Trace Indoleamines in the Central Nervous System
D. L. Murphy, L. Tamarkin, N. A. Garrick, P. L. Taylor, S. P. Markey
Humana Press eBooks January 1, 1985 DOI: 10.1007/978-1-4612-5010-4_36 via OpenAlex
Summary
AI-generated from the abstractTryptamine is widely accepted as a trace amine in the brain, with several reviews covering its metabolism, regional localization, and possible neuroregulatory functions. Other endogenously synthesized indoleamines, such as melatonin, N-acetyl serotonin, 5-methoxytryptamine, and 6-methoxytryptoline, have received minimal attention in trace amine reviews. These substances were primarily regarded as pineal hormones with peripheral actions, but recent evidence suggests they may also act directly in the brain. Hallucinogenic tryptamines like N,N-dimethyltryptamine, 5-methoxy DMT, and N-methyl DMT have also been infrequently discussed in the trace amine literature.
Study at a glance
| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Serotonin |
| Keywords | Tryptamines Biogenic amine Trace psycholinguistics Hallucinogen |
| Citations | 3 |
| Key finding | Tryptamine is a recognized trace amine in the brain, and other indoleamines, including melatonin and hallucinogenic tryptamines, may also have direct brain actions. |
Abstract
Tryptamine has been widely accepted as a trace amine in brain, and several reviews of its metabolism, regional localization in brain, and possible neuroregulatory functions have been published (Jones, 1982; Juorio and Durden, 1984). Other endogenously synthesized indoleamines have received only minimal attention in several review monographs and symposium volumes devoted to the trace amines (Baldessarini and Fischer, 1978; Mosnaim and Wolf, 1978, 1980; Boulton et al., 1984). Among these indoleamines are melatonin, N-acetyl serotonin, 5-methoxytryptamine and 6-methoxytryptoline. While these latter substances have been regarded as principally pineal hormones with peripheral actions, recent evidence has suggested that they may also act directly in the brain. Other indoleamines which also have been infrequently discussed in the trace amine literature include the hallucinogenic tryptamines such as N, N dimethyltryptamine(DMT), 5-methoxy DMT and N-methyl DMT.