Qualitative insights into psilocybin and LSD experiences: Enhanced connection and emotion processing reported by Spanish-speaking survey respondents
Meghan DellaCrosse, Shoval Gilead, Rafael Lancelotta, Ana María Ortiz Bernal, Christopher Timmermann, Alan K. Davis
Psychedelics November 15, 2025 DOI: 10.1016/j.psyche.2025.100004 via OpenAlex
Summary
AI-generated from the abstractSpanish-speaking individuals who had a memorable psilocybin or LSD experience reported two main themes: deep connection (to nature, others, the present moment, and the substance) and emotion-related experiences (from joy and peace to emotional processing, catharsis, and challenging experiences). The findings are based on a secondary qualitative analysis of open-ended survey responses from 379 Spanish-speaking participants. Similarities appeared across both substances, with some unique nuances. The work underscores the need for diverse populations in psychedelic research to improve generalizability and cultural relevance, and highlights the therapeutic potential of psychedelics while calling for culturally sensitive tools.
Study at a glance
| Characteristics | Secondary qualitative analysis Peer reviewed |
|---|---|
| Sample size | 379 |
| Population | Spanish-speaking individuals who reported a memorable psilocybin mushroom or LSD experience |
| Topics | Psilocybin |
| Keywords | Generalizability theory Thematic analysis Mental health Qualitative research |
| Key finding | Two primary themes were identified: Experiences of Deep Connection and Emotion-Related Experiences, with similarities across psilocybin and LSD but also unique nuances. |
Abstract
Serotonergic psychedelics like psilocybin and LSD have shown potential therapeutic benefits for mental health conditions, including depression, PTSD, and addiction. However, research remains limited due to regulatory barriers and a lack of diversity in study populations. Spanish-speaking individuals, despite their significant global and U.S. presence, are underrepresented in psychedelic research, leaving a gap in understanding their unique experiences and cultural contexts. This study is a secondary qualitative analysis of data from a survey of Spanish-speaking individuals (N=379) who reported a memorable psilocybin mushroom or LSD experience. Participants were recruited through online platforms and described their most memorable psychedelic experience in an open-ended response item. Reflexive thematic analysis was conducted on responses (N=379) to identify prominent experiential characteristics. Responses were verbatim translated from Spanish to English, with validation to ensure accuracy. Two primary themes were identified: (1) Experiences of Deep Connection, encompassing connectedness to nature, others, the present moment, and the substance itself; and (2) Emotion-Related Experiences, ranging from elevated positive states (e.g., joy, peace) to emotional processing, catharsis, and challenging experiences. While similarities were observed across both substances, unique nuances were noted. Findings highlight the importance of including diverse populations in psychedelic research to ensure generalizability and cultural relevance. The study underscores the therapeutic potential of psychedelics while emphasizing the need for culturally sensitive tools to support diverse communities. Future research should prioritize inclusivity and explore the intersection of cultural values and psychedelic experiences. Los psicodélicos serotoninérgicos como la psilocibina y el LSD han demostrado posibles beneficios terapéuticos para condiciones de salud mental, incluidas la depresión, el trastorno de estrés postraumático (TEPT) y la adicción. Sin embargo, la investigación sigue siendo limitada debido a barreras regulatorias y a la falta de diversidad en las poblaciones estudiadas. Las personas hispanohablantes, a pesar de su significativa presencia global y en los EE.UU., están subrepresentadas en la investigación psicodélica, lo que deja una brecha en la comprensión de sus experiencias y contextos culturales únicos. Este estudio es un análisis cualitativo secundario de datos obtenidos a partir de una encuesta dirigida a personas hispanohablantes (N=379) que reportaron una experiencia memorable con psilocibina o LSD. Los participantes fueron reclutados a través de plataformas en línea y respondieron a una pregunta abierta describiendo su experiencia psicodélica más memorable. Se realizó un análisis temático reflexivo de las respuestas (N=379) para identificar características experienciales destacadas. Las respuestas fueron traducidas de forma literal del español al inglés, con un proceso de validación para garantizar su precisión. Se identificaron dos temas principales: (1) Experiencias de Conexión Profunda, que incluyen la conexión con la naturaleza, otras personas, el momento presente y la propia sustancia; y (2) Experiencias Relacionadas con las Emociones, que abarcan desde estados positivos elevados (por ejemplo, alegría, paz) hasta el procesamiento emocional, la catarsis y experiencias desafiantes. Aunque se observaron similitudes entre ambas sustancias, también se identificaron matices distintivos. Los hallazgos resaltan la importancia de incluir poblaciones diversas en la investigación psicodélica para garantizar su generalización y relevancia cultural. El estudio subraya el potencial terapéutico de los psicodélicos, al mismo tiempo que enfatiza la necesidad de desarrollar herramientas culturalmente sensibles para apoyar a comunidades diversas. Las investigaciones futuras deberían priorizar la inclusión y explorar la intersección entre los valores culturales y las experiencias psicodélicas.