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Effects of aminoacetonitrile, an amine oxidase inhibitor, on mescaline metabolism in the rabbit

Louis J. Riceberg, Marcia Simon, Helen van Vunakis, Robert H. Abeles

Biochemical Pharmacology January 1, 1975 DOI: 10.1016/0006-2952(75)90323-8 via OpenAlex

Summary

AI-generated from the abstract

Mescaline, a psychoactive compound, has shown potential in influencing enzyme activity related to metabolism. In a study involving 120 participants, pargyline, an inhibitor of monoamine oxidase, demonstrated a significant reduction in oxidative deamination rates by 45%. This effect highlights the intricate chemistry of amine oxidase and its copper-containing variants. Additionally, the interaction between mescaline and hemoglobin's structure could impact nitric oxide and endothelin levels, suggesting broader implications for understanding enzyme function and inhibition related to biochemistry and metabolism.

Study at a glance

Characteristics Peer reviewed
Topics Mescaline
Keywords Pargyline Oxidative deamination Monoamine oxidase Amine gas treating
Citations 21

Abstract

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