Letter to the editor on "Increased low-frequency brain responses to music after psilocybin therapy for depression".
Journal of affective disorders October 1, 2023 DOI: 10.1016/j.jad.2023.05.088 via PubMed
Summary
AI-generated from the abstractA letter to the editor raises methodological concerns about a published study on psilocybin therapy for depression. The original study reported increased low-frequency brain responses to music after treatment, but the letter questions the ANOVA region-of-interest analysis, noting that potential confounds such as age and biological sex may have influenced the reported variance attributed to psilocybin treatment. The letter does not present new data but critiques the statistical approach and suggests the findings may be less robust than claimed.
Study at a glance
| Characteristics | Letter to the editor Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Magic mushroom treatment Brain imaging neuroimaging Brain scanning Neural monitoring |
| Key finding | Methodological concerns about the ANOVA ROI analysis in the original study raise questions about the impact of confounds like age and biological sex on the reported effects of psilocybin therapy. |
Abstract
The recent publication in the Journal of Affective Disorders titled "Increased low-frequency brain responses to music after psilocybin therapy for depression" identified significant region-of-interest based effects of treatment in the task scans. In this letter to the editor, I am hoping to raise methodological concerns with regards to the ANOVA ROI analysis that were otherwise not acknowledged in this study. These concerns raise questions as to the impact of confounds, including as age and biological sex, on the reported proportion variance explained by the effects of psilocybin treatment for depression.