Mescaline elicits behavioral effects in cats by an action at both serotonin and dopamine receptors
Michael E. Trulson, Terriann Crisp, Leslie J. Henderson
European Journal of Pharmacology December 1, 1983 DOI: 10.1016/0014-2999(83)90544-7 via OpenAlex
Summary
AI-generated from the abstractPretreating cats with low doses of either a serotonin antagonist (methysergide) or a dopamine antagonist (haloperidol) nearly completely blocked the characteristic behavioral effects of mescaline. These blocking effects were specific: methysergide did not block apomorphine's effects, and haloperidol did not block 5-methoxy-N,N-dimethyltryptamine's effects. The findings indicate that mescaline's behavioral effects depend on simultaneous action at both serotonin and dopamine receptors.
Study at a glance
| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Cats |
| Interventions | mescaline methysergide haloperidol apomorphine 5-methoxy-N N-dimethyltryptamine |
| Topics | Mescaline Serotonin |
| Keywords | Methysergide Haloperidol Apomorphine Cats |
| Citations | 21 |
| Key finding | Mescaline's behavioral effects in cats require simultaneous action at both serotonin and dopamine receptors. |
Abstract
The characteristic behavioral effects of mescaline in cats were nearly completely blocked by pretreatment with low doses of either a specific serotonin antagonist (methysergide) or a dopamine specific antagonist (haloperidol). These blocking effects were not due to non-specific actions, since methysergide did not block the behavioral effects of apomorphine, and haloperidol did not block the behavioral effects of 5-methoxy-N,N-dimethyltryptamine. Thus, it appears that the behavioral effects of mescaline are dependent upon the simultaneous action of the drug at both serotonin and dopamine receptors.