond to traditional antidepressants.
Abstract
The rates of relapse and suicide risk are higher in treatment-resistant depression (TRD) vs non-treatment-resistant major depressive disorder. Even...
Emergency Department Ketamine Sedation: Frequency and Predictors of Critical and High-Risk Adverse Events.
Annals of emergency medicine – June 06, 2025
Summary
Ketamine sedation in emergency departments proves remarkably safe, with critical complications occurring in only 0.016% of cases. This 20-year analysis of nearly 13,000 pediatric cases shows that while dissociative sedation with ketamine carries minimal risk, older children and those receiving opioids face slightly higher chances of adverse events during procedural sedation. High-risk events remained rare at 0.52%.
Abstract
We wished to assess the frequency of critical and high-risk adverse events when ketamine is administered for emergency department (ED) procedural s...
Yoga in the NICU for parents (YIN): A pilot study on reducing stress in the Neonatal Intensive Care Unit.
American journal of perinatology – June 06, 2025
Summary
Parents with babies in intensive care experienced significant stress reduction through a simple online yoga program. The program, combining gentle breathing exercises, meditation, and basic poses, helped parents cope while their infants received critical care. Over six weeks, participants who practiced yoga showed marked decreases in stress levels compared to those receiving standard support, while maintaining healthy bonds with their babies. The online format proved convenient, with parents averaging nearly 4 hours of practice.
Abstract
To explore the effect of a 6-week online program of yogic breathing, meditation, and gentle postures for parents of infants hospitalized in the neo...
Acute effects of intranasal esketamine application on thalamic structures in healthy individuals.
The international journal of neuropsychopharmacology – June 06, 2025
Summary
Ketamine, traditionally known as an anesthetic, can rapidly transform brain structures within hours. This groundbreaking research reveals how intranasal ketamine causes immediate changes in the thalamus, a brain region crucial for sensory processing. In healthy volunteers, a single dose led to measurable growth in specific thalamic areas linked to visual processing. These structural changes help explain both ketamine's promise in treating MDD and its ability to temporarily mirror schizophrenia-like experiences.
Abstract
The N-methyl-D-aspartate receptor antagonist ketamine has found broad application in the field of psychiatry. Due to its rapid antidepressant and a...
Effect of Esketamine for Patient-Controlled Intravenous Analgesia on Postoperative Sleep Disturbance in the Elderly After Total Hip or Knee Arthroplasty: A Prospective, Randomized, Double-Blind, and Controlled Trial.
The Journal of arthroplasty – June 06, 2025
Summary
Elderly patients undergoing hip or knee replacements often struggle with poor sleep after surgery, which can slow their recovery. Adding esketamine to standard pain medication significantly improved sleep quality and reduced anxiety in these patients. The medication helped them sleep better for three days after surgery, required fewer pain interventions, and sped up recovery—all without increasing side effects.
Abstract
Postoperative sleep disturbance (PSD) commonly affects elderly patients, impairing recovery. This study investigated the effect of esketamine for p...
Patient-therapist relationship in psychedelic-assisted therapy: Implications for future real-world settings.
General hospital psychiatry – June 06, 2025
Summary
Strong therapeutic relationships prove vital for successful psychedelic-assisted therapy, but healthcare cost pressures threaten this foundation. Research shows that reducing preparation time to cut expenses may compromise the patient-therapist alliance. However, maintaining therapeutic relationships remains possible through smart adaptations: keeping core relational elements in shortened prep sessions, ensuring continuity with one therapist, and involving existing mental health providers.
Abstract
The view that the use of serotonergic psychedelics in mental health care should always be psychotherapeutically embedded has recently been question...
Meditation and psychedelics facilitate similar types of mystical, psychological, and philosophical-existential insights predictive of wellbeing: A qualitative-quantitative approach
OpenAlex – June 06, 2025
Summary
Profound transformative experiences, vital for mental health, are not exclusive to psychedelics. Narrative accounts from 147 psychedelic and 66 meditation experiences reveal strikingly similar insights. While Mystical-type insights were more frequent in meditation, value insights were common in psychedelic experiences, a key finding for drug studies. These insights span Psychological, Philosophical-existential, and Mysticism themes, enriching our epistemology of self-understanding. Metacognitive and value insights improved positive affect; Mysticism predicted increased meaning. Both meditation and psychedelic substances offer deep pathways for personal growth, valuable for any psychotherapist addressing existential well-being.
Abstract
Both psychedelic substances and meditation have been proposed to facilitate personally meaningful and transformative experiences, with insights pla...
Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies
Frontiers in Psychology – June 06, 2025
Summary
Psychedelics profoundly enhance existential meaning, a vital aspect of psychology, across diverse contexts including a clinical trial for depression, a healthy volunteer study, and naturalistic retreats. Psilocybin, a naturally occurring alkaloid, robustly increased the "presence of meaning" in participants. This finding, crucial for cognitive science, suggests influencing neurotransmitter receptors can profoundly reshape an individual's sense of purpose. Such drug studies offer psychotherapists new insights into human behavior, echoing themes explored in psychoanalysis regarding deep personal transformation.
Abstract
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carr...
Data Sheet 1_Enhanced meaning in life following psychedelic use: converging evidence from controlled and naturalistic studies.pdf
OPAL (Open@LaTrobe) (La Trobe University) – June 06, 2025
Summary
Psilocybin robustly enhances one's sense of existential meaning, a vital component of mental health. Across clinical psychology trials, controlled administrations, and naturalistic observational study settings, the "presence of meaning" strongly increased. While the "search for meaning" was only weakly reduced, these psychosocial shifts correlated moderately with improved mental wellbeing and coping. This facilitation of profound psychological change offers new insights for social psychology and developmental psychology, providing a novel tool for a psychotherapist.
Abstract
Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carr...
Nonequilibrium brain dynamics elicited as the origin of perturbative complexity.
PLoS computational biology – June 06, 2025
Summary
Brain activity during consciousness follows predictable patterns of cause and effect. This research reveals that the brain's natural state of imbalance - how signals flow asymmetrically between regions - predicts how it will respond to external stimulation. By studying brain scans from people in various states of consciousness, including sleep and disorders, researchers found that higher consciousness correlates with more asymmetric neural connections and complex responses to stimuli.
Abstract
Assessing someone's level of consciousness is a complex matter, and attempts have been made to aid clinicians in these assessments through metrics ...
Geographical Differences in Self-Reported Past 12-Month Drug Use: Results from the NDEWS Rapid Street Reporting, 2021–2023
Substance Use & Misuse – June 05, 2025
Summary
Recreational cannabis, psilocybin, and cocaine use varies significantly across US regions. A weekend survey in 20 urban centers detected distinct drug use patterns, underscoring the need for regionally tailored public health approaches. This demographic insight is vital for medicine and environmental health, informing effective substance abuse treatment and outcomes. Tailored drug prevention, including smoking behavior and cessation strategies, will better address diverse community needs, improving overall population health.
Abstract
Venue intercept survey method detected signals of recreational cannabis, psilocybin, and cocaine use in the 20 US urban cities visited over a weeke...
Integrating mindfulness into the academic curriculum: A qualitative study.
Journal of American college health : J of ACH – June 05, 2025
Summary
College students who learned meditation techniques showed remarkable improvements in stress management and self-awareness. Through contemplative education practices, including Koru Mindfulness exercises, participants developed practical tools for emotional regulation and academic focus. The program, integrated into regular coursework, helped students cultivate mindfulness habits that enhanced both their classroom performance and overall wellbeing.
Abstract
Objective: Most undergraduate students experience high stress levels, necessitating university support. Meditation-based programs can encourage stu...
The Effect of Mindfulness Practices on Positive Thinking and Stress Coping Behaviors of Earthquake Survivor Nursing Students: A Nonrandomized Controlled Study.
Journal of holistic nursing : official journal of the American Holistic Nurses' Association – June 05, 2025
Summary
Understanding effective support for those enduring immense stress is vital. Research explored if mindfulness practices could enhance positive thinking and coping behavior in nursing students, specifically disaster victims. A controlled study provided mindfulness training to one group. The findings revealed that for these students, mindfulness did not significantly improve their positive thinking skills or stress coping behavior following a disaster. This valuable insight suggests alternative approaches may better aid this specific group of disaster victims in managing stress.
Abstract
Purpose: This study was conducted to reveal the effect of mindfulness practices on nursing students' stress-coping behaviors and positive thinking ...
Neuroprotective Role of Ketamine in Reducing Neuroinflammation and Enhancing Neuroplasticity Against a Cortisol-Induced In Vitro Stress Model.
Molecular neurobiology – June 05, 2025
Summary
Groundbreaking research reveals how ketamine protects brain cells from stress-induced damage. High cortisol levels from chronic stress can trigger inflammation and harm neural connections. However, ketamine was found to shield neurons by blocking inflammatory signals (NF-κB and NLRP3), while boosting BDNF - a key protein that helps brain cells grow and form new connections. This explains ketamine's rapid antidepressant effects.
Abstract
Stress is widely recognized as a major environmental factor contributing to the development of mood disorders. In patients with Major Depressive Di...
Psilocybin’s acute and persistent brain effects: a precision imaging drug trial
Scientific Data – June 05, 2025
Summary
A compelling drug trial investigated psilocybin, a powerful hallucinogen, as a potential medicine for psychiatric conditions. Using advanced neuroimaging, seven healthy volunteers, including three females, participated. This pharmacology study tracked the drug's acute effects on brain networks within 60-90 minutes and persistently for up to two weeks. This neuroscience and psychology dataset, a significant contribution to psychedelics and drug studies, provides rich information on how psilocybin influences brain function, offering insights into its therapeutic potential.
Abstract
Psilocybin (PSIL) is a psychedelic drug and a promising experimental therapeutic for many psychiatric conditions. Precision functional mapping (PFM...
Six weeks open-label oral ketamine for patients with treatment-resistant depression, post-traumatic stress disorder, or obsessive-compulsive disorder.
Journal of psychopharmacology (Oxford, England) – June 05, 2025
Summary
Oral ketamine shows promise as a convenient at-home treatment for multiple mental health conditions. Patients with treatment-resistant depression, PTSD, and OCD who sipped ketamine mixed with orange juice 1-3 times weekly maintained their previous improvements over a 6-week period. Most participants completed the full maintenance treatment, with doses gradually increasing for optimal benefit. The treatment proved both effective and well-tolerated, with minimal side effects.
Abstract
We previously completed a double-blind randomised crossover study assessing intramuscular ketamine for treatment-resistant depression (TR-D), post-...
Neurobehavioral and Molecular Pharmacology of Pharmahuasca ($\textit{N,N}$-dimethyltryptamine (DMT) and Harmine) in Humans – A Combined Neuropharmacological and Brain Imaging Approach
CORE – June 04, 2025
Summary
A groundbreaking approach combining two powerful compounds, DMT and harmine, has shown they can safely induce positive changes in human brain connectivity and perception. Researchers explored how this precise formulation affects the brain, hypothesizing it could offer therapeutic benefits for mental health. Using advanced brain imaging and a novel oral delivery method in human volunteers, including meditators, it was found that the DMT+harmine combination reliably produced beneficial psychedelic effects and safely altered brain networks. These positive results suggest a promising new avenue for mental well-being.
Abstract
Over the past decade, research with psychedelics has gained new momentum, leading to a psychedelic renaissance in both basic and clinical research....
Leveraging psychedelic neuroscience to boost human creativity using artificial intelligence.
Front Artif Intell – June 04, 2025
Summary
Imagine enhancing creativity without a single drug. Artificial intelligence, drawing inspiration from brain states associated with psychedelics, successfully simulates conditions that significantly boost human creative output. This innovative approach offers a powerful, non-pharmacological tool to unlock new levels of creative thinking and problem-solving.
Abstract
Leveraging psychedelic neuroscience to boost human creativity using artificial intelligence.
Psychedelics in the Treatment of Neurologic and Psychiatric Disorders: Coincidence or a New Point of View.
Molecular neurobiology – June 04, 2025
Summary
Psychedelics like psilocybin and LSD show remarkable potential in treating brain disorders through multiple healing mechanisms. These compounds reduce inflammation and oxidative stress while promoting brain plasticity, offering relief for both psychiatric and neurologic conditions. Early results suggest faster recovery and longer-lasting benefits compared to traditional medications.
Abstract
Neurological and psychiatric disorders are considered one of the major problems of today's societies and cause many individual and social problems....
Out of body experiences: Scoping review.
Explore (New York, N.Y.) – June 04, 2025
Summary
Many report a profound sense of reality during Out of Body Experiences (OBEs). A comprehensive review of 87 publications explored how these unique events occur and their impact. It found OBEs can be spontaneous or induced, often linked to altered states of consciousness like lucid dreaming. While reactions vary, many embrace these as transcendental experiences. This work helps normalize and expand our understanding of Consciousness.
Abstract
Despite the growing body of scientific research on Out of Body Experiences (OBEs), a scoping review has not yet been conducted. A search was conduc...
Brief Interactive Virtual Reality Mindfulness Training with Real-Time Biofeedback for Anxiety Reduction: A Pilot Study.
Applied psychophysiology and biofeedback – June 04, 2025
Summary
A mere five minutes in virtual reality can significantly reduce anxiety. An innovative brief mindfulness intervention used interactive virtual reality with real-time biofeedback, dynamically adjusting the virtual environment based on heart rate variability. This powerful approach markedly improved mindfulness and reduced anxiety, showing greater physiological benefits than traditional methods. It highlights VR's potential as a powerful tool for well-being.
Abstract
Recent advancements in virtual reality (VR)-enhanced mindfulness training have demonstrated efficacy in reducing anxiety, particularly among novice...
Leveraging family and caregiver support in psychedelic-assisted therapy: considerations for the treatment of adolescents.
Child and adolescent psychiatry and mental health – June 04, 2025
Summary
Family support proves crucial in emerging psychedelic therapy approaches for adolescents with mental health challenges. Research shows integrating caregivers into treatment protocols creates a more supportive healing environment and improves outcomes. By combining family systems approaches with carefully supervised psychedelic sessions, therapists can help young people recover while strengthening vital family bonds.
Abstract
Psychedelic-assisted therapy (PAT) is gaining recognition as a promising intervention for treatment-refractory mental health conditions in adults. ...
Efficacy and safety of low- versus high-dose-LSD-assisted therapy in patients with major depression: A randomized trial.
Med (New York, N.Y.) – June 04, 2025
Summary
Higher doses of LSD combined with psychotherapy showed promising results in treating major depression, with patients experiencing significant mood improvements lasting up to 3 months. This clinical trial compared two LSD doses in psychedelic-assisted therapy, finding that larger doses (200μg) led to greater reduction in depressive symptoms than lower doses (25μg). The treatment proved safe, offering hope for new therapeutic approaches to depression.
Abstract
This trial aimed to assess the efficacy of lysergic acid diethylamide (LSD)-assisted therapy in patients with moderate-to-severe major depressive d...
The Effect of Yoga on Cancer-Related Fatigue and Quality of Life Among Racially and Ethnically Diverse Cancer Survivors: A Secondary Data Analysis.
Journal of integrative and complementary medicine – June 04, 2025
Summary
Yoga practice shows promising benefits for diverse cancer survivors, helping reduce fatigue and improve quality of life. A 4-week mindfulness-based yoga program combining gentle movement, meditation, and breathing techniques helped participants feel better physically and emotionally. Among diverse participants, 86% found the program beneficial for managing symptoms, with notable improvements in physical well-being and fatigue reduction.
Abstract
Introduction: Survivors from racially and ethnically diverse backgrounds tend to experience cancer-related fatigue (CRF) at higher rates than non-H...
Minding the Body: A Meta-analysis of the Effects of Mindfulness Meditation Training on Self-reported Interoception.
Research square – June 04, 2025
Summary
Mindfulness meditation does more than calm the mind - it enhances our ability to sense internal bodily signals. Analysis of 29 studies shows that mindfulness training significantly improves body awareness, particularly through structured programs. These improvements correlate with reduced psychological distress, suggesting that better mind-body connection supports mental wellbeing.
Abstract
Mindfulness meditation training may cultivate interoceptive awareness and provide therapeutic benefit when implemented within mental and physical h...
Modulation of ER Stress and Inflammation by S-Ketamine, R-Ketamine, and Their Metabolites in Human Microglial Cells: Insights into Novel Targets for Depression Therapy.
Cells – June 03, 2025
Summary
Recent breakthroughs show ketamine and its variants can fight depression by reducing cellular stress and inflammation in brain immune cells. Both forms of ketamine and their metabolites decrease key stress proteins (CHOP and GRP78) while lowering inflammatory signals. This suggests new ways to treat resistant depression with fewer side effects than current antidepressants.
Abstract
Despite affecting millions worldwide, major depressive disorder (MDD) remains a therapeutic challenge, with approximately one-third of patients fai...
An international Delphi consensus for reporting of setting in psychedelic clinical trials.
Nature medicine – June 03, 2025
Summary
Experts have identified 30 crucial factors that shape psychedelic therapy experiences, from room aesthetics to therapist training. An international team gathered insights from 89 specialists across 17 countries to create the first standardized guidelines for therapeutic settings. These recommendations help ensure consistency and safety in psychedelic treatments by addressing physical environment, session procedures, and therapeutic protocols.
Abstract
Psychedelic substances exhibit complex interactions with the 'set and setting' of use, that is, the mental state of the user and the environment in...
Effects of Psilocybin on Mouse Brain Microstructure.
AJNR. American journal of neuroradiology – June 03, 2025
Summary
Psilocybin, the active compound in magic mushrooms, creates measurable changes in brain structure that last for days after treatment. Scientists tracked these changes in mice using advanced brain imaging, revealing increased connectivity in areas controlling complex thinking and altered tissue structure in regions involved in memory and visual processing. These physical brain changes may explain psilocybin's promising effects on depression.
Abstract
There is surging interest in the therapeutic potential of psychedelic compounds like psilocybin in the treatment of psychiatric illnesses like majo...
Decoupling of motor cortex to movement in Parkinson's dyskinesia rescued by sub-anaesthetic ketamine.
Brain : a journal of neurology – June 03, 2025
Summary
Ketamine shows promise in treating movement complications from Parkinson's medication. Using in vivo electrophysiology in rats, researchers found that motor cortex activity becomes disconnected from actual movements during levodopa-induced dyskinesia. Sub-anesthetic ketamine helped restore this connection by reorganizing neural population states, reducing unwanted movements without disrupting normal motor function.
Abstract
Gamma-band and single-unit neural activity in primary motor cortex are involved in the control of movement. This activity is disrupted in Parkinson...
Correction: Effectiveness of Neurofeedback-Assisted and Conventional 6-Week Web-Based Mindfulness Interventions on Mental Health of Chinese Nursing Students: Randomized Controlled Trial.
Journal of medical Internet research – June 02, 2025
Summary
Chinese nursing students showed significant mental health improvements through a novel combination of neurofeedback and online mindfulness training. Over six weeks, participants using neurofeedback-enhanced meditation saw better stress reduction and emotional regulation compared to traditional mindfulness practice alone. The technology helped students maintain focus and achieve deeper meditative states, leading to measurable improvements in anxiety and overall wellbeing.
Abstract
[This corrects the article DOI: 10.2196/71741.].
MDMA-Assisted Treatment for PTSD, Anxiety, and Depression: A Visualized Literature Analysis over 30 Years.
Current medicinal chemistry – June 02, 2025
Summary
Over three decades of research reveals MDMA-assisted therapy shows remarkable promise in treating PTSD, anxiety, and depression. Analysis of 30 years of scientific literature shows a dramatic shift from studying MDMA's risks to exploring its therapeutic benefits. The U.S. leads research efforts, with breakthrough results demonstrating MDMA's potential to help patients process trauma and emotional distress in controlled therapeutic settings.
Abstract
The incidence of psychiatric disorders, such as post-traumatic stress disorder (PTSD), anxiety, and depression, has been steadily increasing, while...
Enhancing interoceptive awareness in chronic pain and opioid misuse via mindfulness-oriented recovery enhancement.
Drug and alcohol dependence – June 02, 2025
Summary
Many individuals with substance use issues report altered body awareness. For those with chronic pain, lower interoceptive awareness was specifically linked to higher opioid misuse. A Mindfulness-based program significantly enhanced interoception, successfully reducing opioid misuse over nine months. This suggests that boosting interoceptive awareness is a promising strategy for managing chronic pain and addressing opioid misuse.
Abstract
Individuals with substance use disorders often report altered interoceptive awareness of internal bodily signals. However, it is unclear whether th...