Neuropharmacology
January 6, 2023
Nicolas Singewald, Simone B. Sartori, Andreas Reif et al.
57 citations
Anxiety disorders and PTSD are common and increasing worldwide. Current medications help some patients but have side effects and do not address underlying brain changes. After a period of stagnation, there is renewed interest in developing new drug treatments. This review describes currently available drugs and summarizes recent and ongoing clinical trials of novel medicines, grouped by their neurochemical targets: monoamine (including psychedelics), GABA, glutamate, cannabinoid, cholinergic, and neuropeptide systems. The authors emphasize designing treatments based on an understanding of neurobiology and harnessing neuroplasticity to produce lasting beneficial changes, for example by combining psychotropic drugs with psychotherapy. Emerging trends in this new phase of drug development are noted.
bioRxiv : the preprint server for biology
May 14, 2024
Tobias Teichert, László Papp, Ferenc Vincze et al.
1 citation
preprint
A new recording method called MePhys uses 992 electrode contacts across 62 shafts implanted in a monkey hemisphere to measure brain activity at a mesoscopic scale, bridging the gap between fMRI, EEG, and microelectrode techniques. By analyzing over 300,000 simultaneously recorded electrode pairs, the method reveals that a subanesthetic dose of ketamine, which mimics aspects of psychosis, induces a pronounced state of functional disconnection and prevents the formation of stable large-scale intrinsic brain states. MePhys offers a complementary window into brain function with unique advantages and limitations.
Journal of neurophysiology
April 1, 2025
Tobias Teichert, László Papp, Ferenc Vincze et al.
A new imaging method called MePhys (mesoscopic electrophysiology) records local field potentials from 992 electrode contacts distributed across 62 shafts implanted throughout a monkey hemisphere, enabling simultaneous measurement of over 300,000 electrode pairs. This technique combines millisecond temporal resolution with millimeter spatial resolution across a large field of view. Administering a subanesthetic dose of ketamine, which can mimic aspects of psychosis, induced a pronounced state of functional disconnection and prevented the formation of stable large-scale intrinsic brain states. MePhys offers a complementary window into brain function that bridges the gaps between fMRI, EEG, and microscopic electrophysiology.
Frontiers in behavioral neuroscience
January 1, 2009
Jonathan L Brigman, Jessica Ihne, Lisa M Saksida et al.
Subchronic treatment with the psychotomimetic phencyclidine (PCP) in C57BL/6J mice increased visits to a social stimulus but did not increase time spent with it, and increased visits and time spent investigating a novel social stimulus over a familiar one. The treatment did not significantly affect performance on visual discrimination or reversal learning tasks. These findings suggest the mouse subchronic PCP model may be useful for studying social withdrawal aspects of schizophrenia, but the regimen was insufficient to impair the measured cognitive/executive functions in this strain.