Research
Traumatic Psychedelic Experiences.
Current topics in behavioral neurosciences – April 29, 2025
Summary
No Summary
Abstract
Psychedelic experiences involving extreme feelings of horror, helplessness, and perceived threats can be traumatizing. Traumatic psychedelic experi...
Unlocking the Potential of Ketamine: A Systematic Review and Meta-analysis of its Safety and Efficacy in Acute Pain Management.
Combinatorial chemistry & high throughput screening – April 29, 2025
Summary
As hospitals seek alternatives to opioids like fentanyl for pain management, ketamine shows promise. Analysis of multiple clinical trials reveals that ketamine provides significant pain relief within 15 minutes of administration, matching the effectiveness of traditional painkillers. While showing similar safety profiles to placebo treatments, ketamine offers a viable option for acute pain control without increased side effects.
Abstract
The management of acute pain is a crucial and challenging component of emergency care. The pursuit of an ideal drug that alleviates pain rapidly an...
Esketamine Reduces Lung Injury Caused by Limb Ischemia-Reperfusion by Regulating Oxidative Stress via the TLR4/NF-κB/NLRP3 Pathway.
Endocrine, metabolic & immune disorders drug targets – April 29, 2025
Summary
A breakthrough in treating lung damage reveals that esketamine, a promising medication, can protect against acute lung injury caused by restricted blood flow to limbs. The drug works by controlling harmful oxidative stress and reducing inflammatory responses in lung tissue. It achieves this by regulating a key cellular pathway that affects inflammation, leading to better lung function and reduced tissue damage.
Abstract
Esketamine has shown promise in mitigating tissue damage caused by ischemia- reperfusion injury, making it a potential therapeutic candidate for ac...
Innovation and inequity in psychedelic research at the Mayo Clinic.
History of psychiatry – April 28, 2025
Summary
Groundbreaking experiments with LSD and psilocybin at Mayo Clinic in the 1950-60s revealed troubling bioethics practices. Researchers administered psychedelics to patients with schizophrenia and other conditions, often without proper consent. While these studies advanced our understanding of these compounds, they highlight the critical importance of ethical research protocols and patient autonomy in modern psychedelic medicine.
Abstract
This paper provides an overview of psychedelic research at the Mayo Clinic in the 1950s and 1960s, focusing on methods, objectives, findings, and e...
Liquid chromatography-tandem mass spectrometry-based pharmacokinetic and metabolic analysis of 4-bromo-2,5-dimethoxyphenethylamine and its metabolites in human plasma.
Drug metabolism and disposition: the biological fate of chemicals – April 28, 2025
Summary
A breakthrough in psychedelic medicine reveals how 2C-B, a compound being studied for mental health treatment, breaks down in the human body. Scientists developed a precise method to track the drug's metabolism and movement through the bloodstream. The research showed that while 2C-B activates brain receptors linked to therapeutic effects, its breakdown products don't share this ability, suggesting careful timing may be key for treatment.
Abstract
4-Bromo-2,5-dimethoxyphenethylamine (2C-B) is widely used recreationally and has recently gained interest as a treatment for mental health disorder...
Effect of pretreatment with low-dose Esketamine on the Propofol requirements and the onset time of cisatracurium during the induction of general anesthesia: a prospective, randomized, double-blinded trial.
BMC anesthesiology – April 28, 2025
Summary
A breakthrough in anesthesia management shows that small doses of Esketamine can significantly reduce the amount of Propofol needed during anesthesia induction. In a study of 140 surgical patients, pretreatment with Esketamine at different doses demonstrated that higher amounts (0.5 mg/kg) reduced Propofol requirements while maintaining effective sedation. This finding could lead to more efficient and controlled anesthesia delivery, though onset time remained unchanged.
Abstract
Esketamine has been increasingly used as an adjuvant for propofol-based induction. However, the effective esketamine dose for this indication remai...
Calcium Activation Mechanism of a Noncanonical Aromatic L-Amino Acid Decarboxylase from Psilocybin Mushroom
OpenAlex – April 28, 2025
Summary
Calcium dramatically controls the activity of a key Aromatic L-amino acid decarboxylase (AAAD), PcncAAAD. Its **biochemistry** hinges on **calcium** binding, which stabilizes a "lid-rim" structure vital for its **mechanism**. Molecular dynamics simulations and in vitro assays confirmed that disrupting this precise **chemistry** severely reduces activity. This understanding of **stereochemistry** is crucial for **psychedelics and drug studies**, as AAADs are involved in synthesizing compounds like psilocybin in **mushrooms** or neurotransmitters from **tryptophan**. Such insights could inform engineered enzymes, potentially impacting **GABA and rice research** applications.
Abstract
Abstract PcncAAAD is a calcium-activatable noncanonical aromatic L-amino acid decarboxylase (AAAD) featuring a unique appendage C-terminal domain (...
The landscape of ketamine use disorder: Patient experiences and perspectives on current treatment options.
Addiction (Abingdon, England) – April 28, 2025
Summary
Ketamine addiction affects users across multiple continents, with daily consumption averaging 2 grams. A comprehensive survey revealed that 60% of users experience bladder and nasal problems, yet most don't seek treatment. Those who do pursue help often find services inadequately prepared for ketamine-specific dependence, with only 36% reporting satisfaction with care. Cost remains the primary barrier to treatment-seeking behavior.
Abstract
To report the symptoms and aetiology of ketamine use disorder (KUD), gauge the effectiveness of current treatment services and identify strategies ...
Royal Australian and New Zealand College of Psychiatrists professional practice guidelines for the use of ketamine in psychiatric practice.
The Australian and New Zealand journal of psychiatry – April 28, 2025
Summary
Ketamine, once known primarily as an anesthetic, shows promising results in treating severe depression and other psychiatric disorders. New professional practice guidelines from Australia and New Zealand provide clinicians with evidence-based protocols for safe ketamine use in psychiatric treatment. The guidelines emphasize careful patient selection, proper dosing, and monitoring protocols while highlighting ketamine's potential as a rapid-acting intervention for treatment-resistant mental health conditions.
Abstract
Professional practice guidelines for the use of ketamine in psychiatric practice have been developed by the Royal Australian and New Zealand Colleg...
Evaluation of the Efficacy of Electroconvulsive Therapy in Relation to the Anesthetic Agent Applied: A Retrospective Analysis.
The journal of ECT – April 28, 2025
Summary
Different anesthetic agents can significantly impact treatment success in electroconvulsive therapy, with ketamine showing particularly promising results. In a review of 149 patients, those receiving ketamine alone experienced more effective treatment sessions compared to those given propofol or combination treatments. While both medications proved safe, ketamine emerged as an optimal choice for maximizing therapeutic benefits.
Abstract
The present study aims to make a contribution to the extant literature on the sharing of clinical experiences with electroconvulsive therapy (ECT) ...
The Bereaved Detachment Experience: An NDE-like Phenomenon.
Omega – April 28, 2025
Summary
No Summary
Abstract
When people experience the death of loved ones, some of them report after-death communications (ADCs) in which they have the impression of again en...
Behavioral and psychological correlates of problematic smartphone use in street ketamine users.
BMC psychology – April 27, 2025
Summary
Ketamine users who struggle with smartphone addiction spend significantly more time gaming online and show higher rates of ADHD symptoms. A study of 233 individuals in addiction treatment revealed that excessive smartphone use strongly correlates with online gaming habits and attention difficulties. Those at risk used their phones longer daily and were twice as likely to engage in internet gaming.
Abstract
While problematic smartphone use screening tools are widely used and increasingly evaluated in student populations, their applicability and clinica...
COnventional vs. Optimized PERiprocedural Analgosedation vs. Total IntraVEnous Anesthesia for Pulsed-Field Ablation: a Three-Arm Randomized Controlled Trial (COOPERATIVE-PFA).
Circulation – April 27, 2025
Summary
A groundbreaking finding shows that over 80% of patients receiving conventional sedation during cardiac ablation procedures experience oxygen deficiency. This study compared three different sedation methods for heart rhythm treatment: traditional intermittent sedation, an optimized continuous approach using remimazolam-ketamine, and full anesthesia. The optimized sedation method proved significantly safer, with fewer breathing and blood pressure complications than both alternatives. Patient satisfaction remained high across all methods, but the remimazolam-ketamine combination emerged as the clear winner for both safety and effectiveness.
Abstract
Deep analgosedation (DAS) or general anesthesia (GA) is mandatory for pulsed-field ablation (PFA) of atrial fibrillation (AF). In contrast to DAS, ...
Passive mapping of hand motor cortex across altered states of consciousness.
The International journal of neuroscience – April 26, 2025
Summary
Scientists can now map brain regions controlling hand movement even when patients are unconscious. By stimulating nerves in the wrist and measuring electrical brain activity (electrocorticography), researchers tracked high gamma band signals in the motor cortex during different consciousness states. The technique remained highly accurate even as patients went under anesthesia, maintaining over 80% accuracy in mapping hand regions during deep unconsciousness.
Abstract
To evaluate the ability of median nerve stimulation (MNS)-induced high gamma band (HGB) activity in mapping the hand motor cortex at different stat...
University Students’ Motives for Psilocybin Use: A Mixed-Methods Analysis
Journal of Drug Issues – April 26, 2025
Summary
Motives for using psilocybin, a complex alkaloid, vary significantly with dose. An online survey revealed that reasons for microdosing (0.1–0.4 g) diverge from those for macrodosing (1 g+). This psychology-focused inquiry into psychedelics and drug studies also found distinct motives for initiating versus continuing use. Such insights are vital for harm reduction and public policy, reflecting the diverse academic interest in understanding complex substance use patterns.
Abstract
Motives are a highly influential force in substance use and vary depending on the substance or dose being used. Little research has compared motive...
Dissociable effects of psilocybin and escitalopram for depression on processing of musical surprises
Molecular Psychiatry – April 26, 2025
Summary
Psilocybin therapy significantly reduces anhedonia in Major Depressive Disorder, a key insight for **Psychology** and **Psychiatry**. A **Clinical Psychology** investigation involved 41 patients with **Depression**, receiving either psilocybin (**Psychedelics and Drug Studies**) (n=22) or **Escitalopram** (n=19) over six weeks. Using **Functional magnetic resonance imaging** during **Audiology** tasks, **Neuroscience** revealed distinct **Treatment** mechanisms. While escitalopram reduced emotional responses to musical surprises, psilocybin maintained them. This suggests psilocybin influences **Cognitive Processes** differently, via **Neurotransmitter Receptor Influence on Behavior**, offering varied **Psychometrics** outcomes for **Anxiety** and depression.
Abstract
Abstract Psilocybin therapy (PT) is emerging as an effective intervention for Major Depressive Disorder (MDD), offering comparable efficacy to conv...
Hemodynamic effects in dogs anesthetized with the combination tiletamine-zolazepam-ketamine-xylazine.
Veterinary research communications – April 26, 2025
Summary
A new anesthetic combination shows promise for healthy canines, though it significantly impacts heart function. When veterinarians combined dissociative anesthesia with α2 adrenoceptor agonists, dogs experienced reduced cardiac output but maintained stable blood oxygen levels. While heart rate dropped by up to 43%, blood pressure remained well-controlled, suggesting this protocol is safe for healthy dogs needing short-term sedation.
Abstract
This was a prospective, experimental study, that evaluated the hemodynamic effects in dogs administered the combination tiletamine-zolazepam-ketami...
Evaluation of a Five-Minute Meditation Intervention During Weekly Palliative Care Clinical Rounds.
Journal of palliative medicine – April 26, 2025
Summary
No Summary
Abstract
Introduction: Palliative care professionals experience high levels stress and burnout. Meditation improves stress and well-being, with group interv...
Auto-Induction in Oral Esketamine Treatment for Treatment-Resistant Depression: An Exploratory Study.
Pharmaceuticals (Basel, Switzerland) – April 25, 2025
Summary
Breakthrough depression treatment esketamine shows an unexpected twist: the body adapts to reduce its effectiveness over time. After 39 days of oral treatment, patients had 59% less of the drug in their blood than expected. This auto-induction process, where the body speeds up drug metabolism, helps explain why some patients experience diminishing benefits. The findings suggest new approaches may be needed to maintain esketamine's powerful antidepressant effects.
Abstract
Background: Esketamine is a rapidly acting antidepressant with robust efficacy in treatment-resistant depression (TRD). Diminishing therapeutic eff...
Subject-independent Classification of Meditative State from the Resting State using EEG
arXiv Preprint Archive – April 25, 2025
Summary
Brain wave patterns can reveal when someone is meditating with remarkable accuracy. Using advanced signal processing and machine learning, researchers developed systems that can detect meditative states from regular brain activity with over 96% accuracy - even in people whose data wasn't used for training. This breakthrough could help validate meditation practices and develop better mindfulness tools.
Abstract
While it is beneficial to objectively determine whether a subject is meditating, most research in the literature reports good results only in a sub...
Exploring Factors Affecting Psychological Flexibility After Psychedelic Experiences.
Journal of psychoactive drugs – April 25, 2025
Summary
Profound mystical experiences during psychedelic sessions with substances like LSD and psilocybin can lead to lasting improvements in psychological flexibility—our ability to adapt to life's challenges. People who reported more intense mystical experiences showed greater gains in mental adaptability, particularly in the month following their experience. These benefits align with principles of acceptance and commitment therapy.
Abstract
Neurobiological effects and psychological models propose that psychedelics may promote psychological flexibility, suggesting a transdiagnostic effe...
Striatal functional connectivity associated with Sahaja Yoga meditation.
Scientific reports – April 25, 2025
Summary
No Summary
Abstract
Neuroscience research has associated meditation practice with effects on cognitive, motivational and emotional processes. These processes are media...
A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease.
Brain : a journal of neurology – April 25, 2025
Summary
Scientists have uncovered vital insights into developmental epilepsy by studying a specific genetic mutation in GRIN2D, a crucial brain receptor component. Using an innovative mouse model, researchers revealed how this mutation triggers severe seizures and developmental issues that mirror human symptoms. Brain activity recordings (ECoG) showed distinctive abnormal patterns, while drug response testing found that memantine and phenytoin offered modest benefits, unlike ketamine which worsened symptoms.
Abstract
Pathogenic variants in GRIN2D, encoding one of the subunits of the NMDA receptor (NMDAR), are associated with developmental and epileptic encephalo...
Psilocybin-assisted psychotherapy as a rapid-acting treatment for cancer-related depression and anxiety: Evidence from a network meta-analysis
The International Journal of Psychiatry in Medicine – April 25, 2025
Summary
Psilocybin rapidly reduced anxiety in cancer patients, according to a systematic review and meta-analysis of two randomized controlled trials found via MEDLINE and Cochrane Library searches. This medicine, a psychedelic alkaloid, significantly lowered State-Trait Anxiety Inventory scores by 11.52 points on day one and 12.66 points after two weeks. Beck Depression Inventory scores also improved by 2.26 points initially. The most effective dose achieved over 90% efficacy for anxiety. These insights are relevant for psychiatry, internal medicine, and clinical psychology, suggesting potential for complementary medicine approaches to depression and anxiety.
Abstract
Objective To evaluate psilocybin's efficacy in reducing depressive and anxiety symptoms in cancer patients based on randomized controlled trials (R...
The role of mitochondrial dysfunction and calcium dysregulation in 2C-I and 25I-NBOMe-induced neurotoxicity.
Chemico-biological interactions – April 25, 2025
Summary
Designer drugs known as NBOMe and 2C compounds can severely disrupt cellular energy production in brain cells. Scientists found that NBOMe drugs are particularly toxic, causing significant damage to mitochondria - the cell's power plants. Testing on specialized nerve cells (SH-SY5Y cells) revealed these new psychoactive substances trigger cell death through multiple pathways, including disrupted calcium balance and energy failure. This helps explain their neurotoxicity and dangerous effects.
Abstract
New psychoactive substances (NPS) are designed to evade legal regulation while mimicking the effects of classic illicit drugs such as 3,4-methylene...
Entheogen: an evolutionary medicine for neuropsychiatric disorders.
Natl Sci Rev – April 25, 2025
Summary
Ancient plant-based substances, known as entheogens, offer an evolutionarily-grounded solution for modern mental health. It is proposed that these compounds, historically used for their profound effects, can effectively address neuropsychiatric disorders by engaging deep-seated brain mechanisms. Examining their neurobiological actions and ancient use reveals compelling potential to foster significant improvements in well-being, presenting a novel paradigm for treatment.
Abstract
Entheogen: an evolutionary medicine for neuropsychiatric disorders.
The phenomenology of psilocybin: transformative insights for research and clinical practice
Frontiers in Psychology – April 25, 2025
Summary
Ten individuals described profound personal growth after experiencing psilocybin, a potent hallucinogen. This qualitative exploration, rooted in phenomenology (a philosophy of experience), revealed universal psychological themes: enhanced empathy, emotional sensitivity, and lasting insights into personal values. Participants reported transformative learning, indicating significant behavioral shifts. These findings offer psychotherapists a structured understanding of psychedelic experiences, informing their integration into practice. Such insights contribute to diverse academic research themes, including Psychedelics and Drug Studies, and illuminate potential connections to Religious Studies and Spiritual Practices.
Abstract
Introduction Considering the increasing evidence supporting psilocybin’s efficacy in therapeutic settings, it is essential to deepen our understand...
King Lear in the upper palaeolithic: searching for ethical principles in prehistory.
Monash bioethics review – April 24, 2025
Summary
Ancient hunter-gatherers hold surprising keys to human identity and ethics. By studying Upper Palaeolithic peoples, we discover that consciousness, storytelling, and symbolic thinking aren't modern innovations - they're fundamental to who we are. Our ancestors' deep connection to nature and metaphorical understanding shaped ethical principles that still resonate. Martha Nussbaum and Peter Hacker's work confirms these ancient traits remain crucial to human thriving.
Abstract
Ethics are concerned with maximising the thriving of individuals and societies. One cannot maximise the thriving of a person unless one has some id...
Association of Patient Characteristics With Recovery in Adults With Disorders of Consciousness.
Archives of physical medicine and rehabilitation – April 24, 2025
Summary
Two-thirds of patients with severe brain injuries showed meaningful recovery of consciousness during specialized rehabilitation programs. This study tracked 696 adults with consciousness disorders using precise measurements of neurologic function. Earlier rehabilitation after injury was linked to better outcomes. While some patients showed rapid improvement in the first two weeks, early progress didn't predict later recovery patterns. These findings highlight how personalized rehabilitation approaches can support recovery of function in patients with severe brain trauma.
Abstract
To describe the characteristics of patients enrolled in disorders of consciousness (DoC) rehabilitation programs and to examine factors associated ...
Thoughtseeds: A Hierarchical and Agentic Framework for Investigating Thought Dynamics in Meditative States.
Entropy (Basel, Switzerland) – April 24, 2025
Summary
During meditation, our thoughts behave like competing agents vying for attention. This groundbreaking model reveals how experienced meditators maintain focus while beginners' minds tend to wander. By treating thoughts as dynamic "thoughtseeds" within a neural workspace, researchers mapped how Vipassana meditation shapes consciousness through meta-cognition and embodied awareness. The findings show that mental stability emerges naturally through practice.
Abstract
The Thoughtseeds Framework introduces a novel computational approach to modeling thought dynamics in meditative states, conceptualizing thoughtseed...
A simple method for the determination of stimulant substances in postmortem blood: development, validation, and application in nearly 1000 forensic cases.
Forensic toxicology – April 24, 2025
Summary
In nearly 1000 forensic cases, one in five postmortem blood samples tested positive for stimulant drugs, revealing cocaine and its metabolites as the most commonly detected substances. Scientists developed a rapid testing method using LC-MS/MS technology that can identify 16 different drugs of abuse with high accuracy, helping investigators solve complex forensic cases through precise toxicological analysis.
Abstract
Toxicological analyses of postmortem blood samples are essential to elucidate forensic cases involving toxic agents, such as illicit drugs. A simpl...
Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial.
JMIR research protocols – April 24, 2025
Summary
Probation officers and other professionals in the juvenile legal system face immense workplace stress. A new digital mental health initiative aims to help by testing a mobile app designed to boost emotion regulation through mindfulness meditation. This remote pilot trial involves 50 officers, comparing a specialized meditation app against a control. It uses ecological momentary assessment (EMA) to track real-time emotion regulation and objective app usage. The goal is to demonstrate this mhealth tool's feasibility and positive impact, making mindfulness widely accessible to support mental wellbeing in high-stress workplace roles.
Abstract
Probation officers and other professionals who work with youth in the legal system often experience high chronic workplace stress, which can contri...
Decreasing Preoperative Anxiety in Patients with Newly Available Multimodal Approaches-A Narrative Review.
Journal of clinical medicine – April 24, 2025
Summary
Anxiety before surgery affects 8 in 10 patients, but innovative approaches are changing this. A combination of medication and therapy shows promising results in reducing patient stress. Anti-anxiety agents provide quick relief, while perioperative care teams now use music, virtual reality, and psychotherapy. Informed consent processes have evolved to be more reassuring and comprehensive.
Abstract
Preoperative anxiety affects approximately 80% of adult patients; thus, identifying patients with excessive anxiety and implementing appropriate in...
Development of a nomogram for predicting the outcome in patients with prolonged disorders of consciousness based on the multimodal evaluative information.
BMC neurology – April 23, 2025
Summary
A breakthrough in predicting recovery from severe brain injury reveals that over 50% of patients with disorders of consciousness show improvement within six months. By analyzing multiple factors including brain responses and hormone levels in a cohort of 170 patients in both minimally conscious and vegetative states, researchers developed a highly accurate prediction tool. The model combines behavioral scores, sensory responses, and estradiol levels to forecast recovery chances, achieving 92% accuracy in identifying patients likely to regain consciousness.
Abstract
To establish a nomogram prediction model for the patients with prolonged disorders of consciousness (PDOC) caused by brain injury at six months bas...
Embracing change: impermanence acceptance mediates differences in death processing between long-term ayahuasca users and non-users.
Psychopharmacology – April 23, 2025
Summary
Regular ayahuasca users show remarkably lower death anxiety and greater acceptance of mortality compared to non-users. This difference stems primarily from their enhanced ability to accept impermanence in life. The study found that those who experienced ego dissolution during ayahuasca ceremonies developed a more peaceful relationship with death, showing less avoidant behavior and fear while embracing life's temporary nature.
Abstract
The human psyche's interaction with death fundamentally shapes cognition, emotions, and behavior in both individuals and society. Death-related psy...
TD-ESI-MS/MS for High-Throughput Screening of 13 Common Drugs and 4 Etomidate Analogs in Hair: Method Validation and Forensic Applications.
Toxics – April 23, 2025
Summary
Hair analysis reveals drug use patterns in just 60 seconds! A breakthrough forensic technique combines high-throughput screening with advanced mass spectrometry to detect 17 different drugs of abuse in hair samples. The method accurately identified etomidate analogs and other substances, proving faster and more reliable than traditional testing. This innovation helps law enforcement track emerging drug trends while maintaining 90% accuracy.
Abstract
This study established a dual analytical workflow integrating thermal desorption-electrospray ionization-tandem mass spectrometry (TD-ESI-MS/MS) fo...
5-HT2A receptors: Pharmacology and functional selectivity.
Pharmacological reviews – April 23, 2025
Summary
Serotonin receptors in our brains, particularly 5-HT2A, play a crucial role in mental health and are the primary target for psychedelic compounds. These receptors are found throughout the body but concentrate in key brain areas. Research shows they're not just involved in normal brain function - they're also the gateway through which therapeutic psychedelics like psilocybin and LSD work to treat depression and addiction, offering promising new paths for mental health treatment.
Abstract
Serotonin 5-HT2A receptors were one of the first serotonin receptors to be pharmacologically characterized. In mammals, they are expressed througho...
Detection of hidden populations using illicit substances.
Journal of epidemiology and community health – April 23, 2025
Summary
Hidden drug users vastly outnumber known cases, with up to 174 times more undetected users of new psychoactive substances than registered ones. Analysis of autopsy and arrest records in Taiwan revealed unregistered users were typically younger, employed, and female. Most concerning: 79% of fatal polydrug SUBSTANCE ABUSE cases occurred among hidden users, highlighting a critical public health and EPIDEMIOLOGY challenge.
Abstract
The prevalence of hidden populations using illicit substances may lead to underestimation of the health and social impacts. This study aimed to pre...
Incremental efficacy systematic review and meta-analysis of psilocybin-for-depression RCTs
Psychopharmacology – April 23, 2025
Summary
Psilocybin, a potent hallucinogen, significantly reduces depression, demonstrating a moderate effect (g = 0.62). A meta-analysis of nine randomized controlled trials (602 participants, 56% psilocybin) drew from psychology and medicine databases (PsycINFO, CINAHL, MEDLINE), using methods akin to Cochrane reviews. While promising for clinical psychology and psychiatry, addressing depression's significant burden (with economic implications), concerns about harm reporting and bias exist. The precise neurotransmitter receptor influence on behavior is unclear. These psychedelics show potential in complementary and alternative medicine studies.
Abstract
Abstract Rationale Psilocybin is a potentially paradigm-shifting depression intervention. We conducted a systematic review and meta-analysis of psi...
Opioid-free anesthesia in bariatric surgery: a prospective randomized controlled trial.
European journal of medical research – April 23, 2025
Summary
Patients undergoing bariatric surgery experienced better pain control and needed less morphine when given opioid-free anesthesia compared to traditional methods. The approach combined several non-opioid medications to manage pain, reducing morphine use by more than 50%. Patients reported lower pain levels during rest and movement, with no increase in nausea or vomiting. They were also more satisfied with their care.
Abstract
Bariatric surgeries are increasingly used to manage obesity, presenting significant perioperative challenges, especially with opioid use. Opioid-Fr...
Editorial: Beyond psilocybin: exploring the clinical potential of alternative and novel psychedelics.
Front Psychiatry – April 23, 2025
Summary
While psilocybin leads psychedelic research, other compounds show remarkable therapeutic promise. Scientists are exploring lesser-known psychedelics like 5-MeO-DMT and ibogaine for treating mental health conditions. Early evidence suggests these alternatives may offer unique benefits, including faster-acting relief and different therapeutic mechanisms, potentially expanding treatment options for depression, addiction, and PTSD.
Abstract
Editorial: Beyond psilocybin: exploring the clinical potential of alternative and novel psychedelics.
[Treatment with psychedelics : potential benefits in Parkinson's disease].
Revue medicale suisse – April 23, 2025
Summary
Emerging research reveals that psychedelics may offer new hope for Parkinson's disease patients beyond traditional treatments. These compounds show potential in addressing both motor and non-motor symptoms while possibly protecting brain cells. They stimulate new neural connections, boost protective brain chemicals, and reduce inflammation. Early evidence suggests they could help manage depression and anxiety common in Parkinson's, while their brain-enhancing properties may slow disease progression.
Abstract
Psychedelics, such as psilocybin and lysergic acid diethylamide, modulate neuroplasticity and brain connectivity via 5-HT2A receptors. Their effica...
Racial Differences in Naturalistic Psychedelic Use - Motivations for Use, Communication with Health Care Providers, and Outcomes.
Journal of psychoactive drugs – April 22, 2025
Summary
A groundbreaking survey reveals that people of color are equally interested in psychedelic therapy as white individuals, challenging assumptions about trust barriers in healthcare. While analyzing responses from over 4,300 participants across different race groups, researchers found that people of color were just as motivated to use psychedelics with healthcare providers and reported similar positive outcomes. Though fewer accessed professional support, they disclosed use to doctors at equal rates and sought treatment for comparable issues.
Abstract
People of Color have been under-included in psychedelic-assisted therapy (PAT) research. Researchers have argued that systemic issues resulting in ...
Upper Respiratory Infections and Respiratory Adverse Events and Interventions in Emergency Department Sedation of Children.
Annals of emergency medicine – April 22, 2025
Summary
Children with colds and coughs can safely undergo emergency sedation procedures, according to extensive research across six pediatric emergency departments. The study tracked over 6,000 children receiving sedation for painful procedures, comparing those with and without upper respiratory infections. Results showed no increased risk of breathing problems or need for emergency interventions in children with colds, providing reassurance for pediatric sedation safety.
Abstract
Children with upper respiratory infections (URIs) have an increased risk of respiratory adverse events when undergoing operative anesthesia and in ...
Effectiveness of physical activity, mindfulness and mind-body therapies in improving mental health of university students: a systematic review of RCTS.
Journal of American college health : J of ACH – April 22, 2025
Summary
No Summary
Abstract
University students face mental health (MH) issues like anxiety, depression, and stress, highlighting the need for effective interventions to impro...
Race and Gender Differences in the Moderating Relationship of Psychedelics on Stigma and Distress
Psychedelic Medicine – April 22, 2025
Summary
Psychedelic use, including psilocybin and LSD, is linked to reduced psychological distress stemming from mental health stigma, according to an analysis of 458,372 individuals. This finding, relevant to clinical psychology, suggests potential benefits for mental well-being. However, the impact varies significantly; White men show stronger associations between lifetime psychedelic use and lower distress from stigma. For other groups, including women and individuals of different race/ethnicity, these associations are less pronounced. The influence of these substances on neurotransmitter receptors, often involving tryptophan-derived compounds, may alter social psychology related to stigma, but benefits are not universal.
Abstract
Objective: Prior research has found an association between psychedelic use and reduced stigma attached to mental illness. However, whether psychede...
Comprehensive analysis of 42 psilocybin-producing fungal strains reveals metabolite diversity and species-specific clusters.
Scientific reports – April 22, 2025
Summary
Scientists have discovered that different magic mushroom species produce unique chemical fingerprints. Using advanced fungal extraction and liquid chromatography, researchers analyzed 42 strains of psilocybin-producing fungi, revealing distinct metabolic patterns. Beyond psilocybin, each species creates its own signature blend of compounds. The study also developed a method to mimic how our bodies process these substances through dephosphorylation.
Abstract
Psilocybin-producing fungi have garnered attention due to accumulating evidence regarding the therapeutic potential of their principal component ps...
Chronic, combinatorial targeting of NMDARs and 5-HT4Rs exerts extended behavioral effects against stress-induced perseverative behavior and hyponeophagia.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology – April 22, 2025
Summary
Combining two FDA-approved drugs - ketamine and prucalopride - shows remarkable promise in reducing stress-related behaviors. When administered together chronically, these medications effectively decreased fear responses, behavioral despair, and anxiety-like behaviors in both male and female subjects. The treatment worked through both injection and nasal spray, offering potential new hope for treating various stress-induced mental health conditions.
Abstract
Serotonin (5-HT) receptors and N-methyl-D-aspartate receptors (NMDARs) have both been implicated in stress-induced psychiatric disorders. However, ...
Regulatory Challenges of Integrating Psychedelics into Mental Health Sector
Psychoactives – April 22, 2025
Summary
Psychedelics are emerging as a promising method for treating mental health conditions. Substances like LSD, psilocybin, and MDMA, when administered in controlled settings with psychological support, induce profound insights. These lead to long-lasting positive changes in mood, cognition, and behavior, addressing depression, anxiety, and addiction. This revolutionizes mental health treatment. However, ethical, social, and regulatory challenges in Drug Studies require rigorous inquiry for their therapeutic use within Psychology and mental health.
Abstract
Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite a history of stigmatization and r...
Nebulized ketamine for acute pain management in the Emergency Department: A systematic review and meta-analysis.
The American journal of emergency medicine – April 22, 2025
Summary
Inhaled ketamine shows promise as a safe alternative to traditional pain medications in emergency rooms. When delivered through nebulization, ketamine provides effective acute pain relief comparable to IV morphine, with similar safety profiles. This method offers emergency departments a valuable non-invasive option for managing severe pain, potentially transforming how we approach emergency pain treatment.
Abstract
Ketamine administered in sub-dissociative doses has been effective in managing a variety of painful conditions in the emergency department (ED) and...
Evaluating the effectiveness of psilocybin in alleviating distress among cancer patients: A systematic review.
Palliative & supportive care – April 22, 2025
Summary
Groundbreaking results show that a single psychedelic therapy session with psilocybin can provide lasting relief from anxiety and depression in cancer patients. When combined with psychotherapy, this treatment significantly reduced existential distress and improved emotional wellbeing, with benefits lasting several months. Multiple trials found minimal side effects.
Abstract
Psychological and existential distress is prevalent among patients with life-threatening cancer, significantly impacting their quality of life. Psi...
Drugs Used in "Chemsex"/Sexualized Drug Behaviour-Overview of the Related Clinical Psychopharmacological Issues.
Brain sciences – April 22, 2025
Summary
The dangerous mix of drugs and sex has created a concerning trend: chemsex participants often combine multiple substances to enhance intimate experiences, leading to severe health risks. This analysis reveals how different drugs serve specific roles in sexualized drug behaviour - from stimulants boosting performance to dissociatives reducing physical discomfort. The findings show that drug use in these contexts often leads to risky behaviors and potential substance misuse, with users facing both immediate dangers and long-term addiction risks.
Abstract
Background: "Chemsex" involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL),...
Cognitive flexibility of male rats is increased by augmented punishment in a reversal learning task but ketamine has no detectable long-term effects.
Psychopharmacology – April 22, 2025
Summary
Adding electric shocks to timeouts made rats better at adapting to changing situations, revealing new insights about cognitive flexibility. In this investigation of learning and behavior, researchers tested how rats performed when faced with rewards and punishments, comparing traditional timeout penalties to a combined timeout-shock approach. While the stronger punishment improved the rats' ability to adjust their behavior, the drug ketamine showed no lasting benefits in their learning performance.
Abstract
The probabilistic reversal learning task (PRL) is sometimes used in the context of major depressive disorder (MDD) to assess impairments in cogniti...
Probing the functional magnetic resonance imaging response to psilocybin in functional neurological disorder (PsiFUND): study protocol
Wellcome Open Research – April 22, 2025
Summary
A groundbreaking neuroscience protocol will investigate how psilocybin influences Functional Neurological Disorder (FND), a common cause of debilitating neurological symptoms. Using Functional magnetic resonance imaging (fMRI), a type of functional imaging, brain functional connectivity and response will be examined in 24 individuals receiving 25mg oral psilocybin. This medicine, a psychedelic, aims to probe FND mechanisms, including dissociation and motor agency, offering insights into psychosomatic disorders. Integrating psychology and drug studies, the research will assess safety and feasibility, advancing mental health and psychiatry knowledge.
Abstract
Background Functional neurological disorder (FND) is a common cause of neurological symptoms including seizures and movement disorders. It can be d...
Neuroscience: Special K gets an 'A'.
Current biology : CB – April 21, 2025
Summary
The antidepressant ketamine works by helping the brain maintain active coping strategies during stress. Scientists observed zebrafish behavior when facing challenges, finding that ketamine promotes persistence rather than passive responses. The drug strengthens key neural pathways, leading to lasting improvements in how the brain handles difficult situations - a breakthrough in understanding rapid-acting antidepressants.
Abstract
A hallmark of depression is a tendency to become passive when faced with overwhelming challenges. A recent study models this phenomenon in zebrafis...
Development of a PBPK model of psilocybin/psilocin from Psilocybe cubensis (magic mushroom) in mice, rats, and humans.
Scientific reports – April 21, 2025
Summary
Scientists have mapped how magic mushrooms' active compounds move through the body, revealing that psilocybin rapidly converts to psilocin - the substance responsible for psychedelic effects. This mathematical model tracks how Psilocybe cubensis compounds are processed across species, from mice to humans, showing precise distribution patterns in the brain and other organs. The findings help optimize therapeutic dosing strategies.
Abstract
Psilocybin is an active alkaloid found in magic mushrooms (Psilocybe cubensis). It is classified as a Class I Psychoactive Substance due to its psy...
High-flow oxygenation therapy for a sedated elderly frail patient with hiccups undergoing transcatheter aortic valve implantation.
JA clinical reports – April 21, 2025
Summary
High-flow nasal oxygenation therapy proved remarkably effective in managing hiccups and maintaining stable breathing during a delicate heart valve procedure. The technique helped an 82-year-old patient with severe heart issues undergo transcatheter aortic valve implantation under conscious sedation, preventing complications and unwanted body movements while ensuring proper oxygen levels throughout the procedure.
Abstract
Transcatheter aortic valve implantation (TAVI) can be performed under sedation, but body movements may lower the efficacy of the procedure and may ...
A scoping review of the effects of serotonergic psychedelics on attitudes towards death.
Psychopharmacology – April 21, 2025
Summary
Serotonergic psychedelics show remarkable potential in transforming how people view mortality. Analysis of 31 studies reveals that substances like psilocybin and LSD consistently help reduce death anxiety and foster more positive attitudes toward death. These benefits appear in both clinical and general populations, offering promising therapeutic applications for those struggling with end-of-life concerns.
Abstract
Emerging evidence suggests that psychedelic experiences have the potential to change attitudes towards death and reduce death anxiety. Improved att...
Peri-traumatic consumption of classic psychedelics is associated with lower anxiety and post-traumatic responses 3 weeks after exposure.
Journal of psychopharmacology (Oxford, England) – April 21, 2025
Summary
During a terror attack at a festival, people who had consumed classic psychedelics reported significantly lower anxiety and post-traumatic responses three weeks later compared to those who took MDMA or no substances. Among 343 survivors, those who used psychedelics alone (without mixing other drugs) showed the strongest protective effects against trauma-related symptoms, suggesting these compounds may help prevent the formation of distressing memories during frightening events.
Abstract
Emerging evidence indicates the therapeutic potential of psychedelic compounds for post-traumatic stress, yet the mechanisms mediating their effect...
The Phenomenology of Offline Perception: Multisensory Profiles of Voluntary Mental Imagery and Dream Imagery.
Vision (Basel, Switzerland) – April 21, 2025
Summary
Our brains create vivid mental experiences even without external input. Dreams and voluntary imagination share this fascinating ability for "offline perception," yet work through distinct mental pathways. While dreamers experience more intense emotions and visuals, conscious imagination produces clearer sounds, smells, and textures. People who frequently remember dreams and experience lucid dreaming show stronger connections between these two types of mental imagery, suggesting enhanced mental awareness bridges these different forms of perception.
Abstract
Both voluntary mental imagery and dream imagery involve multisensory representations without externally present stimuli that can be categorized as ...