Systematic Characterization of LSD metabolites in C. elegans by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry
Christiane Martins de Vasconcellos Silveira, Vanessa Farelo Dos Santos, Isis Moraes Ornelas, Beatriz de Sá Carrilho, Matheus Antonio Vieira de Castro Ventura, Henrique Marcelo Gualberto Pereira, Stevens Kastrup Rehen, Magno Junqueira
bioRxiv Preprint Server June 19, 2023 preprint DOI: 10.1101/2023.06.19.545563 via bioRxiv
Summary
AI-generated from the abstractLSD is metabolized into several compounds in the roundworm Caenorhabditis elegans, as shown by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. The identified metabolites reveal specific metabolic pathways and offer insights into LSD's pharmacokinetics. The work demonstrates that C. elegans is a suitable model for studying psychedelic compound metabolism, providing a foundation for further research on LSD's therapeutic potential.
Study at a glance
| Characteristics | Systematic characterization |
|---|---|
| Population | Caenorhabditis elegans |
| Intervention | LSD |
| Key finding | LSD is metabolized into multiple identifiable metabolites in C. elegans, revealing specific metabolic pathways and pharmacokinetic insights. |
Abstract
Psychedelic compounds have gained renewed interest for their potential therapeutic applications, but their metabolism and effects on complex biological systems remain poorly understood. Here, we present a systematic characterization of LSD metabolites in the model organism Caenorhabditis elegans using state-of-the-art analytical techniques. By employing ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), we identified and quantified a range of LSD metabolites, shedding light on their metabolic pathways and offering insights into their pharmacokinetics. Our study demonstrates the suitability of C. elegans as a valuable model system for investigating the metabolism of psychedelic compounds and provides a foundation for further research on the therapeutic potential of LSD. These findings contribute to the growing body of knowledge in the field and highlight the importance of advanced analytical methodologies in elucidating the effects of psychedelic substances on biological systems.