Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.
Frontiers in behavioral neuroscience January 1, 2009 Jonathan L Brigman, Jessica Ihne, Lisa M Saksida et al.
Subchronic treatment with the psychotomimetic phencyclidine (PCP) in C57BL/6J mice increased visits to a social stimulus but did not increase time spent with it, and increased visits and time spent investigating a novel social stimulus over a familiar one. The treatment did not significantly affect performance on visual discrimination or reversal learning tasks. These findings suggest the mouse subchronic PCP model may be useful for studying social withdrawal aspects of schizophrenia, but the regimen was insufficient to impair the measured cognitive/executive functions in this strain.