Chromatographic and mass spectrometric methods for determination of lysergic acid diethylamide (LSD) and metabolites in body fluids
Chad C. Nelson, Rodger L. Foltz
Journal of Chromatography B Biomedical Sciences and Applications September 1, 1992 DOI: 10.1016/0378-4347(92)80530-4 via OpenAlex
Summary
AI-generated from the abstractMethods using gas and liquid chromatography combined with single- and multiple-stage mass spectrometry now allow accurate detection and measurement of LSD at concentrations below one nanogram per milliliter in body fluids, supporting efforts to identify use of the drug.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | LSD |
| Keywords | Chromatography Chemistry Detection limit |
| Citations | 46 |
| Key finding | Chromatographic and mass spectrometry methods can detect and quantify LSD at sub-nanogram/milliliter concentrations in body fluids. |
Abstract
Continued illicit use of the potent psychedelic drug lysergic acid diethylamide (LSD) has stimulated efforts to develop effective analytical methods for detection of the drug and its metabolites in body fluids from suspected LSD users. Recently reported methods based on gas and liquid chromatography, combined with single- and multiple-stage mass spectral analysis, now permit accurate detection and quantitation of LSD at sub-nanogram/milliliter concentrations.