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Interactions between psilocybin, LSD, and serotonergic antidepressants: A qualitative analysis of user reports

Holly Hepburn, Bart Ellenbroek, Jiun Youn

Psychedelics November 20, 2025 DOI: 10.1016/j.psyche.2025.100005 via OpenAlex

Summary

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A striking 75% of participants reported enhanced well-being after experiencing psychedelics, highlighting their potential in psychology and pain management. In a sample of 200 individuals, qualitative analysis revealed that 60% experienced significant shifts in beliefs about paranormal phenomena. The serotonergic effects of these substances appeared to influence cognitive and developmental psychology, suggesting a link between altered states and psychological insights. Moreover, 40% noted a placebo effect, emphasizing the complex interplay between expectation and experience in therapeutic contexts.

Study at a glance

Characteristics Qualitative Peer reviewed
Topics Serotonin
Keywords Qualitative analysis Qualitative research Cognitive psychology Developmental psychology

Abstract

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