Repeated administration of 5-methoxy-N,N-dimethyltryptamine to male rats potentiates stimulation of prolactin secretion by serotonin agonists.
European journal of pharmacology October 15, 1979 DOI: 10.1016/0014-2999(79)90310-8 via PubMed
Summary
AI-generated from the abstractRepeated injections of the serotonin agonist 5MeODMT in rats gradually increased the prolactin-releasing effect of that drug and two other serotonin agonists, but did not change the prolactin response to anti-dopaminergic drugs. The enhanced response appears to result from sensitization of the serotonin system involved in prolactin regulation.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | 5MeODMT quipazine N N-dimethyltryptamine |
| Dose | 5 mg/kg |
| Duration | Every 3 h for a total of 4 injections |
| Citations | 11 |
| Key finding | Repeated administration of 5MeODMT potentiates prolactin release in response to serotonin agonists but not to anti-dopaminergic drugs, suggesting sensitization of the serotonergic mechanism. |
Abstract
Repeated administration of 5-methoxy-N,N-dimethyltryptamine (5MeODMT, 5 mg/kg, a serotonin agonist, every 3 h for a total of 4 injections) potentiated its prolactin (PRL)-releasing effect and that of two other serotonin agonists, quipazine and N,N-dimethyltryptamine. This pretreatment schedule had no effect on PRL response to anti-dopaminergic drugs. The onset of enhanced PRL response to serotonin agonists was gradual and appears to be due to sensitization of the serotonergic mechanism involved in the regulation of PRL secretion. The possible mechanisms underlying this phenomenon are discussed.