POTENTIATION OF SUBSTANCE P BY LYSERGIC ACID DIETHYLAMIDE IN VIVO
British Journal of Pharmacology and Chemotherapy January 1, 1961 DOI: 10.1111/j.1476-5381.1961.tb01084.x via Elsevier
Summary
AI-generated from the abstractLysergic acid diethylamide (LSD) at doses of 10 mcg/kg or more increased the fourth potential (DR IV) of the dorsal root potential complex in cats. Lower doses of LSD did not change DR IV on their own but allowed substance P, which alone had no effect, to enhance the potential. 2-Bromolysergic acid diethylamide had no effect on dorsal root potentials but blocked the effects of LSD.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Interventions | Lysergic acid diethylamide 2-Bromolysergic acid diethylamide substance P |
| Dose | 10 mug/kg or more |
| Citations | 10 |
| Key finding | LSD at higher doses enhances the DR IV potential in cats, and at lower doses reveals an enhancement of this potential by substance P, while 2-bromolysergic acid diethylamide blocks these effects. |
Abstract
In doses of 10 mug/kg or more, lysergic acid diethylamide enhanced the fourth potential (DR IV) of the dorsal root potential complex in the cat. Smaller doses of lysergic acid diethylamide did not in themselves alter the DR IV, but revealed an enhancement of the potential by substance P, which by itself had no effect. 2-Bromolysergic acid diethylamide had no action on the dorsal root potentials, but prevented the actions of lysergic acid diethylamide.