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Nicholas Pintori

2 papers in the library · 20 citations · publishing 2017-2024

Papers

4,4′‐Dimethylaminorex (“4,4′‐DMAR”; “Serotoni”) misuse: A Web‐based study

Human Psychopharmacology Clinical and Experimental May 1, 2017 Barbara Loi, Mire Zloh, Maria Antonietta de Luca et al. 17 citations

4,4'-DMAR ("Serotoni") is a potent stimulant recently linked to multiple fatalities in Europe. Online drug-forum discussions provide technical knowledge about its use, including routes of administration, doses, desired and adverse effects, comparisons with other drugs, combinations, medications used to reverse its action, and harm-reduction advice. A critical review of evidence-based literature together with qualitative data from six website fora reveals that while netnography (social-network web monitoring) has methodological limitations, it can help clarify clinical and psychopharmacological issues for novel psychoactive substances like 4,4'-DMAR, for which scientific knowledge is extremely scarce.

Characterization of the Neurochemical and Behavioral Effects of the Phenethylamine 2-Cl-4,5-MDMA in Adolescent and Adult Male Rats.

The international journal of neuropsychopharmacology May 1, 2024 Gessica Piras, Cristina Cadoni, Francesca Caria et al. 3 citations

The synthetic stimulant 2-Cl-4,5-MDMA, an NPS linked to severe intoxications, increased dopamine and serotonin levels in the nucleus accumbens shell and medial prefrontal cortex of rats in a dose-, brain area-, and age-dependent manner. In adult rats, dopamine rose more markedly in both brain areas, while adolescent rats showed a greater serotonin increase in the nucleus accumbens shell. The drug stimulated locomotion and stereotyped activity more in adolescents but did not trigger 50-kHz ultrasonic vocalizations, suggesting no positive affective properties. These findings indicate age-dependent neurochemical and behavioral effects, helping to assess health risks from human use.