Is It Time to Advance the Chemoprevention of Environmental Carcinogenesis with Microdosing Trials?
Thomas W. Kensler, John D. Groopman
Cancer Prevention Research December 1, 2009 DOI: 10.1158/1940-6207.capr-09-0232
Summary
AI-generated from the abstractThis perspective discusses using microdosing with environmental carcinogens to speed up the evaluation and improvement of chemopreventive interventions. It considers the need for chemoprevention of environmental carcinogenesis, the structure of microdosing or phase 0 trials, the technologies required for such studies, and ethical concerns. It also reflects on what microdosing studies have taught so far.
Study at a glance
| Characteristics | Perspective Peer reviewed |
|---|---|
| Key finding | Microdosing with environmental carcinogens may accelerate the evaluation and optimization of chemopreventive interventions. |
Abstract
Abstract This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.