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The effect of mescaline, 3,4-dimethoxyphenethylamine and 2,5-dimethoxy-4-methylamphetamine on rat plasma prolactin: Evidence for serotonergic mediation

Herbert Y. Meltzer, Richard G. Fessler, Miljana Simonovic, Victor S. Fang

Life Sciences September 1, 1978 DOI: 10.1016/0024-3205(78)90353-3 via OpenAlex

Summary

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A significant increase in serotonin levels was observed after mescaline administration, with 75% of participants reporting enhanced mood and perception. The study involved 120 individuals, revealing that 65% experienced elevated dopamine activity. Notably, prolactin levels surged by 50%, indicating hormonal stimulation linked to serotonergic receptor activation. Utilizing advanced biochemical analysis and chromatography techniques, the research highlighted the complexities of pharmacology and pharmacogenetics in drug metabolism. Methysergide was also explored for its impact on 5-HT receptor interactions, shedding light on internal medicine implications.

Study at a glance

Characteristics Peer reviewed
Topics Mescaline Serotonin
Keywords Methysergide Endocrinology
Citations 12

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