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These aren’t the beliefs you’re looking for: on the limits of affect-neutral accounts of psychedelic therapy

Celia R. Blaise

Synthese January 26, 2026 DOI: 10.1007/s11229-026-05443-x via OpenAlex

Summary

AI-generated from the abstract

A recurring finding in psychedelic-assisted therapy is that the subjective intensity and quality of the psychedelic experience contribute more to therapeutic outcomes than the administered dose. Many explanations appeal to what these experiences reveal or enable, such as acquiring mental representations, expanding awareness, or revising beliefs about the self and the world. This paper argues that even if psychedelics work by loosening beliefs or expanding awareness, this alone does not explain why resulting changes should be beneficial rather than neutral or harmful. Existing theories risk describing processes that could worsen distress as easily as alleviate it. The author argues that without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.

Study at a glance

Characteristics Theoretical or philosophical paper Peer reviewed
Keywords Philosophy of science Philosophy of language Distress Metaphysics Phenomenon
Key finding Without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.

Abstract

Abstract A recurring finding in psychedelic-assisted therapy is that the subjective intensity and quality of the psychedelic experience contribute more to therapeutic outcomes than the administered dose. To explain why such experiences are therapeutic, many have appealed to what these may reveal or enable, such as the types of mental representations that can be acquired, the expansion of what can enter awareness, or the revision of high-level beliefs about the self and the world. Across these proposals, some form of belief disruption is often assigned a causal role. In this paper, I argue that even if psychedelics do work by loosening beliefs or expanding awareness, this alone is not sufficient to explain why the resulting changes should be beneficial rather than neutral or harmful. By implicitly taking for granted the typically positive character of many psychedelic experiences, existing theories risk describing processes that could just as easily worsen distress as alleviate it, and so fail to reflect the literature’s predominantly positive outcomes. Ultimately, I argue that without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.

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