Chemical basis of hashish activity.
R Mechoulam, A Shani, H Edery, Y Grunfeld
Science (New York, N.Y.) August 7, 1970 DOI: 10.1126/science.169.3945.611 via PubMed
Summary
AI-generated from the abstractA sample of hashish was extracted with petroleum ether, benzene, and methanol. Only the petroleum-ether fraction showed activity when tested intravenously in monkeys. Further fractionation isolated Delta(1)-tetrahydrocannabinol as the only active compound. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol, when administered with Delta(1)-tetrahydrocannabinol, did not alter its activity under the experimental conditions. These results indicate that, aside from Delta(1)-tetrahydrocannabinol, no other major psychotomimetic compounds are present in hashish.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Monkeys |
| Interventions | Delta(1)-tetrahydrocannabinol cannabinol cannabidiol cannabichromene cannabigerol cannabicyclol |
| Key finding | Delta(1)-tetrahydrocannabinol is the only major psychotomimetically active compound in hashish. |
Abstract
A sample of hashish was extracted consecutively with petroleum ether, benzene, and methanol. When tested intravenously in monkeys only the petroleum-ether fraction was active. This material was further fractionated. The only active compound isolated was Delta(1)-tetrahydrocannabinol. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with Delta(1)-tetrahydrocannabinol do not cause a change in the activity of the latter, under the experimental conditions used. These results provide evidence that, except for Delta(1)-tetrahydrocannabinol, no other major, psychotomimetically active compounds are present in hashish.