Ketamine induces multiple individually distinct whole-brain functional connectivity signatures
Flora Moujaes, Jie Lisa Ji, Masih Rahmati, Joshua Burt, Charles H. Schleifer, Brendan Adkinson, Aleksandar Savič, Nicole Santamauro, Zailyn Tamayo, Caroline Diehl, Antonija Kolobaric, Morgan Flynn, Nathalie M. Rieser, Clara Fonteneau, Terry Camarro, Junqian Xu, Youngsun T. Cho, Grega Repovš, Sarah K. Fineberg, Peter Morgan, Erich Seifritz, Franz X. Vollenweider, John Krystal, John D. Murray, Katrin H. Preller, Alan Anticevic
bioRxiv Preprint Server November 1, 2022 preprint DOI: 10.1101/2022.11.01.514692 via bioRxiv
Summary
AI-generated from the abstractKetamine is a promising therapy for treatment-resistant depression, but why some people respond better than others remains unclear. The molecular mechanisms of ketamine are not yet connected to its effects on brain activity and behavior.
Study at a glance
| Characteristics | Review |
|---|---|
| Topics | Ketamine |
| Keywords | Ketamine therapy Ketamine treatment Neuroscience Brain activity Neural networks |
| Citations | 4 |
| Key finding | Ketamine's molecular mechanisms are not well linked to its neural and behavioral effects, and inter-individual variability in response is poorly understood. |
Abstract
Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecular mechanisms connect to its neural and behavioral effects.