Studies on lysergic acid diethylamide and related compounds. Part 8. Structural identification of new metabolites of lysergic acid diethylamide obtained by microbial transformation using Streptomyces roseochromogenes
Hisashi Ishii, Tetsukichi Niwaguchi, Yuji Nakahara, Makoto Hayashi
Journal of the Chemical Society Perkin Transactions 1 January 1, 1980 DOI: 10.1039/p19800000902 via Elsevier
Summary
AI-generated from the abstractThe fungus Streptomyces roseochromogenes transforms LSD into three products: a known compound, lysergic acid ethylamide, and two new compounds, lysergic acid ethylvinylamide and lysergic acid ethyl-2-hydroxyethylamide. Their structures were chemically determined.
Study at a glance
| Characteristics | Laboratory experiment Peer reviewed |
|---|---|
| Citations | 6 |
| Key finding | Microbial transformation of LSD by Streptomyces roseochromogenes produces two new metabolites, lysergic acid ethylvinylamide and lysergic acid ethyl-2-hydroxyethylamide. |
Abstract
Microbial transformation of lysergic acid diethylamide (1) by Streptomyces roseochromogenes gave a known product, lysergic acid ethylamide (5), and two new ones. The structures of these new metabolites have been chemically established as lysergic acid ethylvinylamide (7) and lysergic acid ethyl-2-hydroxyethylamide (8).