The identification and determination of lysergic acid diethylamide in narcotic seizures
Journal of Pharmacy and Pharmacology April 1, 1964 DOI: 10.1111/j.2042-7158.1964.tb07452.x
Summary
AI-generated from the abstractThin layer chromatography with Ehrlich's reagent spray can identify and determine lysergic acid diethylamide (LSD) in mixtures containing heroin, other narcotics, and controlled drugs. When ergot alkaloids are present, confirmation requires additional thin layer chromatography after ultraviolet irradiation and acid hydrolysis. Spectrophotofluorometric analysis measures LSD with a standard error of ±2% even when heroin or other controlled drugs are present. If ergot alkaloids interfere, thin layer separation followed by elution and fluorometric analysis is recommended.
Study at a glance
| Characteristics | Method development Peer reviewed |
|---|---|
| Citations | 48 |
| Key finding | LSD can be identified and quantified in the presence of heroin and other controlled drugs using thin layer chromatography and spectrophotofluorometry, with confirmatory steps for ergot alkaloids. |
Abstract
Abstract Methods are described by which lysergic acid diethylamide (LSD) can be identified and determined in the presence of heroin, other narcotics and controlled drugs. Thin layer chromatography and an Ehrlich’s-reagent spray is applied to the LSD-containing material. For confirmation, thin layer chromatography after ultra-violet irradiation and acid hydrolysis should be carried out where ergot alkaloids are present. Spectrophotofluorometric analysis of LSD can be used in the presence of heroin, other narcotics and controlled drugs with a standard error of ±2%. If ergot alkaloids are present, thin layer separation, elution and subsequent fluorometric analysis are recommended.