N. Mason

2 papers in the library · 201 citations · publishing 2019-2022

Papers

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms.

Psychopharmacology (Berl) April 13, 2019 M. V. Uthaug, R. Lancelotta, K. Van Oorsouw et al. 198 citations

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is associated with sustained improvements in life satisfaction and mindfulness-related capacities, along with a reduction in psychopathological symptoms.

DOI: 10.1007/s00213-019-05236-w Full text Mental health Psychological health Emotional well-being Mental wellness +25

A Phase 1, Dose-Ranging Study to Assess Safety and Psychoactive Effects of a Vaporized 5-Methoxy-N,N-Dimethyltryptamine Formulation (GH001) in Healthy Volunteers

European Psychiatry June 1, 2022 Johannes T. Reckweg, N. Mason, C. van Leeuwen et al. 3 citations

A vaporized formulation of 5-MeO-DMT, a fast-acting psychedelic, was tested in 22 healthy volunteers at single doses of 6, 12, and 18 mg and with an individualized dose escalation regimen. The drug produced dose-related increases in the intensity of psychedelic experiences, as measured by several questionnaires, except for challenging experiences. Maximal effects on mystical, ego dissolution, and altered states of consciousness ratings occurred after individualized dose escalation. Cognition, mood, and well-being were not affected. Vital signs remained stable, and adverse events were mild and resolved on their own. Individualized dose escalation may be preferable for clinical applications aiming to enhance short-term psychoactive effects for a strong therapeutic response.

DOI: 10.1192/j.eurpsy.2022.1846 Full text Psilocybin Tolerability Mood Medicine +5