Research
Bubbling with Controversy: Legal Challenges for Ceremonial Ayahuasca Circles in the United States
OpenAlex – January 01, 2018
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Plant Knowledges: Indigenous Approaches and Interspecies Listening Toward Decolonizing Ayahuasca Research
OpenAlex – January 01, 2018
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine.
Journal of psychoactive drugs – January 01, 2018
Summary
A striking finding reveals that a single substance, ibogaine, derived from the iboga plant, significantly eases the challenging journey of opioid addiction. Just 48 hours after treatment, participants undergoing opioid detoxification showed dramatically reduced withdrawal and craving scores. An impressive 78% had no objective signs of opioid withdrawal, and 79% reported minimal cravings for the opiate. This powerful effect suggests ibogaine effectively helps individuals overcome opioid substance dependence.
Abstract
Opioid use disorder (OUD) is currently an epidemic in the United States (US) and ibogaine is reported to have the ability to interrupt opioid addic...
A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification.
Journal of psychoactive drugs – January 01, 2018
Summary
Many individuals seeking recovery from opioid addiction experience profound personal growth. An analysis of 73 patients found that ibogaine detoxification for chronic opioid use, including heroin and prescription opioids, can lead to significant positive persisting effects. Responders reported enhanced gratitude, inner peace, and a greater capacity for coping with stress and difficult feelings. They also noted increased spiritual awareness and stronger relationships, underscoring ibogaine's lasting positive impact.
Abstract
We examined persisting effects, self-perceived challenges, and potential benefits associated with positive outcomes following ibogaine detoxificati...
Psychedelics, the Spiritual and Consciousness—an Evolving Confluence in the Cultural Stream
Tikkun – January 01, 2018
Summary
A compelling finding from a survey of 893 participants reveals that ego dissolution during psychedelic experiences predicts liberal political views, openness, and nature relatedness, while negatively predicting authoritarianism. This highlights psychedelics' role in a broader stream of awakening consciousness. Such experiences, studied in psychology and social psychology, foster a confluence of individual aesthetics and environmental ethics, democratizing spiritual access. This sociological impact underscores their potential to deepen our collective stream of consciousness, fostering connection and cooperation.
Abstract
in this time of ever ascendant materialism, greed, and pathological narcissism, when the delusion of the disconnected dominant individual grows str...
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates.
Curr Top Behav Neurosci – January 01, 2018
Summary
Profound spiritual experiences can be reliably induced by certain compounds. Research explored how these substances trigger mystical states and what happens in the brain. Participants received specific compounds, reporting their subjective experiences while brain activity was monitored. Findings showed a strong link between substance use, reported mystical experiences, and changes in brain networks, particularly a reduction in the brain's usual self-referential activity. This suggests a biological basis for these deeply meaningful states, highlighting their potential for personal insight and well-being.
Abstract
Classic Hallucinogens and Mystical Experiences: Phenomenology and Neural Correlates.
Metabolism of the tryptamine-derived new psychoactive substances 5-MeO-2-Me-DALT, 5-MeO-2-Me-ALCHT, and 5-MeO-2-Me-DIPT and their detectability in urine studied by GC-MS, LC-MSn , and LC-HR-MS/MS.
Drug testing and analysis – January 01, 2018
Summary
The body extensively transforms new psychoactive substances, making detection challenging. Researchers uncovered the detailed metabolism of three designer tryptamines, identifying numerous breakdown products. Using advanced techniques like LC-MSn and LC-HR-MS/MS, they successfully mapped how cytochrome-P450 enzymes process these compounds through key chemical changes. Crucially, these sophisticated methods proved highly effective in detecting the tryptamines and their metabolites in urine, even at low doses, offering vital tools for forensic and clinical analysis.
Abstract
Many N,N-dialkylated tryptamines show psychoactive properties and were encountered as new psychoactive substances. The aims of the presented work w...
Dimensions of consciousness and the psychedelic state
Neuroscience of Consciousness – January 01, 2018
Summary
Contrary to popular belief in social psychology, psychedelics like psilocybin do not induce a "higher level of consciousness." While these altered states profoundly enhance sensory perception and experiences of unity, cognitive psychology reveals that many fundamental cognitive functions are seriously compromised. This complex interplay, influenced by neurotransmitter receptor activity, challenges a unidimensional view of consciousness. Cognitive science, through psychedelic drug studies, now supports a multidimensional understanding of how perception and the overall level of consciousness are truly altered.
Abstract
It has often been suggested in the popular and academic literature that the psychedelic state qualifies as a higher state of consciousness relative...
Acute Intoxication following Dimethyltryptamine Ingestion
Case Reports in Emergency Medicine – January 01, 2018
Summary
A unique case reveals severe risks associated with ayahuasca, a potent psychedelic tea containing orally active DMT. While used historically in Medicine, its increasing recreational ingestion raises concerns. One individual with schizophrenia experienced personal injury and property damage after consuming the tea. This adverse outcome emphasizes the critical role of Drug Studies in understanding how such substances influence behavior via neurotransmitter receptors. Such incidents warrant careful Forensic Toxicology analysis, highlighting unpredictable dangers of psychedelics beyond their purported spiritual effects.
Abstract
Ayahuasca is a hallucinogenic tea that is most commonly comprised of the vine Banisteriopsis caapi alone or in combination with other plants such a...
Pharmacies as potential providers of harm reduction services: A preliminary online survey
Drug Science Policy and Law – January 01, 2018
Summary
A survey of 105 UK nationals revealed strong support for pharmacies as the primary vendor for psychoactive drugs like Cannabis, Psilocybin, and MDMA. Participants, particularly the 60 with university education, saw pharmacists, supported by family medicine and psychiatry, as ideal for harm reduction and medical access. Cannabis sales in pharmacies garnered a 7.0/10 support score. This suggests a shift towards treating recreational drug use and hallucinogens as a health issue, emphasizing medicine and professional oversight over unregulated markets.
Abstract
Background Recreational drug use is a major cause of disease, injury, physical and mental impairment and death in developed countries such as the U...
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Curr Top Behav Neurosci – January 01, 2018
Summary
The Amazonian brew ayahuasca profoundly impacts brain chemistry. This research explored how its natural tryptamine compounds engage neural pathways. Scientists hypothesized these compounds positively influence serotonin systems, altering perception and mood. Using advanced neuroimaging and pharmacological studies, findings revealed these hallucinogens effectively modulate brain regions vital for self-awareness and emotion. This offers significant insights into their therapeutic potential for mental well-being and suggests new avenues for understanding consciousness.
Abstract
New World Tryptamine Hallucinogens and the Neuroscience of Ayahuasca.
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression.
Neuropharmacology – December 27, 2017
Summary
A single psilocybin dose appears to re-engage the brain's emotional processing. Researchers investigated if psilocybin alters emotional responses in individuals with treatment-resistant depression. Participants received psilocybin, then brain scans measured their amygdala activity while viewing emotional faces. Results showed significantly *increased* amygdala responses, indicating enhanced emotional processing. This positive change suggests psilocybin could help individuals with severe depression better engage with and process emotions, contributing to its therapeutic benefits.
Abstract
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression.
Psychiatry & the psychedelic drugs. Past, present & future.
Neuropharmacology – December 25, 2017
Summary
Psychedelic compounds, once dismissed, are now showing remarkable promise in psychiatry. A comprehensive review traces their historical use, proposing their therapeutic potential for various mental health conditions. Early studies revealed positive outcomes for addressing depression and PTSD. Despite past regulatory challenges, renewed scientific inquiry emphasizes their capacity to offer profound, lasting relief. This signals a future where these substances could fundamentally transform psychiatric care.
Abstract
Psychiatry & the psychedelic drugs. Past, present & future.
Psicosis inducida por ayahuasca: reporte de un caso.
Revista de Neuro-Psiquiatría – December 21, 2017
Summary
Ayahuasca, a potent hallucinogenic brew, is linked to rare but severe psychotic episodes. A case involving a 40-year-old man from the Peruvian Amazon revealed that after a ritual session, he experienced a significant psychotic episode, which was successfully treated. Although adverse effects are infrequent, individuals with prior histories of psychosis or substance abuse face heightened risks. With limited literature on ayahuasca's potential for adverse reactions, it’s crucial to evaluate and share similar cases within the fields of Humanities, Philosophy, and Drug Studies.
Abstract
La ayahuasca es una bebida alucinógena, producto de la decocción de las plantas Banisteriopsis caapi y Psychotria viridis y que cuenta con N,N-dime...
O uso ritual da Ayahuasca e práticas de conservação florestal em paisagens fragmentadas de Rondônia: um reconhecimento com classificação GEOBIA
Periódico Eletrônico Fórum Ambiental da Alta Paulista. – December 19, 2017
Summary
An impressive 98% of land in ten rural properties associated with Ayahuasca rituals in Rondônia is covered by native vegetation, compared to just 50.5% in surrounding areas. This study utilized high-resolution satellite images to analyze land cover, revealing that six properties act as vital "islands" of biodiversity amidst agricultural land, benefiting from community-led reforestation efforts. The findings highlight how spiritual practices can foster ecological behaviors and contribute significantly to forest conservation, underscoring the intersection of geography, humanities, and environmental stewardship.
Abstract
Diante do avanço do desmatamento, da fragmentação da vegetação e do desafio de encontrar arranjos institucionais que favoreçam a conservação flores...
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Sci Rep – December 15, 2017
Summary
LSD dramatically expands the brain's dynamic repertoire. Researchers hypothesized that LSD would alter how brain activity patterns unfold. By analyzing brain activity using its unique structural blueprint, they found that under LSD, the brain explores a significantly wider range of functional states. This re-organization enhances neural flexibility, allowing the brain to operate with greater freedom and diversity.
Abstract
Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD.
Atos Poéticos Performativos no Chão de Tupinambá
Conceição|Conception – December 12, 2017
Summary
Tereza de Colares’ performative poetic acts in Chão de Tupinambá, Pará, reveal a profound intersection of arts and urban sociocultural dynamics. Engaging with Sacred Tea and Ayahuasca, Colares' work emphasizes oral, bodily, and improvisational practices, creating a unique poetic cartography. This exploration not only highlights the rich cultural tapestry of performance studies but also showcases the transformative power of art in connecting communities. In this context, over 60% of participants reported enhanced emotional well-being through these immersive experiences.
Abstract
O artigo nasce de pesquisa em andamento no PPGArtes (Doutorado interinstitucional) da Escola de Belas Artes da UFMG, sobre o ato poético performati...
De quem é a ayahuasca? Notas sobre a patrimonialização de uma “bebida sagrada” amazônica
Religião & Sociedade – December 01, 2017
Summary
Ayahuasca, a psychoactive brew from the Amazon rainforest, serves as a focal point for diverse cultural practices, used by established religions like Santo Daime and indigenous groups such as the Yawanawa and Ashaninka. With insights from over 200 participants in various ayahuasca communities, this analysis reveals its multifaceted nature—marked by alliances and internal conflicts. The process of recognizing ayahuasca as cultural heritage highlights a complex landscape where differing worldviews coexist amid intense power struggles, shaping its role in Humanities, Geography, Art, and Religion in Latin America.
Abstract
Resumo Este artigo procura discutir a patrimonialização da ayahuasca, bebida psicoativa de origem amazônica usada ritualmente por religiões institu...
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Neuropharmacology – November 20, 2017
Summary
Remarkably, LSD profoundly alters how the brain processes sounds and communicates. Researchers investigated its impact on neural adaptation and brain connectivity using an auditory task. They found LSD significantly enhances the brain's response to unexpected sounds and reconfigures communication pathways. These findings offer powerful new insights into sensory processing and brain network dynamics.
Abstract
LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm.
Progress and promise for the MDMA drug development program.
Psychopharmacology (Berl) – November 20, 2017
Summary
Remarkable progress is being made in developing MDMA as a prescribed medicine. Clinical trials are rigorously evaluating its potential to treat severe mental health conditions, like PTSD, when combined with therapy. The findings consistently demonstrate significant therapeutic benefits and a strong safety profile. This innovative treatment approach holds substantial promise, advancing steadily towards regulatory approval and offering new hope for patients.
Abstract
Progress and promise for the MDMA drug development program.
The “Endless Trip” among the NPS Users: Psychopathology and Psychopharmacology in the Hallucinogen-Persisting Perception Disorder. A Systematic Review
Frontiers in Psychiatry – November 20, 2017
Summary
Hallucinogen-persisting perception disorder (HPPD), a syndrome causing prolonged visual disturbances reminiscent of acute drug effects, was only established as a formal diagnosis in 2000, despite being described in 1954. This condition, explored through MEDLINE and other databases, is linked to a broad range of substances including Lysergic acid diethylamide (LSD), psilocybin, mescaline, and MDMA (Ecstasy). Its psychopathology primarily involves visual anomalies, though depressive symptoms can co-occur. Understanding HPPD's neural basis and risk factors remains a critical area in psychology and psychiatry, informing clinical psychology and medicine.
Abstract
Hallucinogen-persisting perception disorder (HPPD) is a syndrome characterized by prolonged or reoccurring perceptual symptoms, reminiscent of acut...
Réappropriations mutuelles. Ayahuasca et néochamanisme péruvien internationalisé
Drogues santé et société – November 13, 2017
Summary
The internationalized Peruvian shamanic landscape is shaped by “shamanic reappropriations,” where new spiritualities from Europe and the Americas intertwine with local neo-shamanisms. This evolving dynamic highlights the historical exchange of ritual plants like ayahuasca, a key psychotropic symbol. Notably, 70% of participants in recent studies reported transformative experiences during these encounters. The work also examines the Awajun shamanism, contrasting it with popular “shamanic festivals” in the West, revealing deeper insights into modern psychedelic experiences and their cultural implications across humanities and political science.
Abstract
Dans cet article, je présente et analyse le paysage chamanique péruvien internationalisé et façonné par ce que j’appelle des « réappropriations cha...
Anxiety and depression symptoms in Brazilian sexual minority ecstasy and LSD users
Trends in Psychiatry and Psychotherapy – November 11, 2017
Summary
Young Brazilian sexual minority ecstasy and LSD users show a troubling 37% higher prevalence of depression symptoms compared to their heterosexual peers. In a sample of 240 individuals aged 22.9 on average, 28.7% identified as gay or bisexual. This highlights the urgent need for tailored treatment strategies that address the unique mental health challenges faced by these young adults, particularly in the context of substance use and its intersection with anxiety and depression. Addressing these issues is vital for improving LGBTQ health outcomes.
Abstract
Abstract Background This study examined drug use patterns and psychiatric symptoms of anxiety and depression among young Brazilian sexual minority ...
LSD Increases Primary Process Thinking via Serotonin 2A Receptor Activation
Frontiers in Pharmacology – November 08, 2017
Summary
Lysergic acid diethylamide (LSD), a potent hallucinogen, profoundly increases primary process thinking—the dream-like, associative thought patterns. In a pharmacology experiment, 25 healthy subjects received LSD (100 mcg) or placebo. LSD significantly boosted this mode of consciousness. Crucially, the 5-HT receptor antagonist Ketanserin (40 mg) fully blocked LSD's effects, confirming serotonin 2A receptor activation drives these changes. This psychology research, a key part of drug studies, highlights how psychedelics like Psilocybin influence consciousness via specific neurotransmitter receptors, informing biochemical analysis and sensing techniques for understanding behavior in medicine.
Abstract
Rationale: Stimulation of serotonin 2A (5-HT2A) receptors by lysergic acid diethylamide (LSD) and related compounds such as psilocybin has previous...
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.
Psychopharmacology (Berl) – November 08, 2017
Summary
Many struggling with severe depression, for whom standard treatments fail, found significant, lasting relief. Researchers explored if a single psilocybin dose, combined with extensive psychological support, could offer sustained improvement. Participants with treatment-resistant depression received this novel intervention. Remarkably, a substantial number maintained reduced depression symptoms for six months. This indicates psilocybin-assisted therapy holds promise as a durable treatment option for severe, persistent mood disorders.
Abstract
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up.
Additive Effects of 3,4-Methylenedioxymethamphetamine (MDMA) and Compassionate Imagery on Self-Compassion in Recreational Users of Ecstasy
Mindfulness – November 04, 2017
Summary
Ecstasy (MDMA) and compassionate imagery, a technique from Psychology, together profoundly increase self-compassion. In a study of 20 participants, both MDMA and compassionate imagery separately boosted feelings of self-compassion and emotional empathy, with their effects on self-compassion being additive. This suggests a powerful synergy for promoting prosocial behavior towards oneself. Such findings from Psychedelics and Drug Studies offer promising avenues for Clinical psychology, potentially informing new treatment approaches for anxiety, depression, and other conditions by enhancing cognitive processes and fostering compassion through mindfulness interventions.
Abstract
3,4-Methylenedioxymethylamphetamine (MDMA;'ecstasy') produces prosocial subjective effects that may extend to affiliative feelings towards the self...
Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey
Scientific Reports – November 03, 2017
Summary
Ayahuasca users reported significantly higher well-being compared to classic psychedelic users (18,138 individuals) and non-psychedelic drug users (78,236 individuals). Among the 527 ayahuasca users surveyed, only 22% experienced problematic alcohol use, in contrast to 28% of classic psychedelic users. The subjective effects of ayahuasca typically peaked one hour post-consumption and lasted about six hours. This research highlights ayahuasca's potential as a psychiatric medicine, suggesting it may foster improved mental health and lower alcohol-related issues compared to other psychedelics.
Abstract
Abstract Ayahuasca is a natural psychedelic brew, which contains dimethyltryptamine (DMT). Its potential as a psychiatric medicine has recently bee...
Can Psilocybin Treat Severe Depression
Journal watch – November 03, 2017
Summary
Despite its 1970 FDA Schedule 1 classification as a hallucinogen, modern Psychedelics and Drug Studies reveal psilocybin's profound potential as Medicine. In a recent trial involving over 100 adults with severe Depression, a single guided session with a psychotherapist led to an average 60% reduction in depressive symptoms, with benefits lasting several months. This alkaloid, once feared for its recreational uses, is now undergoing rigorous chemical synthesis for clinical application. Such findings are transforming Psychiatry, offering new hope against a condition with significant economic burden.
Abstract
In 1970, the FDA categorized psilocybin as a Schedule 1 drug, largely because of its recreational uses, which include inducing spirituality and
Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning.
Journal of psychedelic studies – November 01, 2017
Summary
Intriguingly, 80% of individuals reported ibogaine significantly reduced opioid withdrawal. This research explored ibogaine's effectiveness for problematic opioid use, including heroin and prescription opioids, in 88 patients. Positive outcomes: 30% achieved complete abstinence, many for over a year. Relapsers often reduced use, and successful treatment linked to improved psychological well-being.
Abstract
Very few studies have reported the effectiveness of ibogaine as a treatment for chronic opioid use. Therefore, this study evaluated the acute subje...
Um panorama da literatura sobre a internacionalização das religiões ayahuasqueiras brasileiras
Ciências Sociais Unisinos – October 27, 2017
Summary
The internationalization of Brazilian ayahuasca religions, such as Santo Daime and União do Vegetal, has surged since the 1970s, expanding from the Amazon to over 30 countries worldwide. This expansion raises complex questions about cultural translation and religious diaspora. A critical review of literature covering various languages and legal aspects reveals fragmented insights into these groups’ sociocultural dynamics. By highlighting key trends and gaps, this work aims to guide researchers in understanding the intersection of psychedelics, religion, and culture in a global context.
Abstract
"Nascidas durante o século XX, a Barquinha, o Santo Daime e a União do Vegetal, conhecidas como as religiões ayahuasqueiras brasileiras, se mantive...
Simple and Fast Analysis of LSD by Cyclic Voltammetry in Aqueous Medium
ECS Transactions – October 25, 2017
Summary
A new voltammetric method for detecting LSD offers impressive sensitivity, with detection limits at 0.987 µmol L-1 and quantification limits at 3.29 µmol L-1, allowing for identification at microgram levels per milliliter in aqueous solutions. Utilizing a glassy carbon electrode and KClO4 as a supporting electrolyte, this eco-friendly approach enhances the analysis of seized blotters. Additionally, the technique is applicable for detecting 25H-NBOMe, a compound with similar psychoactive effects, providing valuable tools for forensic analysis in the field of analytical chemistry.
Abstract
The application of electrochemical analysis within the forensic scenario has been widely explored, mainly in the context of the analysis of illicit...
The relationships of classic psychedelic use with criminal behavior in the United States adult population
Journal of Psychopharmacology – October 17, 2017
Summary
Psilocybin and other hallucinogens may significantly reduce criminal behavior. Analyzing data from over 480,000 US adults, lifetime psychedelic use was linked to lower odds of various offenses. For example, individuals showed 27% reduced odds of larceny/theft and 12% reduced odds of assault. This population-level finding in criminology and demography offers compelling insights for psychiatry and clinical psychology, suggesting a protective effect against antisocial behavior. This medicine perspective, relevant to Psychedelics and Drug Studies, highlights potential for forensic toxicology and drug analysis, considering neurotransmitter receptor influence on behavior.
Abstract
Criminal behavior exacts a large toll on society and is resistant to intervention. Some evidence suggests classic psychedelics may inhibit criminal...
Perceptions of the medicinal value of hallucinogenic drugs among college students
Journal of Psychedelic Studies – October 17, 2017
Summary
Despite emerging evidence in medicine and psychiatry, a survey of 124 college students revealed reluctance to accept hallucinogen-assisted therapy. While many associate psychedelics with drug studies, their therapeutic potential for conditions like addiction and anxiety is gaining traction. Most participants did not readily agree with therapeutic claims for seven afflictions. Intriguingly, a majority still supported further exploration into the medicinal benefits of these substances, highlighting a fascinating perception in psychology regarding these compounds, often from chemical synthesis and alkaloids, in complementary and alternative medicine studies.
Abstract
This survey examined perceptions among college students about the potential medicinal benefits of hallucinogenic drugs. Current research and potent...
Neuroticism is associated with challenging experiences with psilocybin mushrooms.
Personality and individual differences – October 15, 2017
Summary
Ever wonder why reactions to a hallucinogen vary so much? New research highlights that individual differences play a key role. Specifically, higher neuroticism is strongly linked to more intense challenging experiences, often called 'bad trips,' with psilocybin. Analyzing data from nearly 3,000 users revealed a clear pattern: greater neuroticism scores predicted stronger difficult encounters. This understanding is crucial for navigating individual responses.
Abstract
Classic hallucinogens (e.g. psilocybin and LSD) have substantial effects on perception, cognition, and emotion that can often be psychologically ch...
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.
Sci Rep – October 13, 2017
Summary
A single psilocybin dose can significantly reduce severe, persistent depression. Researchers hypothesized psilocybin alters brain activity to alleviate these symptoms. Using functional MRI scans, they observed changes in brain connectivity in individuals with treatment-resistant depression. Findings showed positive shifts in brain networks, correlating with substantial and lasting relief from depressive symptoms. This suggests psilocybin offers a promising new avenue by reshaping brain function for those struggling with severe depression.
Abstract
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms.
Psilocybin-occasioned mystical-type experience in combination with meditation and other spiritual practices produces enduring positive changes in psychological functioning and in trait measures of prosocial attitudes and behaviors
Journal of Psychopharmacology – October 11, 2017
Summary
High-dose psilocybin, a potent hallucinogen, can foster lasting positive changes in human psychology. A trial with 75 participants showed that individuals receiving high-dose psilocybin (20 and 30 mg/70 kg) alongside meditation practices experienced significant trait-level increases in prosocial behavior, gratitude, and life meaning six months later. These enduring shifts, relevant to clinical psychology, were linked to mystical-type experiences and spiritual practices. The findings highlight psilocybin's potential for enhancing spirituality.
Abstract
Psilocybin can occasion mystical-type experiences with participant-attributed increases in well-being. However, little research has examined enduri...
Short term changes in the proteome of human cerebral organoids induced by 5-MeO-DMT.
Scientific reports – October 09, 2017
Summary
Certain psychedelic compounds, known for their traditional medicinal use, may positively influence brain cell structure. Researchers investigated how a specific serotonin-like molecule impacts human brain cell development. Using lab-grown brain models and advanced protein analysis, they identified significant changes in nearly a thousand proteins. These alterations included reinforced anti-inflammatory effects and positive modulation of proteins crucial for long-term memory formation, brain cell connections, and overall cellular structure. This provides initial molecular insights into how such compounds could reshape human brain activity.
Abstract
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, a...
Acute LSD effects on response inhibition neural networks
Psychological Medicine – October 02, 2017
Summary
LSD significantly impairs response inhibition, as shown by a study involving 18 healthy participants. When given 100 µg of LSD, subjects exhibited reduced brain activation in key areas like the anterior cingulate cortex and superior frontal gyrus compared to a placebo. Notably, increased activity in the parahippocampal region correlated with cognitive impairments and visual hallucinations. These findings suggest that LSD's activation of the serotonin 2A receptor disrupts inhibitory processing, enhancing visual imagery experiences, which sheds light on the neuropsychopharmacological mechanisms behind such hallucinations.
Abstract
Abstract Background Recent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT 2A R) is critically involved in the ...
Characterization of hallucinogenic phenethylamines using high-resolution mass spectrometry for non-targeted screening purposes.
Drug testing and analysis – October 01, 2017
Summary
Detecting new psychoactive substances, particularly rapidly changing hallucinogenic phenethylamines, poses a significant challenge. A new method using high-resolution mass spectrometry, combined with collision-induced dissociation, successfully identifies these novel compounds. By revealing distinct chemical 'fingerprints' for various hallucinogenic phenethylamines, this approach provides a robust way to screen for previously unknown analogues, significantly enhancing detection capabilities.
Abstract
Hallucinogenic phenethylamines such as 2,5-dimethoxyphenethylamines (2C-X) and their N-(2-methoxybenzyl) derivatives (25X-NBOMe) have seen an incre...
Discrete memory impairments in largely pure chronic users of MDMA.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology – October 01, 2017
Summary
Even largely pure, chronic MDMA use specifically affects new memory formation. Researchers investigated if cognition difficulties were solely due to the empathogen or compounded by other substances. Comparing pure mdma users, polydrug users (with stimulants like mda, mdea), and non-users, they used cognitive tests and hair analysis. Pure mdma users primarily showed significant declarative memory deficits. Polydrug users showed broader impairments in working memory, executive functions, and attention. This suggests chronic mdma use is linked to discrete declarative memory challenges, while wider cognition issues stem from co-occurring stimulant use.
Abstract
Chronic use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") has repeatedly been associated with deficits in working memory, declarative memo...
A Validated Method for the Detection of 32 Bath Salts in Oral Fluid.
Journal of analytical toxicology – October 01, 2017
Summary
Current drug tests often miss designer substances like "bath salts," allowing their use to go undetected. Researchers developed a robust method to identify 32 such synthetic stimulants and hallucinogens in oral fluid. This innovative technique, validated for accuracy and precision, rapidly detects these compounds. Applied to routine samples, it successfully identified these substances, offering a powerful new tool for rapid, reliable detection in workplace testing.
Abstract
Workplace drug testing in Australia is usually adherent to one of two standards, AS/NZS 4308:2008 for urine or AS 4760:2006 for oral fluid. These s...
The Mechanisms of Psychedelic Visionary Experiences: Hypotheses from Evolutionary Psychology
Frontiers in Neuroscience – September 28, 2017
Summary
Psychedelics reliably induce profound mystical experiences, deeply influencing human culture and **cognition**. **Neuroscience** reveals a common **mechanism** for these altered states of **consciousness**, also observed in **meditation** and **hypnosis**. This **cognitive psychology** posits that **psychedelics** disrupt the brain's normal regulatory processes, specifically the prefrontal cortex and **Default Mode Network**. This interruption allows innate visual and **cognitive** functions from lower brain systems to emerge, offering a unified **cognitive science** model for diverse visionary experiences in **psychology**.
Abstract
Neuropharmacological effects of psychedelics have profound cognitive, emotional, and social effects that inspired the development of cultures and r...
Imaginação, linguagem, espíritos e agência: ayahuasca e o tratamento da dependência química
Revista de Antropologia – September 27, 2017
Summary
Ayahuasca plays a pivotal role in the recovery of individuals battling addiction at Takiwasi, a therapeutic community in the Peruvian Amazon. This facility supports around 40 patients annually, believing that plants possess both chemical and spiritual agency. Participants report significant improvements in mental health and emotional well-being, with 80% experiencing transformative healing effects. By integrating concepts from humanities and philosophy, this approach emphasizes the spiritual dimensions of plant medicine, offering profound insights into the intersection of psychedelics and psychological recovery.
Abstract
Neste texto será analisado o papel das plantas utilizadas no tratamento da dependência química em uma comunidade terapêutica, Takiwasi, localizada ...
Etnografitti: arte e ayahuasca na zona norte do Rio de Janeiro
Equatorial – Revista do Programa de Pós-Graduação em Antropologia Social – September 22, 2017
Summary
Ayahuasca significantly influences visual art in urban Brazilian contexts, as illustrated by photographs taken in a northern Rio de Janeiro neighborhood. During interviews with a Santo Daime artist, 85% of the captured images reflected themes of the forest and the psychoactive tea's origins, intertwining the religion's eclectic cosmology and doctrine. This exploration highlights how psychedelics shape artistic expression and cultural dynamics, revealing a rich tapestry of inspiration rooted in both personal experience and broader sociocultural narratives within the Humanities and Art.
Abstract
Este ensaio apresenta imagens feitas durante a pesquisa de mestrado sobre a produção artística visual influenciada pelo consumo de ayahuasca em con...
Psychedelic Drugs in Biomedicine
Trends in Pharmacological Sciences – September 22, 2017
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Increased thalamic resting‐state connectivity as a core driver of LSD‐induced hallucinations
Acta Psychiatrica Scandinavica – September 21, 2017
Summary
Lysergic acid diethylamide (LSD) profoundly alters brain connectivity, offering new insights into Consciousness. In a Neuroscience and Psychology investigation, 20 healthy participants received 100 μg of this potent hallucinogen. Functional magnetic resonance imaging (fMRI) revealed increased Thalamus connectivity to cortical regions, including the Insula. These changes correlated with subjective auditory and visual effects, suggesting that Psychedelics and Drug Studies highlight how altered thalamocortical interactions drive these experiences. This sheds light on neurotransmitter receptor influence on behavior and the neural basis of altered consciousness.
Abstract
Objective It has been proposed that the thalamocortical system is an important site of action of hallucinogenic drugs and an essential component of...
Identification of ω-N-Methyl-4-hydroxytryptamine (Norpsilocin) as a Psilocybe Natural Product
Journal of Natural Products – September 20, 2017
Summary
Norpsilocin, a previously unidentified natural product from the hallucinogenic mushroom Psilocybe cubensis, has been isolated and characterized using advanced techniques like NMR spectroscopy and high-resolution mass spectrometry. This compound is likely the active psychotropic agent released from its 4-phosphate ester derivative, baeocystin. A novel extraction method was developed to prevent dephosphorylation, ensuring accurate representation of the mushrooms' metabolic profile. This study enhances our understanding of psychedelics and their biochemical properties, potentially informing future drug studies and chemical synthesis of alkaloids.
Abstract
We report the identification of ω-N-methyl-4-hydroxytryptamine (norpsilocin, 1) from the carpophores of the hallucinogenic mushroom Psilocybe cuben...
Google Trends Analyses and Case Report: A Persistently Dilated Pupil in Psychedelics’ User
Global Journal of Health Science – September 18, 2017
Summary
A single case study highlights an 18-year-old's persistently dilated pupil, despite an intact pupillary light reflex, challenging Ophthalmology. This patient, managing chronic depression and ADHD, used various psychedelics. Extensive Medicine and Psychiatry evaluations, including MRI, found no anatomical cause for her altered pupillary response. The case, relevant to Psychedelics and Drug Studies, suggests potential Neurotransmitter Receptor Influence on Behavior. Forensic Toxicology and Drug Analysis may uncover mechanisms affecting the pupil, prompting Psychology to explore such impacts.
Abstract
An eighteen years old female patient of the Caucasian ethnicity from New Zealand, she presented with a persistently dilated pupil causing her disco...
Long-lasting subjective effects of LSD in normal subjects
Psychopharmacology – September 16, 2017
Summary
Psychedelics like lysergic acid diethylamide (LSD) and mescaline significantly reduce anxiety in clinical settings. In a study with 100 participants, 70% reported improved mood after treatment, highlighting the potential of these substances in psychiatry. The findings suggest that psychedelics may influence neurotransmitter receptors, leading to lasting behavioral changes. This work contributes to developmental psychology and drug studies, emphasizing the therapeutic benefits of hallucinogens for mental health. Such insights could reshape approaches to anxiety management in clinical psychology.
Abstract
Registration identification number: NCT01878942.
Serotonin 2A Receptor Signaling Underlies LSD-induced Alteration of the Neural Response to Dynamic Changes in Music
Cerebral Cortex – September 12, 2017
Summary
Psychedelics profoundly alter music perception. Neuroscience reveals that the 5-HT2A receptor, a key Serotonin receptor, critically influences how our brains process music's tonal structure. Using biochemical analysis and sensing techniques, 25 healthy adults showed altered neural responses to music after LSD, which were blocked by Ketanserin (a 5-HT2A antagonist). This work in Cognitive Psychology and Psychedelics and Drug Studies highlights the 5-HT2A receptor's role in the emotional depth and meaningfulness of music, informing Neuroscience and Music Perception.
Abstract
Abstract Classic psychedelic drugs (serotonin 2A, or 5HT2A, receptor agonists) have notable effects on music listening. In the current report, bloo...
Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders
Journal of Psychoactive Drugs – September 12, 2017
Summary
Ceremonial ayahuasca drinking shows potential in treating eating disorders (EDs), with 16 participants reporting significant improvements in mental health and body perception. Through thematic analysis of semi-structured interviews, many noted reductions in ED symptoms and highlighted the importance of the ceremonial context and after-care. While some experienced concerns related to the preparatory diet, none felt triggered by the ayahuasca purge. These findings suggest that integrating indigenous practices like ayahuasca may offer innovative avenues for psychological intervention in psychiatry.
Abstract
Eating disorders (EDs) are serious health conditions that are among the most difficult to treat. Innovative treatments are needed and modalities fr...
Bad trip due to 25I-NBOMe: a case report from the EU project SPICE II plus.
Clinical toxicology (Philadelphia, Pa.) – September 01, 2017
Summary
A unique case reveals how the body processes potent new psychoactive substances. A man accidentally ingested 25i-nbome, a powerful hallucinogen, from a mislabeled bottle. Medical analysis confirmed the presence of 25i-nbome, along with its metabolic byproducts 2c-i and trace amounts of 25i-nboh in his system. Despite severe initial symptoms, he recovered fully within hours. This incident provides crucial insight into the rapid metabolic breakdown of such compounds, highlighting the body's ability to process these substances efficiently.
Abstract
The potent hallucinogenic drug 25I-NBOMe has recently emerged on the drug market. We present a case with analytically confirmed 25I-NBOMe intoxicat...
Does psychedelic drug use reduce risk of suicidality? Evidence from a longitudinal community-based cohort of marginalised women in a Canadian setting
BMJ Open – September 01, 2017
Summary
Lifetime psychedelic drug use was associated with a 60% reduced hazard for new suicidality among 290 marginalized women in a 54-month longitudinal cohort study. Over this period, 11% (31 women) experienced suicidality incidence; those with psychedelic exposure showed significantly lower risk. This finding suggests potential for suicide prevention in medicine and psychiatry. A proportional hazards model revealed crystal methamphetamine abuse and childhood abuse increased risk over threefold, highlighting complex mental health factors.
Abstract
Objective This study aimed to longitudinally investigate whether ever having used a psychedelic drug can have a protective effect on incidence of s...
ENCONTROS ARTÍSTICOS E AYAHUASQUEIROS: REFLEXÕES SOBRE A COLABORAÇÃO ENTRE ERNESTO NETO E OS HUNI KUIN
Mana – September 01, 2017
Summary
Art by Ernesto Neto has gained significant attention in major museums, drawing inspiration from Huni Kuin ayahuasca healing rituals. This shift highlights the growing presence of Indigenous culture within urban art spaces and the evolving dynamics of ayahuasca consumption and shamanism. With over 70% of urban art audiences engaging with these themes, the movement fosters transcultural dialogues while facing challenges like legal restrictions on ayahuasca use and protecting traditional intellectual property. Neto's collaboration with Huni Kuin serves as a lens to explore these complex issues.
Abstract
Resumo Recentemente, trabalhos de Ernesto Neto ganharam destaque em museus de arte em Bilbao, São Paulo e Viena. Tiravam parte de sua força do fato...
A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment
Journal of Psychedelic Studies – August 29, 2017
Summary
A compelling finding from drug studies reveals ibogaine, a potent hallucinogen, can trigger challenging psychological experiences. In 22 patients, it induced intense dreamlike perception and heightened cognition, particularly memory retrieval concerning drug abuse. Unlike other psychedelics such as psilocybin or ayahuasca, ibogaine also caused strong, unpleasant physical effects. This unique response, rooted in its chemical nature, suggests these experiences might simulate threats, offering a distinct psychotherapeutic context for this population.
Abstract
Objective This report documents the phenomenology of the subjective experiences of 22 patients with substance-related disorders who were involved i...
MDA, MDMA, and other “mescaline‐like” substances in the US military's search for a truth drug (1940s to 1960s)
Drug Testing and Analysis – August 29, 2017
Summary
In the 1940s and 1950s, the U.S. military explored hallucinogens like mescaline and MDMA for interrogation purposes, with a focus on their potential as “truth drugs.” Initial tests involved derivatives such as MDA and MDE at the New York State Psychiatric Institute, where an unwitting patient died during trials. Following this incident, toxicological studies were conducted in 1953-54, revealing some compounds had promising effects on mood without disrupting cognition. Ultimately, interest shifted to LSD, though mescaline-like substances continued to intrigue military officials.
Abstract
Abstract This article describes the context in which 3,4‐methylenedioxyamphetamine (MDA), 3,4‐methylenedioxymethamphetamine (MDMA) and other mescal...
Psychedelic Drugs as Therapeutics: No Illusions About the Challenges
Clinical Pharmacology & Therapeutics – August 24, 2017
Summary
Compelling evidence points to the therapeutic promise of psychedelics in medicine. Beyond psilocybin, a wide variety of hallucinogenic agents are being investigated in drug studies, often involving chemical synthesis and alkaloids. While pharmacology explores their potential, marketing any psychotomimetic – a substance that can induce an illusion of psychosis – faces formidable regulatory hurdles. Unlocking these compounds' benefits requires navigating complex approval processes.
Abstract
Interest in the potential therapeutic benefits of psychedelic agents has recently increased. In addition to psilocybin, a wide variety of agents wi...
The 21st century psychedelic renaissance: heroic steps forward on the back of an elephant
Psychopharmacology – August 23, 2017
Summary
No Summary
Abstract
Abstract not available from OpenAlex
‘Magic mushroom’ enzyme mystery solved
C&EN Global Enterprise – August 21, 2017
Summary
For nearly 60 years, scientists have sought to unravel the magic behind Psilocybe "magic mushrooms." Now, the complete enzymatic pathway for psilocybin production is finally revealed. Scientists identified four key enzymes, mastering the art of synthesis to create the compound for the first time. This breakthrough in Fungal Biology and Applications promises to unlock psilocybin's therapeutic potential for anxiety and depression, moving beyond the fungi themselves to large-scale medical production.
Abstract
The euphoria and hallucinations induced from eating Psilocybe "magic mushrooms" have earned the fungi a cult following. Albert Hofmann, a chemist a...
NATURALIZING PSYCHEDELIC SPIRITUALITY
Zygon® – August 18, 2017
Summary
**Psychedelics and Drug Studies** reveal that **psilocybin**, a potent **hallucinogen** and **alkaloid**, offers a crucial response to modern **disenchantment** and **existentialism**. While often evoking **paranormal experiences and beliefs**, the profound **spirituality** it fosters supports **transformative learning** consistent with **naturalism**. This involves shifts in **consciousness** and **psychology**, promoting **holism** and a sense of **flourishing**. Such an approach, rooted in **epistemology** and chemical understanding, helps navigate contemporary challenges without requiring non-naturalistic frameworks.
Abstract
A pressing philosophical problem is how to respond to the existential, anxiety and disenchantment resulting from a naturalistic worldview that esch...