Defining 5-MeO-DMT in Historical and Cultural Contexts

5-MeO-DMT, a psychedelic compound used for centuries by Indigenous Peoples in the Amazon, Caribbean, and Northern Mexico for ceremonial and nature-connected practices, is now being studied for treating depression, anxiety, and PTSD. This paper examines the limited historical writings and accounts of the compound's origins and original use, placing those accounts in their historical and cultural contexts.

Study at a glance

Abstract

5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychedelic and entheogenic compound that has been used for centuries by Indigenous Peoples in the Amazon, Caribbean, and more recently in communities in Northern Mexico in ceremonial practices and to connect with nature. In recent years, there has been growing interest in 5-MeO-DMT to treat mental health conditions such as depression, anxiety and post-traumatic stress disorder (PTSD). In response, there has been an increase in scientific research of the efficacy of 5-MeO-DMT in treating such conditions. Little is known about the compound's historical use; this paper will explore and examine the known writings about the origins and original use of 5-MeO-DMT. Additionally, this paper will present the limited data and accounts regarding the use of 5-MeO-DMT and the intersection of those accounts in historical and cultural contexts.