Systematic characterization of Lysergic Acid Diethylamide metabolites in Caenorhabditis elegans by ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry.
Christiane Martins de Vasconcellos Silveira, Vanessa Farelo Dos Santos, Isis Moraes Ornelas, Beatriz de Sá Carrilho, Matheus Antonio Vieira de Castro Ventura, Henrique Marcelo Gualberto Pereira, Stevens Kastrup Rehen, Magno Junqueira
Journal of chromatography. A October 11, 2023 DOI: 10.1016/j.chroma.2023.464362 via PubMed
Summary
AI-generated from the abstractLysergic Acid Diethylamide (LSD) is metabolized in the model organism Caenorhabditis elegans, producing a range of metabolites identified through ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry. The findings illuminate metabolic pathways and pharmacokinetics of LSD, demonstrating that C. elegans is a suitable system for studying psychedelic compound metabolism and supporting further research into therapeutic applications.
Study at a glance
| Characteristics | Systematic characterization Peer reviewed |
|---|---|
| Population | Caenorhabditis elegans |
| Intervention | Lysergic Acid Diethylamide (LSD) |
| Topics | LSD |
| Keywords | Uhplc-hrms/ms Psychedelics hallucinogens Psychedelic drugs Psychoactive substances |
| Citations | 3 |
| Key finding | A range of LSD metabolites were putatively identified in C. elegans, revealing metabolic pathways and pharmacokinetics. |
Abstract
Psychedelic compounds have gained renewed interest for their potential therapeutic applications, but their metabolism and effects on complex biological systems remain poorly understood. Here, we present a systematic characterization of Lysergic Acid Diethylamide (LSD) metabolites in the model organism Caenorhabditis elegans using state-of-the-art analytical techniques. By employing ultra-high performance liquid chromatography coupled with high-resolution tandem mass spectrometry, we putatively identified a range of LSD metabolites, shedding light on their metabolic pathways and offering insights into their pharmacokinetics. Our study demonstrates the suitability of Caenorhabditis elegans as a valuable model system for investigating the metabolism of psychedelic compounds and provides a foundation for further research on the therapeutic potential of LSD.