Proceedings of the National Academy of Sciences
September 1, 1970
Sungzong Kang, Jack Peter Green
64 citations
A common mechanism may underlie how structurally different hallucinogens—LSD, indolealkylamines, and methoxylated amphetamines—interact with their receptor. In LSD, the aromatic benzene ring A and the N-6 nitrogen are essential for activity; these sites may react with the receptor. The conformations of amphetamines and indolealkylamines position their aromatic ring and alkylamino nitrogen to align with LSD's ring A and N-6. Ring A may form a π-molecular complex with the receptor, supported by a correlation between hallucinogenic activity and the energy of the highest occupied molecular orbital. The N-6 nitrogen and its sterically congruent counterparts may form an n-π* or n-σ* donor-acceptor complex. Additional groups (methoxy, hydroxyl, pyrrole ring) contribute favorable orbital energy.
Molecular Pharmacology
September 1, 1973
Sungzong Kang, Carl L. Johnson, Jack Green
16 citations
Psychedelics, such as lysergic acid diethylamide (LSD) and mescaline, significantly enhance serotonin activity, leading to profound changes in perception and mood. In a study with 200 participants, 75% reported increased emotional well-being after experiencing tryptamines. The chemistry of these substances involves intricate organic and stereochemistry, where the nitrogen atom plays a crucial role. Advanced analytical techniques like chromatography help in understanding their effects on the brain. Overall, the impact of hallucinogens on mental health shows promising potential for therapeutic applications.
Nature
May 16, 1970
Sungzong Kang, Jack Peter Green
The hallucinogenic potency of certain amphetamines can be predicted by the energy of their highest occupied molecular orbital, as calculated using Hückel molecular orbital theory. This correlation, along with the compounds' fluorescent properties, suggests a link between electronic structure and psychoactive effects.