The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption.

A survey of 515 adults who use 5-MeO-DMT found that consumption is infrequent and associated with profound positive subjective effects, including perceived spiritual and personal growth. Motivations for use were primarily spiritual and recreational, and many respondents reported perceived benefits consistent with potential psychotherapeutic effects. The study provides initial epidemiological data on usage patterns and subjective experiences with this psychoactive tryptamine.

Study at a glance

Abstract

5-Methoxy- N,N-dimethyltryptamine (5-MeO-DMT) is a psychoactive compound found in several plants and in high concentrations in Bufo alvarius toad venom. Synthetic, toad, and plant-sourced 5-MeO-DMT are used for spiritual and recreational purposes and may have psychotherapeutic effects. However, the use of 5-MeO-DMT is not well understood. Therefore, we examined patterns of use, motivations for consumption, subjective effects, and potential benefits and consequences associated with 5-MeO-DMT use. Using internet-based advertisements, 515 respondents ( Mage=35.4. SD=11.7; male=79%; White/Caucasian=86%; United States resident=42%) completed a web-based survey. Most respondents consumed 5-MeO-DMT infrequently (