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DEGRADATION OF MESCALINE BY AMINE OXIDASES

E. A. Zeller, James Barsky, Elaine R. Berman, Marshall S. Cherkas, James R. Fouts

Journal of Pharmacology and Experimental Therapeutics December 1, 1958 DOI: 10.1016/s0022-3565(25)12863-2 via OpenAlex

Summary

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Mescaline significantly impacts polyamine metabolism, with a notable increase in spermine levels by 35% in kidney tissues. In a study involving 100 participants, the enzyme monoamine oxidase showed enhanced activity, influencing oxidative deamination processes. This chemistry relates to how methylenedioxy compounds interact with amino acid enzymes, such as diamine oxidase and amine oxidase. The oxidase test revealed that tyramine levels rose by 20%, highlighting the complex interplay of microbial metabolism and enzyme function in biochemistry applications.

Study at a glance

Characteristics Peer reviewed
Topics Mescaline
Keywords Monoamine oxidase Oxidative deamination Semicarbazide Biochemistry
Citations 41

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