Correlation between Activity and Electronic State of Hallucinogenic Amphetamines
Sungzong Kang, Jack Peter Green
Nature May 16, 1970 DOI: 10.1038/226645a0 via Springer Nature
Summary
AI-generated from the abstractThe hallucinogenic potency of certain amphetamines can be predicted by the energy of their highest occupied molecular orbital, as calculated using Hückel molecular orbital theory. This correlation, along with the compounds' fluorescent properties, suggests a link between electronic structure and psychoactive effects.
Study at a glance
| Characteristics | Theoretical or computational analysis Peer reviewed |
|---|---|
| Key finding | Hallucinogenic activity of three methoxylated amphetamines correlates with the energy of the highest occupied molecular orbital. |
Abstract
THE actions of hallucinogenic agents have been correlated with Hückel molecular orbital calculations of the π-elections^1 and with fluorescent properties^2. The Hückel correlations on three methoxylated amphetamines indicated that hallucinogenic activity correlated with energy of the highest occupied molecular orbital^1.