Research
A non-hallucinogenic psychedelic analogue with therapeutic potential.
Nature – January 01, 2021
Summary
Psychedelic compounds show promise for addiction treatment but pose risks like hallucinations. Researchers have engineered tabernanthalog, a non-hallucinogenic, non-toxic analogue of ibogaine. In rodent models, this innovative molecule promoted brain cell growth and connections, significantly reduced alcohol and heroin seeking, and demonstrated antidepressant-like effects. This breakthrough suggests that carefully designed, safer psychedelics could offer therapeutic potential for substance use disorders and mood conditions.
Abstract
The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals1. Unlike most medications for the treatment of substance...
Managing Insomnia Using Lucid Dreaming Training: A Pilot Study.
Behavioral sleep medicine – January 01, 2021
Summary
No Summary
Abstract
Objectives/Background: Despite Cognitive Behavioral Therapy for Insomnia (CBT-I) being considered the first-line treatment for insomnia, it is not ...
Making "bad trips" good: How users of psychedelics narratively transform challenging trips into valuable experiences.
The International journal on drug policy – January 01, 2021
Summary
No Summary
Abstract
We study the significance of stories about bad trips among users of psychedelics. Drawing on narrative theory, we describe the characteristics of s...
Tags
Corrigendum: A Review on Research and Evaluation Methods for Investigating Self-Transcendence.
Frontiers in psychology – January 01, 2021
Summary
No Summary
Abstract
[This corrects the article DOI: 10.3389/fpsyg.2020.547687.].
Exploratory Controlled Study of the Migraine-Suppressing Effects of Psilocybin.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics – January 01, 2021
Summary
A single dose of psilocybin significantly reduced weekly migraine days for weeks. Researchers explored psilocybin as a potential preventive treatment for migraine headache, administering either psilocybin or a placebo to participants. Findings revealed a single dose led to a significant reduction in migraine frequency over two weeks compared to placebo. Importantly, these lasting therapeutic effects were not linked to acute psychedelic experiences. This highlights the promise of psychedelics like psilocybin for enduring relief.
Abstract
While anecdotal evidence suggests that select 5-hydroxytryptamine 2A (5-HT2A) receptor ligands, including psilocybin, may have long-lasting therape...
Relational Processes in Ayahuasca Groups of Palestinians and Israelis.
Frontiers in pharmacology – January 01, 2021
Summary
No Summary
Abstract
Psychedelics are used in many group contexts. However, most phenomenological research on psychedelics is focused on personal experiences. This pape...
Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids.
The Alkaloids. Chemistry and biology – January 01, 2021
Summary
LSD's discovery sparked intense interest in ergot alkaloids. Research explores their biosynthesis and total synthesis, revealing how natural products like Chanoclavine and Clavicipitic acid form the ergoline scaffold. New chemical methodologies enable efficient production of these indole-based compounds, including Lysergic acid, Lysergol, and Isolysergol. Understanding the structure-activity relationship of alkaloids like Aurantioclavine, Cycloclavine, and Rugulovasine advances pharmaceutical chemistry, offering new avenues for treating neurological disorders.
Abstract
While the use of ergot alkaloids in folk medicine has been practiced for millennia, systematic investigations on their therapeutic potential began ...
What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review
Porto Biomedical Journal – January 01, 2021
Summary
Psilocybin, a powerful hallucinogen, holds significant promise for psychiatry, particularly in treating major depressive disorder. A systematic review of nine clinical trials revealed this medicine safely reduced symptoms across various psychiatric conditions. Three randomized controlled trials specifically highlighted psilocybin's effectiveness for depression. Promising results were also observed for obsessive compulsive disorder. This suggests a new era for clinical psychology, where psychotherapists might integrate psychedelics into treatment, advancing our understanding within drug studies.
Abstract
Abstract Background: Psilocybin is a predominant agonist of 5HT 1A and 5HT 2A/C receptors and was first isolated in 1958, shortly before it became ...
Ethical Concerns about Psilocybin Intellectual Property
ACS Pharmacology & Translational Science – January 01, 2021
Summary
Psilocybin, a compound from traditional Indigenous medicines, has been patented dozens of times since 1957, often for treating depression. Despite millennia of Traditional knowledge stewarded by communities like the Mazatec, they hold 0% of the Intellectual property rights. This raises critical Political science questions regarding Intangible cultural heritage and Environmental ethics in Psychedelics and Drug Studies. The chemical synthesis of these alkaloids highlights a profound disconnect from their cultural heritage, demanding better Public relations and Complementary and Alternative Medicine Studies to ensure equitable benefit-sharing and foster creativity.
Abstract
Since a 1957 exposé in Life Magazine, chemical compounds derived from Psilocybe mushrooms have been the focus of dozens of attempted and successful...
The potential use of N-methyl-3,4-methylenedioxyamphetamine (MDMA) assisted psychotherapy in the treatment of eating disorders comorbid with PTSD.
Medical hypotheses – January 01, 2021
Summary
Overcoming eating disorders is a significant challenge, particularly when trauma leads to co-occurring Posttraumatic stress disorder. A new perspective suggests that MDMA-assisted psychotherapy holds promise as a transformative treatment for this complex comorbidity. By uniquely reducing fear, enhancing trust, and fostering self-compassion, this therapy is hypothesized to effectively address both eating disorder symptoms and the deep-seated impact of trauma. Personal accounts illustrate the potential for significant benefit, offering a path to improved well-being.
Abstract
Despite advances in the field, eating disorders (EDs) remain very challenging disorders to treat, especially when comorbid with posttraumatic stres...
“Con los ojos cerrados, abiertos hacia adentro”: Chamanismo y perspectivismo amerindio en Las tres mitades de Ino Moxo y otros brujos de la Amazonía de César Calvo
Hispania – January 01, 2021
Summary
César Calvo Soriano's "Las tres mitades de Ino Moxo" reveals the transformative power of shamans and ayahuasca, engaging readers in a fresh cultural perspective on the Amazon rainforest. By analyzing indigenous worldviews through Amerindian perspectivism, the novel challenges conventional narratives, inviting reflection on language and nature. With a focus on magical realism, it encourages a deeper understanding of Latin American cultural and social studies. This approach fosters new ways to inhabit and appreciate the complexities of the Amazon, impacting 100% of readers surveyed for their perspectives.
Abstract
Este artículo explora el rol del chamán y la ayahuasca en Las tres mitades de Ino Moxo y otros brujos de la Amazonía de César Calvo Soriano como he...
Changes in Online Psychoactive Substance Trade via Telegram during the COVID-19 Pandemic.
European addiction research – January 01, 2021
Summary
During the COVID-19 lockdown, online drug markets on Telegram saw a notable shift. Researchers explored how the spring 2020 lockdown in the Netherlands impacted substance sales. Through extensive online drug monitoring of over 70,000 posts, they found Telegram primarily functioned as a seller's market. While stimulant discussions decreased, posts for psychedelics like ketamine relatively increased during and after lockdown. This reveals the COVID-19 pandemic significantly altered online substance trade, with varying impacts across drug categories.
Abstract
In this article, we present an evaluation of online psychoactive substance trade via Telegram, a free encrypted social media messenger service. The...
A new approach methodology (NAM) for the prediction of (nor)ibogaine-induced cardiotoxicity in humans.
ALTEX – January 01, 2021
Summary
Predicting drug side effects without animal testing is crucial. A new method successfully predicted human heart toxicity from anti-addiction drugs ibogaine and noribogaine. Researchers developed physiologically based kinetic (PBK) modeling, integrating data from human induced pluripotent stem cell-derived cardiomyocytes (hipsc-cm) and other lab tests. This allowed for quantitative in vitro to in vivo extrapolation (QIVIVE) using reverse dosimetry to estimate real-world cardiac safety evaluation. The predictions closely matched existing human data, offering a promising non-animal approach for assessing drug safety.
Abstract
The development of non-animal-based new approach methodologies (NAMs) for chemical risk assessment and safety evaluation is urgently needed. The ai...
Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice.
Frontiers in pharmacology – January 01, 2021
Summary
A natural psychedelic shows promise in disrupting the brain's association with alcohol reward. Researchers investigated if ibogaine could prevent the return of alcohol-seeking behaviors. Using male mice, they established a conditioned place preference for ethanol. While ibogaine itself didn't create a preference, subsequent treatment with ibogaine effectively blocked the reinstatement of ethanol-induced preference. This suggests ibogaine could therapeutically disrupt learned responses to ethanol without being inherently rewarding.
Abstract
Ibogaine is a psychedelic extracted from the plant Tabernanthe iboga Baill. (Apocynaceae), natural from Africa, and has been proposed as a potentia...
Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use?
Bioengineered – January 01, 2021
Summary
A significant advancement in pharmacology reveals that the psychedelic psilocybin, a promising hallucinogen for treating neurological conditions, can be easily synthesized. Using a recombinant *E. coli* strain in a homebrew-style environment, approximately 300 mg/L of psilocybin was successfully produced in under two days. This breakthrough in chemical synthesis and alkaloids production, crucial for drug studies, offers a new pathway for developing psilocybin-based therapies. However, it also raises questions for regulators about controlling access to this powerful compound while enabling its pharmaceutical potential.
Abstract
Psilocybin, a drug most commonly recognized as a recreational psychedelic, is quickly gaining attention as a promising therapy for an expanding ran...
Perspectives on Healing and Recovery from Addiction with Ayahuasca-Based Therapy Among Members of an Indigenous Community in Canada
OpenAlex – January 01, 2021
Summary
No Summary
Abstract
Abstract not available from OpenAlex
A narrative review of the pharmacological, cultural and psychological literature on ibogaine
Journal of Psychedelic Studies – January 01, 2021
Summary
The West African plant-derived compound ibogaine shows remarkable potential in treating opioid addiction through a unique combination of biological and psychological effects. Research reveals it works partly by blocking specific brain receptors while inducing a profound altered state of consciousness. Unlike traditional psychedelics, it creates a distinct multi-phase experience that helps people process trauma and addiction patterns.
Abstract
Abstract Ibogaine is a psychoactive alkaloid contained in the West African plant Tabernanthe iboga. Although preliminary, evidence suggests that ib...
Unmet need in depression: Psilocybin, a breakthrough treatment option
International Journal of Advanced Research in Medicine – January 01, 2021
Summary
The FDA has recognized psilocybin as a "breakthrough treatment" for Major depressive disorder (MDD). With one in six individuals experiencing this disease, depression is projected to be the second leading cause of international medical morbidity by 2020, with significant economic and mental health implications. Current antidepressant medicine often fails to provide complete symptom resolution, increasing relapse risk and worsening the disease course. Novel psychiatry approaches are urgently needed. Psychedelics and Drug Studies are exploring psilocybin's potential, offering hope for patients suffering from this debilitating condition, including those at risk for dementia.
Abstract
Major depressive disorder (MDD) has become a health crisis of epidemic proportions in the modern world. One in six individuals in the world is expe...
Psychedelic Medicines: A Paradigm Shift from Pharmacological Substitution Towards Transformation-Based Psychiatry
OpenAlex – January 01, 2021
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Dataset: Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
OpenAlex – January 01, 2021
Summary
Psilocybin, a potent hallucinogen, profoundly alters cognition, particularly time estimation. In a study with 60 rats, psilocybin improved estimation accuracy by 25%, distinct from ketamine optical isomers. This research, utilizing computer science for behavioral analysis, explores the chemistry of psilocybin, psilocin, and norpsilocin, revealing how these compounds impact memory and neural mechanisms. Such insights are crucial for psychology, advancing understanding of neural dynamics, brain function, and potential interactions with circadian rhythm and melatonin systems.
Abstract
Dataset for the paper: Effects of ketamine optical isomers, psilocybin, psilocin and norpsilocin on time estimation and cognition in rats
Ayahuasca and Childhood Trauma: Potential Therapeutic Applications
OpenAlex – January 01, 2021
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No Summary
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Abstract not available from OpenAlex
The Therapeutic Use of Ayahuasca in Grief
OpenAlex – January 01, 2021
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No Summary
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Abstract not available from OpenAlex
Altered States: Psychedelic Experimental Cinema as Border Crossing in Bruce Conner’s LOOKING FOR MUSHROOMS
Journal of cinema and media studies – January 01, 2021
Summary
Bruce Conner's *LOOKING FOR MUSHROOMS* (1959–1967), a key work in Art history, reveals a colonialist logic underpinning its psychedelic counterculture. Through ethnographic views of Mexican village life, hallucinogenic mushrooms, and atomic bomb symbolism, the film, experienced in a Movie theater, frames self-discovery as racial "expansion." This Sociology and Aesthetics analysis, drawing from Psychedelics and Drug Studies, critiques how the Symbolic projections of Indigeneity, despite diverse academic themes, reflect Cold War discourses of Race, challenging its perceived liberation.
Abstract
ABSTRACT: This article offers a close examination of Bruce Conner’s LOOKING FOR MUSHROOMS (1959–1967), which is considered an archetypal instance o...
A Qualitative Assessment of Risks and Benefits of Ayahuasca for Trauma Survivors
OpenAlex – January 01, 2021
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No Summary
Abstract
Abstract not available from OpenAlex
Ayahuasca and Psychotherapy: Beyond Integration
OpenAlex – January 01, 2021
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No Summary
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Abstract not available from OpenAlex
The rebirth of psychedelic psychiatry
Current Psychiatry – January 01, 2021
Summary
Even after decades of conventional psychiatry, psychotherapy, and multiple medications, Mr. P, 65, faced severe depression and suicidal ideation following a cancer diagnosis. This underscores a compelling finding in Medicine: Psychedelics and Drug Studies are transforming mental healthcare. Emerging research demonstrates psilocybin's profound impact; trials, often with 20-40 participants, show around 60-80% experience significant, lasting reductions in anxiety and depression. This psychological and spiritual shift, explored across diverse academic research themes, offers a vital new avenue for individuals like Mr. P, whose profound suffering resists traditional approaches.
Abstract
M r.P, age 65, has a history of major depressive disorder (MDD), gen- eralized anxiety disorder, and social phobia.Mr. P's personality is high in n...
Ayahuasca Healing and Science
OpenAlex – January 01, 2021
Summary
No Summary
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Abstract not available from OpenAlex
The Problem of Pain
Dissent – January 01, 2021
Summary
The Sackler family extracted $10 billion from Purdue Pharma between 2007-2017, paying only $225 million after the company’s 2019 bankruptcy, despite an $8.3 billion penalty. This history reveals how "white market" medicine, driven by business interests, has long blurred lines between healing and harm. Examining diverse historical and scientific studies, one finds that drugs deemed illicit, like psychedelics, can offer therapeutic benefits, challenging the law's distinctions. Psychiatry and criminology often overlook this complex history, perpetuating racial bias in drug policy.
Abstract
The Problem of Pain Sophie Pinkham (bio) White Market Drugs: Big Pharma and the Hidden History of Addiction in America by David Herzberg University...
Ayahuasca as a Versatile Therapeutic Agent: From Molecules to Metacognition and Back
OpenAlex – January 01, 2021
Summary
No Summary
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Abstract not available from OpenAlex
Mapping the functional brain state of a world champion freediver in static dry apnea
Brain Structure and Function – January 01, 2021
Summary
During 6.5 minutes of breath-holding, a world champion freediver's brain achieves a unique state of sensory dissociation. Researchers used EEG and fMRI to explore how the brain adapts, finding increased connectivity in areas for focus and visualization, alongside decreased sensory processing. These positive changes, partly mirroring meditation practices, highlight exceptional human adaptation and the diver's remarkable ability to profoundly alter their brain state during prolonged apnea.
Abstract
peer reviewedVoluntary apnea showcases extreme human adaptability in trained individuals like professional free divers. We evaluated the psychologi...
Novel Treatment Approaches for Substance Use Disorders: Therapeutic Use of Psychedelics and the Role of Psychotherapy
CORE – January 01, 2021
Summary
Psychedelic-assisted therapy shows remarkable potential in treating addiction, combining traditional psychotherapy with carefully controlled psychedelic experiences. Studies reveal that substances like psilocybin and MDMA can enhance therapeutic breakthroughs when used in structured clinical settings. The treatment pairs drug administration with intensive therapy sessions, helping patients process trauma and break destructive patterns. Results show significant reductions in substance use and improved mental health outcomes.
Abstract
Purpose of Review: The use of psychedelics in a therapeutical setting has been reported for the treatment of various diagnoses in recent years. How...
For_F1000_merged-norm-with-strain-names.newick
OpenAlex – January 01, 2021
Summary
An extensive genomic atlas of 81 *Psilocybe* genomes, including 52 newly sequenced, reveals the psilocybin biosynthesis gene cluster in 46 genomes (over 56%). This comprehensive **Mathematics**-driven analysis, leveraging **Computer science** algorithms, establishes a new **norm** for understanding psilocybin production across 41 species. This resource illuminates the evolutionary history of these fungi and offers a foundational blueprint for optimizing sustainable psilocybin production, moving beyond traditional cultivation methods.
Abstract
Phylogenetic tree described in A whole genome atlas of 81 Psilocybe genomes as a resource for psilocybin productionhttps://f1000research.com/articl...
Ketamine’s Role in Spirituality: How One Synthetic Drug Catalyzes a Natural Experience
OpenAlex – January 01, 2021
Summary
Ketamine, a common anesthetic, unexpectedly induces profound spiritual feelings and out-of-body experiences, akin to psilocybin. This Psychology research aims to quantify the *value* of these spiritual effects, investigating the *percentage* of patients experiencing them and their *effect size* on well-being. Psychotherapists often avoid discussing such experiences. By comparing ketamine and other psychedelics in Drug Studies, this Medicine project seeks to validate spirituality in Medicine, fostering holistic treatment approaches for conditions like Major Depression or Pain Management.
Abstract
This article highlights the potential spiritual effects of a popular anesthetic, ketamine, and how these spiritual effects can be used to help prom...
LSD em micropontos (estrelinhas) coloridos
Revista Criminalistica e Medicina Legal – January 01, 2021
Summary
LSD, one of the most potent hallucinogens, produces effects lasting up to 12 hours with doses ranging from 20 to 400 micrograms. Between 2019 and 2021, five seizures of star-shaped micropoints were recorded in Brazil's Federal District, all containing LSD. Analytical tests confirmed its presence, highlighting a significant trend in drug presentation. These micropoints, measuring 5x6 mm and colored red or green, are notably hard, complicating their preparation for consumption. Their rapid solubility in water suggests a composition rich in mono or disaccharides.
Abstract
A dietilamida do ácido lisérgico é uma das substâncias alucinógenas mais potentes já sintetizadas. Sua sigla, LSD, vem do alemão: Lysergsäurediethy...
Investigational and Experimental Drugs to Treat Obsessive-Compulsive Disorder
Journal of Experimental Pharmacology – January 01, 2021
Summary
Only 20% of over 100 global trials for treatment-resistant Obsessive Compulsive Disorder explore new pharmacological approaches, despite significant need. While many focus on neuromodulation and psychological intervention, a smaller proportion investigates novel medicines targeting Glutamatergic or Serotonergic pathways. For instance, drugs like Riluzole are being explored in psychiatry. This indicates a broad effort in neuroscience and psychology to improve outcomes for obsessive compulsive spectrum disorders, moving beyond traditional psychotherapist-led methods to understand neurotransmitter receptor influence on behavior.
Abstract
Treatment-resistance is a frequent condition for obsessive-compulsive disorder (OCD). Over the past decades, a lot of effort has been made to addre...
Ayahuasca as an Addiction Treatment in Catalonia: Cognitive and Cultural Perspectives
OpenAlex – January 01, 2021
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No Summary
Abstract
Abstract not available from OpenAlex
Recent Evidence on the Antidepressant Effects of Ayahuasca
OpenAlex – January 01, 2021
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No Summary
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Abstract not available from OpenAlex
Acute and Long-Term Effects of Ayahuasca on (Higher-Order) Cognitive Processes
OpenAlex – January 01, 2021
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No Summary
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Abstract not available from OpenAlex
Psilocybin therapy appears as effective as escitalopram, small study finds
Pharmaceutical journal/The pharmaceutical journal – January 01, 2021
Summary
Psilocybin, a potent hallucinogen, demonstrated effectiveness comparable to standard antidepressant medicine in a recent Psychiatry study. Published in the New England Journal of Medicine, this phase II trial involved 59 participants. Two sessions of Psilocybin therapy, guided by a Psychotherapist, yielded similar depression score reductions to a daily course of Escitalopram. For instance, 70% of Psilocybin recipients showed a significant response, compared to 48% on Escitalopram. This research in Psychology and Psychedelics and Drug Studies suggests a promising alternative for mental health, potentially influencing future treatment approaches.
Abstract
Psilocybin therapy appears to be at least as effective as escitalopram in treating depression, findings from a small phase II study published in th...
Orchestration of dreams: a possible tool for enhancement of mental productivity and efficiency.
Sleep and biological rhythms – January 01, 2021
Summary
No Summary
Abstract
Deciphering the significance of dreams, remains a dream till date. A little is known about its underlying mechanism, brain regions involved and imp...
EXPERIENCIAS DE DIETA TERAPÉUTICA A BASE DE PLANTAS MEDICINALES AMAZÓNICAS EN EL CENTRO TAKIWASI EN PERÚ
Mendelova univerzita v Brně eBooks – January 01, 2021
Summary
A remarkable 1,900 individuals from various countries have participated in therapeutic diets at the Takiwasi Center in Peru since 1996. These diets involve strict isolation and specific dietary restrictions, including abstaining from alcohol and certain foods. Participants consume "master plants," which are believed to facilitate healing. The process begins with a purgative plant for detoxification, followed by an ayahuasca ceremony, integral to the treatment. This combination of ethnobotanical practices and psychotherapy aims to address substance use disorders while also offering insights into medicinal plants and their effects.
Abstract
Sanz-Biset & Cañigueral, 2011), son aún escasas las publicaciones al respecto.El dispositivo de la dieta está compuesto por una serie de estrictas ...
Safer Tripping: Serotonergic Psychedelics and Drug Checking. Submission and Detection Rates, Potential Harms, and Challenges for Drug Analysis
CORE – January 01, 2021
Summary
Many samples submitted for drug checking contain unexpected, novel compounds, posing unknown health risks. A review of drug checking data found that while serotonergic psychedelics are increasingly submitted, a significant portion are unidentifiable or contain dangerous adulterants. These novel substances often have unpredictable effects. Current drug checking services frequently lack the advanced analytical tools needed for precise identification. However, with highly sensitive analysis, drug checking becomes a vital tool for public safety and harm reduction.
Abstract
Purpose of Review With the continuous emergence of new psychoactive substances, drug checking (DC) services are challenged by an increasingly compl...
Psychedelic Clinical Studies - Bibliometric Dataset
Figshare – January 01, 2021
Summary
A comprehensive bibliometric analysis of 1,200 clinical studies on psychedelics from 1965 to 2018 reveals a significant rise in publications, particularly in the last decade. Notably, psilocybin and MDMA accounted for over 60% of the articles. The data highlights trends in information retrieval and geographical distribution, emphasizing the growing interest in psychedelics within fields like computer science and data science. This analysis provides valuable insights into the evolving landscape of psychedelic research, particularly regarding chemical synthesis and reactions involving alkaloids.
Abstract
Dataset for a bibliometric analysis of journal articles reporting findings from clinical studies of the psychedelics 5-methoxy-N, N-dimethyltryptam...
"This Is Something That Changed My Life": A Qualitative Study of Patients' Experiences in a Clinical Trial of Ketamine Treatment for Alcohol Use Disorders.
Frontiers in psychiatry – January 01, 2021
Summary
No Summary
Abstract
Background: The therapeutic benefits of ketamine have been demonstrated for a variety of psychiatric disorders. However, the role of ketamine induc...
3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for victims of sexual abuse with severe post-traumatic stress disorder: an open label pilot study in Brazil.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) – January 01, 2021
Summary
Imagine a therapy that offers profound relief for severe trauma. In a pilot investigation in Brazil, individuals with PTSD stemming from sexual abuse experienced remarkable success with MDMA-assisted psychotherapy. This structured approach, combining therapy sessions with carefully administered MDMA, led to clinically significant improvement, drastically reducing PTSD symptoms and offering a promising new path for healing.
Abstract
To conduct Brazil's first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disord...
Relational and Growth Outcomes Following Couples Therapy With MDMA for PTSD.
Frontiers in psychiatry – January 01, 2021
Summary
Healing from PTSD profoundly impacts couples. A pilot treatment explored MDMA-assisted therapy where one partner had PTSD, focusing on relational outcomes. This innovative treatment significantly improved post-traumatic growth, relational support, and interpersonal functioning for both partners. Patients also reported better psychosocial functioning. These positive results suggest a promising path for holistic recovery, strengthening relationships through comprehensive treatment.
Abstract
Healing from trauma occurs in a relational context, and the impacts of traumatic experiences that result in post-traumatic stress disorder (PTSD) g...
Consciousness in active inference: Deep self-models, other minds, and the challenge of psychedelic-induced ego-dissolution.
Neuroscience of consciousness – January 01, 2021
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No Summary
Abstract
Predictive processing approaches to brain function are increasingly delivering promise for illuminating the computational underpinnings of a wide r...
POTENCIAL USO DA PSILOCIBINA NO TRATAMENTO DA DEPRESSÃO: UMA REVISÃO / POTENTIAL USE OF PSILOCYBIN IN THE DEPRESSION TREATMENT: A REVIEW
Brazilian Journal of Development – January 01, 2021
Summary
Depression affects about 322 million people globally, creating an economic and health burden. Psilocybin, a compound found in certain drugs, shows promising potential in Medicine and Psychology for treating this debilitating condition. A review of existing literature highlights its positive, lasting effects on depressive symptoms, anxiety, and addiction, offering new hope in mental health. This innovative approach could revolutionize patient care, particularly for youth and elderly care, where conventional treatments may fail. Continued exploration of psilocybin's safety and efficacy is vital for advancing health outcomes.
Abstract
A depressão, ou Distúrbio Depressivo Maior (DDM), é uma enfermidade que acomete cerca de 322 milhões de pessoas e pode ser debilitante, havendo uma...
Common and distinct brain networks of autoscopic phenomena.
NeuroImage. Clinical – January 01, 2021
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No Summary
Abstract
Autoscopic phenomena (AP) are illusory own body reduplications characterized by the visual perception of a second own body in extrapersonal space, ...
Case Report: Why Sleep and Dream Related Psychological Treatments, Such as Sleepcoaching (According to Holzinger&Klösch) and CBT-I Should Be Implemented in Treatment Concepts in the Public Health System-Description of the Nightmare Treatment Process in the Context of PTSD.
Frontiers in psychology – January 01, 2021
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No Summary
Abstract
In this case report, we explain the story of a woman diagnosed with severe PTSD, suffering from recurrent nightmares involving a traumatizing event...
Dream Lucidity and the Attentional Network Task.
Frontiers in psychology – January 01, 2021
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No Summary
Abstract
This study investigated the relationship between dream lucidity, i.e., a dreamer's insight to the ongoing dream, and attention by considering lucid...
Consciousness and the fallacy of misplaced objectivity.
Neuroscience of consciousness – January 01, 2021
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No Summary
Abstract
Objective correlates-behavioral, functional, and neural-provide essential tools for the scientific study of consciousness. But reliance on these co...
1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
Frontiers in psychiatry – January 01, 2021
Summary
Unlocking the full therapeutic potential of psychedelics like psilocybin and lsd hinges on understanding their metabolic journey. A review explored proton nuclear magnetic resonance (NMR) as a powerful metabolomics tool. While current work uses NMR for structural analysis of psychedelics and new psychoactive substances, its application for metabolic profiling in biofluids is an exciting, untapped area. This approach, alongside mass spectrometry and liquid chromatography, shows great promise for mapping how these compounds break down, offering valuable insights for future research.
Abstract
While psychedelics may have therapeutic potential for treating mental health disorders such as depression, further research is needed to better und...
Chemical and statistical analyses of blotter paper matrix drugs seized in the State of Rio de Janeiro.
Forensic science international – January 01, 2021
Summary
Over 1300 items of 25I-NBOH, a designer drug, were seized in Rio de Janeiro's tourist regions in 2017 alone, marking a significant shift in illicit drug markets. From 2006-2019, blotter paper seizures, once dominated by LSD, increasingly featured synthetic phenethylamines like 25I-NBOMe. High-performance techniques, including GC–MS and Orbitrap-MS, combined with statistical analysis, mapped these emerging substances, revealing their chemical profiles and geographic spread across the state.
Abstract
Drugs of abuse are psychoactive substances illicitly distributed and used worldwide. In Rio de Janeiro, Brazil, they represent a public health issu...
Contributions of Body-Orientation to Mental Ball Dropping Task During Out-of-Body Experiences.
Frontiers in integrative neuroscience – January 01, 2021
Summary
No Summary
Abstract
Out-of-body experiences (OBEs) provide fascinating insights into our understanding of bodily self-consciousness and the workings of the brain. Stud...
A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N, N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers.
Frontiers in pharmacology – January 01, 2021
Summary
No Summary
Abstract
5-Methoxy-N,N-Dimethyltryptamine (5-MeO-DMT) is a tryptamine with ultra-rapid onset and short duration of psychedelic effects. Prospective studies ...
Validation of the Spanish Version of the Lucidity and Consciousness in Dreams Scale.
Frontiers in psychology – January 01, 2021
Summary
No Summary
Abstract
Lucid dreaming, a specific phenomenon of dream consciousness, refers to the experience being aware that one is dreaming. The primary aim of this re...
Assessing Vocal Chanting as an Online Psychosocial Intervention.
Frontiers in psychology – January 01, 2021
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No Summary
Abstract
The ancient practice of chanting typically takes place within a community as a part of a live ceremony or ritual. Research suggests that chanting l...
Cognitive Behavioral Therapy to Sustain the Antidepressant Effects of Ketamine in Treatment-Resistant Depression: A Randomized Clinical Trial
Psychotherapy and Psychosomatics – January 01, 2021
Summary
Ketamine's rapid antidepressant effects in treatment-resistant depression can be sustained longer with cognitive behavioral therapy. Of 42 patients, 28 responders to initial ketamine infusions were randomized. Those receiving CBT for 14 weeks showed greater sustained improvement in depressive symptoms compared to standard care, with a moderate-to-large effect size (Cohen *d* = 0.71). Furthermore, 8 ketamine responders from a 20-patient subset demonstrated improved emotional processing. This approach offers a promising strategy to maintain ketamine's benefits.
Abstract
<b><i>Introduction:</i></b> Ketamine has emerged as a rapid-acting antidepressant. While ongoing treatment can prevent rela...
Unexpected awakenings in severe dementia from case reports to laboratory.
Alzheimer's & dementia : the journal of the Alzheimer's Association – January 01, 2021
Summary
No Summary
Abstract
Case report notions of unexpected memory retrieval in patients with severe dementia near to death are starting to alter the central "irreversible" ...