LSD in Mice: Abnormalities in Meiotic Chromosomes
Niels E. Skakkebæk, J. Philip, Ole J. Rafaelsen
Science June 14, 1968 DOI: 10.1126/science.160.3833.1246 via OpenAlex
Summary
AI-generated from the abstractIn mice injected with high doses of LSD-25, meiotic chromosomes showed several breaks, gaps, and unidentifiable fragments that were largely absent in control animals. Secondary constrictions were also more numerous in the treated mice. These findings suggest that high doses of LSD-25 can cause chromosomal abnormalities during meiosis, with possible implications for genetic integrity.
Study at a glance
| Characteristics | Controlled experiment Peer reviewed |
|---|---|
| Sample size | 12 |
| Population | Mice |
| Intervention | Lysergic acid diethylamide (LSD-25) |
| Dose | high doses |
| Topics | LSD |
| Keywords | Meiosis Biology Genetics |
| Citations | 62 |
| Key finding | High doses of LSD-25 induced chromosomal breaks, gaps, and fragments in meiotic chromosomes of treated mice compared to controls. |
Abstract
Meiotic chromosomes of six mice injected with high doses of lysergic acid diethylamide (LSD-25) and of six controls were studied. Several breaks, gaps, and unidentifiable fragments were found in the treated but, with a few exceptions, not in the control animals. Secondary constrictions were more numerous in the treated than in the untreated mice. Possible consequences are discussed.