Effect of ketamine/esketamine on postoperative delirium and cognitive dysfunctions: A systematic review and meta-analysis of randomised trials
Qianqian Guo, Xiaoyong Wei, Zhenghua Dong, Tao Wang, 博之 吉留, Na Sun, Changsheng Li
Indian Journal of Anaesthesia November 18, 2025 DOI: 10.4103/ija.ija_770_25 via OpenAlex
Summary
AI-generated from the abstractPerioperative use of (es)ketamine significantly reduces the risk of postoperative delirium (POD) but does not prevent postoperative neurocognitive disorder (POND). Subgroup analyses indicate that esketamine is more effective for delirium prevention, whereas racemic ketamine provides better cognitive protection.
Study at a glance
| Characteristics | Meta-analysis Randomized Peer reviewed |
|---|---|
| Topics | Ketamine |
| Keywords | Delirium Perioperative Cognition Subgroup analysis |
| Key finding | Perioperative (es)ketamine significantly reduces POD risk but not POND, with esketamine excelling in delirium prevention and racemic ketamine showing better cognitive protection. |
Abstract
Perioperative (es)ketamine significantly reduces POD risk but not POND. Subgroup analyses reveal esketamine excels in delirium prevention, while racemic ketamine shows better cognitive protection.