Lysergic Acid Diethylamide: Effects on the Developing Mouse Lens
Science May 2, 1969 DOI: 10.1126/science.164.3879.574
Summary
AI-generated from the abstractA single high dose of LSD-25 given to pregnant mice on specific days of gestation caused frequent lens abnormalities in the offspring, including anterior subcapsular defects, overgrowth of lens epithelium, and a widened lens bow resembling radiation-induced cataracts. The effect was confirmed in a duplicate experiment one year later.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Swiss-Webster female mice |
| Intervention | LSD-25 |
| Dose | 5 × 10⁻⁶ gram |
| Citations | 28 |
| Key finding | High doses of LSD-25 administered on gestation days 6-9 caused a high incidence of anterior subcapsular lens abnormalities and related lens changes in mouse offspring. |
Abstract
High doses (5 × 10- 6 gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a (duplicate) experiment 1 year after the observations reported.