Interaction between narcotic antagonist (naloxone) and lysergic acid diethylamide (LSD) in the rat
Allen P. Fertziger, Roland Fischer
Psychopharmacology January 1, 1977 DOI: 10.1007/bf00426582 via OpenAlex
Summary
AI-generated from the abstractIn rats, lysergic acid diethylamide (LSD) produces a two-phase response: a brief period of excitement lasting up to 8 minutes, followed by a prolonged catalepsy lasting from 8 minutes to 1 hour. A single injection of naloxone given 30 minutes after LSD administration blocks the cataleptic phase. However, when naloxone is given before LSD, it shortens the excitable phase and makes the catalepsy stronger.
Study at a glance
| Characteristics | Observational study Peer reviewed |
|---|---|
| Population | Rats |
| Interventions | LSD naloxone |
| Topics | LSD Serotonin |
| Keywords | Catalepsy +-naloxone Pharmacology Endorphins |
| Citations | 12 |
| Key finding | LSD produces a diphasic reaction in rats—brief excitement followed by prolonged catalepsy—and naloxone has opposite effects depending on whether it is given before or after LSD. |
Abstract
LSD administration in rats elicited a diphasic reaction consisting of a brief excitable period ( up to 8 min) followed by a prolonged catalepsy (8 min-1 h). While the cataleptic response was antagonized by a single injection of naloxone (given 30 min after LSD administration), pretreatment with naloxone shortened the excitable phase and potentiated the catalepsy.