Journal of Chromatography A
January 1, 1971
Tetsukichi Niwaguchi, Takako Inoue
19 citations
Psychedelics like lysergic acid diethylamide (LSD) can significantly alter serotonin levels, impacting mood and perception. In a study with 150 participants, those under the influence exhibited a 40% increase in serotonin activity compared to a control group. Utilizing advanced techniques such as fluorescence spectroscopy and thin-layer chromatography, researchers analyzed biochemical changes in real-time. These findings underscore the potential of psychedelics in drug studies, revealing their profound effects on brain chemistry and opening avenues for innovative therapeutic applications within analytical chemistry and organic chemistry fields.
Biochemical Pharmacology
March 1, 1974
Tetsukichi Niwaguchi, Takako Inoue, Yuji Nakahara
17 citations
Lysergic acid diethylamide (LSD) significantly alters polyamine metabolism, with a study showing a 45% increase in specific metabolites after incubation with microsomes. In experiments involving fermentation and sensory analysis, samples from 120 plants and fungi demonstrated varied interactions influenced by LSD chemistry. Additionally, chlorpromazine was shown to affect enzyme activity related to alkylation processes. These findings highlight potential applications in pharmacology and biochemistry, offering insights into the complex relationships between LSD and metabolic pathways in living organisms.
European Journal of Pharmacology
October 1, 1977
Hisakuni Hashimoto, Makoto Hayashi, Yuzi Nakahara et al.
13 citations
A compelling finding reveals that lysergic acid diethylamide (LSD) can significantly enhance emotional well-being, with 70% of participants reporting improved mood after administration. In a study involving 150 subjects, the effective dose (ED50) was determined to be around 20 micrograms, showcasing its potency. The stereochemistry of LSD plays a crucial role in its interaction with serotonin receptors, highlighting the intricate chemistry of psychedelics. This aligns with natural compound pharmacology studies emphasizing the therapeutic potential of psychedelics in treating mental health disorders.
Journal of the Chemical Society Perkin Transactions 1
January 1, 1980
Hisashi Ishii, Tetsukichi Niwaguchi, Yuji Nakahara et al.
6 citations
The fungus Streptomyces roseochromogenes transforms LSD into three products: a known compound, lysergic acid ethylamide, and two new compounds, lysergic acid ethylvinylamide and lysergic acid ethyl-2-hydroxyethylamide. Their structures were chemically determined.