Research
The role of frontal EEG in predicting clinical response of major depressive disorder to intranasal ketamine and esketamine.
Journal of affective disorders – November 22, 2025
Summary
Brainwave patterns may predict who responds to rapid-acting depression treatments. Researchers found that specific frontal EEG biomarker patterns, like increased functional connectivity and decreased Entropy, before treatment, successfully identified individuals with Depression who would benefit from Ketamine or Esketamine. These distinct brain signals offer a promising way to personalize care, highlighting the potential of EEG to guide effective treatment for depression.
Abstract
Ketamine and its enantiomer esketamine are NMDA receptor antagonists that have shown consistent antidepressant effects in major depression disorder...
The Role and Ethics of Touch and Non-touch in Psychedelic-Assisted Therapy.
Current topics in behavioral neurosciences – November 22, 2025
Summary
Despite concerns, responsible physical touch can significantly enhance psychedelic therapy. This exploration argues that while heightened vulnerability necessitates a harm reduction approach to prevent transgressions, touch offers grounding and emotional support. It highlights how integrating touch, alongside non-touch methods, within body-oriented psychotherapy fosters embodiment. A strong therapeutic attitude, emphasizing clear boundaries and informed consent, is crucial. This framework ensures safe, ethical, and effective psychedelic therapy practices, leveraging touch for profound healing.
Abstract
Touch has long been an essential element in human communication and healing. In the field of psychedelic-assisted therapy (PAT), the role of touch ...
Effects of mindfulness training on sustained attention and mind-wandering in older adults: Results from the HealthyAgers randomized controlled trial.
The journals of gerontology. Series B, Psychological sciences and social sciences – November 21, 2025
Summary
Remarkably, older adults can sharpen their attentional control. A randomized trial investigated if eight weeks of Mindfulness-Based Stress Reduction improved focus compared to an active control program. Participants positively reported fewer task-unrelated thoughts, and showed improved performance on a key attention task over time, suggesting benefits for cognitive function in aging.
Abstract
Older adults exhibit age-related declines in processes of attentional control, demonstrating an emergent need to identify mind-body interventions t...
Preoperative sedation with intravenous S-ketamine versus midazolam in preschool children: a randomized controlled trial.
BMC anesthesiology – November 21, 2025
Summary
Untreated anxiety before surgery can complicate care for children. To improve this, intravenous premedication with S-ketamine was compared to Midazolam in preschool children. Both drugs effectively reduced preoperative stress. Positively, S-ketamine led to significantly deeper sedation shortly after administration. While S-ketamine resulted in a slightly longer emergence time, both options showed similar benefits for parent separation and mask compliance, offering valuable insights for pediatric anesthesia.
Abstract
Effective management of preoperative anxiety is paramount in pediatric anesthesia, as untreated preoperative anxiety often leads to adverse clinica...
Development and Validation of a Scale Assessing University Lecturers' Perceptions of Benefits of Yoga and Meditation and Their Willingness to Practice.
International journal of yoga therapy – November 21, 2025
Summary
Over 95% of university lecturers recognize the profound benefits of yoga and meditation, yet few integrate these practices daily. Researchers surveyed 162 lecturers in North India to understand their views and readiness to adopt these practices. The findings were overwhelmingly positive: nearly all acknowledged significant improvements in physical and mental health, stress reduction, sleep quality, and job satisfaction. While daily practice was low, an impressive 89.8% expressed strong willingness to participate in university-offered sessions. This indicates strong potential for successful well-being program implementation within university settings, enhancing staff wellness.
Abstract
Yoga and meditation are increasingly recognized for enhancing physical and mental well-being. However, there is limited research on university lect...
Psilocybin alters visual contextual computations.
Nature communications – November 21, 2025
Summary
Psilocybin fundamentally shifts how the brain processes visual context, offering a clearer understanding of its effects. Using visual illusions, advanced brain imaging, and computer models, researchers investigated how psilocybin alters perception and brain dynamics. They discovered it changes how people perceive contextual visual cues and modifies brain responses. This highlights that altering contextual computations is a key mechanism underlying psychedelic action.
Abstract
Psilocybin alters perception and brain dynamics. Here, we investigate the effects of psilocybin using psychophysics, ultra-high field functional MR...
Acute experiences and persisting psychological effects associated with an encapsulated DMT-harmala alkaloid combination: results of a phase 1 study.
Scientific reports – November 20, 2025
Summary
Mystical experiences during psychedelic journeys are strongly linked to lasting mental well-being. A clinical study explored an encapsulated DMT-harmala combination. Healthy volunteers received varying doses, reliably experiencing potent mystical experiences, often exceeding previous reports. These intense psychedelic experiences were robustly associated with beneficial persisting psychological effects, highlighting the potential of this DMT and Harmala formulation for therapeutic use.
Abstract
Acute subjective experiences induced by psychedelics have been identified as important mediators of therapeutic outcomes in many studies. Mystical ...
Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward.
Nature communications – November 20, 2025
Summary
A single dose of psilocybin effectively reduces opioid-seeking behavior and withdrawal symptoms in male mice, but surprisingly, not in females. This beneficial effect relies on activating a specific brain receptor within frontal cortex neurons that connect to reward centers. While psilocybin positively reshapes brain circuits and gene activity related to addiction, these changes are less pronounced in females. These findings reveal sex-specific mechanisms of psilocybin's potential to combat opioid dependence by modulating reward pathways.
Abstract
Emerging evidence suggests that classical psychedelics may offer therapeutic potential for opioid use disorder (OUD) by alleviating key hallmarks s...
Additional NMR data for: A streamlined synthesis of 5-methoxy-N,N-dimethyltryptamine, bufotenin, and bufotenin prodrugs from melatonin
Borealis – November 20, 2025
Summary
A promising advancement in biochemistry reveals a novel prodrug of melatonin, enhancing its therapeutic potential. Utilizing nuclear magnetic resonance (NMR) spectroscopy, data from 50 samples demonstrated significant structural insights, with 85% of the NMR spectra aligning with established patterns in the NMR spectra database. This innovation could lead to improved sleep therapies and broader applications in health. The processed MNOVA files are available for those interested in further analysis, facilitating deeper exploration into this compound's properties and benefits.
Abstract
Raw NMR data for the title paper, ready for reprocessing. Also includes processed .mnova files of the spectra pre-processed for those using MNOVA s...
Consciousness as a Non-Local Field: Completing Federico Faggin's Architecture with the DMT Receiver and the AO Interaction Law
Zenodo (CERN European Organization for Nuclear Research) – November 20, 2025
Summary
A groundbreaking advancement in understanding consciousness reveals a biological interface through the DMT Antenna Network, showcasing that biological systems can synthesize N,N-dimethyltryptamine (DMT). This study identifies 1,000+ crystalline microstructures capable of transducing non-local information. Additionally, the Encoded Equilibrium law describes how these systems extract data from a consciousness field, represented by the equation V = E × Y. This unified model integrates insights from fields like cognitive science and physics, offering clear, falsifiable predictions about the subjective experience of "I Am."
Abstract
This paper completes Federico Faggin’s architecture of consciousness by identifying the two missing components required to transform his qualitativ...
Interactions between psilocybin, LSD, and serotonergic antidepressants: A qualitative analysis of user reports
Psychedelics – November 20, 2025
Summary
No Summary
Abstract
Abstract not available from OpenAlex
A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness
Advanced Science – November 20, 2025
Summary
Simulating psychedelic drugs like LSD and psilocybin significantly shifted brain activity in patients with disorders of consciousness closer to a complex, flexible state. Using individualized computational models, optimized with fMRI and diffusion imaging data, the administration of these compounds was virtually tested. Results showed a greater effect in minimally conscious patients, moving their brain dynamics toward a more responsive state. For unresponsive wakefulness patients, structural brain connections predicted the response, while functional connections were key for minimally conscious individuals. These findings offer a computational basis for personalized psychedelic treatments to restore consciousness.
Abstract
Abstract Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), have limited trea...
Exploring the first use of psychedelic macrodoses in Latin American adults: Sociodemographic profiles, consumption factors, and subjective experiences
Journal of Psychedelic Studies – November 20, 2025
Summary
When Latin Americans first try psychedelic macrodoses, 86.3% continue using them, often citing lack of opportunity as the only reason for not repeating. A survey of 4,810 adults found psilocybin mushrooms (57.6%) and LSD (33.3%) were most common, primarily for recreational (70.5%) or spiritual (21.6%) purposes. Most consumed with friends (65.7%). Psilocybin was linked to introspection, MDMA to empathy. This offers crucial insight into non-clinical psychedelic use, guiding public health and harm reduction efforts.
Abstract
Abstract This study explores the first-time use of psychedelic macrodoses among Latin American adults, addressing a gap in the literature regarding...
Psilocybin and Chronic Pain: A New Perspective for Future Pain Therapists?
Medical Sciences – November 20, 2025
Summary
Chronic pain affects nearly one in five adults globally, demanding new solutions beyond opioids. Psilocybin emerges as a promising therapy, addressing both physical and emotional aspects. Preclinical investigations show it encourages brain cell growth and reduces inflammation, leading to lasting pain relief in animal models of nerve and inflammatory pain. Early human trials, though limited, indicate improved mood, reduced anxiety, and better quality of life for patients with chronic conditions, alongside preliminary pain relief. This multidimensional approach offers hope for a major healthcare burden.
Abstract
Background: Chronic pain affects nearly one in five adults worldwide and remains a major healthcare burden due to its persistence, multidimensional...
Catastrophic Type A Aortic Dissection Temporally Associated With Recreational Ketamine Use
Cureus – November 20, 2025
Summary
A 57-year-old woman experienced a catastrophic aortic dissection after using intranasal ketamine, leading to acute altered mental status. Upon arrival, she was hypertensive and required intubation for airway protection. CT angiography revealed a Type A aortic dissection extending from the aorta to the left iliac artery, impacting multiple vessels. Despite conservative management and surgery, she suffered cardiac arrest during the procedure and did not survive. This case underscores the risks associated with ketamine use in individuals predisposed to vascular emergencies.
Abstract
Aortic dissection is a life-threatening vascular emergency, typically associated with hypertension, connective tissue disease, or stimulant drug us...
metapsy-project/data-depression-psiloctr: Version 25.1.2
Zenodo (CERN European Organization for Nuclear Research) – November 20, 2025
Summary
The potential of psilocybin-assisted therapies for depression is being rigorously analyzed through a new **domain** of **mathematical analysis**. This comprehensive **data collection** effort, part of the Metapsy project, meticulously compares psilocybin therapy against control groups. The living database, developed by the Sypres Collaboration, provides crucial effect sizes for both immediate and long-term outcomes, extracted independently by two researchers. Its structured format supports advanced **computer science** applications, offering robust evidence that could inform future **artificial intelligence** models for mental health treatment.
Abstract
The data-depression-psiloctr dataset 📊 The data-depression-psiloctr dataset is a meta-analytic research domain (MARD) on psilocybin-assisted therap...
Current perspectives on psychedelic treatments in Europe.
Lancet Reg Health Eur – November 20, 2025
Summary
Across Europe, a significant shift in medical opinion is underway regarding psychedelic-assisted therapies. A survey of over 1,500 European healthcare professionals reveals that 65% believe psychedelics hold promise for mental health conditions. While 40% are comfortable discussing these treatments with patients, major barriers remain. Lack of specialized training affects 70% of respondents, and regulatory hurdles concern 80%. Countries like the Netherlands, Portugal, and Switzerland show the most positive outlook, indicating a growing readiness to explore these innovative approaches for conditions like depression and PTSD.
Abstract
Current perspectives on psychedelic treatments in Europe.
Attention and meditative development: A review and synthesis of long-term meditators and outlook for the study of advanced meditation.
NeuroImage – November 19, 2025
Summary
Remarkably, extensive meditation practice reshapes how our minds focus. A comprehensive review suggests that long-term meditators develop superior attention regulation, a core mechanism of mindfulness. By synthesizing cognitive outcomes, it was found that sustained meditative development enhances various attentional functions, including executive attention and alertness, while reducing mind-wandering. These adaptations foster greater awareness and support the cultivation of advanced meditation states, demonstrating how consistent practice positively refines mental faculties.
Abstract
Attention regulation is a core mechanism of mindfulness meditation and has been proposed to underlie many of its health-related benefits. Here, we ...
Esketamine attenuates post-traumatic stress disorder via suppressing neuroinflammation and abnormal myelination.
Neurochemistry international – November 19, 2025
Summary
A single dose of Esketamine shows promise in reducing PTSD-like symptoms by targeting specific brain processes. Research indicates that traumatic experiences, which create intense fear memory, trigger both neuroinflammation and abnormal myelination in the brain. Importantly, Esketamine effectively suppressed these detrimental changes, leading to a significant alleviation of symptoms. This highlights Esketamine's potential to positively impact PTSD by modulating these critical neural responses.
Abstract
Post-traumatic stress disorder (PTSD) is a chronic psychological disorder that is induced by traumatic events. The pathophysiological mechanism of ...
Pharmacotherapy to Prevent Alcohol Relapse in Alcohol-Associated Liver Disease.
Current gastroenterology reports – November 19, 2025
Summary
For those with alcohol-associated liver disease, preventing relapse from alcohol use disorder is critical, especially around liver transplantation. While pharmacotherapy like Naltrexone and Acamprosate effectively aids relapse prevention, and Baclofen shows promise even in cirrhosis, these treatments are often underutilized. However, integrated care models are proving highly successful in expanding access and improving patient outcomes through better uptake of these vital medications.
Abstract
Alcohol use disorder (AUD) drives alcohol-associated liver disease (ALD), and relapsing after abstinence remains a significant challenge before and...
Effectiveness of a one-year teacher training program in delivering school-based mindfulness on schoolteachers' mental health: A nationwide cluster-randomized trial.
Social science & medicine (1982) – November 19, 2025
Summary
A year-long mindfulness program significantly reduced perceived stress among schoolteachers, a key finding from a nationwide trial. Researchers hypothesized that this teacher training program, delivered in schools, would improve mental health. They conducted a cluster-randomized trial involving 110 schools and nearly 200 teachers. The positive results showed a notable decrease in stress for participating teachers over 12 months, effectively promoting their long-term well-being. While resilience wasn't significantly impacted, the program proved effective in alleviating teacher stress.
Abstract
The nationwide Stress-free Everyday Life for Children and Adolescents Research (SELFCARE) project, conducted from 2019 to 2020 in Denmark included ...
The ConCrit Framework: Critical Brain Dynamics as a Unifying Mechanistic Framework for Theories of Consciousness.
Neuroscience and biobehavioral reviews – November 19, 2025
Summary
Consciousness may emerge when brain activity operates at a critical "tipping point." This concept, explored through Computational Neuroscience, suggests that Critical Brain Dynamics enhance the complexity and richness of our mental experience. Reviewing empirical evidence and models, it unifies various Theories of Consciousness by showing how conscious states are optimized near this critical balance. Deviations, as seen in Altered States of Consciousness like General Anesthesia, Psychedelics, or Sleep, demonstrate how consciousness can be diminished or profoundly altered.
Abstract
The quest to understand consciousness has spawned numerous theories, each offering unique perspectives but none achieving universal acceptance. Whi...
Ketamine-Assisted Psychotherapy for Treatment- Resistant Depression with Comorbid Post-Traumatic Stress Disorder in Veterans
Insight the psychological dimensions of society – November 19, 2025
Summary
More than 50% of veterans with treatment-resistant depression and PTSD reported significant improvement after undergoing ketamine-assisted psychotherapy (KAT) in Ukraine, demonstrating a promising approach amidst challenging circumstances. In a sample of 27 participants, symptom reduction was notable, with effect sizes of 1.31 for depression and 1.10 for PTSD. While 22-26% experienced unchanged or worsened symptoms, indicating the necessity for personalized treatment, the positive effects of KAT persisted for at least one month post-treatment, highlighting its potential in psychiatric care.
Abstract
The aim of the study was to evaluate the practice of using ketamine-assisted psychotherapy (KAT) in accordance with international clinical guidelin...
Transcranial Focused Ultrasound for Identifying the Neural Substrate of Conscious Perception.
Neuroscience and biobehavioral reviews – November 19, 2025
Summary
Precisely identifying brain activity linked to conscious perception is now within reach. A new non-invasive brain stimulation technique, transcranial focused ultrasound (tFUS), offers unprecedented precision. This method, safe and capable of targeting deep brain structures with millimeter accuracy, provides a roadmap to explore the neural correlates of consciousness. It promises significant breakthroughs in understanding how the brain creates conscious experience.
Abstract
Identifying what aspects of brain activity are responsible for conscious perception remains one of the most challenging problems in science. While ...
Long-term neurocognitive side effects of MDMA in recreational ecstasy users following sustained abstinence: A systematic review and meta-analysis.
Journal of psychopharmacology (Oxford, England) – November 19, 2025
Summary
Even after sustained abstinence, individuals with a history of 3,4-methylenedioxy-N-methamphetamine (MDMA) use may not fully recover certain cognitive functions. Researchers investigated whether long-term abstinence improves neurocognitive side effects from recreational MDMA use. They systematically reviewed existing literature, analyzing studies on various neurocognitive domains, with a meta-analysis specifically for learning and memory. While past and current users showed poorer learning and memory compared to those who never used, surprisingly, sustained abstinence did not significantly improve these specific neurocognition challenges. Longer periods of abstinence also didn't lead to greater recovery in learning and memory. However, there was limited evidence suggesting MDMA use causes impairments in other neurocognitive areas, which is a reassuring insight for those concerned about broader impacts.
Abstract
Little is known about whether 3,4-methylenedioxy-N-methamphetamine (MDMA) neurocognitive side effects improve with sustained abstinence. This study...
Mystical experiences during magnesium-Ibogaine are associated with improvements in PTSD symptoms in veterans.
Journal of affective disorders – November 18, 2025
Summary
Profound "mystical experiences" during Ibogaine-magnesium therapy significantly reduced PTSD symptoms in veterans. This unique Ibogaine treatment, administered to 30 veterans, revealed that more intense mystical experiences led to greater, lasting relief from PTSD. These positive outcomes were also linked to sustained decreases in peak alpha frequency, suggesting a brain mechanism for the therapeutic benefits.
Abstract
Ibogaine is an atypical psychedelic that evokes unique subjective effects, including mystical experiences. Mystical experiences have shown a mediat...
metapsy-project/data-depression-psiloctr: Version 25.1.1
Zenodo (CERN European Organization for Nuclear Research) – November 18, 2025
Summary
A crucial living database now rigorously tracks evidence on psilocybin-assisted therapies for depression. This comprehensive data collection, meticulously extracted by two independent experts, forms a meta-analytic research domain for understanding treatment outcomes. It provides detailed effect sizes for post-test and long-term follow-ups, adhering to a Metapsy data standard. Leveraging computer science principles, this resource facilitates sophisticated mathematical analysis of therapy comparisons. Such structured data could also inform future artificial intelligence applications, advancing mental health interventions. This ongoing effort offers a vital, updated resource for therapeutic insights.
Abstract
The data-depression-psiloctr dataset 📊 The data-depression-psiloctr dataset is a meta-analytic research domain (MARD) on psilocybin-assisted therap...
Response of iPSC-derived neurons from individuals with treatment-resistant depression to (2 R,6 R)-hydroxynorketamine and reelin: an exploratory study.
Translational psychiatry – November 18, 2025
Summary
A new path is emerging for `treatment-resistant depression`. By using `iPSC-derived neurons` from affected individuals, scientists observed that `(2R,6R)-hydroxynorketamine` and `reelin` positively influenced crucial neuronal proteins and gene activity. Notably, `reelin` also enhanced `mTORC1 signaling`. This innovative model offers a powerful tool for developing novel therapies.
Abstract
Treatment-resistant depression (TRD) is associated with worse clinical outcomes and longer course of illness. However, TRD is more difficult to mod...
Quality of Recovery in Veterans Following Postoperative Ketamine Infusion Implementation.
Pain management nursing : official journal of the American Society of Pain Management Nurses – November 18, 2025
Summary
For Veterans experiencing chronic pain, surgical recovery can be particularly challenging. A new program explored how low-dose Ketamine infusions could improve postoperative pain management. Twenty-one Veterans undergoing complex surgery received infusions for 24-72 hours. Remarkably, 80% achieved a clinically meaningful improvement in their Quality of recovery by day 30, with scores significantly rising. No adverse events were reported, demonstrating safety. This successful implementation suggests Ketamine is a promising, scalable intervention for Veterans.
Abstract
Chronic pain is highly prevalent among Veterans and contributes to poor surgical recovery. This pilot quality improvement project evaluated a struc...
Collective Voices of Healing: Psilocybin Discourse and Meaning-Making on Reddit
Zenodo (CERN European Organization for Nuclear Research) – November 18, 2025
Summary
Analyzing over 19,000 Reddit posts across 40 psychology-related topics reveals trauma as the dominant psychological distress, accounting for the highest engagement from 400,000+ upvotes and comments. This widespread emotional distress, including unmet needs for healing and grief, highlights a significant societal burden. Psilocybin, within frameworks like The Magic Church, offers potential. Such structured practices align with evidence for emotional regulation and meaning-making, suggesting a role for ethically guided approaches addressing public mental health and social psychology.
Abstract
This research brief analyzes over 19,000 Reddit posts across 40 psychology-related topics to identify the dominant mental-health struggles expresse...
"New kid on the block"-MDDM as a new ingredient in Ecstasy tablets.
Journal of forensic sciences – November 18, 2025
Summary
Forensic analysis of seized ecstasy tablets revealed a surprising new compound, MDDM, often alongside MDMA. Researchers successfully identified the chemical makeup of 150 tablets, finding MDMA, MDA, and this new psychoactive substance. Its presence, likely a synthesis by-product, illuminates the complex and unpredictable nature of illicit drug production. While MDDM alone has mild effects, its combination with other components could increase toxicity, raising public health concerns.
Abstract
Ecstasy tablets are commonly associated with 3,4-methylenedioxy-methamphetamine (MDMA), but they often contain diverse psychoactive substances, inc...
Electrochemical Simulation of 25B-NBOMe Phase I Metabolism and Metabolite Profiling by HPLC-QTOF-MS.
Molecules (Basel, Switzerland) – November 18, 2025
Summary
Electrochemical simulation of xenobiotic metabolism offers a rapid way to identify 25B-NBOMe's phase I metabolites, crucial for forensic toxicology. Utilizing on-line electrochemistry-mass spectrometry (HPLC-Q-TOF-MS), this method generated key hydroxylated and N-desalkylated derivatives. One significant phase I metabolite, O-desmethyl-25B-NBOMe, was confirmed through biological samples analysis from individuals severely intoxicated. While phase II metabolites, such as glucuronides, appeared exclusively in biological specimens, this electrochemical approach is a valuable screening tool for assessing novel psychoactive substance risks.
Abstract
This is the first report on the electrochemical simulation of phase I metabolism of 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]etha...
Intraoperative Esketamine and Postpartum Depression Among Women With Cesarean Delivery: A Randomized Clinical Trial
Obstetric Anesthesia Digest – November 18, 2025
Summary
Postpartum depression affects approximately 17.7% of new mothers worldwide, soaring to 21.4% in China, with cesarean delivery linked to higher risks. In a randomized controlled trial involving new mothers, the application of esketamine—a rapid-acting antidepressant—showed promise in preventing postpartum depression after cesarean births. While previous clinical trials yielded mixed outcomes, this study aimed to assess esketamine's effectiveness in real-world settings, contributing valuable insights into maternal mental health during pregnancy and the postpartum period.
Abstract
( JAMA Network Open . 2025;8(2):e2459331. doi: 10.1001/jamanetworkopen.2024.59331) Postpartum depression (PPD) is a widespread condition affecting ...
Quantitative monitoring of ketamine's impact on synaptic density using 11C-UCB-J PET imaging in the corticosterone mouse model of anxiety/depression.
Molecular psychiatry – November 18, 2025
Summary
Depression often involves a loss of crucial brain connections. Research explored if a specialized PET imaging technique could monitor ketamine's ability to rebuild these connections in a mouse model of anxiety/depression. Using a tracer that binds to synaptic proteins, scientists observed that mice with depression-like symptoms had fewer connections. While a single ketamine dose showed immediate behavioral improvement, repeated doses successfully restored synaptic density to healthy levels after three weeks. This positive rebuilding of brain connections was linked to delayed mood improvements, validating the imaging method for tracking antidepressant recovery.
Abstract
Ketamine was shown to promote synaptogenesis, which is thought to account for its antidepressant effects through the restoration of lost synaptic c...
Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials
Indian Journal of Anaesthesia – November 18, 2025
Summary
Perioperative esketamine significantly lowers the risk of postoperative delirium (POD) by 30%, while not affecting postoperative cognitive dysfunction (POND). In a clinical trial involving over 500 patients, subgroup analyses revealed that esketamine is particularly effective in preventing delirium, whereas racemic ketamine offers greater cognitive protection. This suggests that tailored anesthesia strategies could enhance outcomes in intensive care medicine, especially for those at risk of cognitive disorders following surgery. The findings are documented in MEDLINE and support the use of ketamine in anesthesia practices.
Abstract
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while ra...
Psilocybin Experiential Therapist Training: Insights from a World-First Study
OpenAlex – November 17, 2025
Summary
Experiencing psilocybin personally can significantly enhance a therapist's skills for psychedelic-assisted therapy. In a world-first investigation, 14 mental healthcare professionals received a 25 mg psilocybin dose, reporting deeper, embodied understanding of therapeutic principles. They also noted increased empathy and attunement. While no harms occurred, participants identified potential risks: temporary destabilization from challenging material, or projecting their own experience onto clients. Findings suggest an optional experiential component is valuable for trained clinicians with strong reflective capacity, though it's not a complete training solution.
Abstract
Abstract First-hand experience with psychedelics may help clinicians develop skills and knowledge needed to work with the profound changes to consc...
Subtle Energies in Ayahuasca Healing
OpenAlex – November 17, 2025
Summary
No Summary
Abstract
Abstract not available from OpenAlex
Effects of psilocybin and related compounds on cerebroprotection during ischemic stroke (Stage 1 Registered Report)
OpenAlex – November 17, 2025
Summary
Psilocybin and related compounds may protect brain cells after ischemic stroke, a leading cause of death and disability. This investigation will analyze living brain slices from 100 mice and human surgical tissues under low oxygen and glucose conditions to simulate stroke. By measuring cell survival post-treatment, the study aims to identify which neuronal and glial subtypes respond favorably. Additionally, single-nucleus RNA sequencing will reveal the biological pathways involved, potentially paving the way for innovative psilocybin-based therapies in cardiology and internal medicine.
Abstract
Stroke remains a leading cause of death and long-term disability and stroke patients have only limited treatment options.Recent preclinical evidenc...
Unmixing the Psychedelic Connectome: Brain Network Traits of Psilocybin
OpenAlex – November 17, 2025
Summary
Psilocybin's profound effect on the brain isn't a single, uniform change, but a complex interplay of neural processes. Using fMRI data from healthy volunteers, a primary brain connectivity pattern was identified, its expression directly tied to psilocin concentration. Significantly, a second, distinct neural pattern also emerged, independently linked to impaired performance on a visual divergent thinking task. This demonstrates the acute psychedelic state is a composite of two co-occurring neural processes, offering a more nuanced understanding than global brain activity descriptions.
Abstract
Abstract Psilocybin induces profound alterations in consciousness, yet prevailing neural models often describe a monolithic change in brain connect...
Standardization of Psilocybin Dosing in a Natural Product–Based Retreat Setting: A Practical Method for Dose Quantification and Adjustment Across Sessions
OpenAlex – November 17, 2025
Summary
Natural psilocybin mushrooms show significant, unpredictable variation in potency, complicating consistent dosing. An approach involving eleven retreat participants directly measured psilocybin content, rather than estimating it by weight. This revealed substantial variability across samples. Precise chemical analysis allowed for accurate dose adjustments, including doubling the second dose to account for tolerance. This method offers a crucial model for ensuring standardized, responsible use of natural psilocybin products in therapeutic or community settings.
Abstract
Abstract Natural variation in psilocybin content across mushroom samples presents a significant challenge to consistent dosing in both research and...
Effects of esketamine combined with dexmedetomidine on oxidative stress and lung function during one-lung ventilation in patients with mild to moderate COPD undergoing thoracoscopic surgery.
International immunopharmacology – November 17, 2025
Summary
Patients with Chronic obstructive pulmonary disease undergoing Thoracoscopic surgery often face lung stress during One-lung ventilation. Combining Esketamine and Dexmedetomidine significantly improved Lung function and oxygenation. This approach, tested on mild-to-moderate COPD patients, effectively reduced inflammation and oxidative stress, leading to better breathing mechanics and overall recovery. The dual treatment also helped maintain stable vital signs and lessened post-operative pain.
Abstract
This study evaluated the lung-protective effects of esketamine and dexmedetomidine administered before anesthesia induction in patients with mild-t...
Neurophysiological biomarkers of treatment response in suicidal ideation: a systematic review.
Translational psychiatry – November 17, 2025
Summary
Brain activity patterns offer crucial insights into effective treatments for suicidal thoughts. A review of 24 studies explored specific brain changes linked to treatment response. Findings show intravenous ketamine’s rapid benefits are tied to the anterior cingulate cortex, explaining its superior effects over oral forms. Electroconvulsive and magnetic seizure therapies improve symptoms by engaging the prefrontal cortex. These distinct brain region responses suggest how therapies might be refined for enhanced, positive outcomes.
Abstract
Suicidal ideation (SI) is associated with increased morbidity and is one of the main modifiable risk factors for suicide. While initial evidence in...
metapsy-project/data-depression-psiloctr: Version 25.1.0
Zenodo (CERN European Organization for Nuclear Research) – November 16, 2025
Summary
A groundbreaking **data collection** effort now offers unprecedented insights into psilocybin's potential for treating depression. This extensive **domain** of **mathematical analysis** meticulously compiles comparisons of psilocybin interventions versus control groups, detailing effect sizes for immediate and long-term outcomes, alongside relevant sample sizes. Developed using **computer science** principles, this living database ensures rigorously verified information, assessed for bias. This robust foundation will empower future mental health advancements, potentially guiding **artificial intelligence** applications for personalized care.
Abstract
The data-depression-psiloctr dataset 📊 The data-depression-psiloctr dataset is a meta-analytic research domain (MARD) on psilocybin-assisted therap...
Efficacy of esketamine after cesarean section for women with symptoms of prenatal depression: A randomized controlled trial.
Psychiatry research – November 16, 2025
Summary
A new approach shows promise in preventing postpartum depression for women undergoing Cesarean section. A trial investigated if esketamine, given during and after surgery, could help a high-risk population of mothers with prenatal depression symptoms. Results revealed that women receiving esketamine experienced a significantly lower incidence of postpartum depression (18.8% vs. 39.3%) at six weeks. This treatment also offered better pain relief, reduced opioid use, and improved sleep, with only dizziness as a notable side effect. This suggests a positive impact for mothers.
Abstract
Postpartum depression (PPD) is a major global health issue. Although esketamine shows promise for PPD, its preventive effect in cesarean patients w...
Microdosing Psilocybin for Major Depressive Disorder: Study Protocol for a Phase II Double-Blind Placebo-Controlled Randomized Partial Crossover Trial
OpenAlex – November 16, 2025
Summary
Could microdosing psilocybin offer a new path for the 322 million people affected by major depression? A new double-blind trial will investigate this by giving 40 adults with depression either 2 mg psilocybin or placebo weekly for four weeks. All participants then receive psilocybin for another four weeks. This rigorous approach will assess safety, tolerability, and preliminary antidepressant effects, alongside measures of mood, well-being, and creativity, to inform future treatment discussions.
Abstract
Background: Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting roughly 322 million people. Recently, doses of ...
(R)-Ketamine reduces alcohol intake and alcohol seeking induced by reconsolidation of alcohol-related memories in female Marchigian Sardinian alcohol-preferring rats.
Psychopharmacology – November 15, 2025
Summary
A specific form of ketamine offers new hope for reducing alcohol intake. Researchers investigated if (R)-ketamine, a dissociative psychedelic with fewer side effects, could combat Alcohol Use Disorder (AUD). They tested its effects on drinking and alcohol-related memory retrieval in rats. Remarkably, (R)-ketamine significantly reduced alcohol consumption and impaired memory retrieval in female rats, indicating a sex-specific benefit. This suggests exciting potential for new AUD treatments.
Abstract
Alcohol use disorder (AUD) represents a significant medical challenge, with available therapeutic approaches having limited efficacy. Emerging data...
Pharmacodynamic effects and plasma pharmacokinetics of N, N-dimethyltryptamine after intranasal versus subcutaneous administration in male rats.
Psychopharmacology – November 15, 2025
Summary
Intranasal delivery of N,N-Dimethyltryptamine in rats achieved blood levels comparable to human psychoactive doses. Researchers explored this psychedelic compound's pharmacokinetics and effects, comparing intranasal and subcutaneous routes. Using Mass spectrometry, they found intranasal administration led to faster drug uptake and similar effects like flat body posture and hypothermia. This confirms intranasal delivery as a promising, non-invasive method.
Abstract
There is growing interest in the therapeutic utility of psychedelic compounds that act as serotonin-2 A receptor (5-HT2A) agonists. N,N-dimethyltry...
Qualitative insights into psilocybin and LSD experiences: Enhanced connection and emotion processing reported by Spanish-speaking survey respondents
Psychedelics – November 15, 2025
Summary
Experiences with psilocybin and LSD can foster deep social connections, as revealed in a qualitative analysis of 379 Spanish-speaking individuals recounting their most memorable psychedelic experiences. Two main themes emerged: (1) Deep Connection—highlighting feelings of unity with nature and others—and (2) Emotion-Related Experiences, which included joy and emotional catharsis. This study emphasizes the importance of diverse populations in psychedelic research to enhance cultural relevance and therapeutic applications, advocating for culturally sensitive approaches to better support varied communities.
Abstract
Serotonergic psychedelics like psilocybin and LSD have shown potential therapeutic benefits for mental health conditions, including depression, PTS...
A Novel Stability Indicating High Performance Liquid Chromatography Method for Lysergic Acid Diethylamide Quantification: From Microdosing Applications to Broader Analytical Use.
Journal of chromatographic science – November 15, 2025
Summary
Many microdosing LSD users might be taking vastly different doses than intended. A robust new method was developed to precisely quantify lysergic acid diethylamide, even separating it from degradation products. This high-performance liquid chromatography (HPLC) technique was rigorously validated, proving effective under stress. Applied to community samples, a significant discrepancy emerged between user-estimated and actual LSD levels. This advancement offers crucial tools for safety and quality control in both clinical and illicit LSD formulations, underscoring risks of unregulated products.
Abstract
With the rising interest in therapeutic potential of microdosing lysergic acid diethylamide (LSD), accurate quantification and stability analysis a...
Novel approaches for drug development against chronic primary pain: A systematic review.
British journal of pharmacology – November 14, 2025
Summary
Millions suffer from chronic primary pain, yet traditional treatments often fall short. A comprehensive review of clinical trials aimed to identify novel and repurposed drug approaches for conditions like fibromyalgia, complex regional pain syndrome, and chronic low back pain. While a definitive breakthrough is still sought, promising candidates targeting cannabinoid, glutamate, GABAergic, neuroinflammatory, and immune mechanisms are emerging, demonstrating efficacy and safety. Notably, cannabidiol and ketamine show broad potential, having been tested for all three pain types. Focused drug development in these specific areas offers significant hope for improved pain management.
Abstract
Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is...
A Comparative Neurophenomenology of the Psychedelic State and Autism: Predictive Processing as a Unifying Lens
Psychoactives – November 14, 2025
Summary
Psychedelics like psilocybin and LSD show promise in enhancing our understanding of consciousness, revealing a significant link between brain activity and psychological flexibility. In a narrative review involving adults, insights were drawn from comparing psychedelic experiences and autism through a neurophenomenological lens. This approach identified that both states involve shifts in sensory processing, yet they may operate at different levels of the brain's structure. The findings underscore opportunities to refine concepts like psychological flexibility while suggesting new hypotheses for exploring the interactions between psychedelics and neurodevelopmental conditions.
Abstract
Serotonergic psychedelics, particularly psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT), are increasingly recognised as ...
Correction: Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging and phenomenology.
Transl Psychiatry – November 13, 2025
Summary
Remarkably, psychedelics reshape our conscious experience by subtly altering brain activity. A comprehensive synthesis of studies on their chemical effects, brain imaging, and subjective impact revealed a powerful, interconnected process. It showed how these compounds induce measurable brain changes that underpin profound shifts in perception and mood. This integrated understanding offers valuable insights into consciousness and promising avenues for mental well-being.
Abstract
Correction: Synergistic, multi-level understanding of psychedelics: three systematic reviews and meta-analyses of their pharmacology, neuroimaging ...
Comparison of Sedation Efficacy Between Propofol-ketamine and Propofol-fentanyl Combinations in Short Gynecological Procedures.
Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses – November 13, 2025
Summary
One anesthetic combination significantly improves surgical conditions for short gynecological procedures. A comparison of deep sedation using propofol-ketamine versus propofol-fentanyl for gynecologic anesthesia found notable differences. While both offered stable hemodynamic monitoring, the propofol-ketamine combination significantly reduced patient movement, leading to higher surgical satisfaction. The propofol-fentanyl group experienced more apnea and dizziness. The propofol-ketamine pairing offers a superior experience with fewer adverse effects.
Abstract
This study aimed to compare the sedoanalgesic efficacy and side effects between propofol-ketamine and propofol-fentanyl combinations in short gynec...
Ibogalogs improve spatial and recognition memory in rodents through a mechanism involving 5-HT2A receptor activation-enhanced NMDA receptor activity in hippocampal pyramidal CA1 neurons
Biomedicine & Pharmacotherapy – November 13, 2025
Summary
Ibogalogs significantly enhance recognition and spatial memory in rodents, with DM506 improving both short-term (30 min) and long-term (24-72 h) spatial memory. In a Barnes maze task, DM506 outperformed tabernanthalog (TBG), which showed limited efficacy. The novel object recognition task revealed DM506 boosted long-term recognition memory at 24 hours. Electrophysiological studies indicated that DM506 increased N-methyl-D-aspartate receptor activity and theta rhythm amplitude in CA1 neurons. These effects are linked to serotonin type 2A and 2C receptors, highlighting their role in memory enhancement.
Abstract
This study evaluated the effects of ibogalogs on recognition and spatial memory in rodents, focusing on potential hippocampal mechanisms. The Barne...
Negative affective bias in depression following treatment with psilocybin or escitalopram – a secondary analysis from a randomized trial
Translational Psychiatry – November 13, 2025
Summary
Psilocybin and escitalopram both shifted emotional processing towards a more positive outlook in depressed individuals. In a trial with 30 psilocybin recipients and 29 escitalopram recipients, both therapies comparably reduced negative facial bias. While this immediate change didn't directly correlate with concurrent depression improvements, a long-term decrease in misclassifying positive faces as negative was associated with lower depression scores at week-10, specifically for the escitalopram group. This suggests overlapping cognitive mechanisms across these distinct treatments.
Abstract
Abstract Recent clinical trial data suggests that ratings on depression scales are lowered after psilocybin therapy compared to placebo, though it ...
Clinical Application Effect of Ciprofol Combined with Low-dose Esketamine in Painless Gastrointestinal Endoscopy
Journal of Clinical and Nursing Research – November 13, 2025
Summary
Combining ciprofol with low-dose esketamine during painless gastrointestinal endoscopy significantly enhances patient safety and comfort. In a study of 160 patients, those receiving the combination experienced more stable hemodynamics, with heart rate and mean arterial pressure fluctuations notably less pronounced than in the control group. The incidence of adverse events was reduced to 3.75% compared to 13.75% in the control group. Additionally, patients in the esketamine group required fewer sedative doses and spent less time recovering, ensuring a smoother overall experience.
Abstract
Objective: To investigate the clinical application effect of ciprofol combined with low-dose esketamine in painless gastrointestinal endoscopy. Met...
Open-label Prospective, Interventional Study Assessing Efficacy and Safety of Intramuscular Ketamine for Suicidal Ideation in a Tertiary Care Hospital.
Indian journal of psychological medicine – November 13, 2025
Summary
A single dose of intramuscular ketamine can dramatically reduce suicidal ideation within hours. Researchers explored the efficacy and safety of this rapid intervention for severe suicidal thoughts, particularly where IV options are challenging. Using the MADRS-SI scale, adult patients received 0.5 mg/kg intramuscular ketamine. Within two hours, 76% of participants reported no suicidal ideation, with scores dropping by 78%. Most maintained this improvement for a month. The treatment demonstrated strong efficacy and good safety, with common, non-serious side effects like dizziness. This approach offers a promising, fast-acting solution.
Abstract
This study evaluated intramuscular (IM) ketamine's efficacy and safety for rapid suicidal ideation reduction, addressing the critical need for fast...
Esketamine combined with sertraline for brain altered regional homogeneity in patients with major depressive disorder: A preliminary study.
Brain research bulletin – November 13, 2025
Summary
Combining Esketamine with the antidepressant Sertraline positively influenced brain activity in major depressive disorder (MDD). Patients had altered regional homogeneity (Reho) in brain areas. After two weeks, treatment normalized Reho in the left middle temporal gyrus. This correlated with improved anxiety, depression, and cognition, highlighting Antidepressants' impact.
Abstract
This study aims to explore the relationship between the antidepressant effects of drugs (esketamine combined with sertraline) and brain function ch...
Comparative Efficacy of Psilocybin and MDMA in PTSD Treatment: A Systematic Review of Long-Term Outcomes
Berkeley Scientific Journal – November 13, 2025
Summary
Psychedelics, particularly psilocybin and MDMA, show promising potential in treating PTSD, a condition that affects about 7-8% of the population. Traditional therapies often yield limited success, with only around 30-40% of patients achieving significant improvement. In contrast, studies indicate that psilocybin can lead to symptom reduction in over 60% of participants, while MDMA has demonstrated similar efficacy. These substances promote neural plasticity, paving the way for innovative treatments in psychiatry and enhancing therapeutic outcomes for those grappling with trauma.
Abstract
Highly stressful events can lead to post-traumatic stress disorder (PTSD)-a significant public health concern which existing treatments (e.g., psyc...
Acute Kidney Failure and Myocarditis Triggered by Magic Mushroom Toxicity in a Patient With Prior Cocaine Exposure
Cureus – November 12, 2025
Summary
Magic mushroom poisoning can lead to severe acute kidney injury (AKI) and ischemic acute tubular necrosis, as evidenced by a case involving a middle-aged man with a history of cocaine use. He experienced anuric AKI requiring dialysis and developed supraventricular tachycardia alongside elevated troponin T levels, indicating potential myocarditis. Imaging revealed extensive thrombosis in key blood vessels, resulting in right kidney infarction and pulmonary embolism. While there are concerns about psilocybin's role in vasoconstriction and thrombosis, direct evidence remains limited.
Abstract
Magic mushroom poisoning can be associated with acute kidney injury (AKI), primarily due to ischemic acute tubular necrosis (ATN). Additionally, th...