Neuropharmacology of New Psychoactive Substances (NPS): Focus on the Rewarding and Reinforcing Properties of Cannabimimetics and Amphetamine-Like Stimulants
Frontiers in Neuroscience April 19, 2016 Cristina Miliano, Giovanni Serpelloni, Claudia Rimondo et al. 195 citations
New psychoactive substances (NPS) are a diverse and rapidly expanding group of molecules sold as substitutes for controlled drugs, often consumed with other substances or alcohol, and linked to rising overdose deaths and emergency admissions. Their chemical classes include phenethylamines, piperazines, cathinones, tryptamines, and synthetic cannabinoids, with the latter accounting for 50% of newly identified NPS. Many NPS show addictive properties. This review examines the rewarding and addictive effects of cannabimimetics (JWH, HU, CP series) and amphetamine-like stimulants, including recent lab data showing that JWH-018, a potent CB1/CB2 agonist, increases dopamine signaling in the nucleus accumbens shell, contributing to dependence associated with 'Spice' use.