Ibogaine Has Sex-Specific Plasma Bioavailability, Histopathological and Redox/Antioxidant Effects in Rat Liver and Kidneys: A Study on Females.
Nikola Tatalović, Teodora Vidonja Uzelac, Milica Mijović, Gordana Koželj, Aleksandra Nikolić-kokić, Zorana Oreščanin Dušić, Mara Bresjanac, Duško Blagojević
Life (Basel, Switzerland) December 23, 2021 DOI: 10.3390/life12010016 via PubMed
Summary
AI-generated from the abstractIn female rats, ibogaine treatment produced lower liver glycogen breakdown than previously seen in males, along with dilation of liver blood vessels and increased thiol concentrations six hours after dosing. After 24 hours, liver catalase activity and lipid peroxidation rose while xanthine oxidase activity fell. Kidneys showed mild damage, decreased glutathione reductase, and increased catalase and xanthine oxidase activity at various time points. Ibogaine did not alter antioxidant enzymes in red blood cells. Bioavailability of ibogaine was two to three times higher in females than males. Effects were sex- and tissue-specific, and also dose- and time-dependent.
Study at a glance
| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Female rats |
| Intervention | Ibogaine |
| Dose | 1 and 20 mg/kg b.w. per os |
| Duration | 6 and 24 hours after treatment |
| Topics | Ibogaine |
| Keywords | Erythrocytes Kidney Lipid peroxidation Liver |
| Citations | 8 |
| Key finding | Ibogaine's effects on antioxidant systems and glycogen metabolism in rats are sex-specific, with females showing lower liver glycogenolytic activity, higher thiol levels, and two to three times greater ibogaine bioavailability than males. |
Abstract
Ibogaine induces rapid changes in cellular energetics followed by the elevation of antioxidant activities. As shown earlier in male rats, ibogaine treatment with both 1 and 20 mg/kg b.w. per os led to significant glycogenolytic activity in the liver. In this work, female rats treated with the same doses of ibogaine per os displayed lower liver glycogenolytic activity relative to males, dilatation of the central vein and branches of the portal vein, and increased concentration of thiols 6 h after treatment. These changes were followed by increased catalase activity and lipid peroxidation, and decreased xanthine oxidase activity after 24 h. In kidneys, mild histopathological changes were found in all treated animals, accompanied by a decrease of glutathione reductase (after 6 and 24 h at both doses) and an increase of catalase (6 h) and xanthine oxidase activity (6 and 24 h). Ibogaine did not affect antioxidant enzymes activity in erythrocytes. Bioavailability of ibogaine was two to three times higher in females than males, with similar kinetic profiles. Compared to previous results in males, ibogaine showed sex specific effect at the level of antioxidant cellular system. Effects of ibogaine in rats are sex- and tissue-specific, and also dose- and time-dependent.