Journal of ethnopharmacology
August 30, 2012
Roman Paškulin, Polona Jamnik, Tjaša Danevčič et al.
19 citations
Ibogaine, a compound from the iboga plant, temporarily increases cellular energy consumption and carbon dioxide production in a dose-dependent manner, as shown in a yeast model. This energy mobilization paradoxically reduces the ATP pool while simultaneously lowering overall oxidative load. Ibogaine does not act as a direct antioxidant but instead stimulates the cell's own oxidative stress defense systems, leading to metabolic remodeling. The initial energy cost results in improved efficiency of antioxidative systems, reduced oxidative damage, and lower basal metabolic needs. This new metabolic equilibrium saves energy and makes it readily available for extra demands, suggesting benefits for health, stress resistance, and recovery from diseases including addiction.
Life (Basel, Switzerland)
December 23, 2021
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović et al.
8 citations
In female rats, ibogaine treatment produced lower liver glycogen breakdown than previously seen in males, along with dilation of liver blood vessels and increased thiol concentrations six hours after dosing. After 24 hours, liver catalase activity and lipid peroxidation rose while xanthine oxidase activity fell. Kidneys showed mild damage, decreased glutathione reductase, and increased catalase and xanthine oxidase activity at various time points. Ibogaine did not alter antioxidant enzymes in red blood cells. Bioavailability of ibogaine was two to three times higher in females than males. Effects were sex- and tissue-specific, and also dose- and time-dependent.
Archives of Biological Sciences
December 5, 2018
Teodora Vidonja Uzelac, Nikola Tatalović, Milica Mijović et al.
7 citations
A single oral dose of ibogaine (1 or 20 mg/kg body weight) in rats did not alter the activities of superoxide dismutases, catalase, glutathione peroxidase, glutathione reductase, or glutathione-S-transferase in the liver or erythrocytes at 6 or 24 hours after administration. However, hepatic xanthine oxidase activity increased in rats receiving 20 mg/kg, indicating faster adenosine turnover. TBARS concentration rose in the 1 mg/kg group after 24 hours, suggesting mild oxidative stress. Histological examination revealed glycogenolytic activity in hepatocytes, peaking at 24 hours in the higher-dose group. Ibogaine influenced hepatic redox homeostasis but not enough to remodel antioxidant enzyme activities within the timeframe studied.
Toxicon : official journal of the International Society on Toxinology
September 15, 2016
Vid Leban, Gordana Koželj, Miran Brvar
A 44-year-old woman in Slovenia developed severe hyponatremia (116 mmol/L) and plasma hypoosmolality (251 mOsm/kg) after participating in a Kambô ritual that involved applying dried skin secretion from the giant leaf frog (Phyllomedusa bicolor) to five fresh burns on her shoulder, followed by drinking 6 liters of water. Laboratory findings showed inappropriately elevated urine osmolality (523 mOsm/kg) and high urine sodium (87 mmol/L), indicating syndrome of inappropriate antidiuretic hormone secretion (SIADH). She experienced nausea, vomiting, confusion, lethargy, muscle weakness, spasms, cramps, seizure, decreased consciousness, and short-term memory loss. Treatment with 0.9% sodium chloride and water restriction improved plasma osmolality and sodium within one day, but symptoms resolved only after three days.