British Journal of Pharmacology and Chemotherapy
December 1, 1957
T. E. Mansour
51 citations
5-hydroxytryptamine and lysergic acid diethylamide stimulate the rhythmical activity of the liver fluke Fasciola hepatica at very low concentrations, acting peripherally rather than through the central ganglion. Other amines, particularly indolamines, also stimulate rhythmical activity. Bromolysergic acid diethylamide, yohimbine, harmine, and dopamine depress rhythmical movement and counteract the stimulant effects of 5-hydroxytryptamine and lysergic acid diethylamide. Evidence suggests the presence of tryptamine receptors in the trematode.
British Journal of Pharmacology and Chemotherapy
September 1, 1957
William A. Krivoy
23 citations
Lysergic acid diethylamide (LSD) enhances the response of guinea pig ileum to substance P, but not to histamine, and prevents substance P from being broken down by guinea pig brain extract, though not by chymotrypsin. Other substances tested—eserine, morphine, mescaline, chlorpromazine, ergometrine, strychnine, and 2-bromo-LSD—did not produce this effect. Oxytocin was not degraded by brain extract. The inhibitory effect of LSD on substance P destruction was counteracted by 2-bromo-LSD, suggesting a potential link to LSD's pharmacological actions.
British Journal of Pharmacology and Chemotherapy
January 1, 1961
W. A. Krivoy
10 citations
Lysergic acid diethylamide (LSD) at doses of 10 mcg/kg or more increased the fourth potential (DR IV) of the dorsal root potential complex in cats. Lower doses of LSD did not change DR IV on their own but allowed substance P, which alone had no effect, to enhance the potential. 2-Bromolysergic acid diethylamide had no effect on dorsal root potentials but blocked the effects of LSD.
British Journal of Pharmacology and Chemotherapy
January 1, 1960
M. Draskoci
1 citation
Lysergic acid diethylamide (LSD) stimulates contractions in the isolated rat uterus at a concentration of 2×10⁻⁸. At lower concentrations (10⁻⁹ to 10⁻¹⁰), which do not themselves cause contractions, LSD enhances contractions induced by acetylcholine. This potentiating effect provides a method to measure tiny amounts of LSD. Using this assay in cats, during intravenous infusion of LSD at 10 μg/min/kg, between 0.4 and 2 ng/min of the substance entered the cerebral ventricles perfused with a fluid resembling cerebrospinal fluid.